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Sebaceous hyperplasia

MedGen UID:
98352
•Concept ID:
C0406484
•
Disease or Syndrome
Synonyms: Benign seborrheic hyperplasia; Sebaceous gland hyperplasia; Sebaceous Hyperplasia
SNOMED CT: Sebaceous gland hyperplasia (238748009); Sebaceous hyperplasia (238748009); Benign seborrheic hyperplasia (238748009)
 
HPO: HP:0032227

Definition

A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elsewhere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSebaceous hyperplasia

Conditions with this feature

Sebaceous gland hyperplasia, familial presenile
MedGen UID:
356529
•Concept ID:
C1866428
•
Disease or Syndrome
Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently in older individuals, particularly in men past middle age (Nomland, 1930). A premature form has its appearance during puberty or just afterwards, male predominance, and excessive sebaceous secretion. Most cases are sporadic (summary by Boonchai and Leenutaphong, 1997).
See: Condition Record
Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
•Concept ID:
CN375946
•
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.
See: Condition Record
Birt-Hogg-Dube syndrome 1
Sebaceous gland hyperplasia, familial presenile

Professional guidelines

PubMed

Clinical and histological features and treatment outcomes of patients with Morbihan disease: a systematic review.
Mayur O, Martinez R, McNichol MC, McGee JS
Arch Dermatol Res 2023 Oct;315(8):2427-2429. Epub 2023 Apr 16 doi: 10.1007/s00403-023-02621-6. PMID: 37062777
An update on Becker's nevus: Pathogenesis and treatment.
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346

Recent clinical studies

Etiology

Treatment of Sebaceous Hyperplasia by Laser Modalities: A Review of the Literature and Presentation of Our Experience With Erbium-doped Yttrium Aluminium Garnet (Er:YAG).
Liu A, Taylor MB, Sotoodian B
J Drugs Dermatol 2020 May 1;19(5):547-552. PMID: 32484621
Combination of CO2 laser therapy and curettage for sebaceous gland hyperplasia.
Kavoussi H, Rezaei M, Azimi M, Kavoussi R
Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):11-14. PMID: 30901063
Dermatological Complications After Solid Organ Transplantation.
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Diagnosis

Molecular Genetics of Sebaceous Neoplasia.
North JP
Surg Pathol Clin 2021 Jun;14(2):273-284. doi: 10.1016/j.path.2021.03.005. PMID: 34023105
Sebaceous lesions of the skin.
Iacobelli J, Harvey NT, Wood BA
Pathology 2017 Dec;49(7):688-697. Epub 2017 Oct 25 doi: 10.1016/j.pathol.2017.08.012. PMID: 29078997
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Sebaceous gland neoplasia.
Prioleau PG, Santa Cruz DJ
J Cutan Pathol 1984 Oct;11(5):396-414. doi: 10.1111/j.1600-0560.1984.tb00397.x. PMID: 6392373

Therapy

Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346
Combination of CO2 laser therapy and curettage for sebaceous gland hyperplasia.
Kavoussi H, Rezaei M, Azimi M, Kavoussi R
Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):11-14. PMID: 30901063
Dermatological Complications After Solid Organ Transplantation.
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Perioral dermatitis.
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555

Prognosis

Impaired Wnt/beta-catenin and protein patched homolog 1 signaling in extraocular sebaceous carcinoma: A clinical and histopathological study.
Cheng AY, Lan J, Lee CH
J Dermatol 2022 Jun;49(6):600-606. Epub 2022 Mar 22 doi: 10.1111/1346-8138.16351. PMID: 35318716
Holistic Patient Assessment: Dermatology in Dental Practice.
Chapireau D, Bashir SJ, Fan K
Prim Dent J 2020 Mar;9(1):37-42. doi: 10.1177/2050168420911028. PMID: 32519610
Combination of CO2 laser therapy and curettage for sebaceous gland hyperplasia.
Kavoussi H, Rezaei M, Azimi M, Kavoussi R
Acta Dermatovenerol Alp Pannonica Adriat 2019 Mar;28(1):11-14. PMID: 30901063
Treatment of sebaceous hyperplasia with a novel 1,720-nm laser.
Winstanley D, Blalock T, Houghton N, Ross EV
J Drugs Dermatol 2012 Nov;11(11):1323-6. PMID: 23135082
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Clinical prediction guides

Dermoscopic features of benign sebaceous proliferations in dogs: Description, assessment and inter-observer agreement.
Scarampella F, Colombo S, Dehesa A, Godizzi F, Cavicchini S, Fabbri E, Roccabianca P
Vet Dermatol 2023 Dec;34(6):597-607. Epub 2023 Jul 28 doi: 10.1111/vde.13196. PMID: 37503675
Neonatal Dermatologic Findings in Uruguay: Epidemiology and Predisposing Factors.
De María MK, Borda KM, Arretche VN, Gugelmeier N, Mombelli R, de Los Santos AV, Acosta MA, Álvarez M, Pose GL, Borbonet D, Martínez MA
Actas Dermosifiliogr (Engl Ed) 2021 May;112(5):414-424. Epub 2020 Dec 13 doi: 10.1016/j.ad.2020.11.019. PMID: 33321117
Dermatological Complications After Solid Organ Transplantation.
Naldi L, Venturuzzo A, Invernizzi P
Clin Rev Allergy Immunol 2018 Feb;54(1):185-212. doi: 10.1007/s12016-017-8657-9. PMID: 29177692
Linear ectopic sebaceous hyperplasia of the penis: the last memory of Tyson's glands.
Paolino G, Muscardin LM, Panetta C, Donati M, Donati P
G Ital Dermatol Venereol 2018 Jun;153(3):429-431. Epub 2016 Sep 6 doi: 10.23736/S0392-0488.16.05129-4. PMID: 27598618
Diseases of the male nipple and areola.
Krause W
J Dtsch Dermatol Ges 2011 Dec;9(12):1004-9. Epub 2011 Jun 9 doi: 10.1111/j.1610-0387.2011.07720.x. PMID: 21651722

Recent systematic reviews

Clinical and histological features and treatment outcomes of patients with Morbihan disease: a systematic review.
Mayur O, Martinez R, McNichol MC, McGee JS
Arch Dermatol Res 2023 Oct;315(8):2427-2429. Epub 2023 Apr 16 doi: 10.1007/s00403-023-02621-6. PMID: 37062777
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA
Arch Dermatol Res 2021 Aug;313(6):391-430. Epub 2020 Nov 5 doi: 10.1007/s00403-020-02152-4. PMID: 33151346

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