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Metastatic Malignant Neoplasm in the Small Intestine

MedGen UID:
99212
•Concept ID:
C0494164
•
Neoplastic Process
Synonyms: Cancer metastatic to small intestine; Metastases to Small Intestine; Metastasis to small intestine; Metastasis to the Small Bowel; Metastasis to the Small Intestine; Metastatic malignant neoplasm of small intestine; Metastatic malignant neoplasm to small intestine; Metastatic Malignant Neoplasm to the Small Intestine; Metastatic Neoplasm to the Small Intestine; Secondary malignant neoplasm of small intestine; Secondary Malignant Neoplasm to the Small Bowel; Secondary Malignant Neoplasm to the Small Intestine; Secondary Malignant Tumor to the Small Bowel; Secondary Malignant Tumor to the Small Intestine
SNOMED CT: Metastasis to small intestine (94580002); Secondary malignant neoplasm of small intestine (94580002); Metastatic malignant neoplasm to small intestine (94580002); Cancer metastatic to small intestine (94580002); Metastatic malignant neoplasm of small intestine (94580002)

Definition

A malignant neoplasm that has spread to the small intestine from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Small Intestine

Professional guidelines

PubMed

Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options.
Kohoutova D, Worku D, Aziz H, Teare J, Weir J, Larkin J
Cells 2021 Feb 5;10(2) doi: 10.3390/cells10020327. PMID: 33562484Free PMC Article
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Recent clinical studies

Etiology

Dietary fat, bile acid metabolism and colorectal cancer.
Ocvirk S, O'Keefe SJD
Semin Cancer Biol 2021 Aug;73:347-355. Epub 2020 Oct 16 doi: 10.1016/j.semcancer.2020.10.003. PMID: 33069873
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
The epidemiology of metastases in neuroendocrine tumors.
Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K
Int J Cancer 2016 Dec 15;139(12):2679-2686. Epub 2016 Sep 9 doi: 10.1002/ijc.30400. PMID: 27553864
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Diagnosis

Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.
Bonds M, Rocha FG
Surg Clin North Am 2020 Jun;100(3):635-648. Epub 2020 Apr 1 doi: 10.1016/j.suc.2020.02.010. PMID: 32402306
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
The epidemiology of metastases in neuroendocrine tumors.
Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K
Int J Cancer 2016 Dec 15;139(12):2679-2686. Epub 2016 Sep 9 doi: 10.1002/ijc.30400. PMID: 27553864
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Therapy

Dietary fat, bile acid metabolism and colorectal cancer.
Ocvirk S, O'Keefe SJD
Semin Cancer Biol 2021 Aug;73:347-355. Epub 2020 Oct 16 doi: 10.1016/j.semcancer.2020.10.003. PMID: 33069873
Malignant gastric outlet obstruction: Which is the best therapeutic option?
Troncone E, Fugazza A, Cappello A, Del Vecchio Blanco G, Monteleone G, Repici A, Teoh AYB, Anderloni A
World J Gastroenterol 2020 Apr 28;26(16):1847-1860. doi: 10.3748/wjg.v26.i16.1847. PMID: 32390697Free PMC Article
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056

Prognosis

Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts.
Bonds M, Rocha FG
Surg Clin North Am 2020 Jun;100(3):635-648. Epub 2020 Apr 1 doi: 10.1016/j.suc.2020.02.010. PMID: 32402306
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Clinical prediction guides

Evaluation of Pathologic Prognostic Factors in Neuroendocrine Tumors of the Small Intestine.
Polydorides AD, Liu Q
Am J Surg Pathol 2022 Apr 1;46(4):547-556. doi: 10.1097/PAS.0000000000001808. PMID: 35192293
Management of primary and metastatic malignant small bowel obstruction, operate or palliate. A systematic review.
Banting SP, Waters PS, Peacock O, Narasimhan V, Lynch AC, McCormick JJ, Warrier SK, Heriot AG
ANZ J Surg 2021 Mar;91(3):282-290. Epub 2020 Aug 31 doi: 10.1111/ans.16188. PMID: 32869479
Prehabilitation in patients undergoing pancreaticoduodenectomy: a randomized controlled trial.
Ausania F, Senra P, Meléndez R, Caballeiro R, Ouviña R, Casal-Núñez E
Rev Esp Enferm Dig 2019 Aug;111(8):603-608. doi: 10.17235/reed.2019.6182/2019. PMID: 31232076
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Recent systematic reviews

Ileorectal anastomosis in patients with Crohn's disease. Postoperative complications and functional outcome-a systematic review.
Baelum JK, Qvist N, Ellebaek MB
Colorectal Dis 2021 Oct;23(10):2501-2514. Epub 2021 Aug 10 doi: 10.1111/codi.15839. PMID: 34309170
Management of primary and metastatic malignant small bowel obstruction, operate or palliate. A systematic review.
Banting SP, Waters PS, Peacock O, Narasimhan V, Lynch AC, McCormick JJ, Warrier SK, Heriot AG
ANZ J Surg 2021 Mar;91(3):282-290. Epub 2020 Aug 31 doi: 10.1111/ans.16188. PMID: 32869479
Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Abdel-Rahman O, Elsayed Z, Elhalawani H
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD011746. doi: 10.1002/14651858.CD011746.pub2. PMID: 29624208Free PMC Article
Role of palliative resection of the primary tumour in advanced pancreatic and small intestinal neuroendocrine tumours: A systematic review and meta-analysis.
Almond LM, Hodson J, Ford SJ, Gourevitch D, Roberts KJ, Shah T, Isaac J, Desai A
Eur J Surg Oncol 2017 Oct;43(10):1808-1815. Epub 2017 May 25 doi: 10.1016/j.ejso.2017.05.016. PMID: 28583792
Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance.
Luchini C, Veronese N, Pea A, Sergi G, Manzato E, Nottegar A, Solmi M, Capelli P, Scarpa A
Eur J Gastroenterol Hepatol 2016 Feb;28(2):205-9. doi: 10.1097/MEG.0000000000000520. PMID: 26566063

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