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Benign neoplasm of rectum

MedGen UID:
99222
•Concept ID:
C0496867
•
Neoplastic Process
Synonyms: Benign Neoplasm of Rectum; benign neoplasm of rectum; Benign Neoplasm of the Rectum; benign neoplasm of the rectum; Benign Rectal Neoplasm; benign rectal neoplasm; Benign Rectal Neoplasms; benign rectal neoplasms; Benign Rectal Tumor; benign rectal tumor; Benign Rectal Tumors; benign rectal tumors; benign rectal tumour; benign rectal tumours; Benign tumor of rectum; Benign Tumor of Rectum; benign tumor of rectum; Benign Tumor of the Rectum; benign tumor of the rectum; benign tumour of rectum; benign tumour of the rectum; Rectal Neoplasms, Benign; rectal neoplasms, benign; Rectal Tumors, Benign; rectal tumors, benign; rectum benign neoplasm
SNOMED CT: Benign tumor of rectum (92318000); Benign neoplasm of rectum (92318000)
 
Monarch Initiative: MONDO:0021462

Definition

A neoplasm that arises from the rectum and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review.
Murthy SK, Feuerstein JD, Nguyen GC, Velayos FS
Gastroenterology 2021 Sep;161(3):1043-1051.e4. doi: 10.1053/j.gastro.2021.05.063. PMID: 34416977
Colorectal Cancer Screening Methods and Molecular Markers for Early Detection.
Wu Z, Li Y, Zhang Y, Hu H, Wu T, Liu S, Chen W, Xie S, Lu Z
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820980426. doi: 10.1177/1533033820980426. PMID: 33353503Free PMC Article
MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article

Recent clinical studies

Etiology

Rectal MRI Interpretation After Neoadjuvant Therapy.
Horvat N, El Homsi M, Miranda J, Mazaheri Y, Gollub MJ, Paroder V
J Magn Reson Imaging 2023 Feb;57(2):353-369. Epub 2022 Sep 8 doi: 10.1002/jmri.28426. PMID: 36073323Free PMC Article
The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
Management of the adenocarcinoma of the upper rectum: a reappraisal.
Pechlivanides G, Gourtsoyianni S, Gouvas N, Sougklakos J, Xynos E
Updates Surg 2021 Apr;73(2):513-526. Epub 2020 Oct 27 doi: 10.1007/s13304-020-00903-6. PMID: 33108641
Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
The Intestinal Microbiota in Colorectal Cancer.
Tilg H, Adolph TE, Gerner RR, Moschen AR
Cancer Cell 2018 Jun 11;33(6):954-964. Epub 2018 Apr 12 doi: 10.1016/j.ccell.2018.03.004. PMID: 29657127

Diagnosis

Serrated polyps of the colon and rectum: a concise review.
Monreal-Robles R, Jáquez-Quintana JO, Benavides-Salgado DE, González-González JA
Rev Gastroenterol Mex (Engl Ed) 2021 Jul-Sep;86(3):276-286. Epub 2021 Jun 9 doi: 10.1016/j.rgmxen.2021.06.001. PMID: 34116964
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
MRI of Rectal Cancer: Tumor Staging, Imaging Techniques, and Management.
Horvat N, Carlos Tavares Rocha C, Clemente Oliveira B, Petkovska I, Gollub MJ
Radiographics 2019 Mar-Apr;39(2):367-387. Epub 2019 Feb 15 doi: 10.1148/rg.2019180114. PMID: 30768361Free PMC Article
Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.
Geramizadeh B, Robertson S
J Gastrointest Cancer 2017 Dec;48(4):291-298. doi: 10.1007/s12029-017-9977-y. PMID: 28639142
Retrorectal tumors.
Bullard Dunn K
Surg Clin North Am 2010 Feb;90(1):163-71, Table of Contents. doi: 10.1016/j.suc.2009.09.009. PMID: 20109640

Therapy

Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study.
Ciseł B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E, Cencelewicz A, Spałek M, Polkowski W, Jankiewicz M, Styliński R, Bębenek M, Kapturkiewicz B, Maciejczyk A, Sadowski J, Zygulska J, Zegarski W, Jankowski M, Las-Jankowska M, Toczko Z, Żelazowska-Omiotek U, Kępka L, Socha J, Wasilewska-Tesluk E, Markiewicz W, Kładny J, Majewski A, Kapuściński W, Suwiński R, Bujko K; Polish Colorectal Study Group
Ann Oncol 2019 Aug 1;30(8):1298-1303. doi: 10.1093/annonc/mdz186. PMID: 31192355
Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Gurski L, Freedman-Cass DA
J Natl Compr Canc Netw 2018 Jul;16(7):874-901. doi: 10.6004/jnccn.2018.0061. PMID: 30006429Free PMC Article
Robotic surgery: colon and rectum.
Baek SK, Carmichael JC, Pigazzi A
Cancer J 2013 Mar-Apr;19(2):140-6. doi: 10.1097/PPO.0b013e31828ba0fd. PMID: 23528722
Technical aspects of robotic proctectomy.
Peterson CY, McLemore EC, Horgan S, Talamini MA, Ramamoorthy SL
Surg Laparosc Endosc Percutan Tech 2012 Jun;22(3):189-93. doi: 10.1097/SLE.0b013e31824be924. PMID: 22678311

Prognosis

The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Imaging and Management of Rectal Cancer.
Arya S, Sen S, Engineer R, Saklani A, Pandey T
Semin Ultrasound CT MR 2020 Apr;41(2):183-206. Epub 2020 Jan 24 doi: 10.1053/j.sult.2020.01.001. PMID: 32446431
Long-course preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized Polish II study.
Ciseł B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E, Cencelewicz A, Spałek M, Polkowski W, Jankiewicz M, Styliński R, Bębenek M, Kapturkiewicz B, Maciejczyk A, Sadowski J, Zygulska J, Zegarski W, Jankowski M, Las-Jankowska M, Toczko Z, Żelazowska-Omiotek U, Kępka L, Socha J, Wasilewska-Tesluk E, Markiewicz W, Kładny J, Majewski A, Kapuściński W, Suwiński R, Bujko K; Polish Colorectal Study Group
Ann Oncol 2019 Aug 1;30(8):1298-1303. doi: 10.1093/annonc/mdz186. PMID: 31192355
Rectal Cancer in 2018: A Primer for the Gastroenterologist.
Goldenberg BA, Holliday EB, Helewa RM, Singh H
Am J Gastroenterol 2018 Dec;113(12):1763-1771. doi: 10.1038/s41395-018-0180-y. PMID: 30008472Free PMC Article

Clinical prediction guides

Gastrointestinal Stromal Tumours (GIST) of the Rectum: A Systematic Review and Meta-Analysis.
Khan SI, O'Sullivan NJ, Temperley HC, Rausa E, Mehigan BJ, McCormick P, Larkin JO, Kavanagh DO, Kelly ME
Curr Oncol 2022 Dec 28;30(1):416-429. doi: 10.3390/curroncol30010034. PMID: 36661683Free PMC Article
The importance of MRI for rectal cancer evaluation.
Fernandes MC, Gollub MJ, Brown G
Surg Oncol 2022 Aug;43:101739. Epub 2022 Mar 18 doi: 10.1016/j.suronc.2022.101739. PMID: 35339339Free PMC Article
ESTRO ACROP consensus guideline on CT- and MRI-based target volume delineation for primary radiation therapy of localized prostate cancer.
Salembier C, Villeirs G, De Bari B, Hoskin P, Pieters BR, Van Vulpen M, Khoo V, Henry A, Bossi A, De Meerleer G, Fonteyne V
Radiother Oncol 2018 Apr;127(1):49-61. doi: 10.1016/j.radonc.2018.01.014. PMID: 29496279
LAPAROSCOPIC TREATMENT OF RECTAL CANCER.
Todorov G, Maslyankov S
Khirurgiia (Sofiia) 2015;81(2):13-28. PMID: 26668986
Anatomy of the lateral ligaments of the rectum: a controversial point of view.
Wang GJ, Gao CF, Wei D, Wang C, Meng WJ
World J Gastroenterol 2010 Nov 21;16(43):5411-5. doi: 10.3748/wjg.v16.i43.5411. PMID: 21086557Free PMC Article

Recent systematic reviews

Delta radiomics: a systematic review.
Nardone V, Reginelli A, Grassi R, Boldrini L, Vacca G, D'Ippolito E, Annunziata S, Farchione A, Belfiore MP, Desideri I, Cappabianca S
Radiol Med 2021 Dec;126(12):1571-1583. Epub 2021 Dec 4 doi: 10.1007/s11547-021-01436-7. PMID: 34865190
Total Neoadjuvant Therapy (TNT) versus Standard Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Metaanalysis of Oncological and Operative Outcomes.
Kong JC, Soucisse M, Michael M, Tie J, Ngan SY, Leong T, McCormick J, Warrier SK, Heriot AG
Ann Surg Oncol 2021 Nov;28(12):7476-7486. Epub 2021 Apr 23 doi: 10.1245/s10434-021-09837-8. PMID: 33891203
Mortality due to cancer treatment delay: systematic review and meta-analysis.
Hanna TP, King WD, Thibodeau S, Jalink M, Paulin GA, Harvey-Jones E, O'Sullivan DE, Booth CM, Sullivan R, Aggarwal A
BMJ 2020 Nov 4;371:m4087. doi: 10.1136/bmj.m4087. PMID: 33148535Free PMC Article
A systematic review of the supportive care needs of people living with and beyond cancer of the colon and/or rectum.
Kotronoulas G, Papadopoulou C, Burns-Cunningham K, Simpson M, Maguire R
Eur J Oncol Nurs 2017 Aug;29:60-70. Epub 2017 May 30 doi: 10.1016/j.ejon.2017.05.004. PMID: 28720267

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