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Cauda equina syndrome

MedGen UID:
98229
Concept ID:
C0392548
Disease or Syndrome
Synonyms: Cauda Equina Syndrome; Cauda Equina Syndromes
SNOMED CT: Cauda equina syndrome (192970008)
 
Monarch Initiative: MONDO:0005693

Definition

A rare neurologic disorder caused by impingement of the nerve roots of the cauda equina secondary to disc herniation, spinal stenosis, vertebral fracture, neoplasm or infection. Clinical signs may include bladder or bowel dysfunction, paresthesia and weakness of the lower extremities. The clinical course rapidly deteriorates and necessitates emergent surgical decompression to minimize risk of incontinence, sexual dysfunction and permanent paralysis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCauda equina syndrome

Professional guidelines

PubMed

Zhang AS, Xu A, Ansari K, Hardacker K, Anderson G, Alsoof D, Daniels AH
Am J Med 2023 Jul;136(7):645-651. Epub 2023 Apr 17 doi: 10.1016/j.amjmed.2023.03.024. PMID: 37072094
Finucane LM, Downie A, Mercer C, Greenhalgh SM, Boissonnault WG, Pool-Goudzwaard AL, Beneciuk JM, Leech RL, Selfe J
J Orthop Sports Phys Ther 2020 Jul;50(7):350-372. Epub 2020 May 21 doi: 10.2519/jospt.2020.9971. PMID: 32438853
Larson ST, Wilbur J
Am Fam Physician 2020 Jan 15;101(2):95-108. PMID: 31939642

Curated

UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

Recent clinical studies

Etiology

Kuris EO, McDonald CL, Palumbo MA, Daniels AH
Am J Med 2021 Dec;134(12):1483-1489. Epub 2021 Aug 30 doi: 10.1016/j.amjmed.2021.07.021. PMID: 34473966
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Greenhalgh S, Finucane L, Mercer C, Selfe J
Musculoskelet Sci Pract 2018 Oct;37:69-74. Epub 2018 Jun 7 doi: 10.1016/j.msksp.2018.06.002. PMID: 29935940
Bardin LD, King P, Maher CG
Med J Aust 2017 Apr 3;206(6):268-273. doi: 10.5694/mja16.00828. PMID: 28359011
Kinkade S
Am Fam Physician 2007 Apr 15;75(8):1181-8. PMID: 17477101

Diagnosis

Zhang AS, Xu A, Ansari K, Hardacker K, Anderson G, Alsoof D, Daniels AH
Am J Med 2023 Jul;136(7):645-651. Epub 2023 Apr 17 doi: 10.1016/j.amjmed.2023.03.024. PMID: 37072094
Bulloch L, Thompson K, Spector L
Orthop Clin North Am 2022 Apr;53(2):247-254. Epub 2022 Mar 8 doi: 10.1016/j.ocl.2021.11.010. PMID: 35365269
Lavy C, Marks P, Dangas K, Todd N
Int Orthop 2022 Feb;46(2):165-169. Epub 2021 Dec 4 doi: 10.1007/s00264-021-05273-1. PMID: 34862914Free PMC Article
Kuris EO, McDonald CL, Palumbo MA, Daniels AH
Am J Med 2021 Dec;134(12):1483-1489. Epub 2021 Aug 30 doi: 10.1016/j.amjmed.2021.07.021. PMID: 34473966
Finucane LM, Downie A, Mercer C, Greenhalgh SM, Boissonnault WG, Pool-Goudzwaard AL, Beneciuk JM, Leech RL, Selfe J
J Orthop Sports Phys Ther 2020 Jul;50(7):350-372. Epub 2020 May 21 doi: 10.2519/jospt.2020.9971. PMID: 32438853

Therapy

Barraclough K
BMJ 2021 Jan 12;372:n32. doi: 10.1136/bmj.n32. PMID: 33436390
Xu J, Ding X, Wu J, Zhou X, Jin K, Yan M, Ma J, Wu X, Ye J, Mo W
Medicine (Baltimore) 2020 Dec 18;99(51):e23812. doi: 10.1097/MD.0000000000023812. PMID: 33371159Free PMC Article
Smith MS, Olivas J, Smith K
Am Fam Physician 2019 Feb 15;99(4):248-252. PMID: 30763049
Will JS, Bury DC, Miller JA
Am Fam Physician 2018 Oct 1;98(7):421-428. PMID: 30252425
Kinkade S
Am Fam Physician 2007 Apr 15;75(8):1181-8. PMID: 17477101

Prognosis

Hoeritzauer I, Paterson M, Jamjoom AAB, Srikandarajah N, Soleiman H, Poon MTC, Copley PC, Graves C, MacKay S, Duong C, Leung AHC, Eames N, Statham PFX, Darwish S, Sell PJ, Thorpe P, Shekhar H, Roy H, Woodfield J; Understanding Cauda Equina Syndrome (UCES) Study Collaborators, and the British Neurosurgical Trainee Research Collaborative
Bone Joint J 2023 Sep 1;105-B(9):1007-1012. doi: 10.1302/0301-620X.105B9.BJJ-2022-1343.R1. PMID: 37652459
Bulloch L, Thompson K, Spector L
Orthop Clin North Am 2022 Apr;53(2):247-254. Epub 2022 Mar 8 doi: 10.1016/j.ocl.2021.11.010. PMID: 35365269
Lavy C, Marks P, Dangas K, Todd N
Int Orthop 2022 Feb;46(2):165-169. Epub 2021 Dec 4 doi: 10.1007/s00264-021-05273-1. PMID: 34862914Free PMC Article
Will JS, Bury DC, Miller JA
Am Fam Physician 2018 Oct 1;98(7):421-428. PMID: 30252425
Kinkade S
Am Fam Physician 2007 Apr 15;75(8):1181-8. PMID: 17477101

Clinical prediction guides

Hoeritzauer I, Paterson M, Jamjoom AAB, Srikandarajah N, Soleiman H, Poon MTC, Copley PC, Graves C, MacKay S, Duong C, Leung AHC, Eames N, Statham PFX, Darwish S, Sell PJ, Thorpe P, Shekhar H, Roy H, Woodfield J; Understanding Cauda Equina Syndrome (UCES) Study Collaborators, and the British Neurosurgical Trainee Research Collaborative
Bone Joint J 2023 Sep 1;105-B(9):1007-1012. doi: 10.1302/0301-620X.105B9.BJJ-2022-1343.R1. PMID: 37652459
Bulloch L, Thompson K, Spector L
Orthop Clin North Am 2022 Apr;53(2):247-254. Epub 2022 Mar 8 doi: 10.1016/j.ocl.2021.11.010. PMID: 35365269
Ma Z, Yu P, Jiang H, Li X, Qian X, Yu Z, Zhu Y, Liu J
Pain Physician 2021 Aug;24(5):E639-E648. PMID: 34323452
Xu J, Ding X, Wu J, Zhou X, Jin K, Yan M, Ma J, Wu X, Ye J, Mo W
Medicine (Baltimore) 2020 Dec 18;99(51):e23812. doi: 10.1097/MD.0000000000023812. PMID: 33371159Free PMC Article
Verhagen AP, Downie A, Popal N, Maher C, Koes BW
Eur Spine J 2016 Sep;25(9):2788-802. Epub 2016 Jul 4 doi: 10.1007/s00586-016-4684-0. PMID: 27376890

Recent systematic reviews

Mustafa MA, Richardson GE, Gillespie CS, Islim AI, Wilby M, Clark S, Srikandarajah N
PLoS One 2023;18(5):e0285006. Epub 2023 May 4 doi: 10.1371/journal.pone.0285006. PMID: 37141301Free PMC Article
Palmisciano P, Zaidi SE, Shlobin NA, Sagoo NS, Bin Alamer O, Scalia G, Ferini G, Umana GE, Aoun SG, Haider AS
Anticancer Res 2022 Apr;42(4):1661-1669. doi: 10.21873/anticanres.15643. PMID: 35346985
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Todd NV
Br J Neurosurg 2017 Jun;31(3):336-339. Epub 2017 Mar 2 doi: 10.1080/02688697.2017.1297364. PMID: 28637110
Brouwers E, van de Meent H, Curt A, Starremans B, Hosman A, Bartels R
Spinal Cord 2017 Oct;55(10):886-890. Epub 2017 May 23 doi: 10.1038/sc.2017.54. PMID: 28534496

Supplemental Content

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    Clinical resources

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    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical guideline (CG148), Urinary incontinence in neurological disease: assessment and management, 2023

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