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AIDS

MedGen UID:
99
Concept ID:
C0001175
Disease or Syndrome
Synonyms: Acquired Immune Deficiency Syndrome; Acquired Immuno Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immuno-Deficiency Syndromes; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndromes; Immuno-Deficiency Syndrome, Acquired; Immuno-Deficiency Syndromes, Acquired; Immunodeficiency Syndrome, Acquired; Immunodeficiency Syndromes, Acquired; Immunologic Deficiency Syndrome, Acquired; Syndrome, Acquired Immuno-Deficiency; Syndrome, Acquired Immunodeficiency; Syndromes, Acquired Immuno-Deficiency; Syndromes, Acquired Immunodeficiency
SNOMED CT: AIDS (62479008); Acquired immune deficiency syndrome (62479008); Acquired immunodeficiency syndrome (62479008); Acquired immune deficiency syndrome (AIDS) (62479008); Immunodeficiency due to human immunodeficiency virus infection (62479008); AIDS - Acquired immunodeficiency syndrome (62479008)
 
Monarch Initiative: MONDO:0012268

Definition

A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. [from NCI]

Professional guidelines

PubMed

Patil A, Goldust M, Wollina U
Viruses 2022 Jan 19;14(2) doi: 10.3390/v14020192. PMID: 35215786Free PMC Article
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Tunkel DE, Bauer CA, Sun GH, Rosenfeld RM, Chandrasekhar SS, Cunningham ER Jr, Archer SM, Blakley BW, Carter JM, Granieri EC, Henry JA, Hollingsworth D, Khan FA, Mitchell S, Monfared A, Newman CW, Omole FS, Phillips CD, Robinson SK, Taw MB, Tyler RS, Waguespack R, Whamond EJ
Otolaryngol Head Neck Surg 2014 Oct;151(2 Suppl):S1-S40. doi: 10.1177/0194599814545325. PMID: 25273878

Recent clinical studies

Etiology

Benagiano M, Bianchi P, D'Elios MM, Brosens I, Benagiano G
Best Pract Res Clin Obstet Gynaecol 2019 Oct;60:24-34. Epub 2019 Mar 16 doi: 10.1016/j.bpobgyn.2019.03.001. PMID: 31047850
Liu Y, Chen C
Adv Drug Deliv Rev 2016 Aug 1;103:76-89. Epub 2016 Mar 4 doi: 10.1016/j.addr.2016.02.010. PMID: 26952542
Rubinstein PG, Aboulafia DM, Zloza A
AIDS 2014 Feb 20;28(4):453-65. doi: 10.1097/QAD.0000000000000071. PMID: 24401642Free PMC Article
Groce NE, Rohleder P, Eide AH, MacLachlan M, Mall S, Swartz L
Soc Sci Med 2013 Jan;77:31-40. Epub 2012 Nov 7 doi: 10.1016/j.socscimed.2012.10.024. PMID: 23219851
Elwyn G, O'Connor A, Stacey D, Volk R, Edwards A, Coulter A, Thomson R, Barratt A, Barry M, Bernstein S, Butow P, Clarke A, Entwistle V, Feldman-Stewart D, Holmes-Rovner M, Llewellyn-Thomas H, Moumjid N, Mulley A, Ruland C, Sepucha K, Sykes A, Whelan T; International Patient Decision Aids Standards (IPDAS) Collaboration
BMJ 2006 Aug 26;333(7565):417. Epub 2006 Aug 14 doi: 10.1136/bmj.38926.629329.AE. PMID: 16908462Free PMC Article

Diagnosis

Manna R, Rigante D
Intern Emerg Med 2021 Oct;16(7):1759-1770. Epub 2021 May 17 doi: 10.1007/s11739-021-02751-7. PMID: 33999387Free PMC Article
Alebiosu CO
West Afr J Med 2021 Apr 23;38(4):300-301. PMID: 33900703
Zhai X, Zhang Y, Xin S, Cao P, Lu J
Front Immunol 2021;12:622316. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.622316. PMID: 33717126Free PMC Article
Xirotagaros G, Hernández-Ostiz S, Aróstegui JI, Torrelo A
Pediatr Dermatol 2016 Nov;33(6):602-614. Epub 2016 Oct 4 doi: 10.1111/pde.12984. PMID: 27699831
Carr ER
Clin J Oncol Nurs 2013 Apr;17(2):201-4. doi: 10.1188/13.CJON.201-204. PMID: 23538257

Therapy

Zimmerman KO, Perry B, Hanlen-Rosado E, Nsonwu A, Lane MD, Benjamin DK, Becker M, Corneli A; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee
Health Expect 2022 Jun;25(3):1029-1037. Epub 2022 Mar 4 doi: 10.1111/hex.13448. PMID: 35246906Free PMC Article
Majersik JJ
Curr Cardiol Rep 2019 Apr 22;21(6):49. doi: 10.1007/s11886-019-1139-3. PMID: 31011843
Rao M, Alving CR
Curr Opin HIV AIDS 2016 Nov;11(6):585-592. doi: 10.1097/COH.0000000000000315. PMID: 27607594
Kelly SG, Nyaku AN, Taiwo BO
Drugs 2016 Apr;76(5):523-31. doi: 10.1007/s40265-016-0553-8. PMID: 26886135
Molenaar S, Sprangers MA, Postma-Schuit FC, Rutgers EJ, Noorlander J, Hendriks J, de Haes HC
Med Decis Making 2000 Jan-Mar;20(1):112-27. doi: 10.1177/0272989X0002000114. PMID: 10638544

Prognosis

GBD 2019 Adolescent Young Adult Cancer Collaborators
Lancet Oncol 2022 Jan;23(1):27-52. Epub 2021 Dec 3 doi: 10.1016/S1470-2045(21)00581-7. PMID: 34871551Free PMC Article
GBD 2017 HIV collaborators
Lancet HIV 2019 Dec;6(12):e831-e859. Epub 2019 Aug 19 doi: 10.1016/S2352-3018(19)30196-1. PMID: 31439534Free PMC Article
Fasanmade OA, Dagogo-Jack S
Ann Glob Health 2015 Nov-Dec;81(6):821-9. doi: 10.1016/j.aogh.2015.12.012. PMID: 27108149
Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 2011 Jun 3;60(21):689-93. PMID: 21637182
Zelenetz PD, Epstein ME
AIDS Patient Care STDS 1998 Apr;12(4):255-62. doi: 10.1089/apc.1998.12.255. PMID: 11361952

Clinical prediction guides

Bruno G, Saracino A, Monno L, Angarano G
AIDS Rev 2017 Apr-Jun;19(2):81-88. PMID: 28182620
Woodward M, Tunstall-Pedoe H, Peters SA
Heart 2017 Apr;103(7):538-545. Epub 2017 Feb 8 doi: 10.1136/heartjnl-2016-310210. PMID: 28179372Free PMC Article
Elder A, Japp A, Verghese A
BMJ 2016 Jul 27;354:i3309. doi: 10.1136/bmj.i3309. PMID: 27598000
Jerger J
J Am Acad Audiol 2011 Mar;22(3):128. doi: 10.3766/jaaa.22.3.1. PMID: 21545765
Robertson F, Leander P, Ekberg O
Eur Radiol 2001;11(1):80-95. doi: 10.1007/s003300000528. PMID: 11194923

Recent systematic reviews

Ayano G, Demelash S, Abraha M, Tsegay L
AIDS Res Ther 2021 Apr 27;18(1):23. doi: 10.1186/s12981-021-00351-1. PMID: 33906698Free PMC Article
Kotsakis GA, Lian Q, Ioannou AL, Michalowicz BS, John MT, Chu H
J Periodontol 2018 May;89(5):558-570. doi: 10.1002/JPER.17-0368. PMID: 29520910Free PMC Article
Stacey D, Légaré F, Lewis K, Barry MJ, Bennett CL, Eden KB, Holmes-Rovner M, Llewellyn-Thomas H, Lyddiatt A, Thomson R, Trevena L
Cochrane Database Syst Rev 2017 Apr 12;4(4):CD001431. doi: 10.1002/14651858.CD001431.pub5. PMID: 28402085Free PMC Article
Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD004310. doi: 10.1002/14651858.CD004310.pub3. PMID: 23543530Free PMC Article
Savage J, Waddell A
BMJ Clin Evid 2012 Feb 3;2012 PMID: 22331367Free PMC Article

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