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Non-functioning pituitary adenoma

MedGen UID:
976328
Concept ID:
CN294234
Disease or Syndrome
Synonyms: functionless adenoma of pituitary; functionless adenoma of pituitary gland; functionless adenoma of the pituitary; functionless adenoma of the pituitary gland; functionless pituitary adenoma; functionless pituitary gland adenoma; NFPA; non-functioning adenoma of pituitary; non-functioning adenoma of pituitary gland; non-functioning adenoma of the pituitary; non-functioning adenoma of the pituitary gland; non-functioning pituitary adenoma; non-functioning pituitary gland adenoma; non-secretory adenoma of pituitary; non-secretory adenoma of pituitary gland; non-secretory adenoma of the pituitary; non-secretory adenoma of the pituitary gland; non-secretory pituitary adenoma; non-secretory pituitary gland adenoma; nonfunctional pituitary gland adenoma; silent pituitary gland adenoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019613
Orphanet: ORPHA91349

Definition

A rare pituitary tumor originating from normally hormone-producing cells of the adenohypophysis, characterized by a sellar or extrasellar mass manifesting with clinical signs secondary to mass effect, but without evidence for hormonal hypersecretion. Typical manifestations are visual disturbances, headaches, cranial nerve dysfunction, and hypopituitarism but the mass may also be discovered incidentally. [from ORDO]

Professional guidelines

PubMed

Thakkar K, Sarathi V, Shah NS
Neurol India 2020 May-Jun;68(Supplement):S13-S19. doi: 10.4103/0028-3886.287680. PMID: 32611887
Even-Zohar N, Greenman Y
Pituitary 2018 Apr;21(2):168-175. doi: 10.1007/s11102-018-0865-7. PMID: 29344905
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Recent clinical studies

Etiology

Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Tampourlou M, Fountas A, Ntali G, Karavitaki N
Pituitary 2018 Apr;21(2):203-207. doi: 10.1007/s11102-018-0863-9. PMID: 29344906Free PMC Article
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

Diagnosis

Rajani M, Mirza Y, Advani R, Adnan Ali SM, Enam SA
J Pak Med Assoc 2022 Jan;72(1):126-133. doi: 10.47391/JPMA.3149. PMID: 35099451
Biermasz NR
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101309. Epub 2019 Aug 2 doi: 10.1016/j.beem.2019.101309. PMID: 31405752
Tampourlou M, Fountas A, Ntali G, Karavitaki N
Pituitary 2018 Apr;21(2):203-207. doi: 10.1007/s11102-018-0863-9. PMID: 29344906Free PMC Article
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Castinetti F, Dufour H, Gaillard S, Jouanneau E, Vasiljevic A, Villa C, Trouillas J
Ann Endocrinol (Paris) 2015 Jul;76(3):220-7. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.007. PMID: 26070464

Therapy

Olsson DS, Svensson M, Labori F, De Geer A, Johannsson G
Eur J Endocrinol 2023 Jun 7;188(6):477-484. doi: 10.1093/ejendo/lvad057. PMID: 37232269
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Iglesias P, Rodríguez Berrocal V, Díez JJ
Endocrine 2018 Sep;61(3):407-421. Epub 2018 Jun 16 doi: 10.1007/s12020-018-1645-x. PMID: 29909598
Even-Zohar N, Greenman Y
Pituitary 2018 Apr;21(2):168-175. doi: 10.1007/s11102-018-0865-7. PMID: 29344905
Cortet-Rudelli C, Bonneville JF, Borson-Chazot F, Clavier L, Coche Dequéant B, Desailloud R, Maiter D, Rohmer V, Sadoul JL, Sonnet E, Toussaint P, Chanson P
Ann Endocrinol (Paris) 2015 Jul;76(3):228-38. Epub 2015 Jun 23 doi: 10.1016/j.ando.2015.04.003. PMID: 26116412

Prognosis

Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Iglesias P, Arcano K, Triviño V, Guerrero-Pérez F, Rodríguez Berrocal V, Vior C, Cordido F, Villabona C, Díez JJ
Exp Clin Endocrinol Diabetes 2021 Mar;129(4):309-313. Epub 2020 Jan 2 doi: 10.1055/a-1017-3288. PMID: 31896156
Tampourlou M, Fountas A, Ntali G, Karavitaki N
Pituitary 2018 Apr;21(2):203-207. doi: 10.1007/s11102-018-0863-9. PMID: 29344906Free PMC Article
Abouaf L, Vighetto A, Lebas M
Ann Endocrinol (Paris) 2015 Jul;76(3):210-9. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.006. PMID: 26070465
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

Clinical prediction guides

Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N
Eur J Endocrinol 2023 Jul 20;189(1):87-95. doi: 10.1093/ejendo/lvad070. PMID: 37345849
Qin J, Li K, Wang X, Bao Y
Medicine (Baltimore) 2021 Apr 9;100(14):e25306. doi: 10.1097/MD.0000000000025306. PMID: 33832102Free PMC Article
Tampourlou M, Fountas A, Ntali G, Karavitaki N
Pituitary 2018 Apr;21(2):203-207. doi: 10.1007/s11102-018-0863-9. PMID: 29344906Free PMC Article
Abouaf L, Vighetto A, Lebas M
Ann Endocrinol (Paris) 2015 Jul;76(3):210-9. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.006. PMID: 26070465
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

Recent systematic reviews

Caulley L, Whelan J, Khoury M, Mavedatnia D, Sahlollbey N, Amrani L, Eid A, Doyle MA, Malcolm J, Alkherayf F, Ramsay T, Moher D, Johnson-Obaseki S, Schramm D, Hunink MGM, Kilty SJ
Pituitary 2023 Feb;26(1):73-93. Epub 2022 Nov 23 doi: 10.1007/s11102-022-01289-x. PMID: 36422846
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Hosseinkhan N, Honardoost M, Emami Z, Cheraghi S, Hashemi-Madani N, Khamseh ME
Endocrine 2022 Sep;77(3):500-509. Epub 2022 Jun 16 doi: 10.1007/s12020-022-03105-9. PMID: 35711030
Pelsma ICM, Verstegen MJT, de Vries F, Notting IC, Broekman MLD, van Furth WR, Biermasz NR, Pereira AM
Pituitary 2020 Aug;23(4):417-429. doi: 10.1007/s11102-020-01044-0. PMID: 32419072Free PMC Article

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