U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Autosomal recessive familial Mediterranean fever

MedGen UID:
976601
•Concept ID:
CN293506
•
Disease or Syndrome
Synonyms: autosomal recessive familial Mediterranean fever; familial Mediterranean fever; familial MEDITERRANEAN FEVER; familial Mediterranean fever, AR; familial Mediterranean fever, autosomal recessive; FMF; polyserositis, familial paroxysmal; polyserositis, recurrent
 
Monarch Initiative: MONDO:0009572

Definition

Autosomal recessive form of familial Mediterranean fever. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

French protocol for the diagnosis and management of familial Mediterranean fever.
Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, Boffa JJ, Delplanque M, Bourguiba R, Monfort JB, Touitou I, Grateau G; Collaborators, Kone-Paut I, Hentgen V
Rev Med Interne 2023 Nov;44(11):602-616. Epub 2023 Oct 29 doi: 10.1016/j.revmed.2023.10.441. PMID: 37903671
Novel therapeutics for the treatment of familial Mediterranean fever: from colchicine to biologics.
Grattagliano I, Bonfrate L, Ruggiero V, Scaccianoce G, Palasciano G, Portincasa P
Clin Pharmacol Ther 2014 Jan;95(1):89-97. Epub 2013 Jul 18 doi: 10.1038/clpt.2013.148. PMID: 23867542
IL-1β biological treatment of familial Mediterranean fever.
Soriano A, Verecchia E, Afeltra A, Landolfi R, Manna R
Clin Rev Allergy Immunol 2013 Aug;45(1):117-30. doi: 10.1007/s12016-013-8358-y. PMID: 23322405

Recent clinical studies

Etiology

Familial Mediterranean fever in the pediatric population.
Llobet-Agulló P, Sanromà-Nogués L, Salguero-Pérez IM, Aróstegui JI, Corral-Arboledas S, Coll-Sibina MT, Masiques-Mas L
Allergol Immunopathol (Madr) 2022;50(1):25-30. Epub 2022 Jan 1 doi: 10.15586/aei.v50i1.446. PMID: 34873893
Sacroiliitis associated with familial Mediterranean fever in childhood: a case series and review of literature.
Yıldırım DG, Fidan HK, Gönen S, Söylemezoğlu O
Turk J Pediatr 2020;62(2):175-181. doi: 10.24953/turkjped.2020.02.002. PMID: 32419408
Familial Mediterranean Fever.
Ozdogan H, Ugurlu S
Presse Med 2019 Feb;48(1 Pt 2):e61-e76. Epub 2019 Jan 25 doi: 10.1016/j.lpm.2018.08.014. PMID: 30686512
Familial Mediterranean fever.
Onen F
Rheumatol Int 2006 Apr;26(6):489-96. Epub 2005 Nov 10 doi: 10.1007/s00296-005-0074-3. PMID: 16283319
Familial Mediterranean fever.
Bakkaloglu A
Pediatr Nephrol 2003 Sep;18(9):853-9. Epub 2003 Jun 27 doi: 10.1007/s00467-003-1185-2. PMID: 12836090

Diagnosis

Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever.
Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D
Medicina (Kaunas) 2021 Oct 1;57(10) doi: 10.3390/medicina57101049. PMID: 34684086Free PMC Article
Familial Mediterranean Fever.
Ozdogan H, Ugurlu S
Presse Med 2019 Feb;48(1 Pt 2):e61-e76. Epub 2019 Jan 25 doi: 10.1016/j.lpm.2018.08.014. PMID: 30686512
Familial Mediterranean fever, review of the literature.
Alghamdi M
Clin Rheumatol 2017 Aug;36(8):1707-1713. Epub 2017 Jun 18 doi: 10.1007/s10067-017-3715-5. PMID: 28624931
Familial Mediterranean Fever.
Kucuk A, Gezer IA, Ucar R, Karahan AY
Acta Medica (Hradec Kralove) 2014;57(3):97-104. doi: 10.14712/18059694.2014.47. PMID: 25649364
Familial Mediterranean fever.
Onen F
Rheumatol Int 2006 Apr;26(6):489-96. Epub 2005 Nov 10 doi: 10.1007/s00296-005-0074-3. PMID: 16283319

Therapy

Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever.
Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D
Medicina (Kaunas) 2021 Oct 1;57(10) doi: 10.3390/medicina57101049. PMID: 34684086Free PMC Article
Familial Mediterranean Fever.
Ozdogan H, Ugurlu S
Presse Med 2019 Feb;48(1 Pt 2):e61-e76. Epub 2019 Jan 25 doi: 10.1016/j.lpm.2018.08.014. PMID: 30686512
Familial Mediterranean fever, review of the literature.
Alghamdi M
Clin Rheumatol 2017 Aug;36(8):1707-1713. Epub 2017 Jun 18 doi: 10.1007/s10067-017-3715-5. PMID: 28624931
Familial Mediterranean Fever.
Kucuk A, Gezer IA, Ucar R, Karahan AY
Acta Medica (Hradec Kralove) 2014;57(3):97-104. doi: 10.14712/18059694.2014.47. PMID: 25649364
Familial Mediterranean fever.
Onen F
Rheumatol Int 2006 Apr;26(6):489-96. Epub 2005 Nov 10 doi: 10.1007/s00296-005-0074-3. PMID: 16283319

Prognosis

Familial Mediterranean fever in the pediatric population.
Llobet-Agulló P, Sanromà-Nogués L, Salguero-Pérez IM, Aróstegui JI, Corral-Arboledas S, Coll-Sibina MT, Masiques-Mas L
Allergol Immunopathol (Madr) 2022;50(1):25-30. Epub 2022 Jan 1 doi: 10.15586/aei.v50i1.446. PMID: 34873893
Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever.
Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D
Medicina (Kaunas) 2021 Oct 1;57(10) doi: 10.3390/medicina57101049. PMID: 34684086Free PMC Article
Potential of miRNAs to predict and treat inflammation from the perspective of Familial Mediterranean Fever.
Balci-Peynircioglu B, Akkaya-Ulum YZ, Akbaba TH, Tavukcuoglu Z
Inflamm Res 2019 Nov;68(11):905-913. Epub 2019 Jul 24 doi: 10.1007/s00011-019-01272-6. PMID: 31342094
Familial Mediterranean Fever.
Kucuk A, Gezer IA, Ucar R, Karahan AY
Acta Medica (Hradec Kralove) 2014;57(3):97-104. doi: 10.14712/18059694.2014.47. PMID: 25649364
Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder.
Portincasa P, Scaccianoce G, Palasciano G
Eur J Clin Invest 2013 Dec;43(12):1314-27. Epub 2013 Oct 14 doi: 10.1111/eci.12170. PMID: 24117178

Clinical prediction guides

Role of E148Q in familial Mediterranean fever with an exon 10 mutation in MEFV.
Miyashita K, Matsuda Y, Okajima M, Toma T, Yachie A, Wada T
Pediatr Int 2022 Jan;64(1):e14696. Epub 2021 Oct 28 doi: 10.1111/ped.14696. PMID: 33715276
Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever.
Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D
Medicina (Kaunas) 2021 Oct 1;57(10) doi: 10.3390/medicina57101049. PMID: 34684086Free PMC Article
Familial Mediterranean Fever without Fever.
Hotta Y, Kawasaki T, Kotani T, Okada H, Ikeda K, Yamane S, Yamada N, Sekoguchi S, Isozaki Y, Nagao Y, Murotani M, Oyamada H
Intern Med 2020 May 15;59(10):1267-1270. Epub 2020 Feb 12 doi: 10.2169/internalmedicine.3175-19. PMID: 32051376Free PMC Article
Potential of miRNAs to predict and treat inflammation from the perspective of Familial Mediterranean Fever.
Balci-Peynircioglu B, Akkaya-Ulum YZ, Akbaba TH, Tavukcuoglu Z
Inflamm Res 2019 Nov;68(11):905-913. Epub 2019 Jul 24 doi: 10.1007/s00011-019-01272-6. PMID: 31342094
Familial Mediterranean fever: new phenotypes.
Soriano A, Manna R
Autoimmun Rev 2012 Nov;12(1):31-7. Epub 2012 Aug 2 doi: 10.1016/j.autrev.2012.07.019. PMID: 22878273

Recent systematic reviews

Lack of clear and univocal genotype-phenotype correlation in familial Mediterranean fever patients: A systematic review.
Gangemi S, Manti S, Procopio V, Casciaro M, Di Salvo E, Cutrupi M, Ganci G, Salpietro C, Chimenz R, Cuppari C
Clin Genet 2018 Jul;94(1):81-94. Epub 2018 Mar 9 doi: 10.1111/cge.13223. PMID: 29393966

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...