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Neoplasm of the lip

MedGen UID:
9777
•Concept ID:
C0023761
•
Neoplastic Process
Synonym: Lip neoplasm
SNOMED CT: Tumor of lip (126770008); Neoplasm of lip (126770008)
 
HPO: HP:0100604
Monarch Initiative: MONDO:0021249

Definition

A tumor (abnormal growth of tissue) of the lip. [from HPO]

Professional guidelines

PubMed

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).
Lyon AR, López-Fernández T, Couch LS, Asteggiano R, Aznar MC, Bergler-Klein J, Boriani G, Cardinale D, Cordoba R, Cosyns B, Cutter DJ, de Azambuja E, de Boer RA, Dent SF, Farmakis D, Gevaert SA, Gorog DA, Herrmann J, Lenihan D, Moslehi J, Moura B, Salinger SS, Stephens R, Suter TM, Szmit S, Tamargo J, Thavendiranathan P, Tocchetti CG, van der Meer P, van der Pal HJH; ESC Scientific Document Group
Eur Heart J 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244. PMID: 36017568
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; ESC Scientific Document Group
Eur Heart J 2016 Jul 14;37(27):2129-2200. Epub 2016 May 20 doi: 10.1093/eurheartj/ehw128. PMID: 27206819
2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL; ESC Scientific Document Group
Eur Heart J 2015 Nov 21;36(44):3075-3128. Epub 2015 Aug 29 doi: 10.1093/eurheartj/ehv319. PMID: 26320109

Recent clinical studies

Etiology

Occupational variation in the incidence of lip cancer in the Nordic countries.
Mroueh R, Carpén T, Mäkitie A, Hansen J, Heikkinen S, Lynge E, Martinsen JI, Selander J, Mehlum IS, Torfadottir JE, Salo T, Pukkala E
Acta Oncol 2023 Jun;62(6):541-549. Epub 2023 Jun 19 doi: 10.1080/0284186X.2023.2224053. PMID: 37337140
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Lip reconstruction.
Ishii LE, Byrne PJ
Facial Plast Surg Clin North Am 2009 Aug;17(3):445-53. doi: 10.1016/j.fsc.2009.05.007. PMID: 19698922

Diagnosis

Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
Squamous cell carcinoma of the head and neck in children.
Dombrowski ND, Wolter NE, Irace AL, Robson CD, Perez-Atayde AR, Mack JW, Rahbar R
Int J Pediatr Otorhinolaryngol 2019 Feb;117:131-137. Epub 2018 Nov 20 doi: 10.1016/j.ijporl.2018.11.019. PMID: 30579067
Risk of lip cancer after solid organ transplantation in the United States.
Laprise C, Cahoon EK, Lynch CF, Kahn AR, Copeland G, Gonsalves L, Madeleine MM, Pfeiffer RM, Engels EA
Am J Transplant 2019 Jan;19(1):227-237. Epub 2018 Sep 5 doi: 10.1111/ajt.15052. PMID: 30074684Free PMC Article
Differential diagnoses of elevated lesions of the upper lip: An overview.
Bhandarkar GP, Shetty KV
J Cancer Res Ther 2017 Apr-Jun;13(2):170-174. doi: 10.4103/0973-1482.204890. PMID: 28643729
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
Vieira RA, Minicucci EM, Marques ME, Marques SA
An Bras Dermatol 2012 Jan-Feb;87(1):105-14. doi: 10.1590/s0365-05962012000100013. PMID: 22481658

Therapy

Fighting drug-resistant lung cancer by induction of NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated ferroptosis.
Yu J, Zhong B, Zhao L, Hou Y, Ai N, Lu JJ, Ge W, Chen X
Drug Resist Updat 2023 Sep;70:100977. Epub 2023 Jun 2 doi: 10.1016/j.drup.2023.100977. PMID: 37321064
Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
Reconstruction of Mohs Defects of the Lips and Chin.
Larrabee YC, Moyer JS
Facial Plast Surg Clin North Am 2017 Aug;25(3):427-442. doi: 10.1016/j.fsc.2017.03.012. PMID: 28676167
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article
Ultraviolet radiation.
Gallagher RP, Lee TK, Bajdik CD, Borugian M
Chronic Dis Can 2010;29 Suppl 1:51-68. PMID: 21199599

Prognosis

Occupational variation in the incidence of lip cancer in the Nordic countries.
Mroueh R, Carpén T, Mäkitie A, Hansen J, Heikkinen S, Lynge E, Martinsen JI, Selander J, Mehlum IS, Torfadottir JE, Salo T, Pukkala E
Acta Oncol 2023 Jun;62(6):541-549. Epub 2023 Jun 19 doi: 10.1080/0284186X.2023.2224053. PMID: 37337140
Does hydrochlorothiazide increase the incidence of skin, lip and oral cancer in a UK population?
Carney K, Cousins M
Evid Based Dent 2022 Mar;23(1):38-39. Epub 2022 Mar 25 doi: 10.1038/s41432-022-0255-x. PMID: 35338330
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Clinical features and management of schwannoma affecting the upper and lower lips.
Sitenga J, Aird G, Vaudreuil A, Huerter CJ
Int J Dermatol 2018 Sep;57(9):1047-1052. Epub 2018 Jan 29 doi: 10.1111/ijd.13920. PMID: 29377087
Global epidemiology of oral and oropharyngeal cancer.
Warnakulasuriya S
Oral Oncol 2009 Apr-May;45(4-5):309-16. Epub 2008 Sep 18 doi: 10.1016/j.oraloncology.2008.06.002. PMID: 18804401

Clinical prediction guides

Occupational variation in the incidence of lip cancer in the Nordic countries.
Mroueh R, Carpén T, Mäkitie A, Hansen J, Heikkinen S, Lynge E, Martinsen JI, Selander J, Mehlum IS, Torfadottir JE, Salo T, Pukkala E
Acta Oncol 2023 Jun;62(6):541-549. Epub 2023 Jun 19 doi: 10.1080/0284186X.2023.2224053. PMID: 37337140
The winning score.
Brown AC, Mortimer NJ, Salmon PJM
Australas J Dermatol 2022 Nov;63(4):e329-e330. Epub 2022 Oct 5 doi: 10.1111/ajd.13931. PMID: 36197678
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Pointless spatial modeling.
Wilson K, Wakefield J
Biostatistics 2020 Apr 1;21(2):e17-e32. doi: 10.1093/biostatistics/kxy041. PMID: 30202860Free PMC Article
Colposcopy.
Pretorius RG, Belinson JL
Minerva Ginecol 2012 Apr;64(2):173-80. PMID: 22481626

Recent systematic reviews

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019.
GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators, Cunha ARD, Compton K, Xu R, Mishra R, Drangsholt MT, Antunes JLF, Kerr AR, Acheson AR, Lu D, Wallace LE, Kocarnik JM, Fu W, Dean FE, Pennini A, Henrikson HJ, Alam T, Ababneh E, Abd-Elsalam S, Abdoun M, Abidi H, Abubaker Ali H, Abu-Gharbieh E, Adane TD, Addo IY, Ahmad A, Ahmad S, Ahmed Rashid T, Akonde M, Al Hamad H, Alahdab F, Alimohamadi Y, Alipour V, Al-Maweri SA, Alsharif U, Ansari-Moghaddam A, Anwar SL, Anyasodor AE, Arabloo J, Aravkin AY, Aruleba RT, Asaad M, Ashraf T, Athari SS, Attia S, Azadnajafabad S, Azangou-Khyavy M, Badar M, Baghcheghi N, Banach M, Bardhan M, Barqawi HJ, Bashir NZ, Bashiri A, Benzian H, Bernabe E, Bhagat DS, Bhojaraja VS, Bjørge T, Bouaoud S, Braithwaite D, Briko NI, Calina D, Carreras G, Chakraborty PA, Chattu VK, Chaurasia A, Chen MX, Cho WCS, Chu DT, Chukwu IS, Chung E, Cruz-Martins N, Dadras O, Dai X, Dandona L, Dandona R, Daneshpajouhnejad P, Darvishi Cheshmeh Soltani R, Darwesh AM, Debela SA, Derbew Molla M, Dessalegn FN, Dianati-Nasab M, Digesa LE, Dixit SG, Dixit A, Djalalinia S, El Sayed I, El Tantawi M, Enyew DB, Erku DA, Ezzeddini R, Fagbamigbe AF, Falzone L, Fetensa G, Fukumoto T, Gaewkhiew P, Gallus S, Gebrehiwot M, Ghashghaee A, Gill PS, Golechha M, Goleij P, Gomez RS, Gorini G, Guimaraes ALS, Gupta B, Gupta S, Gupta VB, Gupta VK, Haj-Mirzaian A, Halboub ES, Halwani R, Hanif A, Hariyani N, Harorani M, Hasani H, Hassan AM, Hassanipour S, Hassen MB, Hay SI, Hayat K, Herrera-Serna BY, Holla R, Horita N, Hosseinzadeh M, Hussain S, Ilesanmi OS, Ilic IM, Ilic MD, Isola G, Jaiswal A, Jani CT, Javaheri T, Jayarajah U, Jayaram S, Joseph N, Kadashetti V, Kandaswamy E, Karanth SD, Karaye IM, Kauppila JH, Kaur H, Keykhaei M, Khader YS, Khajuria H, Khanali J, Khatib MN, Khayat Kashani HR, Khazeei Tabari MA, Kim MS, Kompani F, Koohestani HR, Kumar GA, Kurmi OP, La Vecchia C, Lal DK, Landires I, Lasrado S, Ledda C, Lee YH, Libra M, Lim SS, Listl S, Lopukhov PD, Mafi AR, Mahumud RA, Malik AA, Mathur MR, Maulud SQ, Meena JK, Mehrabi Nasab E, Mestrovic T, Mirfakhraie R, Misganaw A, Misra S, Mithra P, Mohammad Y, Mohammadi M, Mohammadi E, Mokdad AH, Moni MA, Moraga P, Morrison SD, Mozaffari HR, Mubarik S, Murray CJL, Nair TS, Narasimha Swamy S, Narayana AI, Nassereldine H, Natto ZS, Nayak BP, Negru SM, Nggada HA, Nouraei H, Nuñez-Samudio V, Oancea B, Olagunju AT, Omar Bali A, Padron-Monedero A, Padubidri JR, Pandey A, Pardhan S, Patel J, Pezzani R, Piracha ZZ, Rabiee N, Radhakrishnan V, Radhakrishnan RA, Rahmani AM, Rahmanian V, Rao CR, Rao SJ, Rath GK, Rawaf DL, Rawaf S, Rawassizadeh R, Razeghinia MS, Rezaei N, Rezaei N, Rezaei N, Rezapour A, Riad A, Roberts TJ, Romero-Rodríguez E, Roshandel G, S M, S N C, Saddik B, Saeb MR, Saeed U, Safaei M, Sahebazzamani M, Sahebkar A, Salek Farrokhi A, Samy AM, Santric-Milicevic MM, Sathian B, Satpathy M, Šekerija M, Senthilkumaran S, Seylani A, Shafaat O, Shahsavari HR, Shamsoddin E, Sharew MM, Sharifi-Rad J, Shetty JK, Shivakumar KM, Shobeiri P, Shorofi SA, Shrestha S, Siddappa Malleshappa SK, Singh P, Singh JA, Singh G, Sinha DN, Solomon Y, Suleman M, Suliankatchi Abdulkader R, Taheri Abkenar Y, Talaat IM, Tan KK, Tbakhi A, Thiyagarajan A, Tiyuri A, Tovani-Palone MR, Unnikrishnan B, Vo B, Volovat SR, Wang C, Westerman R, Wickramasinghe ND, Xiao H, Yu C, Yuce D, Yunusa I, Zadnik V, Zare I, Zhang ZJ, Zoladl M, Force LM, Hugo FN
JAMA Oncol 2023 Oct 1;9(10):1401-1416. doi: 10.1001/jamaoncol.2023.2960. PMID: 37676656Free PMC Article
Laser Therapy for the Treatment of Actinic Cheilitis: A Systematic Review.
Ayen-Rodriguez A, Naranjo-Diaz MJ, Ruiz-Villaverde R
Int J Environ Res Public Health 2022 Apr 11;19(8) doi: 10.3390/ijerph19084593. PMID: 35457467Free PMC Article
The cost of oral cancer: A systematic review.
Ribeiro-Rotta RF, Rosa EA, Milani V, Dias NR, Masterson D, da Silva EN, Zara ALSA
PLoS One 2022;17(4):e0266346. Epub 2022 Apr 21 doi: 10.1371/journal.pone.0266346. PMID: 35446870Free PMC Article
Canalicular adenoma: A systematic review.
Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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