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Philadelphia-positive myelogenous leukemia

MedGen UID:
9731
•Concept ID:
C0023476
•
Neoplastic Process
Synonyms: Ph1-positive granulocytic leukaemia; Ph1-Positive Granulocytic Leukemia; Ph1-positive granulocytic leukemia; Ph1-positive myelocytic leukaemia; Ph1-Positive Myelocytic Leukemia; Ph1-positive myelocytic leukemia; Ph1-positive myelogenous leukaemia; Ph1-Positive Myelogenous Leukemia; Ph1-positive myelogenous leukemia; Ph1-positive myeloid leukaemia; Ph1-Positive Myeloid Leukemia; Ph1-positive myeloid leukemia; Philadelphia-positive granulocytic leukaemia; Philadelphia-Positive Granulocytic Leukemia; Philadelphia-positive granulocytic leukemia; Philadelphia-positive myelocytic leukaemia; Philadelphia-Positive Myelocytic Leukemia; Philadelphia-positive myelocytic leukemia; Philadelphia-Positive Myelogenous Leukemia; Philadelphia-positive myeloid leukaemia; Philadelphia-Positive Myeloid Leukemia; Philadelphia-positive myeloid leukemia
 
Monarch Initiative: MONDO:0024685

Professional guidelines

PubMed

Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Ponatinib in the treatment of chronic myeloid leukemia and philadelphia chromosome positive acute lymphoblastic leukemia.
Pavlovsky C, Chan O, Talati C, Pinilla-Ibarz J
Future Oncol 2019 Jan;15(3):257-269. Epub 2018 Sep 25 doi: 10.2217/fon-2018-0371. PMID: 30251548
Dasatinib for the treatment of Philadelphia chromosome-positive leukemias.
Santos FP, Cortes J
Expert Opin Pharmacother 2012 Nov;13(16):2381-95. Epub 2012 Sep 20 doi: 10.1517/14656566.2012.725722. PMID: 22992064

Recent clinical studies

Etiology

Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Cost-effectiveness analysis of dasatinib versus imatinib in pediatric philadelphia chromosome-positive acute lymphoblastic leukemia patients in China.
Cao W, Yu Y, Qiu Y, Liu L, Zhang H, Shi L, Xiao Y, Jia L, Zhang R, Wang X
BMC Health Serv Res 2022 Dec 26;22(1):1580. doi: 10.1186/s12913-022-08971-7. PMID: 36567324Free PMC Article
Demographics and Outcome of Philadelphia-positive ALL in a Pediatric Population in North India: a Single-center Experience.
Pant G, Kumar A, Verma N, Pooniya V, Sharma A, Gupta B
J Pediatr Hematol Oncol 2019 Jul;41(5):376-381. doi: 10.1097/MPH.0000000000001492. PMID: 31033785
Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review.
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467

Diagnosis

Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Do we need more drugs for chronic myeloid leukemia?
Holyoake TL, Helgason GV
Immunol Rev 2015 Jan;263(1):106-23. doi: 10.1111/imr.12234. PMID: 25510274
Molecular pathogenesis of Philadelphia-positive chronic myeloid leukemia - is it all BCR-ABL?
Rumpold H, Webersinke G
Curr Cancer Drug Targets 2011 Jan;11(1):3-19. doi: 10.2174/156800911793743619. PMID: 21062244
Diagnostic pathways in acute leukemias: a proposal for a multimodal approach.
Haferlach T, Bacher U, Kern W, Schnittger S, Haferlach C
Ann Hematol 2007 May;86(5):311-27. Epub 2007 Feb 14 doi: 10.1007/s00277-007-0253-2. PMID: 17375301

Therapy

Ponatinib in the treatment of chronic myeloid leukemia and philadelphia chromosome positive acute lymphoblastic leukemia.
Pavlovsky C, Chan O, Talati C, Pinilla-Ibarz J
Future Oncol 2019 Jan;15(3):257-269. Epub 2018 Sep 25 doi: 10.2217/fon-2018-0371. PMID: 30251548
Dasatinib for the treatment of Philadelphia chromosome-positive leukemias.
Santos FP, Cortes J
Expert Opin Pharmacother 2012 Nov;13(16):2381-95. Epub 2012 Sep 20 doi: 10.1517/14656566.2012.725722. PMID: 22992064
Dasatinib and nilotinib in imatinib-resistant Philadelphia-positive chronic myelogenous leukemia: a 'head-to-head comparison'.
Rosti G, Castagnetti F, Gugliotta G, Palandri F, Martinelli G, Baccarani M
Leuk Lymphoma 2010 Apr;51(4):583-91. doi: 10.3109/10428191003637282. PMID: 20302388
Targeted therapy and the T315I mutation in Philadelphia-positive leukemias.
Soverini S, Iacobucci I, Baccarani M, Martinelli G
Haematologica 2007 Apr;92(4):437-9. doi: 10.3324/haematol.11248. PMID: 17488653
Chronic myeloid leukemia.
Deininger MW, Goldman JM
Curr Opin Hematol 1998 Jul;5(4):302-8. doi: 10.1097/00062752-199807000-00010. PMID: 9747637

Prognosis

Philadelphia chromosome- positive myelodysplastic syndrome with single lineage dysplasia.
Kumar A, Tilak V, Arora D, Marisha, Rahul, Gautam D, Ali A
Cancer Genet 2023 Aug;276-277:12-16. Epub 2023 May 27 doi: 10.1016/j.cancergen.2023.05.002. PMID: 37267684
Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review.
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467

Clinical prediction guides

Ponatinib Tyrosine Kinase Inhibitor Induces a Thromboinflammatory Response.
Hamadi A, Grigg AP, Dobie G, Burbury KL, Schwarer AP, Kwa FA, Jackson DE
Thromb Haemost 2019 Jul;119(7):1112-1123. Epub 2019 May 12 doi: 10.1055/s-0039-1688787. PMID: 31079415
A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review.
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Driving Toward Precision Medicine for Acute Leukemias: Are We There Yet?
Chung C, Ma H
Pharmacotherapy 2017 Sep;37(9):1052-1072. Epub 2017 Jul 31 doi: 10.1002/phar.1977. PMID: 28654205
Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review.
Secker-Walker LM, Craig JM
Leukemia 1993 Feb;7(2):147-51. PMID: 8426467
Expression of c-abl in Philadelphia-positive acute myelogenous leukemia.
Kurzrock R, Shtalrid M, Talpaz M, Kloetzer WS, Gutterman JU
Blood 1987 Nov;70(5):1584-8. PMID: 3311207

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