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Leiomyoma

MedGen UID:
9710
Concept ID:
C0023267
Neoplastic Process
Synonyms: Fibroid; Fibroid Tumor; Fibroid Tumors; Fibroids; Fibromyoma; Fibromyomas; Leiomyomas; Tumor, Fibroid; Tumors, Fibroid
SNOMED CT: Fibromyoma (1162890002); Leiomyofibroma (1162890002); Plexiform leiomyoma (1162890002); Fibroleiomyoma (1162890002); Fibroid (1162890002); Leiomyoma (1162890002); Soft tissue tumor of smooth muscle differentiation (1187125003); Leiomyomatous neoplasm (1187125003)
 
Monarch Initiative: MONDO:0001572

Definition

A well-circumscribed benign smooth muscle neoplasm characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeiomyoma

Professional guidelines

PubMed

Achanna KS, Nanda J
Med J Malaysia 2022 May;77(3):374-383. PMID: 35638495
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128

Recent clinical studies

Etiology

Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:3-11. Epub 2017 Oct 1 doi: 10.1016/j.bpobgyn.2017.09.004. PMID: 29054502
Jenabi E, Khazaei S
J Matern Fetal Neonatal Med 2018 Jan;31(1):87-92. Epub 2017 Jan 17 doi: 10.1080/14767058.2016.1275553. PMID: 28027686
McWilliams MM, Chennathukuzhi VM
Semin Reprod Med 2017 Mar;35(2):181-189. Epub 2017 Mar 9 doi: 10.1055/s-0037-1599090. PMID: 28278535Free PMC Article
Jenabi E, Ebrahimzadeh Zagami S
J Matern Fetal Neonatal Med 2017 Nov;30(22):2742-2746. Epub 2016 Nov 29 doi: 10.1080/14767058.2016.1261401. PMID: 27844480

Diagnosis

Long M, Hu XL, Zhao G, Liu Y, Hu T
BMC Womens Health 2022 Apr 14;22(1):119. doi: 10.1186/s12905-022-01700-6. PMID: 35421983Free PMC Article
Wei JJ
Semin Diagn Pathol 2022 May;39(3):187-200. Epub 2022 Feb 2 doi: 10.1053/j.semdp.2022.01.006. PMID: 35144823Free PMC Article
Lumsden MA, Hamoodi I, Gupta J, Hickey M
BMJ 2015 Oct 13;351:h4887. doi: 10.1136/bmj.h4887. PMID: 26463991
Arleo EK, Schwartz PE, Hui P, McCarthy S
AJR Am J Roentgenol 2015 Oct;205(4):912-21. doi: 10.2214/AJR.14.13946. PMID: 26397344
Pastor Navarro H, Martínez Ruiz J, Martínez Sanchíz C, Perán Teruel M, Segura Martín M, Pastor Guzman JM, Virseda Rodríguez J
Arch Esp Urol 2013 Oct;66(8):820-3. PMID: 24136487

Therapy

Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Schorge JO
Obstet Gynecol 2018 Jun;131(6):959-960. doi: 10.1097/AOG.0000000000002610. PMID: 29688918
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article

Prognosis

Harmon QE, Patchel SA, Zhao S, Umbach DM, Cooper TE, Baird DD
Obstet Gynecol 2022 May 1;139(5):797-807. Epub 2022 Apr 5 doi: 10.1097/AOG.0000000000004745. PMID: 35576339Free PMC Article
Marnach ML, Laughlin-Tommaso SK
Mayo Clin Proc 2019 Feb;94(2):326-335. doi: 10.1016/j.mayocp.2018.12.012. PMID: 30711128
Laughlin-Tommaso SK, Jacoby VL, Myers ER
Obstet Gynecol Clin North Am 2017 Mar;44(1):81-94. doi: 10.1016/j.ogc.2016.11.007. PMID: 28160895
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article
Casper ES
Curr Treat Options Oncol 2000 Aug;1(3):267-73. doi: 10.1007/s11864-000-0039-4. PMID: 12057170

Clinical prediction guides

Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Manyonda I, Belli AM, Lumsden MA, Moss J, McKinnon W, Middleton LJ, Cheed V, Wu O, Sirkeci F, Daniels JP, McPherson K; FEMME Collaborative Group
N Engl J Med 2020 Jul 30;383(5):440-451. doi: 10.1056/NEJMoa1914735. PMID: 32726530
Jenabi E, Khazaei S
J Matern Fetal Neonatal Med 2018 Jan;31(1):87-92. Epub 2017 Jan 17 doi: 10.1080/14767058.2016.1275553. PMID: 28027686
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Payson M, Leppert P, Segars J
Obstet Gynecol Clin North Am 2006 Mar;33(1):1-11. doi: 10.1016/j.ogc.2005.12.004. PMID: 16504803Free PMC Article

Recent systematic reviews

Akhatova A, Aimagambetova G, Bapayeva G, Laganà AS, Chiantera V, Oppelt P, Sarria-Santamera A, Terzic M
Int J Environ Res Public Health 2023 Mar 2;20(5) doi: 10.3390/ijerph20054480. PMID: 36901489Free PMC Article
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Somigliana E, Reschini M, Bonanni V, Busnelli A, Li Piani L, Vercellini P
Reprod Biomed Online 2021 Jul;43(1):100-110. Epub 2021 Mar 23 doi: 10.1016/j.rbmo.2021.03.013. PMID: 33903032
Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R
BJOG 2017 Sep;124(10):1501-1512. Epub 2017 May 13 doi: 10.1111/1471-0528.14640. PMID: 28296146
Pritts EA, Parker WH, Olive DL
Fertil Steril 2009 Apr;91(4):1215-23. Epub 2008 Mar 12 doi: 10.1016/j.fertnstert.2008.01.051. PMID: 18339376

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