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Mastocytosis

MedGen UID:
9902
Concept ID:
C0024899
Neoplastic Process
Synonym: Mast cell disease
SNOMED CT: Mastocytosis (127581004)
 
HPO: HP:0100495
Monarch Initiative: MONDO:0007950
Orphanet: ORPHA98292

Definition

The presence of an increased number of mast cells and CD34+ mast cell precursors in the body. [from HPO]

Professional guidelines

PubMed

Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312
Castells M, Butterfield J
J Allergy Clin Immunol Pract 2019 Apr;7(4):1097-1106. doi: 10.1016/j.jaip.2019.02.002. PMID: 30961835

Recent clinical studies

Etiology

Veitch S, Radia DH
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):396-406. doi: 10.1182/hematology.2023000505. PMID: 38066855Free PMC Article
Bonadonna P, Nalin F, Olivieri F
Curr Opin Allergy Clin Immunol 2022 Oct 1;22(5):277-282. Epub 2022 Aug 4 doi: 10.1097/ACI.0000000000000849. PMID: 35942852
Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Hussain SH
Curr Opin Pediatr 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050
Schuch A, Brockow K
Immunol Allergy Clin North Am 2017 Feb;37(1):153-164. Epub 2016 Oct 28 doi: 10.1016/j.iac.2016.08.017. PMID: 27886904

Diagnosis

Costa A, Scalzulli E, Carmosino I, Capriata M, Ielo C, Masucci C, Passucci M, Martelli M, Breccia M
Expert Opin Emerg Drugs 2023 Dec;28(3):153-165. Epub 2023 Jun 6 doi: 10.1080/14728214.2023.2221028. PMID: 37256917
Valent P, Akin C, Sperr WR, Horny HP, Arock M, Metcalfe DD, Galli SJ
Annu Rev Pathol 2023 Jan 24;18:361-386. Epub 2022 Oct 21 doi: 10.1146/annurev-pathmechdis-031521-042618. PMID: 36270293
Leguit RJ, Wang SA, George TI, Tzankov A, Orazi A
Virchows Arch 2023 Jan;482(1):99-112. Epub 2022 Oct 10 doi: 10.1007/s00428-022-03423-3. PMID: 36214901
Di Raimondo C, Del Duca E, Silvaggio D, Di Prete M, Lombardo P, Mazzeo M, Spallone G, Campione E, Botti E, Bianchi L
Australas J Dermatol 2021 Feb;62(1):e1-e7. Epub 2020 Oct 11 doi: 10.1111/ajd.13443. PMID: 33040350
Theoharides TC, Valent P, Akin C
N Engl J Med 2015 Jul 9;373(2):163-72. doi: 10.1056/NEJMra1409760. PMID: 26154789

Therapy

Pardanani A
Am J Hematol 2021 Apr 1;96(4):508-525. Epub 2021 Feb 21 doi: 10.1002/ajh.26118. PMID: 33524167
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Hussain SH
Curr Opin Pediatr 2020 Aug;32(4):531-538. doi: 10.1097/MOP.0000000000000922. PMID: 32692050
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312
Theoharides TC, Valent P, Akin C
N Engl J Med 2015 Jul 9;373(2):163-72. doi: 10.1056/NEJMra1409760. PMID: 26154789

Prognosis

Costa A, Scalzulli E, Carmosino I, Capriata M, Ielo C, Masucci C, Passucci M, Martelli M, Breccia M
Expert Opin Emerg Drugs 2023 Dec;28(3):153-165. Epub 2023 Jun 6 doi: 10.1080/14728214.2023.2221028. PMID: 37256917
Tzankov A, Duncavage E, Craig FE, Kelemen K, King RL, Orazi A, Quintanilla-Martinez L, Reichard KK, Rimsza LM, Wang SA, Horny HP, George TI
Am J Clin Pathol 2021 Feb 4;155(2):239-266. doi: 10.1093/ajcp/aqaa183. PMID: 33313644
Di Raimondo C, Del Duca E, Silvaggio D, Di Prete M, Lombardo P, Mazzeo M, Spallone G, Campione E, Botti E, Bianchi L
Australas J Dermatol 2021 Feb;62(1):e1-e7. Epub 2020 Oct 11 doi: 10.1111/ajd.13443. PMID: 33040350
Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJ
J Allergy Clin Immunol Pract 2017 Sep-Oct;5(5):1169-1178. doi: 10.1016/j.jaip.2017.06.031. PMID: 28888247Free PMC Article
Hartmann K, Escribano L, Grattan C, Brockow K, Carter MC, Alvarez-Twose I, Matito A, Broesby-Olsen S, Siebenhaar F, Lange M, Niedoszytko M, Castells M, Oude Elberink JNG, Bonadonna P, Zanotti R, Hornick JL, Torrelo A, Grabbe J, Rabenhorst A, Nedoszytko B, Butterfield JH, Gotlib J, Reiter A, Radia D, Hermine O, Sotlar K, George TI, Kristensen TK, Kluin-Nelemans HC, Yavuz S, Hägglund H, Sperr WR, Schwartz LB, Triggiani M, Maurer M, Nilsson G, Horny HP, Arock M, Orfao A, Metcalfe DD, Akin C, Valent P
J Allergy Clin Immunol 2016 Jan;137(1):35-45. Epub 2015 Oct 21 doi: 10.1016/j.jaci.2015.08.034. PMID: 26476479

Clinical prediction guides

Batiha GE, Al-Kuraishy HM, Al-Gareeb AI, Welson NN
Virol J 2022 Oct 9;19(1):158. doi: 10.1186/s12985-022-01891-2. PMID: 36210445Free PMC Article
DeAngelo DJ, Radia DH, George TI, Robinson WA, Quiery AT, Drummond MW, Bose P, Hexner EO, Winton EF, Horny HP, Tugnait M, Schmidt-Kittler O, Evans EK, Lin HM, Mar BG, Verstovsek S, Deininger MW, Gotlib J
Nat Med 2021 Dec;27(12):2183-2191. Epub 2021 Dec 6 doi: 10.1038/s41591-021-01538-9. PMID: 34873347Free PMC Article
Matito A, Escribese MM, Longo N, Mayorga C, Luengo-Sánchez O, Pérez-Gordo M, Matheu V, Labrador-Horrillo M, Pascal M, Seoane-Reula ME; Comité de Inmunología de la Sociedad Española de Alergología e Inmunología Clínica (SEAIC)
J Investig Allergol Clin Immunol 2021 Dec 21;31(6):461-470. Epub 2020 Feb 5 doi: 10.18176/jiaci.0675. PMID: 33541851
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312
Hartmann K, Escribano L, Grattan C, Brockow K, Carter MC, Alvarez-Twose I, Matito A, Broesby-Olsen S, Siebenhaar F, Lange M, Niedoszytko M, Castells M, Oude Elberink JNG, Bonadonna P, Zanotti R, Hornick JL, Torrelo A, Grabbe J, Rabenhorst A, Nedoszytko B, Butterfield JH, Gotlib J, Reiter A, Radia D, Hermine O, Sotlar K, George TI, Kristensen TK, Kluin-Nelemans HC, Yavuz S, Hägglund H, Sperr WR, Schwartz LB, Triggiani M, Maurer M, Nilsson G, Horny HP, Arock M, Orfao A, Metcalfe DD, Akin C, Valent P
J Allergy Clin Immunol 2016 Jan;137(1):35-45. Epub 2015 Oct 21 doi: 10.1016/j.jaci.2015.08.034. PMID: 26476479

Recent systematic reviews

Seirafianpour F, Pourriyahi H, Gholizadeh Mesgarha M, Pour Mohammad A, Shaka Z, Goodarzi A
Dermatol Ther 2022 Jun;35(6):e15461. Epub 2022 Apr 11 doi: 10.1111/dth.15461. PMID: 35316551Free PMC Article
Le M, Miedzybrodzki B, Olynych T, Chapdelaine H, Ben-Shoshan M
Postgrad Med 2017 Nov;129(8):896-901. Epub 2017 Aug 21 doi: 10.1080/00325481.2017.1364124. PMID: 28770635
Paratz ED, Khav N, Burns AT
Heart Lung Circ 2017 Aug;26(8):772-778. Epub 2017 Feb 15 doi: 10.1016/j.hlc.2016.12.009. PMID: 28242292
Méni C, Bruneau J, Georgin-Lavialle S, Le Saché de Peufeilhoux L, Damaj G, Hadj-Rabia S, Fraitag S, Dubreuil P, Hermine O, Bodemer C
Br J Dermatol 2015 Mar;172(3):642-51. Epub 2015 Feb 8 doi: 10.1111/bjd.13567. PMID: 25662299
Andersen CL, Kristensen TK, Severinsen MT, Møller MB, Vestergaard H, Bergmann OJ, Hasselbalch HC, Bjerrum OW
Dan Med J 2012 Mar;59(3):A4397. PMID: 22381091

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