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Trisomy 10

MedGen UID:
98493
•Concept ID:
C0432410
•
Cell or Molecular Dysfunction
SNOMED CT: Trisomy 10 (205651007)

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 10 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 10

Professional guidelines

PubMed

Evaluating Airway Management in Patients With Trisomy 21 in the PICU and Cardiac ICU: A Retrospective Cohort Study.
Wilsterman EJ Jr, Nellis ME, Panisello J, Al-Subu A, Breuer R, Kimura D, Krawiec C, Mallory PP, Nett S, Owen E, Parsons SJ, Sanders RC Jr, Garcia-Marcinkiewicz A, Napolitano N, Shults J, Nadkarni VM, Nishisaki A; National Emergency Airway Registry for Children (NEAR4KIDS) and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Pediatr Crit Care Med 2024 Apr 1;25(4):335-343. Epub 2023 Dec 7 doi: 10.1097/PCC.0000000000003418. PMID: 38059735Free PMC Article
Routine prenatal diagnosis of aneuploidy by FISH studies in high-risk pregnancies.
Feldman B, Ebrahim SA, Hazan SL, Gyi K, Johnson MP, Johnson A, Evans MI
Am J Med Genet 2000 Jan 31;90(3):233-8. PMID: 10678661
Chromosomal mosaicism in prenatal diagnosis: a problem still unsolved.
Kerber S, Held KR
Acta Univ Carol Med (Praha) 1992;38(1-4):75-82. PMID: 8904914

Recent clinical studies

Etiology

Microarray testing as an efficient tool to redefine hyperdiploid paediatric B-cell precursor acute lymphoblastic leukaemia patients.
Lejman M, Zawitkowska J, Styka B, Babicz M, Winnicka D, Zaucha-Prażmo A, Pastorczak A, Taha J, Młynarski W, Kowalczyk JR
Leuk Res 2019 Aug;83:106163. Epub 2019 May 28 doi: 10.1016/j.leukres.2019.05.013. PMID: 31202078
High hyperdiploid acute lymphoblastic leukemia (ALL)-A 25-year population-based survey of the Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group.
Reismüller B, Steiner M, Pichler H, Dworzak M, Urban C, Meister B, Schmitt K, Pötschger U, König M, Mann G, Haas OA, Attarbaschi A; Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group
Pediatr Blood Cancer 2017 Jun;64(6) Epub 2016 Nov 2 doi: 10.1002/pbc.26327. PMID: 27804199
Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence.
Qu X, Jeldres C, Glaskova L, Friedman C, Schroeder S, Nelson PS, Porter C, Fang M
J Mol Diagn 2016 Mar;18(2):215-24. Epub 2016 Jan 2 doi: 10.1016/j.jmoldx.2015.10.001. PMID: 26752304Free PMC Article
Incidence of malignancy and clonal chromosomal abnormalities in Fanconi anemia.
Vundinti BR, Korgaonkar S, Ghosh K
Indian J Cancer 2010 Oct-Dec;47(4):397-9. doi: 10.4103/0019-509X.73575. PMID: 21131752
Trisomy 10: age and leukemic lineage associations.
Morgan R, Chen Z, Stone JF, Cohen J, Gustafson E, Jolly PC, Sandberg AA
Cancer Genet Cytogenet 1996 Jul 15;89(2):173-4. doi: 10.1016/0165-4608(96)00075-1. PMID: 8697428

Diagnosis

The first reported case of double trisomy 10 and 20 in a product of conception.
Fernandez De La Vega J, Lahiji AP, Raymond C, Han S, Thaker H, Dong J
Lab Med 2024 Mar 7;55(2):245-248. doi: 10.1093/labmed/lmad052. PMID: 37294932
Mosaicism trisomy 10 in a 14-month-old child with additional neurological abnormalities: case report and literature review.
Gao Y, Ma YC, Ju YH, Li YN
BMC Pediatr 2018 Aug 6;18(1):266. doi: 10.1186/s12887-018-1237-1. PMID: 30081864Free PMC Article
Trisomy 10: ultrasound features and natural history after first trimester diagnosis.
Brizot ML, Schultz R, Patroni LT, Lopes LM, Armbruster-Moraes E, Zugaib M
Prenat Diagn 2001 Aug;21(8):672-5. doi: 10.1002/pd.129. PMID: 11536269
Trisomy 10 survival: a literature review and presentation of seven new cases.
Pedersen B, Andersen CL, Søgaard MM, Nørgaard JM, Koch J, Krejci K, Brandsborg M, Clausen N
Cancer Genet Cytogenet 1998 Jun;103(2):130-2. doi: 10.1016/s0165-4608(97)00387-7. PMID: 9614911
Partial trisomy 10 mosaicism with cutaneous manifestations: report of a case and review of the literature.
Boon C, Markello T, Jackson-Cook C, Pandya A
Clin Genet 1996 Nov;50(5):417-21. doi: 10.1111/j.1399-0004.1996.tb02399.x. PMID: 9007335

Therapy

Microarray testing as an efficient tool to redefine hyperdiploid paediatric B-cell precursor acute lymphoblastic leukaemia patients.
Lejman M, Zawitkowska J, Styka B, Babicz M, Winnicka D, Zaucha-Prażmo A, Pastorczak A, Taha J, Młynarski W, Kowalczyk JR
Leuk Res 2019 Aug;83:106163. Epub 2019 May 28 doi: 10.1016/j.leukres.2019.05.013. PMID: 31202078
High hyperdiploid acute lymphoblastic leukemia (ALL)-A 25-year population-based survey of the Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group.
Reismüller B, Steiner M, Pichler H, Dworzak M, Urban C, Meister B, Schmitt K, Pötschger U, König M, Mann G, Haas OA, Attarbaschi A; Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group
Pediatr Blood Cancer 2017 Jun;64(6) Epub 2016 Nov 2 doi: 10.1002/pbc.26327. PMID: 27804199
Utilization of Chromogenic In Situ Hybridization to Assess Ploidy in the Diagnosis of Hydatidiform Mole.
Kunesh JP, Kunesh JG, Jorgensen RJ, Corral CD, Blakey JD
Am J Clin Pathol 2016 Jul;146(1):125-31. doi: 10.1093/ajcp/aqw095. PMID: 27402609
Isolated trisomy 10 in an infant with acute myeloid leukemia: a case report and review of literature.
Yuan J, McDonough C, Kulharya A, Ramalingam P, Manaloor E
Int J Clin Exp Pathol 2010 Aug 17;3(7):718-22. PMID: 20830243Free PMC Article
Significance of the clonal and sporadic chromosome abnormalities in non-neoplastic renal tissue.
Casalone R, Granata Casalone P, Minelli E, Portentoso P, Righi R, Meroni E, Giudici A, Donati D, Riva C, Salvatore S
Hum Genet 1992 Sep-Oct;90(1-2):71-8. doi: 10.1007/BF00210747. PMID: 1427791

Prognosis

Microarray testing as an efficient tool to redefine hyperdiploid paediatric B-cell precursor acute lymphoblastic leukaemia patients.
Lejman M, Zawitkowska J, Styka B, Babicz M, Winnicka D, Zaucha-Prażmo A, Pastorczak A, Taha J, Młynarski W, Kowalczyk JR
Leuk Res 2019 Aug;83:106163. Epub 2019 May 28 doi: 10.1016/j.leukres.2019.05.013. PMID: 31202078
Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence.
Qu X, Jeldres C, Glaskova L, Friedman C, Schroeder S, Nelson PS, Porter C, Fang M
J Mol Diagn 2016 Mar;18(2):215-24. Epub 2016 Jan 2 doi: 10.1016/j.jmoldx.2015.10.001. PMID: 26752304Free PMC Article
Trisomy 10 mosaicism and maternal uniparental disomy 10 in a liveborn infant with severe congenital malformations.
Hahnemann JM, Nir M, Friberg M, Engel U, Bugge M
Am J Med Genet A 2005 Oct 1;138A(2):150-4. doi: 10.1002/ajmg.a.30908. PMID: 16114048
Trisomy 10 and acute myeloid leukemia.
Czepulkowski B, Powell AR, Pagliuca A, Mufti GJ
Cancer Genet Cytogenet 2002 Apr 1;134(1):81-3. doi: 10.1016/s0165-4608(01)00593-3. PMID: 11996802
Trisomy 10 survival: a literature review and presentation of seven new cases.
Pedersen B, Andersen CL, Søgaard MM, Nørgaard JM, Koch J, Krejci K, Brandsborg M, Clausen N
Cancer Genet Cytogenet 1998 Jun;103(2):130-2. doi: 10.1016/s0165-4608(97)00387-7. PMID: 9614911

Clinical prediction guides

Microarray testing as an efficient tool to redefine hyperdiploid paediatric B-cell precursor acute lymphoblastic leukaemia patients.
Lejman M, Zawitkowska J, Styka B, Babicz M, Winnicka D, Zaucha-Prażmo A, Pastorczak A, Taha J, Młynarski W, Kowalczyk JR
Leuk Res 2019 Aug;83:106163. Epub 2019 May 28 doi: 10.1016/j.leukres.2019.05.013. PMID: 31202078
Utilization of Chromogenic In Situ Hybridization to Assess Ploidy in the Diagnosis of Hydatidiform Mole.
Kunesh JP, Kunesh JG, Jorgensen RJ, Corral CD, Blakey JD
Am J Clin Pathol 2016 Jul;146(1):125-31. doi: 10.1093/ajcp/aqw095. PMID: 27402609
Trisomy 10: age and leukemic lineage associations.
Morgan R, Chen Z, Stone JF, Cohen J, Gustafson E, Jolly PC, Sandberg AA
Cancer Genet Cytogenet 1996 Jul 15;89(2):173-4. doi: 10.1016/0165-4608(96)00075-1. PMID: 8697428
Chromosomal abnormalities in non-neoplastic renal tissue.
van den Berg E, Dijkhuizen T, Störkel S, Molenaar WM, de Jong B
Cancer Genet Cytogenet 1995 Dec;85(2):152-4. doi: 10.1016/0165-4608(95)00035-6. PMID: 8548740
Interstitial 9q deletion in T-lymphoid/myeloid biphenotypic leukaemia.
Akashi K, Shibuya T, Harada M, Oogami A, Teshima T, Takamatsu Y, Kikuchi M, Niho Y
Br J Haematol 1992 Feb;80(2):172-7. doi: 10.1111/j.1365-2141.1992.tb08896.x. PMID: 1550772

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