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Decitabine response

MedGen UID:
979014
Concept ID:
CN297880
Sign or Symptom
Drug:
decitabine
MedGen UID:
25072
Concept ID:
C0049065
Pharmacologic Substance
A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04) [from NCI]

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762

Curated

DailyMed Drug Label, decitabine, 2014

Recent clinical studies

Etiology

Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
Ohmoto A, Fuji S
Expert Rev Hematol 2023 Jul-Dec;16(10):761-771. Epub 2023 Sep 8 doi: 10.1080/17474086.2023.2256472. PMID: 37670667
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Lee P, Yim R, Yung Y, Chu HT, Yip PK, Gill H
Int J Mol Sci 2021 Sep 23;22(19) doi: 10.3390/ijms221910232. PMID: 34638574Free PMC Article
Montoro J, Yerlikaya A, Ali A, Raza A
Curr Treat Options Oncol 2018 Oct 25;19(12):66. doi: 10.1007/s11864-018-0583-4. PMID: 30362079

Diagnosis

Patnaik MM, Tefferi A
Am J Hematol 2024 Jun;99(6):1142-1165. Epub 2024 Mar 7 doi: 10.1002/ajh.27271. PMID: 38450850Free PMC Article
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585
Richard-Carpentier G, Jabbour E, Short NJ, Rausch CR, Savoy JM, Bose P, Yilmaz M, Jain N, Borthakur G, Ohanian M, Alvarado Y, Rytting M, Kebriaei P, Konopleva M, Kantarjian H, Ravandi F
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):212-218. Epub 2019 Sep 30 doi: 10.1016/j.clml.2019.09.608. PMID: 32035785

Therapy

Guo HZ, Feng RX, Zhang YJ, Yu YH, Lu W, Liu JJ, Yang SX, Zhao C, Zhang ZL, Yu SH, Jin H, Qian SX, Li JY, Zhu J, Shi J
Cell Rep Med 2024 Jun 18;5(6):101592. Epub 2024 Jun 5 doi: 10.1016/j.xcrm.2024.101592. PMID: 38843841Free PMC Article
Am J Health Syst Pharm 2020 Oct 30;77(22):1809-1811. doi: 10.1093/ajhp/zxaa276. PMID: 32945859
Montoro J, Yerlikaya A, Ali A, Raza A
Curr Treat Options Oncol 2018 Oct 25;19(12):66. doi: 10.1007/s11864-018-0583-4. PMID: 30362079
Konopleva M, Letai A
Blood 2018 Sep 6;132(10):1007-1012. Epub 2018 Jul 23 doi: 10.1182/blood-2018-03-828269. PMID: 30037885Free PMC Article
Gardin C, Dombret H
Curr Hematol Malig Rep 2017 Feb;12(1):1-10. doi: 10.1007/s11899-017-0363-4. PMID: 28286907

Prognosis

Kitajima S, Tani T, Springer BF, Campisi M, Osaki T, Haratani K, Chen M, Knelson EH, Mahadevan NR, Ritter J, Yoshida R, Köhler J, Ogino A, Nozawa RS, Sundararaman SK, Thai TC, Homme M, Piel B, Kivlehan S, Obua BN, Purcell C, Yajima M, Barbie TU, Lizotte PH, Jänne PA, Paweletz CP, Gokhale PC, Barbie DA
Cancer Cell 2022 Oct 10;40(10):1128-1144.e8. Epub 2022 Sep 22 doi: 10.1016/j.ccell.2022.08.015. PMID: 36150391Free PMC Article
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585
Richard-Carpentier G, Jabbour E, Short NJ, Rausch CR, Savoy JM, Bose P, Yilmaz M, Jain N, Borthakur G, Ohanian M, Alvarado Y, Rytting M, Kebriaei P, Konopleva M, Kantarjian H, Ravandi F
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):212-218. Epub 2019 Sep 30 doi: 10.1016/j.clml.2019.09.608. PMID: 32035785
Gardin C, Dombret H
Curr Hematol Malig Rep 2017 Feb;12(1):1-10. doi: 10.1007/s11899-017-0363-4. PMID: 28286907

Clinical prediction guides

Rodríguez-Medina C, Stuckey R, Bilbao-Sieyro C, Gómez-Casares MT
Int J Mol Sci 2024 Jan 24;25(3) doi: 10.3390/ijms25031421. PMID: 38338698Free PMC Article
Ohmoto A, Fuji S
Expert Rev Hematol 2023 Jul-Dec;16(10):761-771. Epub 2023 Sep 8 doi: 10.1080/17474086.2023.2256472. PMID: 37670667
Kayser S, Levis MJ
Br J Haematol 2022 Jan;196(2):316-328. Epub 2021 Aug 4 doi: 10.1111/bjh.17746. PMID: 34350585
Diamantopoulos PT, Viniou NA
Leuk Res 2021 Apr;103:106543. Epub 2021 Feb 20 doi: 10.1016/j.leukres.2021.106543. PMID: 33640709
Gardin C, Dombret H
Curr Hematol Malig Rep 2017 Feb;12(1):1-10. doi: 10.1007/s11899-017-0363-4. PMID: 28286907

Recent systematic reviews

Li X, Suh HS, Lachaine J, Schuh AC, Pratz K, Betts KA, Song J, Dua A, Bui CN
Value Health 2023 Dec;26(12):1689-1696. Epub 2023 Sep 21 doi: 10.1016/j.jval.2023.09.001. PMID: 37741447
Li J, Yin X
Hematology 2022 Dec;27(1):300-309. doi: 10.1080/16078454.2022.2042964. PMID: 35225170
Stone A, Zukerman T, Flaishon L, Yakar RB, Rowe JM
Leuk Res 2019 Jul;82:36-42. Epub 2019 May 21 doi: 10.1016/j.leukres.2019.05.007. PMID: 31152922
He PF, Zhou JD, Yao DM, Ma JC, Wen XM, Zhang ZH, Lian XY, Xu ZJ, Qian J, Lin J
Oncotarget 2017 Jun 20;8(25):41498-41507. doi: 10.18632/oncotarget.17241. PMID: 28489568Free PMC Article
Linnekamp JF, Butter R, Spijker R, Medema JP, van Laarhoven HWM
Cancer Treat Rev 2017 Mar;54:10-23. Epub 2017 Jan 18 doi: 10.1016/j.ctrv.2017.01.004. PMID: 28189913

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