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Synovium neoplasm

MedGen UID:
99197
•Concept ID:
C0476203
•
Neoplastic Process
Synonyms: neoplasm of synovial membrane of synovial joint; Neoplasm of Synovium; neoplasm of synovium; Neoplasm of the Synovium; neoplasm of the synovium; synovial membrane of synovial joint neoplasm; synovial membrane of synovial joint neoplasm (disease); synovial membrane of synovial joint tumor; synovial membrane of synovial joint tumour; Synovial Neoplasm; synovial neoplasm; synovial neoplasm (morphologic abnormality); synovial neoplasm NOS (morphologic abnormality); Synovial Tumor; synovial tumor; synovial tumour; synovium neoplasm; tumor of synovial membrane of synovial joint; Tumor of Synovium; tumor of synovium; Tumor of the Synovium; tumor of the synovium; tumour of synovial membrane of synovial joint; tumour of synovium; tumour of the synovium
 
Monarch Initiative: MONDO:0002528

Definition

A benign or malignant soft tissue neoplasm arising exclusively from the synovial membrane. Examples include the diffuse giant cell tumor of tendon sheath, localized giant cell tumor of tendon sheath, and malignant giant cell tumor of tendon sheath. [from NCI]

Professional guidelines

PubMed

Treatment updates on tenosynovial giant cell tumor.
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Diffuse-type tenosynovial giant cell tumour: Current treatment concepts and future perspectives.
Staals EL, Ferrari S, Donati DM, Palmerini E
Eur J Cancer 2016 Aug;63:34-40. Epub 2016 Jun 5 doi: 10.1016/j.ejca.2016.04.022. PMID: 27267143
Anterior knee pain in the young athlete: diagnosis and treatment.
Kodali P, Islam A, Andrish J
Sports Med Arthrosc Rev 2011 Mar;19(1):27-33. doi: 10.1097/JSA.0b013e3182045aa1. PMID: 21293235

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Imaging features of lipoma arborescens.
Huang Y, Liu H, Wang Y, Chu X, Liu H, Wang H
Acta Radiol 2022 Aug;63(8):1043-1050. Epub 2021 Jun 25 doi: 10.1177/02841851211027388. PMID: 34171969
Musculoskeletal Manifestations of Amyloidosis: A Focused Review.
Nguyen TX, Naqvi A, Thompson TL, Wilson RH
J Surg Orthop Adv 2018 Spring;27(1):1-5. PMID: 29762107
Dosimetry perspectives in radiation synovectomy.
Ahmad I, Nisar H
Phys Med 2018 Mar;47:64-72. Epub 2018 Feb 28 doi: 10.1016/j.ejmp.2018.02.015. PMID: 29609820
Pigmented villonodular synovitis.
Ofluoglu O
Orthop Clin North Am 2006 Jan;37(1):23-33. doi: 10.1016/j.ocl.2005.08.002. PMID: 16311109

Diagnosis

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Synovial Tumors and Proliferative Diseases.
Levine BD, Motamedi K, Seeger LL
Rheum Dis Clin North Am 2016 Nov;42(4):753-768. Epub 2016 Sep 7 doi: 10.1016/j.rdc.2016.07.008. PMID: 27742025
Lipoma arborescens.
Sanamandra SK, Ong KO
Singapore Med J 2014 Jan;55(1):5-10; quiz 11. doi: 10.11622/smedj.2014003. PMID: 24452971Free PMC Article
Benign synovial disorders.
Adelani MA, Wupperman RM, Holt GE
J Am Acad Orthop Surg 2008 May;16(5):268-75. doi: 10.5435/00124635-200805000-00005. PMID: 18460687
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576

Therapy

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Radiosynoviorthesis: almost seventy years of experience but still somewhat fameless.
van der Zant FM, Knol RJ, Broos WA
Q J Nucl Med Mol Imaging 2022 Dec;66(4):293-303. Epub 2022 Jun 16 doi: 10.23736/S1824-4785.22.03470-7. PMID: 35708601
Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts.
Zhang Q, Peng W, Wei S, Wei D, Li R, Liu J, Peng L, Yang S, Gao Y, Wu C, Pu X
Biomed Pharmacother 2019 Oct;118:109367. Epub 2019 Aug 21 doi: 10.1016/j.biopha.2019.109367. PMID: 31545276
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604
Dosimetry perspectives in radiation synovectomy.
Ahmad I, Nisar H
Phys Med 2018 Mar;47:64-72. Epub 2018 Feb 28 doi: 10.1016/j.ejmp.2018.02.015. PMID: 29609820

Prognosis

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
MRI of synovitis and joint fluid.
Burke CJ, Alizai H, Beltran LS, Regatte RR
J Magn Reson Imaging 2019 Jun;49(6):1512-1527. Epub 2019 Jan 8 doi: 10.1002/jmri.26618. PMID: 30618151Free PMC Article
Lipoma arborescens.
Sanamandra SK, Ong KO
Singapore Med J 2014 Jan;55(1):5-10; quiz 11. doi: 10.11622/smedj.2014003. PMID: 24452971Free PMC Article
Pigmented villonodular synovitis.
Mendenhall WM, Mendenhall CM, Reith JD, Scarborough MT, Gibbs CP, Mendenhall NP
Am J Clin Oncol 2006 Dec;29(6):548-50. doi: 10.1097/01.coc.0000239142.48188.f6. PMID: 17148989
Synovial sarcoma.
Fisher C
Ann Diagn Pathol 1998 Dec;2(6):401-21. doi: 10.1016/s1092-9134(98)80042-7. PMID: 9930576

Clinical prediction guides

The cholinergic system in joint health and osteoarthritis: a narrative-review.
Lauwers M, Courties A, Sellam J, Wen C
Osteoarthritis Cartilage 2021 May;29(5):643-653. Epub 2021 Feb 17 doi: 10.1016/j.joca.2021.02.005. PMID: 33609692
Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts.
Zhang Q, Peng W, Wei S, Wei D, Li R, Liu J, Peng L, Yang S, Gao Y, Wu C, Pu X
Biomed Pharmacother 2019 Oct;118:109367. Epub 2019 Aug 21 doi: 10.1016/j.biopha.2019.109367. PMID: 31545276
Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review.
Burks SS, Puffer RC, Cajigas I, Valdivia D, Rosenberg AE, Spinner RJ, Levi AD
Neurosurgery 2019 Dec 1;85(6):E975-E991. doi: 10.1093/neuros/nyz321. PMID: 31435657Free PMC Article
Unusual Findings in Synovial Fluid Analysis: A Review.
Oliviero F, Galozzi P, Ramonda R, de Oliveira FL, Schiavon F, Scanu A, Punzi L
Ann Clin Lab Sci 2017 May;47(3):253-259. PMID: 28667024
Metal-on-metal total hip replacement.
Silva M, Heisel C, Schmalzried TP
Clin Orthop Relat Res 2005 Jan;(430):53-61. doi: 10.1097/01.blo.0000149995.84350.d7. PMID: 15662304

Recent systematic reviews

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Surgical management of upper limb lipoma arborescens: a systematic review.
Kalifis G, Maffulli N, Migliorini F, Marín Fermín T, Hovsepian JM, Stefanou N, Hantes M
J Orthop Surg Res 2022 Mar 4;17(1):138. doi: 10.1186/s13018-022-02997-7. PMID: 35246183Free PMC Article
Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis.
Siegel M, Bode L, Südkamp N, Kühle J, Zwingmann J, Schmal H, Herget GW
PLoS One 2021;16(12):e0260795. Epub 2021 Dec 2 doi: 10.1371/journal.pone.0260795. PMID: 34855875Free PMC Article
Synovial Sarcoma of the Nerve-Clinical and Pathological Features: Case Series and Systematic Review.
Burks SS, Puffer RC, Cajigas I, Valdivia D, Rosenberg AE, Spinner RJ, Levi AD
Neurosurgery 2019 Dec 1;85(6):E975-E991. doi: 10.1093/neuros/nyz321. PMID: 31435657Free PMC Article
Pigmented Villonodular Synovitis of the Hip: A Systematic Review.
Levy DM, Haughom BD, Nho SJ, Gitelis S
Am J Orthop (Belle Mead NJ) 2016 Jan;45(1):23-8. PMID: 26761914

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