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Opsoclonus-myoclonus syndrome

MedGen UID:
97955
•Concept ID:
C0393626
•
Disease or Syndrome
Synonyms: Dancing eyes-dancing feet syndrome; Infantile polymyoclonus; Kinsbourne syndrome
SNOMED CT: Opsoclonus-myoclonus syndrome (230350000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015247
Orphanet: ORPHA1183

Definition

Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Opsoclonus-myoclonus syndrome

Professional guidelines

PubMed

Opsoclonus-myoclonus Syndrome with Neuroblastoma in Children and their Anaesthetic Management.
Gupta A, Kundal R, Pandey M
J Coll Physicians Surg Pak 2022 Aug;32(8):1086-1088. doi: 10.29271/jcpsp.2022.08.1086. PMID: 35932142
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.
Grativvol RS, Cavalcante WCP, Castro LHM, Nitrini R, Simabukuro MM
Curr Oncol Rep 2018 Nov 10;20(11):92. doi: 10.1007/s11912-018-0721-y. PMID: 30415318

Recent clinical studies

Etiology

Immune-mediated ataxias: Guide to clinicians.
Meira AT, de Moraes MPM, Ferreira MG, Franklin GL, Rezende Filho FM, Teive HAG, Barsottini OGP, Pedroso JL
Parkinsonism Relat Disord 2023 Dec;117:105861. Epub 2023 Sep 20 doi: 10.1016/j.parkreldis.2023.105861. PMID: 37748994
Clinical features and outcomes of opsoclonus myoclonus ataxia syndrome.
Yıldırım M, Öncel İ, Bektaş Ö, Tanalı G, Şahin S, Kutluk T, Teber S, Anlar B
Eur J Paediatr Neurol 2022 Nov;41:19-26. Epub 2022 Sep 20 doi: 10.1016/j.ejpn.2022.09.002. PMID: 36155293
Paraneoplastic syndrome in neuroophthalmology.
Kang L, Wan C
J Neurol 2022 Oct;269(10):5272-5282. Epub 2022 Jul 2 doi: 10.1007/s00415-022-11247-z. PMID: 35779086
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Immune-mediated ataxias.
Joubert B, Rostásy K, Honnorat J
Handb Clin Neurol 2018;155:313-332. doi: 10.1016/B978-0-444-64189-2.00021-4. PMID: 29891069

Diagnosis

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Opsoclonus-myoclonus-ataxia syndrome in children.
Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC
J Neurol 2022 Feb;269(2):750-757. Epub 2021 Mar 29 doi: 10.1007/s00415-021-10536-3. PMID: 33779841
Update on opsoclonus-myoclonus syndrome in adults.
Oh SY, Kim JS, Dieterich M
J Neurol 2019 Jun;266(6):1541-1548. Epub 2018 Nov 27 doi: 10.1007/s00415-018-9138-7. PMID: 30483882
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Opsoclonus-myoclonus syndrome.
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330

Therapy

Clinical features and outcomes of opsoclonus myoclonus ataxia syndrome.
Yıldırım M, Öncel İ, Bektaş Ö, Tanalı G, Şahin S, Kutluk T, Teber S, Anlar B
Eur J Paediatr Neurol 2022 Nov;41:19-26. Epub 2022 Sep 20 doi: 10.1016/j.ejpn.2022.09.002. PMID: 36155293
Postinfectious SARS-CoV-2 Opsoclonus-Myoclonus-Ataxia Syndrome.
Nelson JL, Blume GM, Bansal SK, Kaufman JR, Woods FR, Zhang X, Kattah JC
J Neuroophthalmol 2022 Jun 1;42(2):251-255. Epub 2021 Dec 30 doi: 10.1097/WNO.0000000000001498. PMID: 34974489
The Treatment of Opsoclonus-Myoclonus Syndrome Secondary to Neuroblastic Tumours-Single-Centre Experience and Literature Review.
Mizia-Malarz A, Stolpa W, Sobol-Milejska G
Medicina (Kaunas) 2020 Aug 14;56(8) doi: 10.3390/medicina56080412. PMID: 32823831Free PMC Article
Opsoclonus-myoclonus syndrome.
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330
Rituximab.
Borker A, Choudhary N
Indian Pediatr 2011 Aug;48(8):627-32. doi: 10.1007/s13312-011-0098-6. PMID: 21918268

Prognosis

Opsoclonus-myoclonus syndrome associated with neuroblastoma: Insights into antitumor immunity.
Du H, Cai W
Pediatr Blood Cancer 2022 Nov;69(11):e29949. Epub 2022 Sep 12 doi: 10.1002/pbc.29949. PMID: 36094353
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges.
Mitoma H, Manto M, Hampe CS
Curr Neuropharmacol 2019;17(1):33-58. doi: 10.2174/1570159X16666180917105033. PMID: 30221603Free PMC Article
Trends and tenets in relapsing and progressive opsoclonus-myoclonus syndrome.
Pranzatelli MR, Tate ED
Brain Dev 2016 May;38(5):439-48. Epub 2016 Jan 16 doi: 10.1016/j.braindev.2015.11.007. PMID: 26786246
Opsoclonus-myoclonus syndrome.
Pike M
Handb Clin Neurol 2013;112:1209-11. doi: 10.1016/B978-0-444-52910-7.00042-8. PMID: 23622330

Clinical prediction guides

Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma.
Rosenberg MI, Greenstein E, Buchkovich M, Peres A, Santoni-Rugiu E, Yang L, Mikl M, Vaksman Z, Gibbs DL, Reshef D, Salovin A, Irwin MS, Naranjo A, Ulitsky I, de Alarcon PA, Matthay KK, Weigman V, Yaari G, Panzer JA, Friedman N, Maris JM
Cell Rep 2023 Aug 29;42(8):112879. Epub 2023 Aug 2 doi: 10.1016/j.celrep.2023.112879. PMID: 37537844Free PMC Article
Autoimmune and paraneoplastic movement disorders: An update.
Baizabal-Carvallo JF, Jankovic J
J Neurol Sci 2018 Feb 15;385:175-184. Epub 2017 Dec 30 doi: 10.1016/j.jns.2017.12.035. PMID: 29406902
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA
Semin Fetal Neonatal Med 2012 Aug;17(4):207-215. Epub 2012 Jun 4 doi: 10.1016/j.siny.2012.05.002. PMID: 22673527
Paraneoplastic neurological disorders.
Blaes F, Tschernatsch M
Expert Rev Neurother 2010 Oct;10(10):1559-68. doi: 10.1586/ern.10.134. PMID: 20925471
Symptomatic myoclonus.
Borg M
Neurophysiol Clin 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17 doi: 10.1016/j.neucli.2006.12.006. PMID: 17336775

Recent systematic reviews

Covid-19 vaccines and neurological complications: a systematic review.
Allahyari F, Molaee H, Hosseini Nejad J
Z Naturforsch C J Biosci 2023 Jan 27;78(1-2):1-8. Epub 2022 Sep 12 doi: 10.1515/znc-2022-0092. PMID: 36087300
Systematic review of immunoglobulin use in paediatric neurological and neurodevelopmental disorders.
Gadian J, Kirk E, Holliday K, Lim M, Absoud M
Dev Med Child Neurol 2017 Feb;59(2):136-144. Epub 2016 Nov 30 doi: 10.1111/dmcn.13349. PMID: 27900773
Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review.
Sweeney M, Sweney M, Soldán MM, Clardy SL
Pediatr Neurol 2016 Dec;65:86-89. Epub 2016 Sep 2 doi: 10.1016/j.pediatrneurol.2016.08.024. PMID: 27707529
Cognitive and psychiatric phenotypes of movement disorders in children: a systematic review.
Ben-Pazi H, Jaworowski S, Shalev RS
Dev Med Child Neurol 2011 Dec;53(12):1077-84. Epub 2011 Sep 27 doi: 10.1111/j.1469-8749.2011.04134.x. PMID: 21950517

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