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Aplastic anemia due to radiation

MedGen UID:
99172
•Concept ID:
C0472734
•
Disease or Syndrome
Synonyms: Aplastic anemia caused by radiation; Aplastic Anemia due to Radiation; Radiation aplastic anemia
SNOMED CT: Aplastic anemia due to radiation (191247005); Radiation aplastic anemia (191247005); Aplastic anemia caused by radiation (191247005)

Definition

Aplastic anemia caused by excessive absorption of radiation by the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAplastic anemia due to radiation

Professional guidelines

PubMed

Beyond current treatment of Fanconi Anemia: What do advances in cell and gene-based approaches offer?
Martínez-Balsalobre E, Guervilly JH, van Asbeck-van der Wijst J, Pérez-Oliva AB, Lachaud C
Blood Rev 2023 Jul;60:101094. Epub 2023 Apr 28 doi: 10.1016/j.blre.2023.101094. PMID: 37142543
Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes.
Lee RH, Kang H, Yom SS, Smogorzewska A, Johnson DE, Grandis JR
Clin Cancer Res 2021 Oct 1;27(19):5168-5187. doi: 10.1158/1078-0432.CCR-21-1259. PMID: 34045293Free PMC Article
Management of Fanconi Anemia patients with head and neck carcinoma: Diagnosis and treatment adaptation.
Beddok A, Krieger S, Castera L, Stoppa-Lyonnet D, Thariat J
Oral Oncol 2020 Sep;108:104816. Epub 2020 May 30 doi: 10.1016/j.oraloncology.2020.104816. PMID: 32480311

Recent clinical studies

Etiology

Metformin for treatment of cytopenias in children and young adults with Fanconi anemia.
Pollard JA, Furutani E, Liu S, Esrick E, Cohen LE, Bledsoe J, Liu CW, Lu K, de Haro MJR, Surrallés J, Malsch M, Kuniholm A, Galvin A, Armant M, Kim AS, Ballotti K, Moreau L, Zhou Y, Babushok D, Boulad F, Carroll C, Hartung H, Hont A, Nakano T, Olson T, Sze SG, Thompson AA, Wlodarski MW, Gu X, Libermann TA, D'Andrea A, Grompe M, Weller E, Shimamura A
Blood Adv 2022 Jun 28;6(12):3803-3811. doi: 10.1182/bloodadvances.2021006490. PMID: 35500223Free PMC Article
Clonal hematopoiesis: Pre-cancer PLUS.
Silver AJ, Jaiswal S
Adv Cancer Res 2019;141:85-128. Epub 2019 Jan 14 doi: 10.1016/bs.acr.2018.12.003. PMID: 30691686
Fanconi anemia pathway.
Rodríguez A, D'Andrea A
Curr Biol 2017 Sep 25;27(18):R986-R988. doi: 10.1016/j.cub.2017.07.043. PMID: 28950089
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Chromosome instability syndromes.
Taylor AM
Best Pract Res Clin Haematol 2001 Sep;14(3):631-44. doi: 10.1053/beha.2001.0158. PMID: 11640873

Diagnosis

Management of Fanconi Anemia patients with head and neck carcinoma: Diagnosis and treatment adaptation.
Beddok A, Krieger S, Castera L, Stoppa-Lyonnet D, Thariat J
Oral Oncol 2020 Sep;108:104816. Epub 2020 May 30 doi: 10.1016/j.oraloncology.2020.104816. PMID: 32480311
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Susceptibility pathways in Fanconi's anemia and breast cancer.
D'Andrea AD
N Engl J Med 2010 May 20;362(20):1909-19. doi: 10.1056/NEJMra0809889. PMID: 20484397Free PMC Article
The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks.
Macé-Aimé G, Couvé S, Khassenov B, Rosselli F, Saparbaev MK
Environ Mol Mutagen 2010 Jul;51(6):508-19. doi: 10.1002/em.20548. PMID: 20120016
Chromosome instability syndromes.
Taylor AM
Best Pract Res Clin Haematol 2001 Sep;14(3):631-44. doi: 10.1053/beha.2001.0158. PMID: 11640873

Therapy

Metformin for treatment of cytopenias in children and young adults with Fanconi anemia.
Pollard JA, Furutani E, Liu S, Esrick E, Cohen LE, Bledsoe J, Liu CW, Lu K, de Haro MJR, Surrallés J, Malsch M, Kuniholm A, Galvin A, Armant M, Kim AS, Ballotti K, Moreau L, Zhou Y, Babushok D, Boulad F, Carroll C, Hartung H, Hont A, Nakano T, Olson T, Sze SG, Thompson AA, Wlodarski MW, Gu X, Libermann TA, D'Andrea A, Grompe M, Weller E, Shimamura A
Blood Adv 2022 Jun 28;6(12):3803-3811. doi: 10.1182/bloodadvances.2021006490. PMID: 35500223Free PMC Article
A Review of Romiplostim Mechanism of Action and Clinical Applicability.
Bussel JB, Soff G, Balduzzi A, Cooper N, Lawrence T, Semple JW
Drug Des Devel Ther 2021;15:2243-2268. Epub 2021 May 26 doi: 10.2147/DDDT.S299591. PMID: 34079225Free PMC Article
Clonal hematopoiesis: Pre-cancer PLUS.
Silver AJ, Jaiswal S
Adv Cancer Res 2019;141:85-128. Epub 2019 Jan 14 doi: 10.1016/bs.acr.2018.12.003. PMID: 30691686
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Aplastic anemia.
Stohlman F
Blood 1972 Aug;40(2):282-6. PMID: 4557987

Prognosis

Foreign Letters: London.
JAMA 2021 May 11;325(18):1907. doi: 10.1001/jama.2020.17930. PMID: 33974028
Therapeutic research in the crystal chromosome disease Fanconi anemia.
Minguillón J, Surrallés J
Mutat Res Genet Toxicol Environ Mutagen 2018 Dec;836(Pt A):104-108. Epub 2018 May 7 doi: 10.1016/j.mrgentox.2018.05.012. PMID: 30389152
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Susceptibility pathways in Fanconi's anemia and breast cancer.
D'Andrea AD
N Engl J Med 2010 May 20;362(20):1909-19. doi: 10.1056/NEJMra0809889. PMID: 20484397Free PMC Article
Acquired aplastic anemia: correlation between etiology, pathophysiology, bone marrow histology and prognosis factors.
Găman A, Găman G, Bold A
Rom J Morphol Embryol 2009;50(4):669-74. PMID: 19942964

Clinical prediction guides

Metformin for treatment of cytopenias in children and young adults with Fanconi anemia.
Pollard JA, Furutani E, Liu S, Esrick E, Cohen LE, Bledsoe J, Liu CW, Lu K, de Haro MJR, Surrallés J, Malsch M, Kuniholm A, Galvin A, Armant M, Kim AS, Ballotti K, Moreau L, Zhou Y, Babushok D, Boulad F, Carroll C, Hartung H, Hont A, Nakano T, Olson T, Sze SG, Thompson AA, Wlodarski MW, Gu X, Libermann TA, D'Andrea A, Grompe M, Weller E, Shimamura A
Blood Adv 2022 Jun 28;6(12):3803-3811. doi: 10.1182/bloodadvances.2021006490. PMID: 35500223Free PMC Article
Management of Fanconi Anemia patients with head and neck carcinoma: Diagnosis and treatment adaptation.
Beddok A, Krieger S, Castera L, Stoppa-Lyonnet D, Thariat J
Oral Oncol 2020 Sep;108:104816. Epub 2020 May 30 doi: 10.1016/j.oraloncology.2020.104816. PMID: 32480311
Clonal hematopoiesis: Pre-cancer PLUS.
Silver AJ, Jaiswal S
Adv Cancer Res 2019;141:85-128. Epub 2019 Jan 14 doi: 10.1016/bs.acr.2018.12.003. PMID: 30691686
Sonic Hedgehog, VACTERL, and Fanconi anemia: Pathogenetic connections and therapeutic implications.
Lubinsky M
Am J Med Genet A 2015 Nov;167A(11):2594-8. Epub 2015 Jul 21 doi: 10.1002/ajmg.a.37257. PMID: 26198446
Susceptibility pathways in Fanconi's anemia and breast cancer.
D'Andrea AD
N Engl J Med 2010 May 20;362(20):1909-19. doi: 10.1056/NEJMra0809889. PMID: 20484397Free PMC Article

Recent systematic reviews

Treatment of Fanconi Anemia-Associated Head and Neck Cancer: Opportunities to Improve Outcomes.
Lee RH, Kang H, Yom SS, Smogorzewska A, Johnson DE, Grandis JR
Clin Cancer Res 2021 Oct 1;27(19):5168-5187. doi: 10.1158/1078-0432.CCR-21-1259. PMID: 34045293Free PMC Article
Systematic review and individual patient data analysis of pediatric head and neck squamous cell carcinoma: An analysis of 217 cases.
Bhanu Prasad V, Mallick S, Upadhyay AD, Rath GK
Int J Pediatr Otorhinolaryngol 2017 Jan;92:75-81. Epub 2016 Nov 12 doi: 10.1016/j.ijporl.2016.11.005. PMID: 28012539

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