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Post-transplant lymphoproliferative disease

MedGen UID:
98160
Concept ID:
C0432487
Neoplastic Process
Synonyms: Lymphoproliferative disorder following transplantation; post-transplant lymphoproliferative disease; Post-transplant lymphoproliferative disorder; Post-Transplant Lymphoproliferative Disorder; post-transplant lymphoproliferative disorder; Post-transplantation lymphoproliferation; Post-transplantation lymphoproliferative syndrome; PTLD; PTLD - Post-transplant lymphoproliferative disorder
SNOMED CT: Post-transplantation lymphoproliferative syndrome (254290004); Lymphoproliferative disorder following transplantation (254290004); Post-transplant lymphoproliferative disorder (254290004); PTLD - Post-transplant lymphoproliferative disorder (254290004); Post-transplantation lymphoproliferation (1155771008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019088
Orphanet: ORPHA70568

Definition

A group of rare immunodeficiency-associated lymphoproliferative disorders characterized by lymphoid or plasmacytic proliferations developing in the context of immunosuppression in a recipient of a solid organ or stem cell allograft. The group includes non-destructive post-transplant lymphoproliferative disorders (PTLDs), polymorphic PTLD, monomorphic PTLDs, and classic Hodgkin lymphoma PTLD. Patients may have more than one type of PTLD in a single or in different locations. The most commonly involved sites are lymph nodes, gastrointestinal tract, lungs, and liver, although the disease may occur almost anywhere in the body. In solid organ transplant recipients, PTLD may also involve the allograft. [from ORDO]

Professional guidelines

PubMed

Al Hamed R, Bazarbachi AH, Mohty M
Bone Marrow Transplant 2020 Jan;55(1):25-39. Epub 2019 May 14 doi: 10.1038/s41409-019-0548-7. PMID: 31089285
Angarone M, Snydman DR; AST ID Community of Practice
Clin Transplant 2019 Sep;33(9):e13550. Epub 2019 Apr 10 doi: 10.1111/ctr.13550. PMID: 30913334
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Recent clinical studies

Etiology

Gross TG, Rubinstein JD
Hematol Oncol 2023 Jun;41 Suppl 1:48-56. doi: 10.1002/hon.3139. PMID: 37294957
Ambinder RF
Recent Results Cancer Res 2021;217:197-207. doi: 10.1007/978-3-030-57362-1_9. PMID: 33200367
Al Hamed R, Bazarbachi AH, Mohty M
Bone Marrow Transplant 2020 Jan;55(1):25-39. Epub 2019 May 14 doi: 10.1038/s41409-019-0548-7. PMID: 31089285
Llaurador G, McLaughlin L, Wistinghausen B
Curr Opin Pediatr 2017 Feb;29(1):34-40. doi: 10.1097/MOP.0000000000000445. PMID: 27906865
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Diagnosis

Gross TG, Rubinstein JD
Hematol Oncol 2023 Jun;41 Suppl 1:48-56. doi: 10.1002/hon.3139. PMID: 37294957
Ambinder RF
Recent Results Cancer Res 2021;217:197-207. doi: 10.1007/978-3-030-57362-1_9. PMID: 33200367
Angarone M, Snydman DR; AST ID Community of Practice
Clin Transplant 2019 Sep;33(9):e13550. Epub 2019 Apr 10 doi: 10.1111/ctr.13550. PMID: 30913334
Llaurador G, McLaughlin L, Wistinghausen B
Curr Opin Pediatr 2017 Feb;29(1):34-40. doi: 10.1097/MOP.0000000000000445. PMID: 27906865
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Therapy

Keam SJ
Mol Diagn Ther 2023 May;27(3):425-431. Epub 2023 Apr 5 doi: 10.1007/s40291-023-00648-z. PMID: 37016096
Sausen DG, Bhutta MS, Gallo ES, Dahari H, Borenstein R
Biomolecules 2021 Sep 18;11(9) doi: 10.3390/biom11091380. PMID: 34572593Free PMC Article
Al Hamed R, Bazarbachi AH, Mohty M
Bone Marrow Transplant 2020 Jan;55(1):25-39. Epub 2019 May 14 doi: 10.1038/s41409-019-0548-7. PMID: 31089285
Angarone M, Snydman DR; AST ID Community of Practice
Clin Transplant 2019 Sep;33(9):e13550. Epub 2019 Apr 10 doi: 10.1111/ctr.13550. PMID: 30913334
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Prognosis

Al-Adra D, Al-Qaoud T, Fowler K, Wong G
Clin J Am Soc Nephrol 2022 Mar;17(3):434-443. Epub 2021 Mar 29 doi: 10.2215/CJN.14570920. PMID: 33782034Free PMC Article
Ru Y, Chen J, Wu D
Eur J Haematol 2018 Sep;101(3):283-290. Epub 2018 Aug 3 doi: 10.1111/ejh.13131. PMID: 29949208
Rubio-Manzanares Dorado M, Álamo Martínez JM, Bernal Bellido C, Marín Gómez LM, Suárez Artacho G, Cepeda Franco C, Wang J, Gómez Bravo MÁ, Padillo FJ
Rev Esp Enferm Dig 2017 Jun;109(6):406-413. doi: 10.17235/reed.2017.4228/2016. PMID: 28508661
Boluda ER
Curr Opin Organ Transplant 2015 Oct;20(5):550-6. doi: 10.1097/MOT.0000000000000231. PMID: 26262456
Wistinghausen B, Gross TG, Bollard C
Pediatr Hematol Oncol 2013 Sep;30(6):520-31. Epub 2013 Jun 26 doi: 10.3109/08880018.2013.798844. PMID: 23802715

Clinical prediction guides

Zrzavy T, Endmayr V, Bauer J, Macher S, Mossaheb N, Schwaiger C, Ricken G, Winklehner M, Glatter S, Breu M, Wimmer I, Kovacs GG, Risser DU, Klupp N, Simonitsch-Klupp I, Roetzer T, Rommer P, Berger T, Gelpi E, Lassmann H, Graus F, Dalmau J, Höftberger R
Ann Neurol 2021 Nov;90(5):725-737. Epub 2021 Oct 9 doi: 10.1002/ana.26223. PMID: 34562035
Ru Y, Chen J, Wu D
Eur J Haematol 2018 Sep;101(3):283-290. Epub 2018 Aug 3 doi: 10.1111/ejh.13131. PMID: 29949208
Rubio-Manzanares Dorado M, Álamo Martínez JM, Bernal Bellido C, Marín Gómez LM, Suárez Artacho G, Cepeda Franco C, Wang J, Gómez Bravo MÁ, Padillo FJ
Rev Esp Enferm Dig 2017 Jun;109(6):406-413. doi: 10.17235/reed.2017.4228/2016. PMID: 28508661
San-Juan R, Comoli P, Caillard S, Moulin B, Hirsch HH, Meylan P; ESCMID Study Group of Infection in Compromised Hosts
Clin Microbiol Infect 2014 Sep;20 Suppl 7:109-18. doi: 10.1111/1469-0691.12534. PMID: 24475976
Colita A, Colita A, Moise L, Arion C, Popescu I
Chirurgia (Bucur) 2012 Jul-Aug;107(4):431-7. PMID: 23025107

Recent systematic reviews

Masson P, Henderson L, Chapman JR, Craig JC, Webster AC
Cochrane Database Syst Rev 2014 Nov 24;2014(11):CD010699. doi: 10.1002/14651858.CD010699.pub2. PMID: 25416857Free PMC Article
Penninga L, Wettergren A, Wilson CH, Chan AW, Steinbrüchel DA, Gluud C
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD010253. doi: 10.1002/14651858.CD010253.pub2. PMID: 24901467Free PMC Article

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