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Alcoholic liver diseases

MedGen UID:
9793
Concept ID:
C0023896
Disease or Syndrome
Synonyms: Alcoholic Liver Disease; Alcoholic Liver Diseases; Liver Disease, Alcoholic; Liver Diseases, Alcoholic
SNOMED CT: ALD - Alcoholic liver disease (41309000); Alcoholic liver disease (41309000)
 
Monarch Initiative: MONDO:0043693

Definition

A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis. [from NCI]

Professional guidelines

PubMed

Bakasis AD, Androutsakos T
Cells 2021 May 15;10(5) doi: 10.3390/cells10051212. PMID: 34063534Free PMC Article
Sacco R, Eggenhoffner R, Giacomelli L
Minerva Gastroenterol Dietol 2016 Dec;62(4):316-324. Epub 2016 Sep 7 PMID: 27603810
Suk KT, Kim MY, Baik SK
World J Gastroenterol 2014 Sep 28;20(36):12934-44. doi: 10.3748/wjg.v20.i36.12934. PMID: 25278689Free PMC Article

Recent clinical studies

Etiology

Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Bajaj JS
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):235-246. doi: 10.1038/s41575-018-0099-1. PMID: 30643227
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Dunn W, Shah VH
Clin Liver Dis 2016 Aug;20(3):445-56. Epub 2016 Mar 28 doi: 10.1016/j.cld.2016.02.004. PMID: 27373608Free PMC Article
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Diagnosis

Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H
Nat Rev Dis Primers 2018 Aug 16;4(1):16. doi: 10.1038/s41572-018-0014-7. PMID: 30115921
Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH
Am J Gastroenterol 2018 Feb;113(2):175-194. Epub 2018 Jan 16 doi: 10.1038/ajg.2017.469. PMID: 29336434Free PMC Article
Rocco A, Compare D, Angrisani D, Sanduzzi Zamparelli M, Nardone G
World J Gastroenterol 2014 Oct 28;20(40):14652-9. doi: 10.3748/wjg.v20.i40.14652. PMID: 25356028Free PMC Article

Therapy

Wu X, Fan X, Miyata T, Kim A, Cajigas-Du Ross CK, Ray S, Huang E, Taiwo M, Arya R, Wu J, Nagy LE
Annu Rev Pathol 2023 Jan 24;18:411-438. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-030435. PMID: 36270295Free PMC Article
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Liu SY, Tsai IT, Hsu YC
Int J Mol Sci 2021 May 13;22(10) doi: 10.3390/ijms22105170. PMID: 34068269Free PMC Article
Bajaj JS
Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):235-246. doi: 10.1038/s41575-018-0099-1. PMID: 30643227
Gao B, Bataller R
Gastroenterology 2011 Nov;141(5):1572-85. Epub 2011 Sep 12 doi: 10.1053/j.gastro.2011.09.002. PMID: 21920463Free PMC Article

Prognosis

Crabb DW, Im GY, Szabo G, Mellinger JL, Lucey MR
Hepatology 2020 Jan;71(1):306-333. doi: 10.1002/hep.30866. PMID: 31314133
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Marroni CA, Fleck AM Jr, Fernandes SA, Galant LH, Mucenic M, de Mattos Meine MH, Mariante-Neto G, Brandão ABM
World J Gastroenterol 2018 Jul 14;24(26):2785-2805. doi: 10.3748/wjg.v24.i26.2785. PMID: 30018475Free PMC Article
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article
Szabo G
Gastroenterology 2015 Jan;148(1):30-6. Epub 2014 Nov 11 doi: 10.1053/j.gastro.2014.10.042. PMID: 25447847Free PMC Article

Clinical prediction guides

Jophlin LL, Singal AK, Bataller R, Wong RJ, Sauer BG, Terrault NA, Shah VH
Am J Gastroenterol 2024 Jan 1;119(1):30-54. Epub 2023 Sep 1 doi: 10.14309/ajg.0000000000002572. PMID: 38174913
Zhang Z, Burrows K, Fuller H, Speliotes EK, Abeysekera KWM, Thorne JL, Lewis SJ, Zulyniak MA, Moore JB
Nutrients 2023 Mar 16;15(6) doi: 10.3390/nu15061442. PMID: 36986172Free PMC Article
Singal AK, Mathurin P
JAMA 2021 Jul 13;326(2):165-176. doi: 10.1001/jama.2021.7683. PMID: 34255003
Lamas-Paz A, Hao F, Nelson LJ, Vázquez MT, Canals S, Gómez Del Moral M, Martínez-Naves E, Nevzorova YA, Cubero FJ
World J Gastroenterol 2018 Dec 7;24(45):5063-5075. doi: 10.3748/wjg.v24.i45.5063. PMID: 30568384Free PMC Article
Stickel F, Datz C, Hampe J, Bataller R
Gut Liver 2017 Mar 15;11(2):173-188. doi: 10.5009/gnl16477. PMID: 28274107Free PMC Article

Recent systematic reviews

Xue H, Wei M, Ji L
Phytomedicine 2023 Sep;118:154961. Epub 2023 Jul 9 doi: 10.1016/j.phymed.2023.154961. PMID: 37453191
Amonker S, Houshmand A, Hinkson A, Rowe I, Parker R
Hepatol Commun 2023 May 1;7(5) Epub 2023 Apr 26 doi: 10.1097/HC9.0000000000000133. PMID: 37102767Free PMC Article
Mezzano G, Juanola A, Cardenas A, Mezey E, Hamilton JP, Pose E, Graupera I, Ginès P, Solà E, Hernaez R
Gut 2022 Jan;71(1):148-155. Epub 2021 Jan 12 doi: 10.1136/gutjnl-2020-322161. PMID: 33436495
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM
Hepatology 2020 Nov;72(5):1605-1616. Epub 2020 Oct 27 doi: 10.1002/hep.31173. PMID: 32043613

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