U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bullous lichen planus

MedGen UID:
9755
•Concept ID:
C0023648
•
Disease or Syndrome
Synonyms: Bullous Lichen Planus; bullous lichen planus; Lichen planus bullosus
SNOMED CT: Bullous lichen planus (6111009); Lichen planus bullosus (6111009)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
•Concept ID:
C0443147
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Autosomal dominant inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018056
Orphanet: ORPHA33408

Definition

Bullous lichen planus is a variant of rare lichen planus (see this term) characterized by the development of vesico-bullous lesions. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBullous lichen planus
Follow this link to review classifications for Bullous lichen planus in Orphanet.

Professional guidelines

PubMed

Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment.
Shao S, Fang H, Li Q, Wang G
Theranostics 2020;10(22):9937-9955. Epub 2020 Aug 7 doi: 10.7150/thno.45488. PMID: 32929326Free PMC Article
Concepts and controversies in the treatment of cutaneous lichen planus.
Puza C, Cardones AR
G Ital Dermatol Venereol 2017 Dec;152(6):607-614. Epub 2017 Sep 12 doi: 10.23736/S0392-0488.17.05778-9. PMID: 28895668

Recent clinical studies

Etiology

Concepts and controversies in the treatment of cutaneous lichen planus.
Puza C, Cardones AR
G Ital Dermatol Venereol 2017 Dec;152(6):607-614. Epub 2017 Sep 12 doi: 10.23736/S0392-0488.17.05778-9. PMID: 28895668
A retrospective and comparative study of familial and non-familial bullous lichen planus.
Huang C, Yan X, Yang L, Zhang J, Tian J, Li J, Wang C, Tu Y
J Huazhong Univ Sci Technolog Med Sci 2007 Jun;27(3):336-8. doi: 10.1007/s11596-007-0331-7. PMID: 17641857
Familial bullous lichen planus (FBLP): Pedigree analysis and clinical characteristics.
Huang C, Chen S, Liu Z, Tao J, Wang C, Zhou Y
J Cutan Med Surg 2005 Oct;9(5):217-22. doi: 10.1007/s10227-005-0146-8. PMID: 16502199
Mycophenolate in dermatology.
Liu V, Mackool BT
J Dermatolog Treat 2003 Dec;14(4):203-11. doi: 10.1080/09546630310016826. PMID: 14660264

Diagnosis

Lichen-planus-pemphigoides-like reaction to PD-1 checkpoint blockade.
Wat M, Mollanazar NK, Ellebrecht CT, Forrestel A, Elenitsas R, Chu EY
J Cutan Pathol 2022 Nov;49(11):978-987. Epub 2022 Aug 23 doi: 10.1111/cup.14299. PMID: 36054729
Challenges and pitfalls between lichen planus pemphigoides and bullous lichen planus.
Papara C, Danescu S, Sitaru C, Baican A
Australas J Dermatol 2022 May;63(2):165-171. Epub 2022 Feb 23 doi: 10.1111/ajd.13808. PMID: 35196400
Bullous Lichen Planus of the Nails.
Khullar G, Handa S, De D, Saikia UN
JAMA Dermatol 2015 Jun;151(6):674-5. doi: 10.1001/jamadermatol.2014.5701. PMID: 25739002
Mycophenolate in dermatology.
Liu V, Mackool BT
J Dermatolog Treat 2003 Dec;14(4):203-11. doi: 10.1080/09546630310016826. PMID: 14660264
Bullous lichen planus.
Haselden FG
Oral Surg Oral Med Oral Pathol 1967 Oct;24(4):472-9. doi: 10.1016/0030-4220(67)90421-5. PMID: 5235469

Therapy

Lichen-planus-pemphigoides-like reaction to PD-1 checkpoint blockade.
Wat M, Mollanazar NK, Ellebrecht CT, Forrestel A, Elenitsas R, Chu EY
J Cutan Pathol 2022 Nov;49(11):978-987. Epub 2022 Aug 23 doi: 10.1111/cup.14299. PMID: 36054729
Bullous lichen planus and anti-programmed cell death-1 therapy: Case report and literature review.
de Lorenzi C, André R, Vuilleumier A, Kaya G, Abosaleh M
Ann Dermatol Venereol 2020 Mar;147(3):221-227. Epub 2020 Jan 22 doi: 10.1016/j.annder.2019.07.008. PMID: 31982173
Concepts and controversies in the treatment of cutaneous lichen planus.
Puza C, Cardones AR
G Ital Dermatol Venereol 2017 Dec;152(6):607-614. Epub 2017 Sep 12 doi: 10.23736/S0392-0488.17.05778-9. PMID: 28895668
Mycophenolate in dermatology.
Liu V, Mackool BT
J Dermatolog Treat 2003 Dec;14(4):203-11. doi: 10.1080/09546630310016826. PMID: 14660264
Bullous lichen planus.
Haselden FG
Oral Surg Oral Med Oral Pathol 1967 Oct;24(4):472-9. doi: 10.1016/0030-4220(67)90421-5. PMID: 5235469

Prognosis

Familial bullous lichen planus (FBLP): Pedigree analysis and clinical characteristics.
Huang C, Chen S, Liu Z, Tao J, Wang C, Zhou Y
J Cutan Med Surg 2005 Oct;9(5):217-22. doi: 10.1007/s10227-005-0146-8. PMID: 16502199
Bullous lichen planus and lichen planus pemphigoides--clinico-pathological comparisons.
Gawkrodger DJ, Stavropoulos PG, McLaren KM, Buxton PK
Clin Exp Dermatol 1989 Mar;14(2):150-3. doi: 10.1111/j.1365-2230.1989.tb00914.x. PMID: 2598489

Clinical prediction guides

Bazex syndrome (acrokeratosis paraneoplastica). An analytic review.
Bolognia JL, Brewer YP, Cooper DL
Medicine (Baltimore) 1991 Jul;70(4):269-80. doi: 10.1097/00005792-199107000-00004. PMID: 2067411
Lichen planus pemphigoides: a clinicopathological study of nine cases.
Willsteed E, Bhogal BS, Das AK, Wojnarowska F, Black MM, McKee PH
Histopathology 1991 Aug;19(2):147-54. doi: 10.1111/j.1365-2559.1991.tb00005.x. PMID: 1757068
Evolution, maturation, and regression of lesions of lichen planus. New observations and correlations of clinical and histologic findings.
Ragaz A, Ackerman AB
Am J Dermatopathol 1981 Spring;3(1):5-25. doi: 10.1097/00000372-198100310-00002. PMID: 7235199

Recent systematic reviews

Bullous lichen planus and anti-programmed cell death-1 therapy: Case report and literature review.
de Lorenzi C, André R, Vuilleumier A, Kaya G, Abosaleh M
Ann Dermatol Venereol 2020 Mar;147(3):221-227. Epub 2020 Jan 22 doi: 10.1016/j.annder.2019.07.008. PMID: 31982173

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...