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Malignant melanocytic neoplasm of the peripheral nerve sheath

MedGen UID:
99184
Concept ID:
C0474847
Neoplastic Process
Synonyms: Malignant Melanocytic Neoplasm of Peripheral Nerve Sheath; malignant melanocytic neoplasm of peripheral nerve sheath; Malignant Melanocytic Neoplasm of the Peripheral Nerve Sheath; malignant melanocytic neoplasm of the peripheral nerve sheath; Malignant Melanocytic Peripheral Nerve Sheath Tumor; malignant melanocytic peripheral nerve sheath tumor; malignant melanocytic peripheral nerve sheath tumour; Malignant Melanotic Nerve Sheath Tumor; Malignant melanotic neurilemmoma; Malignant Melanotic Peripheral Nerve Sheath Tumor; malignant melanotic peripheral nerve sheath tumor; malignant melanotic peripheral nerve sheath tumour; Malignant Melanotic Schwannian Tumor; Malignant melanotic schwannoma; Melanocytic MPNST; melanocytic MPNST; Melanotic malignant nerve sheath tumor; melanotic malignant nerve sheath tumor; melanotic malignant nerve sheath tumour; Melanotic malignant peripheral nerve sheath tumor; melanotic malignant peripheral nerve sheath tumor; melanotic malignant peripheral nerve sheath tumor (morphologic abnormality); melanotic malignant peripheral nerve sheath tumour; melanotic malignant peripheral nerve sheath tumour (morphologic abnormality)
SNOMED CT: Melanotic malignant nerve sheath tumor (404039004); Malignant melanotic schwannoma (404039004); Malignant melanotic neurilemmoma (404039004); Malignant melanotic schwannoma (253094006); Malignant melanotic neurilemmoma (253094006); Melanotic malignant peripheral nerve sheath tumor (253094006)
 
Monarch Initiative: MONDO:0003863

Definition

A rare variant of malignant peripheral nerve sheath tumor. It is characterized by the presence of malignant cells that contain melanin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant melanocytic neoplasm of the peripheral nerve sheath

Professional guidelines

PubMed

Ghaith AK, Johnson SE, El-Hajj VG, Akinduro OO, Ghanem M, De Biase G, Michaelides L, Bon Nieves A, Marsh WR, Currier BL, Atkinson JL, Spinner RJ, Bydon M
J Neurosurg Spine 2024 Jan 1;40(1):28-37. Epub 2023 Oct 20 doi: 10.3171/2023.8.SPINE23427. PMID: 37862711

Recent clinical studies

Etiology

Thangaiah JJ, Westling BE, Roden AC, Giannini C, Tetzlaff M, Cho WC, Folpe AL
Ann Diagn Pathol 2022 Aug;59:151967. Epub 2022 May 6 doi: 10.1016/j.anndiagpath.2022.151967. PMID: 35567887
Kim JY, Jeon JH, Choi TH, Kim BJ
Dermatol Surg 2022 Feb 1;48(2):171-175. doi: 10.1097/DSS.0000000000003341. PMID: 34935754
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487
Hölzel M, Landsberg J, Glodde N, Bald T, Rogava M, Riesenberg S, Becker A, Jönsson G, Tüting T
Cancer Res 2016 Jan 15;76(2):251-63. Epub 2015 Oct 28 doi: 10.1158/0008-5472.CAN-15-1090. PMID: 26511633
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291

Diagnosis

Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Sy AL, Hoang MP
J Clin Pathol 2023 Oct;76(10):649-653. Epub 2023 Jun 19 doi: 10.1136/jcp-2023-208924. PMID: 37336549
McAfee JL, Dermawan JK, Billings SD, Ko JS
J Cutan Pathol 2021 Oct;48(10):1223-1230. Epub 2021 Apr 14 doi: 10.1111/cup.14014. PMID: 33745212
Sahm F, Reuss DE, Giannini C
Neuropathol Appl Neurobiol 2018 Feb;44(2):163-171. doi: 10.1111/nan.12397. PMID: 28295484
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291

Therapy

Ghaith AK, Johnson SE, El-Hajj VG, Akinduro OO, Ghanem M, De Biase G, Michaelides L, Bon Nieves A, Marsh WR, Currier BL, Atkinson JL, Spinner RJ, Bydon M
J Neurosurg Spine 2024 Jan 1;40(1):28-37. Epub 2023 Oct 20 doi: 10.3171/2023.8.SPINE23427. PMID: 37862711
Wang JY, Nuovo G, Kline M, Magro CM
Am J Dermatopathol 2017 Jan;39(1):49-52. doi: 10.1097/DAD.0000000000000671. PMID: 27749287
Ambros T, Furian R, Riccardi F
Pediatr Dermatol 2011 Nov-Dec;28(6):729-731. Epub 2011 Sep 25 doi: 10.1111/j.1525-1470.2011.01398.x. PMID: 21950562

Prognosis

Kim JY, Jeon JH, Choi TH, Kim BJ
Dermatol Surg 2022 Feb 1;48(2):171-175. doi: 10.1097/DSS.0000000000003341. PMID: 34935754
Alyousef MJ, Alratroot JA, ElSharkawy T, Shawarby MA, Al Hamad MA, Hashem TM, Alsayyah A
Diagn Pathol 2017 Mar 20;12(1):29. doi: 10.1186/s13000-017-0620-9. PMID: 28320420Free PMC Article
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487
Spina A, Gagliardi F, Boari N, Terreni MR, Mortini P
J Neurol Surg A Cent Eur Neurosurg 2015 Sep;76(5):399-406. Epub 2015 May 8 doi: 10.1055/s-0034-1393926. PMID: 26302291
Kurtkaya-Yapicier O, Scheithauer B, Woodruff JM
Histol Histopathol 2003 Jul;18(3):925-34. doi: 10.14670/HH-18.925. PMID: 12792904

Clinical prediction guides

Ranson M, Lai J, Van Brenk B, McCalmont TH, Walsh NM
Am J Dermatopathol 2022 Dec 1;44(12):943-947. Epub 2022 Nov 2 doi: 10.1097/DAD.0000000000002311. PMID: 36395450
Hrycaj SM, Szczepanski JM, Zhao L, Siddiqui J, Thomas DG, Lucas DR, Patel RM, Harms PW, Bresler SC, Chan MP
Histopathology 2022 Dec;81(6):818-825. Epub 2022 Sep 28 doi: 10.1111/his.14797. PMID: 36102613Free PMC Article
Alyousef MJ, Alratroot JA, ElSharkawy T, Shawarby MA, Al Hamad MA, Hashem TM, Alsayyah A
Diagn Pathol 2017 Mar 20;12(1):29. doi: 10.1186/s13000-017-0620-9. PMID: 28320420Free PMC Article
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487
Jokinen CH, Dadras SS, Goldblum JR, van de Rijn M, West RB, Rubin BP
Am J Clin Pathol 2008 Jun;129(6):886-93. doi: 10.1309/M7D5KTVYYE51XYQA. PMID: 18480004

Recent systematic reviews

Ghaith AK, Johnson SE, El-Hajj VG, Akinduro OO, Ghanem M, De Biase G, Michaelides L, Bon Nieves A, Marsh WR, Currier BL, Atkinson JL, Spinner RJ, Bydon M
J Neurosurg Spine 2024 Jan 1;40(1):28-37. Epub 2023 Oct 20 doi: 10.3171/2023.8.SPINE23427. PMID: 37862711
Carlson ML, Jacob JT, Habermann EB, Glasgow AE, Raghunathan A, Link MJ
J Neurosurg 2016 Nov;125(5):1120-1129. Epub 2016 Jan 8 doi: 10.3171/2015.7.JNS151056. PMID: 26745487

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