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Ciliary body cancer

MedGen UID:
99219
Concept ID:
C0496833
Neoplastic Process
Synonyms: cancer of ciliary body; ciliary body cancer; Malignant Ciliary Body Neoplasm; malignant ciliary body neoplasm; Malignant Ciliary Body Tumor; malignant ciliary body tumor; malignant ciliary body tumour; Malignant neoplasm of ciliary body; Malignant Neoplasm of Ciliary Body; malignant neoplasm of ciliary body; Malignant Neoplasm of the Ciliary Body; malignant neoplasm of the ciliary body; Malignant tumor of ciliary body; Malignant Tumor of Ciliary Body; malignant tumor of ciliary body; Malignant Tumor of the Ciliary Body; malignant tumor of the ciliary body; malignant tumour of ciliary body; malignant tumour of the ciliary body
SNOMED CT: Malignant neoplasm of ciliary body (188263008); Malignant tumor of ciliary body (188263008)
 
Monarch Initiative: MONDO:0002969

Definition

A malignant neoplasm that affects the ciliary body. Representative examples include melanoma and malignant medulloepithelioma. [from NCI]

Professional guidelines

PubMed

Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Diagnosis

Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC Jr, Bastian BC, Bloomer MM, Pekmezci M
Ophthalmology 2022 Dec;129(12):1429-1439. Epub 2022 Jul 12 doi: 10.1016/j.ophtha.2022.07.002. PMID: 35835335
Gündüz AK, Mirzayev I
Turk J Ophthalmol 2022 Apr 28;52(2):125-138. doi: 10.4274/tjo.galenos.2021.24376. PMID: 35481734Free PMC Article
Méndez-Martínez S, Santiago Varela M, Blanco-Teijeiro MJ, Piñeiro-Ces A
Eur J Ophthalmol 2021 Jul;31(4):2032-2041. Epub 2020 Aug 24 doi: 10.1177/1120672120952645. PMID: 32830591
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Therapy

Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Wagle AM, Wu BC, Gopal L, Sundar G
Indian J Ophthalmol 2022 May;70(5):1837-1840. doi: 10.4103/ijo.IJO_3040_21. PMID: 35502089Free PMC Article
Liang WC, Ren JL, Yu QX, Li J, Ng TK, Chu WK, Qin YJ, Chu KO, Schally AV, Pang CP, Chan SO
Proc Natl Acad Sci U S A 2020 Mar 17;117(11):6067-6074. Epub 2020 Mar 2 doi: 10.1073/pnas.1904532117. PMID: 32123064Free PMC Article
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article

Prognosis

González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775

Clinical prediction guides

Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

Stålhammar G, Gill VT
Crit Rev Oncol Hematol 2022 Apr;172:103652. Epub 2022 Mar 15 doi: 10.1016/j.critrevonc.2022.103652. PMID: 35304261
Messineo D, Barile G, Morrone S, La Torre G, Turchetti P, Accetta L, Trovato Battagliola E, Agostinelli E, Pacella F
Clin Ter 2020 Jan-Feb;170(1):e89-e98. doi: 10.7417/CT.2020.2195. PMID: 31916427
Schmalfuss TR, Picetti E, Pakter HM
Arq Bras Oftalmol 2018 Jun;81(3):254-261. doi: 10.5935/0004-2749.20180051. PMID: 29924202
de Jong MC, de Graaf P, Noij DP, Göricke S, Maeder P, Galluzzi P, Brisse HJ, Moll AC, Castelijns JA; European Retinoblastoma Imaging Collaboration (ERIC)
Ophthalmology 2014 May;121(5):1109-18. Epub 2014 Mar 1 doi: 10.1016/j.ophtha.2013.11.021. PMID: 24589388
Singh AD, Turell ME, Topham AK
Ophthalmology 2011 Sep;118(9):1881-5. Epub 2011 Jun 24 doi: 10.1016/j.ophtha.2011.01.040. PMID: 21704381

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