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Kikuchi-Fujimoto disease

MedGen UID:
97979
Concept ID:
C0398367
Disease or Syndrome
Synonyms: Histiocytic necrotising lymphadenitis; Kikuchi disease; Kikuchi necrotizing lymphadenitis; Kikuchi's disease; Kikuchi-Fujimoto's disease; Nosocomial Kikuchi's disease
SNOMED CT: Kikuchi disease (127217009); Histiocytic necrotizing lymphadenopathy (127217009); Histiocytic necrotizing lymphadenitis (127217009)
 
Monarch Initiative: MONDO:0018864
Orphanet: ORPHA50918

Definition

Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disorder, characterized by regional cervical lymphadenopathy with tenderness, usually accompanied with mild fever and night sweats. Less frequent symptoms include weight loss, nausea, vomiting, sore throat. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKikuchi-Fujimoto disease

Professional guidelines

PubMed

Sharath M, Gupta YK
Trop Doct 2023 Apr;53(2):301-302. Epub 2022 Nov 15 doi: 10.1177/00494755221137971. PMID: 36380612
Deaver D, Horna P, Cualing H, Sokol L
Cancer Control 2014 Oct;21(4):313-21. doi: 10.1177/107327481402100407. PMID: 25310212
Monaco SE, Khalbuss WE, Pantanowitz L
Diagn Cytopathol 2012 Oct;40(10):925-38. Epub 2012 Feb 20 doi: 10.1002/dc.21767. PMID: 22351626

Recent clinical studies

Etiology

Choi S, Choi HS, Ryu YJ, Kim JY, Paik JH, Ahn S, Lee H
J Pediatr 2023 Sep;260:113515. Epub 2023 May 25 doi: 10.1016/j.jpeds.2023.113515. PMID: 37244579
Selvanathan SN, Suhumaran S, Sahu VK, Chong CY, Tan NWH, Thoon KC
J Paediatr Child Health 2020 Mar;56(3):389-393. Epub 2019 Oct 1 doi: 10.1111/jpc.14628. PMID: 31576642
Salamat S, Chan J, Jolly K, Powell G, Harrison K, Ahanger S, Hari C
Head Neck Pathol 2020 Mar;14(1):272-275. Epub 2019 Mar 19 doi: 10.1007/s12105-019-01026-0. PMID: 30888636Free PMC Article
Pepe F, Disma S, Teodoro C, Pepe P, Magro G
Pathologica 2016 Sep;108(3):120-129. PMID: 28195263
Deaver D, Horna P, Cualing H, Sokol L
Cancer Control 2014 Oct;21(4):313-21. doi: 10.1177/107327481402100407. PMID: 25310212

Diagnosis

Perry AM, Choi SM
Arch Pathol Lab Med 2018 Nov;142(11):1341-1346. doi: 10.5858/arpa.2018-0219-RA. PMID: 30407860
Cuglievan B, Miranda RN
Blood 2017 Feb 16;129(7):917. doi: 10.1182/blood-2016-08-736413. PMID: 28209753
Liao CY, Chien ST, Wang CC
QJM 2014 Nov;107(11):931-2. Epub 2014 Mar 25 doi: 10.1093/qjmed/hcu065. PMID: 24667099
Dalton J, Shaw R, Democratis J
Lancet 2014 Mar 22;383(9922):1098. doi: 10.1016/S0140-6736(14)60262-2. PMID: 24656202
Hutchinson CB, Wang E
Arch Pathol Lab Med 2010 Feb;134(2):289-93. doi: 10.5858/134.2.289. PMID: 20121621

Therapy

Choi S, Choi HS, Ryu YJ, Kim JY, Paik JH, Ahn S, Lee H
J Pediatr 2023 Sep;260:113515. Epub 2023 May 25 doi: 10.1016/j.jpeds.2023.113515. PMID: 37244579
Rodríguez-Ferreras A, Maray I, Coya-Fernández C, Octavio-Bocigas MM, Fernández-Del Río MF, Casares-López S, Ruiz-Salazar J
Eur Ann Allergy Clin Immunol 2023 Nov;55(6):278-282. Epub 2022 Nov 15 doi: 10.23822/EurAnnACI.1764-1489.273. PMID: 36458479
Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier L, Meyer O, Rapp C, Deligny C, Godeau B, Aslangul E, Lambotte O, Papo T, Pouchot J, Hamidou M, Bachmeyer C, Hachulla E, Carmoi T, Dhote R, Gerin M, Mekinian A, Stirnemann J, Charlotte F, Farge D, Molina T, Fain O
Medicine (Baltimore) 2014 Nov;93(24):372-382. doi: 10.1097/MD.0000000000000220. PMID: 25500707Free PMC Article
Spooner BB, Rahman I, Langford N, Ferner RE
BMJ Case Rep 2010 May 19;2010 doi: 10.1136/bcr.11.2009.2469. PMID: 22750925Free PMC Article
Zou CC, Zhao ZY, Liang L
Indian J Pediatr 2009 Sep;76(9):959-62. Epub 2009 Nov 4 doi: 10.1007/s12098-009-0194-y. PMID: 19904514

Prognosis

Salamat S, Chan J, Jolly K, Powell G, Harrison K, Ahanger S, Hari C
Head Neck Pathol 2020 Mar;14(1):272-275. Epub 2019 Mar 19 doi: 10.1007/s12105-019-01026-0. PMID: 30888636Free PMC Article
Mathew LM, Kapila R, Schwartz RA
Int J Dermatol 2016 Oct;55(10):1069-75. Epub 2016 May 21 doi: 10.1111/ijd.13314. PMID: 27207311
Duskin-Bitan H, Kivity S, Olchovsky D, Schiby G, Ezra D, Mouallem M
Isr Med Assoc J 2010 Oct;12(10):617-21. PMID: 21090519
Parveen R, Rahman SH, Yasmin R, Quadir MS, Muazzam N, Alam MN
Mymensingh Med J 2009 Jan;18(1):95-8. PMID: 19182759
Onciu M, Medeiros LJ
Adv Anat Pathol 2003 Jul;10(4):204-11. doi: 10.1097/00125480-200307000-00003. PMID: 12826826

Clinical prediction guides

Cheng MH, Xie LJ
Medicine (Baltimore) 2024 Apr 19;103(16):e37779. doi: 10.1097/MD.0000000000037779. PMID: 38640333Free PMC Article
Lin YC, Huang HH, Nong BR, Liu PY, Chen YY, Huang YF, Chiou YH, Lee HS
J Microbiol Immunol Infect 2019 Jun;52(3):395-401. Epub 2017 Sep 29 doi: 10.1016/j.jmii.2017.08.023. PMID: 29050748
Pepe F, Disma S, Teodoro C, Pepe P, Magro G
Pathologica 2016 Sep;108(3):120-129. PMID: 28195263
Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier L, Meyer O, Rapp C, Deligny C, Godeau B, Aslangul E, Lambotte O, Papo T, Pouchot J, Hamidou M, Bachmeyer C, Hachulla E, Carmoi T, Dhote R, Gerin M, Mekinian A, Stirnemann J, Charlotte F, Farge D, Molina T, Fain O
Medicine (Baltimore) 2014 Nov;93(24):372-382. doi: 10.1097/MD.0000000000000220. PMID: 25500707Free PMC Article
Lamzaf L, Harmouche H, Maamar M, Adnaoui M, Aouni M, Tazi Mezalek Z
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):329-332. Epub 2014 Oct 5 doi: 10.1016/j.anorl.2013.01.007. PMID: 25294358

Recent systematic reviews

Zaccarelli F, de Vincentiis M, D'Erme G, Greco A, Natalucci F, Fusconi M
Curr Rheumatol Rev 2023;19(2):159-167. doi: 10.2174/1573397118666220903123128. PMID: 36056828
Rai B, Pillinger MH, Panush RS
Clin Rheumatol 2021 Dec;40(12):4791-4805. Epub 2021 Jun 7 doi: 10.1007/s10067-021-05769-6. PMID: 34100163

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