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Astrocytic tumor

MedGen UID:
977562
•Concept ID:
CN294317
•
Disease or Syndrome
Synonyms: astrocytic neoplasm; astrocytic tumor; Astrocytoma; astrocytoma of brain; astrocytoma, no ICD-O subtype; astroglioma
 
Monarch Initiative: MONDO:0021636
Orphanet: ORPHA94

Definition

A complex group of benign and malignant cerebral tumors arising at any age. [from ORDO]

Professional guidelines

PubMed

Differential diagnosis of oligodendroglial and astrocytic tumors using imaging results: the added value of perfusion MR imaging.
Yoon HJ, Ahn KJ, Lee S, Jang JH, Choi HS, Jung SL, Kim BS, Jeun SS, Hong YK
Neuroradiology 2017 Jul;59(7):665-675. Epub 2017 May 26 doi: 10.1007/s00234-017-1851-x. PMID: 28550465
Targeted drug delivery for treatment and imaging of glioblastoma multiforme.
Stukel JM, Caplan MR
Expert Opin Drug Deliv 2009 Jul;6(7):705-18. doi: 10.1517/17425240902988470. PMID: 19538036
Pleomorphic xanthoastrocytoma with anaplastic features presenting without GFAP immunoreactivity: implications for differential diagnosis.
Gelpi E, Popovic M, Preusser M, Budka H, Hainfellner J
Neuropathology 2005 Sep;25(3):241-6. doi: 10.1111/j.1440-1789.2005.00612.x. PMID: 16193842

Recent clinical studies

Etiology

An enduring debate on gliomatosis cerebri.
Akimoto J
Brain Tumor Pathol 2023 Apr;40(2):78-84. Epub 2023 Apr 6 doi: 10.1007/s10014-023-00454-9. PMID: 37022648
The histological representativeness of glioblastoma tissue samples.
Mikkelsen VE, Solheim O, Salvesen Ø, Torp SH
Acta Neurochir (Wien) 2021 Jul;163(7):1911-1920. Epub 2020 Oct 21 doi: 10.1007/s00701-020-04608-y. PMID: 33085022Free PMC Article
Reactivation of Retinopathy of Prematurity in Adults and Adolescents.
Uner OE, Rao P, Hubbard GB 3rd
Ophthalmol Retina 2020 Jul;4(7):720-727. Epub 2020 Feb 11 doi: 10.1016/j.oret.2020.02.001. PMID: 32224099Free PMC Article
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
MR and CT imaging of 24 pleomorphic xanthoastrocytomas (PXA) and a review of the literature.
Crespo-Rodríguez AM, Smirniotopoulos JG, Rushing EJ
Neuroradiology 2007 Apr;49(4):307-15. Epub 2007 Jan 5 doi: 10.1007/s00234-006-0191-z. PMID: 17205313

Diagnosis

An enduring debate on gliomatosis cerebri.
Akimoto J
Brain Tumor Pathol 2023 Apr;40(2):78-84. Epub 2023 Apr 6 doi: 10.1007/s10014-023-00454-9. PMID: 37022648
Leptomeningeal metastases and dural spread in adult high-grade astrocytomas.
Kleinschmidt-DeMasters BK, Ormond DR
J Neuropathol Exp Neurol 2023 Feb 21;82(3):194-201. doi: 10.1093/jnen/nlac126. PMID: 36637258
The histological representativeness of glioblastoma tissue samples.
Mikkelsen VE, Solheim O, Salvesen Ø, Torp SH
Acta Neurochir (Wien) 2021 Jul;163(7):1911-1920. Epub 2020 Oct 21 doi: 10.1007/s00701-020-04608-y. PMID: 33085022Free PMC Article
Reactivation of Retinopathy of Prematurity in Adults and Adolescents.
Uner OE, Rao P, Hubbard GB 3rd
Ophthalmol Retina 2020 Jul;4(7):720-727. Epub 2020 Feb 11 doi: 10.1016/j.oret.2020.02.001. PMID: 32224099Free PMC Article
Grading of Diffuse Astrocytic Gliomas: A Review of Studies Before and After the Advent of IDH Testing.
von Deimling A, Ono T, Shirahata M, Louis DN
Semin Neurol 2018 Feb;38(1):19-23. Epub 2018 Mar 16 doi: 10.1055/s-0038-1636430. PMID: 29548048

Therapy

p53 expression and subcellular survivin localization improve the diagnosis and prognosis of patients with diffuse astrocytic tumors.
Faccion RS, Bernardo PS, de Lopes GPF, Bastos LS, Teixeira CL, de Oliveira JA, Fernandes PV, Dubois LG, Chimelli L, Maia RC
Cell Oncol (Dordr) 2018 Apr;41(2):141-157. Epub 2018 Jan 26 doi: 10.1007/s13402-017-0361-5. PMID: 29374392
Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells.
Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP
Clin Cancer Res 2017 Jun 15;23(12):3109-3119. Epub 2016 Dec 30 doi: 10.1158/1078-0432.CCR-16-1508. PMID: 28039266Free PMC Article
ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis.
Qin LS, Jia PF, Zhang ZQ, Zhang SM
J Exp Clin Cancer Res 2015 May 30;34(1):57. doi: 10.1186/s13046-015-0174-1. PMID: 26024660Free PMC Article
Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article
Targeted drug delivery for treatment and imaging of glioblastoma multiforme.
Stukel JM, Caplan MR
Expert Opin Drug Deliv 2009 Jul;6(7):705-18. doi: 10.1517/17425240902988470. PMID: 19538036

Prognosis

Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy.
Khatami SH, Karami N, Taheri-Anganeh M, Taghvimi S, Tondro G, Khorsand M, Soltani Fard E, Sedighimehr N, Kazemi M, Rahimi Jaberi K, Moradi M, Nafisi Fard P, Darvishi MH, Movahedpour A
Mol Neurobiol 2023 Aug;60(8):4659-4678. Epub 2023 May 3 doi: 10.1007/s12035-023-03365-0. PMID: 37138197Free PMC Article
Molecular and Cellular Mechanisms of Human Astrocytoma Progression: Advances in Knowledge to Reach Therapeutic Horizons.
Comincini S
Cells 2020 Sep 30;9(10) doi: 10.3390/cells9102216. PMID: 33007988Free PMC Article
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888
Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article

Clinical prediction guides

Reactivation of Retinopathy of Prematurity in Adults and Adolescents.
Uner OE, Rao P, Hubbard GB 3rd
Ophthalmol Retina 2020 Jul;4(7):720-727. Epub 2020 Feb 11 doi: 10.1016/j.oret.2020.02.001. PMID: 32224099Free PMC Article
Clinical significance of CD133 and Nestin in astrocytic tumor: The correlation with pathological grade and survival.
Zhang Q, Xu B, Chen J, Chen F, Chen Z
J Clin Lab Anal 2020 Mar;34(3):e23082. Epub 2019 Nov 1 doi: 10.1002/jcla.23082. PMID: 31677196Free PMC Article
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888
Toxin-based targeted therapy for malignant brain tumors.
Chandramohan V, Sampson JH, Pastan I, Bigner DD
Clin Dev Immunol 2012;2012:480429. Epub 2012 Feb 9 doi: 10.1155/2012/480429. PMID: 22400035Free PMC Article

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