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Orofacial granulomatosis

MedGen UID:
98000
•Concept ID:
C0399496
•
Disease or Syndrome
Synonyms: Granulomatoses, Orofacial; Granulomatosis, Orofacial; Orofacial Granulomatoses; Orofacial Granulomatosis
SNOMED CT: Orofacial granulomatosis (235048000); OFG - Orofacial granulomatosis (235048000)

Definition

A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. Among experts there is disagreement on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOrofacial granulomatosis

Professional guidelines

PubMed

Management of orofacial granulomatosis.
Joshi S, Mawdsley J, Hullah E, Ormond M, Carey B
Br J Hosp Med (Lond) 2023 Mar 2;29(3):1-16. Epub 2023 Mar 29 doi: 10.12968/hmed.2022.0416. PMID: 36989148
Current treatment modalities in granulomatous cheilitis.
Pathania YS
Int J Dermatol 2022 Jun;61(6):755-759. Epub 2022 Feb 17 doi: 10.1111/ijd.16126. PMID: 35174873
Orofacial granulomatosis: presentation and management.
Tailor A, Hegarty AM, Brierley DJ
Br J Hosp Med (Lond) 2021 Mar 2;82(3):1-6. Epub 2021 Mar 22 doi: 10.12968/hmed.2020.0509. PMID: 33792397

Recent clinical studies

Etiology

Orofacial Granulomatosis and Crohn Disease: Coincidence or Pattern? A Systematic Review.
Gavioli CFB, Florezi GP, Dabronzo MLD, Jiménez MR, Nico MMS, Lourenço SV
Dermatology 2021;237(4):635-640. Epub 2021 Feb 12 doi: 10.1159/000513446. PMID: 33582676
Non-infectious Granulomatous Lesions of the Orofacial Region.
Müller S
Head Neck Pathol 2019 Sep;13(3):449-456. Epub 2019 Jan 9 doi: 10.1007/s12105-018-00997-w. PMID: 30627963Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Association between orofacial granulomatosis and Crohn's disease in children: systematic review.
Lazzerini M, Bramuzzo M, Ventura A
World J Gastroenterol 2014 Jun 21;20(23):7497-504. doi: 10.3748/wjg.v20.i23.7497. PMID: 24966621Free PMC Article

Diagnosis

Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature.
Galdiero MR, Maio F, Arcoleo F, Boni E, Bonzano L, Brussino L, Cancian M, Cremonte L, Del Giacco SR, De Paulis A, Detoraki A, Firinu D, Lamacchia D, Loffredo S, Nettis E, Parente R, Parronchi P, Pellacani G, Petraroli A, Rolla G, Senter R, Triggiani M, Vitiello G, Spadaro G, Bova M
Allergy 2021 Jul;76(7):2189-2200. Epub 2021 May 15 doi: 10.1111/all.14799. PMID: 33641182
Oral Granulomatous Disease.
Alawi F, Shields BE, Omolehinwa T, Rosenbach M
Dermatol Clin 2020 Oct;38(4):429-439. doi: 10.1016/j.det.2020.05.004. PMID: 32892852
Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities.
McNamara KK, Kalmar JR
Head Neck Pathol 2019 Mar;13(1):4-15. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01002-8. PMID: 30693460Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome.
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816

Therapy

Current treatment modalities in granulomatous cheilitis.
Pathania YS
Int J Dermatol 2022 Jun;61(6):755-759. Epub 2022 Feb 17 doi: 10.1111/ijd.16126. PMID: 35174873
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome.
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816
Orofacial Granulomatosis.
Kacher JE
Tex Dent J 2015 Jul;132(7):428, 466-7. PMID: 26470520
Association between orofacial granulomatosis and Crohn's disease in children: systematic review.
Lazzerini M, Bramuzzo M, Ventura A
World J Gastroenterol 2014 Jun 21;20(23):7497-504. doi: 10.3748/wjg.v20.i23.7497. PMID: 24966621Free PMC Article
Granulomatous cheilitis.
Baqai MF, Baqai MT, Kashif T
J R Coll Physicians Edinb 2013;43(4):312-4. doi: 10.4997/JRCPE.2013.408. PMID: 24350313

Prognosis

Current treatment modalities in granulomatous cheilitis.
Pathania YS
Int J Dermatol 2022 Jun;61(6):755-759. Epub 2022 Feb 17 doi: 10.1111/ijd.16126. PMID: 35174873
An update on investigations of autoimmune diseases affecting orofacial region.
Garlapati K, Rallabandi M, Shalini S
J Immunoassay Immunochem 2020;41(1):1-19. Epub 2019 Oct 23 doi: 10.1080/15321819.2019.1680387. PMID: 31645179
Streptococcus Salivarius: A Potential Salivary Biomarker for Orofacial Granulomatosis and Crohn's Disease?
Goel RM, Prosdocimi EM, Amar A, Omar Y, Escudier MP, Sanderson JD, Wade WG, Prescott NJ
Inflamm Bowel Dis 2019 Jul 17;25(8):1367-1374. doi: 10.1093/ibd/izz022. PMID: 30796823Free PMC Article
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome.
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816
Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis.
Campbell HE, Escudier MP, Patel P, Challacombe SJ, Sanderson JD, Lomer MC
Aliment Pharmacol Ther 2011 Oct;34(7):687-701. Epub 2011 Aug 4 doi: 10.1111/j.1365-2036.2011.04792.x. PMID: 21815899

Clinical prediction guides

Current treatment modalities in granulomatous cheilitis.
Pathania YS
Int J Dermatol 2022 Jun;61(6):755-759. Epub 2022 Feb 17 doi: 10.1111/ijd.16126. PMID: 35174873
Clinical Profile of Melkersson-Rosenthal Syndrome/Orofacial Granulomatosis: A Review of 51 Patients.
Gavioli CF, Florezi GP, Lourenço SV, Nico MM
J Cutan Med Surg 2021 Jul-Aug;25(4):390-396. Epub 2021 Feb 11 doi: 10.1177/1203475421995132. PMID: 33573395
Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients.
Petti S, Polimeni A, Berloco PB, Scully C
Oral Dis 2013 Jan;19(1):18-36. Epub 2012 Mar 28 doi: 10.1111/j.1601-0825.2012.01925.x. PMID: 22458357
Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis.
Campbell HE, Escudier MP, Patel P, Challacombe SJ, Sanderson JD, Lomer MC
Aliment Pharmacol Ther 2011 Oct;34(7):687-701. Epub 2011 Aug 4 doi: 10.1111/j.1365-2036.2011.04792.x. PMID: 21815899
Orofacial granulomatosis: clinical features and long-term outcome of therapy.
Al Johani KA, Moles DR, Hodgson TA, Porter SR, Fedele S
J Am Acad Dermatol 2010 Apr;62(4):611-20. Epub 2010 Feb 4 doi: 10.1016/j.jaad.2009.03.051. PMID: 20137827

Recent systematic reviews

Orofacial Granulomatosis and Crohn Disease: Coincidence or Pattern? A Systematic Review.
Gavioli CFB, Florezi GP, Dabronzo MLD, Jiménez MR, Nico MMS, Lourenço SV
Dermatology 2021;237(4):635-640. Epub 2021 Feb 12 doi: 10.1159/000513446. PMID: 33582676
A Systematic Review of the Literature of the Three Related Disease Entities Cheilitis Granulomatosa, Orofacial Granulomatosis and Melkersson - Rosenthal Syndrome.
Wehl G, Rauchenzauner M
Curr Pediatr Rev 2018;14(3):196-203. doi: 10.2174/1573396314666180515113941. PMID: 29766816
World Workshop on Oral Medicine VI: Patient-reported outcome measures and oral mucosal disease: current status and future direction.
Ní Ríordáin R, Shirlaw P, Alajbeg I, Al Zamel GY, Fung PL, Yuan AD, McCreary C, Stoopler ET, De Rossi SS, Lodi G, Greenberg MS, Brennan MT
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Aug;120(2):152-60.e11. Epub 2015 Mar 17 doi: 10.1016/j.oooo.2015.01.023. PMID: 25934415
Association between orofacial granulomatosis and Crohn's disease in children: systematic review.
Lazzerini M, Bramuzzo M, Ventura A
World J Gastroenterol 2014 Jun 21;20(23):7497-504. doi: 10.3748/wjg.v20.i23.7497. PMID: 24966621Free PMC Article
A comprehensive review of current treatments for granulomatous cheilitis.
Banks T, Gada S
Br J Dermatol 2012 May;166(5):934-7. doi: 10.1111/j.1365-2133.2011.10794.x. PMID: 22187977

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