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Familial or sporadic hemiplegic migraine

MedGen UID:
977550
Concept ID:
CN295307
Disease or Syndrome
Synonyms: familial or sporadic hemiplegic migraine; hemiplegic migraine; Hemiplegic Migraine
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
 
Related genes: SCN1A, CACNA1A, ATP1A2
 
Monarch Initiative: MONDO:0018925
Orphanet: ORPHA569

Definition

A rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. There are two main forms depending on the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM). [from ORDO]

Professional guidelines

PubMed

Artto V, Nissilä M, Wessman M, Palotie A, Färkkilä M, Kallela M
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Recent clinical studies

Etiology

Gomes P, Pietrabissa G, Silva ER, Silva J, Matos PM, Costa ME, Bertuzzi V, Silva E, Neves MC, Sales CMD
Int J Environ Res Public Health 2022 Jan 30;19(3) doi: 10.3390/ijerph19031603. PMID: 35162625Free PMC Article
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Oncotarget 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. PMID: 27191890Free PMC Article
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Black DF
Curr Pain Headache Rep 2004 Jun;8(3):223-8. doi: 10.1007/s11916-004-0056-2. PMID: 15115642

Diagnosis

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Nandyala A, Shah T, Ailani J
Curr Neurol Neurosci Rep 2023 Jul;23(7):381-387. Epub 2023 May 29 doi: 10.1007/s11910-023-01277-z. PMID: 37247170
Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
Scheffer IE, Nabbout R
Epilepsia 2019 Dec;60 Suppl 3:S17-S24. doi: 10.1111/epi.16386. PMID: 31904117
Karst JS, Van Hecke AV
Clin Child Fam Psychol Rev 2012 Sep;15(3):247-77. doi: 10.1007/s10567-012-0119-6. PMID: 22869324

Therapy

Di Stefano V, Rispoli MG, Pellegrino N, Graziosi A, Rotondo E, Napoli C, Pietrobon D, Brighina F, Parisi P
J Neurol Neurosurg Psychiatry 2020 Jul;91(7):764-771. Epub 2020 May 19 doi: 10.1136/jnnp-2020-322850. PMID: 32430436Free PMC Article
Silveira RC, Mendes EW, Fuentefria RN, Valentini NC, Procianoy RS
BMC Pediatr 2018 Aug 9;18(1):268. doi: 10.1186/s12887-018-1240-6. PMID: 30092772Free PMC Article
Srisuk N, Cameron J, Ski CF, Thompson DR
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Russell MB
Expert Rev Neurother 2010 Mar;10(3):381-7. doi: 10.1586/ern.09.127. PMID: 20187861
Viera AJ, Bangdiwala SI
Fam Med 2007 Feb;39(2):132-7. PMID: 17273956

Prognosis

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Cohan JN, Horns JJ, Ramsay JM, Huang LC, Allen-Brady K
J Am Coll Surg 2023 Nov 1;237(5):689-696. Epub 2023 Jul 5 doi: 10.1097/XCS.0000000000000799. PMID: 37403933
Rönkkö R, Hirvonen E, Malila N, Kilpivaara O, Wartiovaara-Kautto U, Pitkäniemi J
Br J Haematol 2021 Jun;193(6):1134-1141. Epub 2021 May 18 doi: 10.1111/bjh.17477. PMID: 34002362
Rod NH, Bengtsson J, Budtz-Jørgensen E, Clipet-Jensen C, Taylor-Robinson D, Andersen AN, Dich N, Rieckmann A
Lancet 2020 Aug 15;396(10249):489-497. doi: 10.1016/S0140-6736(20)30621-8. PMID: 32798491
van Dijk IK
Popul Stud (Camb) 2019 Mar;73(1):79-99. Epub 2018 May 4 doi: 10.1080/00324728.2018.1448434. PMID: 29726744

Clinical prediction guides

de Boer I, Hansen JM, Terwindt GM
Handb Clin Neurol 2024;199:353-365. doi: 10.1016/B978-0-12-823357-3.00015-X. PMID: 38307656
Antonaci F, Ravaglia S, Grieco GS, Gagliardi S, Cereda C, Costa A
J Headache Pain 2021 Mar 12;22(1):12. doi: 10.1186/s10194-021-01221-x. PMID: 33711927Free PMC Article
Pelzer N, Haan J, Stam AH, Vijfhuizen LS, Koelewijn SC, Smagge A, de Vries B, Ferrari MD, van den Maagdenberg AMJM, Terwindt GM
Neurology 2018 Feb 13;90(7):e575-e582. Epub 2018 Jan 17 doi: 10.1212/WNL.0000000000004966. PMID: 29343472
Prontera P, Sarchielli P, Caproni S, Bedetti C, Cupini LM, Calabresi P, Costa C
Cephalalgia 2018 Feb;38(2):361-373. Epub 2017 Jan 6 doi: 10.1177/0333102416686347. PMID: 28058944
Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J
Oncotarget 2016 Aug 2;7(31):50708-50718. doi: 10.18632/oncotarget.9367. PMID: 27191890Free PMC Article

Recent systematic reviews

Boehm LM, Jones AC, Selim AA, Virdun C, Garrard CF, Walden RL, Wesley Ely E, Hosie A
Int J Nurs Stud 2021 Oct;122:104030. Epub 2021 Jul 3 doi: 10.1016/j.ijnurstu.2021.104030. PMID: 34343884Free PMC Article
Weaver MS, Mooney-Doyle K, Kelly KP, Montgomery K, Newman AR, Fortney CA, Bell CJ, Spruit JL, Kurtz Uveges M, Wiener L, Schmidt CM, Madrigal VN, Hinds PS
J Palliat Med 2019 Aug;22(8):915-926. Epub 2019 Mar 5 doi: 10.1089/jpm.2018.0483. PMID: 30835596Free PMC Article
Davidson JE, Aslakson RA, Long AC, Puntillo KA, Kross EK, Hart J, Cox CE, Wunsch H, Wickline MA, Nunnally ME, Netzer G, Kentish-Barnes N, Sprung CL, Hartog CS, Coombs M, Gerritsen RT, Hopkins RO, Franck LS, Skrobik Y, Kon AA, Scruth EA, Harvey MA, Lewis-Newby M, White DB, Swoboda SM, Cooke CR, Levy MM, Azoulay E, Curtis JR
Crit Care Med 2017 Jan;45(1):103-128. doi: 10.1097/CCM.0000000000002169. PMID: 27984278
Söderström-Anttila V, Wennerholm UB, Loft A, Pinborg A, Aittomäki K, Romundstad LB, Bergh C
Hum Reprod Update 2016 Mar-Apr;22(2):260-76. Epub 2015 Oct 9 doi: 10.1093/humupd/dmv046. PMID: 26454266
Halal CS, Nunes ML
J Pediatr (Rio J) 2014 Sep-Oct;90(5):449-56. Epub 2014 Jun 25 doi: 10.1016/j.jped.2014.05.001. PMID: 24973469

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