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Essential hypertension, genetic(EHT)

MedGen UID:
987958
•Concept ID:
CN305331
•
Disease or Syndrome
Synonym: EHT
 
Genes (locations): ADD1 (4p16.3); AGT (1q42.2); AGTR1 (3q24); ATP1B1 (1q24.2); CYP3A5 (7q22.1); ECE1 (1p36.12); GNB3 (12p13.31); NOS3 (7q36.1); PTGIS (20q13.13); RGS5 (1q23.3)
 
Monarch Initiative: MONDO:0007781
OMIM®: 145500

Definition

An instance of essential hypertension that is caused by a modification of the individual's genome. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021.
Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, Assi HI
Int J Mol Sci 2022 Jan 12;23(2) doi: 10.3390/ijms23020786. PMID: 35054972Free PMC Article
Why primary obesity is a disease?
De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L
J Transl Med 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y. PMID: 31118060Free PMC Article
Childhood Obesity: Causes, Consequences, and Management.
Gurnani M, Birken C, Hamilton J
Pediatr Clin North Am 2015 Aug;62(4):821-40. Epub 2015 May 23 doi: 10.1016/j.pcl.2015.04.001. PMID: 26210619

Recent clinical studies

Etiology

Pediatric Primary Hypertension: An Underrecognized Condition: A Scientific Statement From the American Heart Association.
Falkner B, Gidding SS, Baker-Smith CM, Brady TM, Flynn JT, Malle LM, South AM, Tran AH, Urbina EM; American Heart Association Council on Hypertension; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Cardiovascular and Stroke Nursing
Hypertension 2023 Jun;80(6):e101-e111. Epub 2023 Mar 30 doi: 10.1161/HYP.0000000000000228. PMID: 36994715
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects.
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E
Hypertension 2022 Sep;79(9):1962-1970. Epub 2022 Jul 25 doi: 10.1161/HYPERTENSIONAHA.122.19120. PMID: 35876003
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Gut microbiota dysbiosis contributes to the development of hypertension.
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J
Microbiome 2017 Feb 1;5(1):14. doi: 10.1186/s40168-016-0222-x. PMID: 28143587Free PMC Article
Essential hypertension.
Staessen JA, Wang J, Bianchi G, Birkenhäger WH
Lancet 2003 May 10;361(9369):1629-41. doi: 10.1016/S0140-6736(03)13302-8. PMID: 12747893

Diagnosis

Exploring the genetic association of allergic diseases with cardiovascular diseases: a bidirectional Mendelian randomization study.
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Pediatric Primary Hypertension: An Underrecognized Condition: A Scientific Statement From the American Heart Association.
Falkner B, Gidding SS, Baker-Smith CM, Brady TM, Flynn JT, Malle LM, South AM, Tran AH, Urbina EM; American Heart Association Council on Hypertension; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Cardiovascular and Stroke Nursing
Hypertension 2023 Jun;80(6):e101-e111. Epub 2023 Mar 30 doi: 10.1161/HYP.0000000000000228. PMID: 36994715
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
The Orexin System and Hypertension.
Huber MJ, Chen QH, Shan Z
Cell Mol Neurobiol 2018 Mar;38(2):385-391. Epub 2017 Mar 27 doi: 10.1007/s10571-017-0487-z. PMID: 28349223Free PMC Article
Essential hypertension.
Staessen JA, Wang J, Bianchi G, Birkenhäger WH
Lancet 2003 May 10;361(9369):1629-41. doi: 10.1016/S0140-6736(03)13302-8. PMID: 12747893

Therapy

Exploring the genetic association of allergic diseases with cardiovascular diseases: a bidirectional Mendelian randomization study.
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects.
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E
Hypertension 2022 Sep;79(9):1962-1970. Epub 2022 Jul 25 doi: 10.1161/HYPERTENSIONAHA.122.19120. PMID: 35876003
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Essential hypertension.
Staessen JA, Wang J, Bianchi G, Birkenhäger WH
Lancet 2003 May 10;361(9369):1629-41. doi: 10.1016/S0140-6736(03)13302-8. PMID: 12747893
Nitric oxide.
Moncada S
J Hypertens Suppl 1994 Dec;12(10):S35-9. PMID: 7539493

Prognosis

Acquired risk factors and incident atrial fibrillation according to age and genetic predisposition.
Wang N, Yu Y, Sun Y, Zhang H, Wang Y, Chen C, Tan X, Wang B, Lu Y
Eur Heart J 2023 Dec 14;44(47):4982-4993. doi: 10.1093/eurheartj/ehad615. PMID: 37723974Free PMC Article
Exploring the genetic association of allergic diseases with cardiovascular diseases: a bidirectional Mendelian randomization study.
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
The associations between modifiable risk factors and nonalcoholic fatty liver disease: A comprehensive Mendelian randomization study.
Xie J, Huang H, Liu Z, Li Y, Yu C, Xu L, Xu C
Hepatology 2023 Mar 1;77(3):949-964. Epub 2023 Feb 17 doi: 10.1002/hep.32728. PMID: 35971878
Strokes in young adults: epidemiology and prevention.
Smajlović D
Vasc Health Risk Manag 2015;11:157-64. Epub 2015 Feb 24 doi: 10.2147/VHRM.S53203. PMID: 25750539Free PMC Article
Bariatric surgery: to whom and when?
Benaiges D, Goday A, Pedro-Botet J, Más A, Chillarón JJ, Flores-Le Roux JA
Minerva Endocrinol 2015 Jun;40(2):119-28. Epub 2015 Feb 10 PMID: 25665592

Clinical prediction guides

Exploring the genetic association of allergic diseases with cardiovascular diseases: a bidirectional Mendelian randomization study.
Wang S, Liu H, Yang P, Wang Z, Hu P, Ye P, Xia J, Chen S
Front Immunol 2023;14:1175890. Epub 2023 Jun 2 doi: 10.3389/fimmu.2023.1175890. PMID: 37334359Free PMC Article
Association between vascular risk factors and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.
Deng Z, Wang H, Huang K, Li Y, Ran Y, Chen Y, Zhou L
J Neurol 2023 May;270(5):2724-2733. Epub 2023 Feb 11 doi: 10.1007/s00415-023-11604-6. PMID: 36773060
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects.
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E
Hypertension 2022 Sep;79(9):1962-1970. Epub 2022 Jul 25 doi: 10.1161/HYPERTENSIONAHA.122.19120. PMID: 35876003
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei WQ, Gifford A, Yang T, Varley T, Tzoulaki I, Joshi P, Denny JC, Mckeigue P, Campbell H, Theodoratou E
PLoS Med 2019 Oct;16(10):e1002937. Epub 2019 Oct 18 doi: 10.1371/journal.pmed.1002937. PMID: 31626644Free PMC Article
Gut microbiota dysbiosis contributes to the development of hypertension.
Li J, Zhao F, Wang Y, Chen J, Tao J, Tian G, Wu S, Liu W, Cui Q, Geng B, Zhang W, Weldon R, Auguste K, Yang L, Liu X, Chen L, Yang X, Zhu B, Cai J
Microbiome 2017 Feb 1;5(1):14. doi: 10.1186/s40168-016-0222-x. PMID: 28143587Free PMC Article

Recent systematic reviews

Impact of stress and hypertension on the cerebrovasculature.
Elsaid N, Saied A, Kandil H, Soliman A, Taher F, Hadi M, Giridharan G, Jennings R, Casanova M, Keynton R, El-Baz A
Front Biosci (Landmark Ed) 2021 Dec 30;26(12):1643-1652. doi: 10.52586/5057. PMID: 34994178
Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis.
Yako YY, Balti EV, Matsha TE, Dzudie A, Kruger D, Sobngwi E, Agyemang C, Kengne AP
J Clin Hypertens (Greenwich) 2018 Mar;20(3):485-495. Epub 2018 Mar 9 doi: 10.1111/jch.13225. PMID: 29520984Free PMC Article
Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.
Wang J, Wang Z, Yu C
Int J Environ Res Public Health 2016 Apr 29;13(5) doi: 10.3390/ijerph13050458. PMID: 27136577Free PMC Article
Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review.
Reiter LM, Christensen DL, Gjesing AP
J Hum Hypertens 2016 Aug;30(8):467-78. Epub 2015 Nov 26 doi: 10.1038/jhh.2015.114. PMID: 26607294
STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
Xi B, Chen M, Chandak GR, Shen Y, Yan L, He J, Mou SH
PLoS One 2013;8(3):e59584. Epub 2013 Mar 18 doi: 10.1371/journal.pone.0059584. PMID: 23527223Free PMC Article

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