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Trisomy 12

MedGen UID:
98492
Concept ID:
C0432408
Disease or Syndrome
SNOMED CT: Trisomy 12 (205653005)

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 12 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 12

Professional guidelines

PubMed

Nguyen-Khac F, Balogh Z, Chauzeix J, Veronese L, Chapiro E
Curr Res Transl Med 2023 Oct-Dec;71(4):103410. Epub 2023 Sep 17 doi: 10.1016/j.retram.2023.103410. PMID: 38039634
Gaidano G, Rossi D
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. PMID: 29222275Free PMC Article
Kay NE, Rai KR, O'Brien S
Clin Adv Hematol Oncol 2006 Nov;4(11 Suppl 22):1-10; quiz 11-2. PMID: 17143256

Recent clinical studies

Etiology

Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh PR, Kamatani Y
Nature 2020 Aug;584(7819):130-135. Epub 2020 Jun 24 doi: 10.1038/s41586-020-2426-2. PMID: 32581364Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Javandoost E, Firoozi-Majd E, Rostamian H, Khakpoor-Koosheh M, Mirzaei HR
Curr Med Chem 2020;27(2):282-297. doi: 10.2174/0929867326666190911114842. PMID: 31544709
Amaya-Chanaga CI, Rassenti LZ
Best Pract Res Clin Haematol 2016 Mar;29(1):79-89. Epub 2016 Aug 10 doi: 10.1016/j.beha.2016.08.005. PMID: 27742074
Tsimberidou AM, Keating MJ
Cancer 2005 Jan 15;103(2):216-28. doi: 10.1002/cncr.20773. PMID: 15578683

Diagnosis

Hui HYL, Erber WN, Fuller KA
Methods Mol Biol 2023;2635:149-171. doi: 10.1007/978-1-0716-3020-4_9. PMID: 37074662
Javandoost E, Firoozi-Majd E, Rostamian H, Khakpoor-Koosheh M, Mirzaei HR
Curr Med Chem 2020;27(2):282-297. doi: 10.2174/0929867326666190911114842. PMID: 31544709
Gaidano G, Rossi D
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. PMID: 29222275Free PMC Article
Amaya-Chanaga CI, Rassenti LZ
Best Pract Res Clin Haematol 2016 Mar;29(1):79-89. Epub 2016 Aug 10 doi: 10.1016/j.beha.2016.08.005. PMID: 27742074
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059

Therapy

Jain N, Croner LJ, Allan JN, Siddiqi T, Tedeschi A, Badoux XC, Eckert K, Cheung LWK, Mukherjee A, Dean JP, Szafer-Glusman E, Seymour JF
Clin Cancer Res 2024 Feb 1;30(3):498-505. doi: 10.1158/1078-0432.CCR-22-3934. PMID: 37955424Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Gaidano G, Rossi D
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):329-337. doi: 10.1182/asheducation-2017.1.329. PMID: 29222275Free PMC Article
Amin NA, Balasubramanian S, Saiya-Cork K, Shedden K, Hu N, Malek SN
Clin Cancer Res 2017 Feb 15;23(4):1049-1059. Epub 2016 Aug 17 doi: 10.1158/1078-0432.CCR-15-2921. PMID: 27535981Free PMC Article
Tsimberidou AM, Keating MJ
Cancer 2005 Jan 15;103(2):216-28. doi: 10.1002/cncr.20773. PMID: 15578683

Prognosis

Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Amaya-Chanaga CI, Rassenti LZ
Best Pract Res Clin Haematol 2016 Mar;29(1):79-89. Epub 2016 Aug 10 doi: 10.1016/j.beha.2016.08.005. PMID: 27742074
Puiggros A, Blanco G, Espinet B
Biomed Res Int 2014;2014:435983. Epub 2014 May 22 doi: 10.1155/2014/435983. PMID: 24967369Free PMC Article
Sagatys EM, Zhang L
Cancer Control 2012 Jan;19(1):18-25. doi: 10.1177/107327481201900103. PMID: 22143059
Crossen PE
Cancer Genet Cytogenet 1997 Mar;94(1):44-51. doi: 10.1016/s0165-4608(96)00253-1. PMID: 9078290

Clinical prediction guides

Terao C, Suzuki A, Momozawa Y, Akiyama M, Ishigaki K, Yamamoto K, Matsuda K, Murakami Y, McCarroll SA, Kubo M, Loh PR, Kamatani Y
Nature 2020 Aug;584(7819):130-135. Epub 2020 Jun 24 doi: 10.1038/s41586-020-2426-2. PMID: 32581364Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Panayiotidis P, Kotsi P
Semin Hematol 1999 Apr;36(2):171-7. PMID: 10319386
Mertens F, Mandahl N, Mitelman F, Heim S
Pediatr Hematol Oncol 1994 Jul-Aug;11(4):361-77. doi: 10.3109/08880019409140536. PMID: 7947009
Dighiero G
Baillieres Clin Haematol 1993 Dec;6(4):807-20. doi: 10.1016/s0950-3536(05)80177-5. PMID: 8038491

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