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Benign neoplasm of ciliary body

MedGen UID:
96927
•Concept ID:
C0496894
•
Neoplastic Process
Synonyms: Benign Ciliary Body Neoplasm; benign ciliary body neoplasm; Benign Ciliary Body Tumor; benign ciliary body tumor; benign ciliary body tumour; Benign Neoplasm of Ciliary Body; benign neoplasm of ciliary body; Benign Neoplasm of the Ciliary Body; benign neoplasm of the ciliary body; Benign tumor of ciliary body; Benign Tumor of Ciliary Body; benign tumor of ciliary body; Benign Tumor of the Ciliary Body; benign tumor of the ciliary body; benign tumour of ciliary body; benign tumour of the ciliary body; ciliary body benign neoplasm
SNOMED CT: Benign tumor of ciliary body (92060009); Benign neoplasm of ciliary body (92060009)
 
Monarch Initiative: MONDO:0021486

Definition

A neoplasm that arises from the ciliary body and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Diagnosis

Surgical Approach in Intraocular Tumors.
Gündüz AK, Mirzayev I
Turk J Ophthalmol 2022 Apr 28;52(2):125-138. doi: 10.4274/tjo.galenos.2021.24376. PMID: 35481734Free PMC Article
Clinicopathologic analysis of 32 ciliary body tumors.
Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
Diagnosis and long-term monitoring of adenomas of the ciliary body epithelium by ultrasound biomicroscopy.
Méndez-Martínez S, Santiago Varela M, Blanco-Teijeiro MJ, Piñeiro-Ces A
Eur J Ophthalmol 2021 Jul;31(4):2032-2041. Epub 2020 Aug 24 doi: 10.1177/1120672120952645. PMID: 32830591
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Ocular melanoma.
Grin-Jorgensen C, Berke A, Grin M
Dermatol Clin 1992 Oct;10(4):663-8. PMID: 1395150

Therapy

Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
Proton Therapy for 166 Patients with Iris Melanoma: Side Effects and Oncologic Outcomes.
Gollrad J, Böker A, Vitzthum S, Besserer A, Heufelder J, Gauger U, Böhmer D, Budach V, Zeitz O, Joussen AM
Ophthalmol Retina 2023 Mar;7(3):266-274. Epub 2022 Sep 8 doi: 10.1016/j.oret.2022.08.026. PMID: 36087876
Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article

Prognosis

DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
The lymphangiogenic and hemangiogenic privilege of the human sclera.
Atta G, Tempfer H, Kaser-Eichberger A, Guo Y, Schroedl F, Traweger A, Heindl LM
Ann Anat 2020 Jul;230:151485. Epub 2020 Feb 28 doi: 10.1016/j.aanat.2020.151485. PMID: 32120002
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.
Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma.
Messineo D, Barile G, Morrone S, La Torre G, Turchetti P, Accetta L, Trovato Battagliola E, Agostinelli E, Pacella F
Clin Ter 2020 Jan-Feb;170(1):e89-e98. doi: 10.7417/CT.2020.2195. PMID: 31916427
Glaucoma due to ciliary body cysts and pseudoplateau iris: a systematic review of the literature.
Schmalfuss TR, Picetti E, Pakter HM
Arq Bras Oftalmol 2018 Jun;81(3):254-261. doi: 10.5935/0004-2749.20180051. PMID: 29924202
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Uveal melanoma: trends in incidence, treatment, and survival.
Singh AD, Turell ME, Topham AK
Ophthalmology 2011 Sep;118(9):1881-5. Epub 2011 Jun 24 doi: 10.1016/j.ophtha.2011.01.040. PMID: 21704381

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