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Philadelphia-positive myelogenous leukemia

MedGen UID:
9731
Concept ID:
C0023476
Neoplastic Process
Synonyms: Ph1-positive granulocytic leukaemia; Ph1-Positive Granulocytic Leukemia; Ph1-positive granulocytic leukemia; Ph1-positive myelocytic leukaemia; Ph1-Positive Myelocytic Leukemia; Ph1-positive myelocytic leukemia; Ph1-positive myelogenous leukaemia; Ph1-Positive Myelogenous Leukemia; Ph1-positive myelogenous leukemia; Ph1-positive myeloid leukaemia; Ph1-Positive Myeloid Leukemia; Ph1-positive myeloid leukemia; Philadelphia-positive granulocytic leukaemia; Philadelphia-Positive Granulocytic Leukemia; Philadelphia-positive granulocytic leukemia; Philadelphia-positive myelocytic leukaemia; Philadelphia-Positive Myelocytic Leukemia; Philadelphia-positive myelocytic leukemia; Philadelphia-Positive Myelogenous Leukemia; Philadelphia-positive myeloid leukaemia; Philadelphia-Positive Myeloid Leukemia; Philadelphia-positive myeloid leukemia
 
Monarch Initiative: MONDO:0024685

Professional guidelines

PubMed

Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Pavlovsky C, Chan O, Talati C, Pinilla-Ibarz J
Future Oncol 2019 Jan;15(3):257-269. Epub 2018 Sep 25 doi: 10.2217/fon-2018-0371. PMID: 30251548
Santos FP, Cortes J
Expert Opin Pharmacother 2012 Nov;13(16):2381-95. Epub 2012 Sep 20 doi: 10.1517/14656566.2012.725722. PMID: 22992064

Recent clinical studies

Etiology

Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Pant G, Kumar A, Verma N, Pooniya V, Sharma A, Gupta B
J Pediatr Hematol Oncol 2019 Jul;41(5):376-381. doi: 10.1097/MPH.0000000000001492. PMID: 31033785
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Haferlach T, Bacher U, Kern W, Schnittger S, Haferlach C
Ann Hematol 2007 May;86(5):311-27. Epub 2007 Feb 14 doi: 10.1007/s00277-007-0253-2. PMID: 17375301
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467

Diagnosis

Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Holyoake TL, Helgason GV
Immunol Rev 2015 Jan;263(1):106-23. doi: 10.1111/imr.12234. PMID: 25510274
Rumpold H, Webersinke G
Curr Cancer Drug Targets 2011 Jan;11(1):3-19. doi: 10.2174/156800911793743619. PMID: 21062244
Haferlach T, Bacher U, Kern W, Schnittger S, Haferlach C
Ann Hematol 2007 May;86(5):311-27. Epub 2007 Feb 14 doi: 10.1007/s00277-007-0253-2. PMID: 17375301

Therapy

Pavlovsky C, Chan O, Talati C, Pinilla-Ibarz J
Future Oncol 2019 Jan;15(3):257-269. Epub 2018 Sep 25 doi: 10.2217/fon-2018-0371. PMID: 30251548
Santos FP, Cortes J
Expert Opin Pharmacother 2012 Nov;13(16):2381-95. Epub 2012 Sep 20 doi: 10.1517/14656566.2012.725722. PMID: 22992064
Rosti G, Castagnetti F, Gugliotta G, Palandri F, Martinelli G, Baccarani M
Leuk Lymphoma 2010 Apr;51(4):583-91. doi: 10.3109/10428191003637282. PMID: 20302388
Soverini S, Iacobucci I, Baccarani M, Martinelli G
Haematologica 2007 Apr;92(4):437-9. doi: 10.3324/haematol.11248. PMID: 17488653
Deininger MW, Goldman JM
Curr Opin Hematol 1998 Jul;5(4):302-8. doi: 10.1097/00062752-199807000-00010. PMID: 9747637

Prognosis

Kumar A, Tilak V, Arora D, Marisha, Rahul, Gautam D, Ali A
Cancer Genet 2023 Aug;276-277:12-16. Epub 2023 May 27 doi: 10.1016/j.cancergen.2023.05.002. PMID: 37267684
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467

Clinical prediction guides

Yoshinobu S, Honda G, Kawano N, Uchiyama T, Kawasugi K, Madoiwa S, Takezako N, Takayuki I, Wada H
Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211054094. doi: 10.1177/10760296211054094. PMID: 34870471Free PMC Article
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467
Kurzrock R, Shtalrid M, Talpaz M, Kloetzer WS, Gutterman JU
Blood 1987 Nov;70(5):1584-8. PMID: 3311207

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