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Non-cardiac chest pain

MedGen UID:
99198
Concept ID:
C0476281
Sign or Symptom
Synonyms: Non-Cardiac Chest Pain; Noncardiac chest pain
SNOMED CT: Noncardiac chest pain (274668005); Non-cardiac chest pain (274668005)

Definition

Pain in the chest unrelated to a heart disorder. [from NCI]

Professional guidelines

PubMed

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Khan A, Yadlapati R, Gonlachanvit S, Katzka DA, Park MI, Vaezi M, Vela M, Pandolfino J
Neurogastroenterol Motil 2021 Jul;33(7):e14182. Epub 2021 Jun 30 doi: 10.1111/nmo.14182. PMID: 34190376
George N, Abdallah J, Maradey-Romero C, Gerson L, Fass R
Aliment Pharmacol Ther 2016 Jan;43(2):213-39. Epub 2015 Nov 23 doi: 10.1111/apt.13458. PMID: 26592490

Recent clinical studies

Etiology

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Khan A, Yadlapati R, Gonlachanvit S, Katzka DA, Park MI, Vaezi M, Vela M, Pandolfino J
Neurogastroenterol Motil 2021 Jul;33(7):e14182. Epub 2021 Jun 30 doi: 10.1111/nmo.14182. PMID: 34190376
Yadlapati R, Pandolfino JE, Fox MR, Bredenoord AJ, Kahrilas PJ
Neurogastroenterol Motil 2021 Jan;33(1):e14053. Epub 2020 Dec 19 doi: 10.1111/nmo.14053. PMID: 33340190Free PMC Article
Ahuja A, Ahuja NK
Curr Gastroenterol Rep 2019 Jul 10;21(8):39. doi: 10.1007/s11894-019-0707-4. PMID: 31289950
Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S, Jackson R, Rahneva T, Wage R, Smith G, Venneri L, Tayal U, Auger D, Midwinter W, Whiffin N, Rajani R, Dungu JN, Pantazis A, Cook SA, Ware JS, Baksi AJ, Pennell DJ, Rosen SD, Cowie MR, Cleland JGF, Prasad SK
Lancet 2019 Jan 5;393(10166):61-73. Epub 2018 Nov 11 doi: 10.1016/S0140-6736(18)32484-X. PMID: 30429050Free PMC Article

Diagnosis

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Beltrame JF, Tavella R, Jones D, Zeitz C
BMJ 2021 Nov 26;375:e060602. doi: 10.1136/bmj-2021-060602. PMID: 34836873
Yadlapati R, Pandolfino JE, Fox MR, Bredenoord AJ, Kahrilas PJ
Neurogastroenterol Motil 2021 Jan;33(1):e14053. Epub 2020 Dec 19 doi: 10.1111/nmo.14053. PMID: 33340190Free PMC Article
Gómez-Escudero O, Coss-Adame E, Amieva-Balmori M, Carmona-Sánchez RI, Remes-Troche JM, Abreu Y Abreu AT, Cerda-Contreras E, Gómez-Castaños PC, González-Martínez MA, Huerta-Iga FM, Ibarra-Palomino J, Icaza-Chávez ME, López-Colombo A, Márquez-Murillo MF, Mejía-Rivas M, Morales-Arámbula M, Rodríguez-Chávez JL, Torres-Barrera G, Valdovinos-García LR, Valdovinos-Díaz MA, Vázquez-Elizondo G, Villar-Chávez AS, Zavala-Solares M, Achem SR
Rev Gastroenterol Mex (Engl Ed) 2019 Jul-Sep;84(3):372-397. Epub 2019 Jun 15 doi: 10.1016/j.rgmx.2019.05.002. PMID: 31213326
Durazzo M, Gargiulo G, Pellicano R
Minerva Cardioangiol 2018 Dec;66(6):770-783. Epub 2018 Apr 11 doi: 10.23736/S0026-4725.18.04681-9. PMID: 29642692

Therapy

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Ahuja A, Ahuja NK
Curr Gastroenterol Rep 2019 Jul 10;21(8):39. doi: 10.1007/s11894-019-0707-4. PMID: 31289950
Gómez-Escudero O, Coss-Adame E, Amieva-Balmori M, Carmona-Sánchez RI, Remes-Troche JM, Abreu Y Abreu AT, Cerda-Contreras E, Gómez-Castaños PC, González-Martínez MA, Huerta-Iga FM, Ibarra-Palomino J, Icaza-Chávez ME, López-Colombo A, Márquez-Murillo MF, Mejía-Rivas M, Morales-Arámbula M, Rodríguez-Chávez JL, Torres-Barrera G, Valdovinos-García LR, Valdovinos-Díaz MA, Vázquez-Elizondo G, Villar-Chávez AS, Zavala-Solares M, Achem SR
Rev Gastroenterol Mex (Engl Ed) 2019 Jul-Sep;84(3):372-397. Epub 2019 Jun 15 doi: 10.1016/j.rgmx.2019.05.002. PMID: 31213326
Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S, Jackson R, Rahneva T, Wage R, Smith G, Venneri L, Tayal U, Auger D, Midwinter W, Whiffin N, Rajani R, Dungu JN, Pantazis A, Cook SA, Ware JS, Baksi AJ, Pennell DJ, Rosen SD, Cowie MR, Cleland JGF, Prasad SK
Lancet 2019 Jan 5;393(10166):61-73. Epub 2018 Nov 11 doi: 10.1016/S0140-6736(18)32484-X. PMID: 30429050Free PMC Article
Durazzo M, Gargiulo G, Pellicano R
Minerva Cardioangiol 2018 Dec;66(6):770-783. Epub 2018 Apr 11 doi: 10.23736/S0026-4725.18.04681-9. PMID: 29642692

Prognosis

Khalaf MHG, Chowdhary S, Elmunzer BJ, Elias PS, Castell D
Dig Dis Sci 2019 Aug;64(8):2214-2218. Epub 2019 Feb 15 doi: 10.1007/s10620-019-05523-8. PMID: 30771044
Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S, Jackson R, Rahneva T, Wage R, Smith G, Venneri L, Tayal U, Auger D, Midwinter W, Whiffin N, Rajani R, Dungu JN, Pantazis A, Cook SA, Ware JS, Baksi AJ, Pennell DJ, Rosen SD, Cowie MR, Cleland JGF, Prasad SK
Lancet 2019 Jan 5;393(10166):61-73. Epub 2018 Nov 11 doi: 10.1016/S0140-6736(18)32484-X. PMID: 30429050Free PMC Article
Alkhatatbeh MJ, Abdul-Razzak KK, Amara NA, Al-Jarrah M
J Clin Psychol Med Settings 2019 Jun;26(2):194-199. doi: 10.1007/s10880-018-9579-2. PMID: 30151664
Park HW, Choi YJ, Jeong SJ
J Korean Med Sci 2016 Feb;31(2):270-4. Epub 2016 Jan 14 doi: 10.3346/jkms.2016.31.2.270. PMID: 26839482Free PMC Article
Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955

Clinical prediction guides

Yoldaş T, Yoldaş TÇ, Beyazal M, Sayıcı Uİ, Örün UA
Cardiol Young 2020 Sep;30(9):1261-1265. Epub 2020 Jul 16 doi: 10.1017/S1047951120001948. PMID: 32669139
Halliday BP, Wassall R, Lota AS, Khalique Z, Gregson J, Newsome S, Jackson R, Rahneva T, Wage R, Smith G, Venneri L, Tayal U, Auger D, Midwinter W, Whiffin N, Rajani R, Dungu JN, Pantazis A, Cook SA, Ware JS, Baksi AJ, Pennell DJ, Rosen SD, Cowie MR, Cleland JGF, Prasad SK
Lancet 2019 Jan 5;393(10166):61-73. Epub 2018 Nov 11 doi: 10.1016/S0140-6736(18)32484-X. PMID: 30429050Free PMC Article
Alkhatatbeh MJ, Abdul-Razzak KK, Amara NA, Al-Jarrah M
J Clin Psychol Med Settings 2019 Jun;26(2):194-199. doi: 10.1007/s10880-018-9579-2. PMID: 30151664
Serlie AW, Erdman RA, Passchier J, Trijsburg RW, ten Cate FJ
Psychother Psychosom 1995;64(2):62-73. doi: 10.1159/000288993. PMID: 8559955
Richter JE
Baillieres Clin Gastroenterol 1991 Jun;5(2):281-306. doi: 10.1016/0950-3528(91)90031-u. PMID: 1912653

Recent systematic reviews

Mohr C, Ciomperlik H, Dhanani N, Olavarria OA, Hannon C, Hope W, Roth S, Liang MK, Holihan JL
J Gastrointest Surg 2023 Feb;27(2):390-397. Epub 2023 Jan 17 doi: 10.1007/s11605-023-05590-3. PMID: 36650419
Webster R, Norman P, Goodacre S, Thompson A
Emerg Med J 2012 Apr;29(4):267-73. Epub 2011 Oct 27 doi: 10.1136/emermed-2011-200526. PMID: 22034535
Hungin AP, Raghunath AS, Wiklund I
Fam Pract 2005 Dec;22(6):591-603. Epub 2005 Jul 15 doi: 10.1093/fampra/cmi061. PMID: 16024554
Mant J, McManus RJ, Oakes RA, Delaney BC, Barton PM, Deeks JJ, Hammersley L, Davies RC, Davies MK, Hobbs FD
Health Technol Assess 2004 Feb;8(2):iii, 1-158. doi: 10.3310/hta8020. PMID: 14754562
McManus RJ, Mant J, Davies MK, Davis RC, Deeks JJ, Oakes RA, Hobbs FD
Int J Clin Pract 2002 Jan-Feb;56(1):29-33. PMID: 11833553

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