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Recurrent Neoplasm

MedGen UID:: 99262
•Concept ID:: C0521158
•: Neoplastic Process

Synonyms:	Neoplasm recurrence; Neoplasm Recurrence; Recurrence of tumor; Recurrent neoplasm; Recurrent tumor; Recurrent Tumor
SNOMED CT:	Recurrent tumor (25173007); Recurrence of tumor (25173007); Recurrent neoplasm (25173007); Neoplasm recurrence (25173007)

Definition

The reemergence of a neoplasm after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplasm by Special Category
        Recurrent Neoplasm
        Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor
        Recurrent Childhood Kidney Neoplasm
        Recurrent Rhabdoid Tumor of the Kidney
        Recurrent Desmoid Fibromatosis
        Recurrent Gastrointestinal Stromal Tumor
        Recurrent Gestational Trophoblastic Tumor
        Recurrent Histiocytic and Dendritic Cell Neoplasm
        Recurrent Langerhans Cell Histiocytosis
        Recurrent Lymphomatoid Granulomatosis
        Recurrent Childhood Lymphomatoid Granulomatosis
        Recurrent Childhood Grade III Lymphomatoid Granulomatosis
        Recurrent Grade I Lymphomatoid Granulomatosis
        Recurrent Grade II Lymphomatoid Granulomatosis
        Recurrent Grade III Lymphomatoid Granulomatosis
        Recurrent Adult Grade III Lymphomatoid Granulomatosis
        Recurrent Malignant Neoplasm
        Locally Recurrent Malignant Neoplasm
        Locally Recurrent Anal Canal Squamous Cell Carcinoma
        Locally Recurrent Head and Neck Squamous Cell Carcinoma
        Locally Recurrent Merkel Cell Carcinoma
        Locally Recurrent Skin Squamous Cell Carcinoma
        Locally Recurrent Uterine Corpus Leiomyosarcoma
        Recurrent Carcinoma
        Recurrent Adenocarcinoma
        Recurrent Adenoid Cystic Carcinoma
        Recurrent Breast Carcinoma
        Recurrent Carcinoma of Unknown Primary
        Recurrent Digestive System Carcinoma
        Recurrent Female Reproductive System Carcinoma
        Recurrent Head and Neck Carcinoma
        Recurrent Lung Carcinoma
        Recurrent Male Reproductive System Carcinoma
        Recurrent Malignant Myoepithelioma
        Recurrent Neuroendocrine Carcinoma
        Recurrent Primary Peritoneal Carcinoma
        Recurrent Skin Carcinoma
        Recurrent Squamous Cell Carcinoma
        Recurrent Thymic Carcinoma
        Recurrent Urinary System Carcinoma
        Recurrent Childhood Malignant Neoplasm
        Recurrent Childhood Acute Lymphoblastic Leukemia
        Recurrent Childhood Acute Myeloid Leukemia
        Recurrent Childhood Anaplastic Astrocytoma
        Recurrent Childhood Anaplastic Oligoastrocytoma
        Recurrent Childhood Anaplastic Oligodendroglioma
        Recurrent Childhood Central Nervous System Embryonal Neoplasm
        Recurrent Childhood Glioblastoma
        Recurrent Childhood Gliomatosis Cerebri
        Recurrent Childhood Hodgkin Lymphoma
        Recurrent Childhood Malignant Germ Cell Tumor
        Recurrent Childhood Malignant Liver Neoplasm
        Recurrent Childhood Malignant Solid Neoplasm
        Recurrent Childhood Non-Hodgkin Lymphoma
        Recurrent Childhood Soft Tissue Sarcoma
        Recurrent Extrarenal Rhabdoid Tumor of the Ovary
        Recurrent Hematologic Malignancy
        Recurrent Leukemia
        Recurrent Malignant Lymphoid Neoplasm
        Recurrent Myeloid Neoplasm
        Recurrent Human Papillomavirus-Related Malignant Neoplasm
        Recurrent Endocervical Adenocarcinoma, Usual-Type
        Recurrent Malignant Abdominal Neoplasm
        Recurrent Pseudomyxoma Peritonei
        Recurrent Malignant Bone Neoplasm
        Recurrent Bone Ewing Sarcoma
        Recurrent Chordoma
        Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone
        Recurrent Primary Bone Lymphoma
        Recurrent Malignant Breast Neoplasm
        Recurrent Breast Lymphoma
        Recurrent Breast Sarcoma
        Recurrent Malignant Duodenal Neoplasm
        Recurrent Duodenal Carcinoma
        Recurrent Malignant Endocrine Neoplasm
        Recurrent Adrenal Cortical Carcinoma
        Recurrent Differentiated Thyroid Gland Carcinoma
        Recurrent Parathyroid Gland Carcinoma
        Recurrent Poorly Differentiated Thyroid Gland Carcinoma
        Recurrent Malignant Gastric Neoplasm
        Recurrent Gastric Carcinoma
        Recurrent Malignant Genitourinary System Neoplasm
        Recurrent Malignant Female Reproductive System Neoplasm
        Recurrent Malignant Male Reproductive System Neoplasm
        Recurrent Malignant Urinary System Neoplasm
        Recurrent Malignant Germ Cell Tumor
        Recurrent Malignant Extragonadal Germ Cell Tumor
        Recurrent Malignant Nongerminomatous Germ Cell Tumor
        Recurrent Malignant Testicular Germ Cell Tumor
        Recurrent Ovarian Germ Cell Tumor
        Recurrent Malignant Head and Neck Neoplasm
        Recurrent Malignant Oral Neoplasm
        Recurrent Malignant Pharyngeal Neoplasm
        Recurrent Malignant Salivary Gland Neoplasm
        Recurrent Malignant Thyroid Gland Neoplasm
        Recurrent Neck Squamous Cell Carcinoma of Unknown Primary
        Recurrent Malignant Mesothelioma
        Recurrent Epithelioid Mesothelioma
        Recurrent Pericardial Malignant Mesothelioma
        Recurrent Peritoneal Malignant Mesothelioma
        Recurrent Pleural Malignant Mesothelioma
        Recurrent Malignant Retroperitoneal Neoplasm
        Recurrent Malignant Skin Neoplasm
        Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
        Recurrent Malignant Scrotal Neoplasm
        Recurrent Melanoma
        Recurrent Primary Cutaneous Lymphoma
        Recurrent Skin Angiosarcoma
        Recurrent Malignant Soft Tissue Neoplasm
        Recurrent Soft Tissue Sarcoma
        Recurrent Malignant Solid Neoplasm
        Recurrent Extracranial Malignant Solid Neoplasm
        Recurrent Malignant Thymoma
        Recurrent Metastatic Malignant Neoplasm
        Recurrent Metastatic Digestive System Carcinoma
        Recurrent Metastatic Malignant Neoplasm in the Leptomeninges
        Recurrent Metastatic Merkel Cell Carcinoma
        Recurrent Metastatic Skin Squamous Cell Carcinoma
        Recurrent Primary Malignant Central Nervous System Neoplasm
        Recurrent Anaplastic (Malignant) Meningioma
        Recurrent Anaplastic Ganglioglioma
        Recurrent Atypical Teratoid/Rhabdoid Tumor
        Recurrent Central Nervous System Lymphoma
        Recurrent Malignant Brain Neoplasm
        Recurrent Malignant Glioma
        Recurrent Retinoblastoma
        Recurrent Primary Malignant Neoplasm
        Recurrent Adult Liver Carcinoma
        Recurrent Combined Thymic Epithelial Neoplasm
        Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
        Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Recurrent Hepatocellular Carcinoma
        Recurrent Hepatosplenic T-Cell Lymphoma
        Recurrent Kidney Wilms Tumor
        Recurrent Malignant Neoplasm of Multiple Primary Sites
        Recurrent Medulloblastoma
        Recurrent Primary Amyloidosis
        Recurrent Primary Effusion Lymphoma
        Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma
        Recurrent Primary Systemic Anaplastic Large Cell Lymphoma, ALK-Positive
        Recurrent Primitive Neuroectodermal Tumor
        Recurrent Splenic Marginal Zone Lymphoma
        Recurrent Testicular Lymphoma
        Recurrent Rhabdoid Tumor
        Recurrent Sarcoma
        Recurrent Angiosarcoma
        Recurrent Chondrosarcoma
        Recurrent Ectomesenchymoma
        Recurrent Ewing Sarcoma
        Recurrent Fibrosarcoma
        Recurrent Leiomyosarcoma
        Recurrent Liposarcoma
        Recurrent Malignant Peripheral Nerve Sheath Tumor
        Recurrent Osteosarcoma
        Recurrent Sarcoma of the Extremity
        Recurrent Spindle Cell Sarcoma
        Recurrent Subsequent Malignant Neoplasm
        Recurrent Neuroendocrine Neoplasm
        Recurrent Abdominal Neuroendocrine Neoplasm
        Recurrent Pancreatic Neuroendocrine Carcinoma
        Recurrent Lung Neuroendocrine Neoplasm
        Recurrent Lung Small Cell Carcinoma
        Recurrent Paraganglioma
        Recurrent Adrenal Gland Pheochromocytoma
        Recurrent Neurofibromatosis Type 1
        Recurrent Nevus
        Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder
        Recurrent Primary Central Nervous System Neoplasm
        Recurrent Childhood Central Nervous System Neoplasm
        Recurrent Childhood Astrocytic Tumor
        Recurrent Childhood Brain Neoplasm
        Recurrent Childhood Ependymoma
        Recurrent Childhood Oligoastrocytoma
        Recurrent Childhood Oligodendroglioma
        Recurrent Childhood Spinal Cord Neoplasm
        Recurrent Gangliocytoma
        Recurrent Glioma
        Recurrent Childhood Brain Stem Glioma
        Recurrent Ependymal Tumor
        Recurrent Low Grade Glioma
        Recurrent Tectal Glioma
        Recurrent Visual Pathway Glioma
        Recurrent Intracranial Neoplasm
        Recurrent Brain Neoplasm
        Recurrent Meningioma
        Recurrent Atypical Meningioma
        Recurrent Myxoid Glioneuronal Tumor
        Recurrent Polymorphous Low Grade Neuroepithelial Tumor of the Young
        Recurrent Spinal Cord Neoplasm
        Recurrent Adult Spinal Cord Neoplasm
        Recurrent respiratory papillomatosis
        Laryngeal papillomatosis
        Recurrent Sinonasal Inverted Papilloma

Professional guidelines

PubMed

Multiphasic helical CT criteria for differentiation of recurrent neoplasm and desmoplastic reaction after laparoscopic resection of renal mass lesions.

Lang EK, Thomas R, Davis R, Shore B, Ruiz-Deya G, Macchia RJ, Gayle B, Watson RA, Richter F
J Endourol 2004 Mar;18(2):167-71. doi: 10.1089/089277904322959815. PMID: 15072625

Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment.

Kumar AJ, Leeds NE, Fuller GN, Van Tassel P, Maor MH, Sawaya RE, Levin VA
Radiology 2000 Nov;217(2):377-84. doi: 10.1148/radiology.217.2.r00nv36377. PMID: 11058631

Non-neoplastic causes of high signal intensity at T2-weighted MR imaging after treatment for musculoskeletal neoplasm.

Panicek DM, Schwartz LH, Heelan RT, Caravelli JF
Skeletal Radiol 1995 Apr;24(3):185-90. doi: 10.1007/BF00228920. PMID: 7610410

See all (3)

Recent clinical studies

Etiology

Classic polymorphous adenocarcinoma: Fine needle aspiration cytopathology of eight cases.

Wakely PE Jr, Lott-Limbach AA
Cytopathology 2021 Nov;32(6):789-794. Epub 2021 Aug 14 doi: 10.1111/cyt.13046. PMID: 34346533

Comparison of Diffusion Tensor Imaging and Magnetic Resonance Perfusion Imaging in Differentiating Recurrent Brain Neoplasm From Radiation Necrosis.

Masch WR, Wang PI, Chenevert TL, Junck L, Tsien C, Heth JA, Sundgren PC
Acad Radiol 2016 May;23(5):569-76. Epub 2016 Feb 23 doi: 10.1016/j.acra.2015.11.015. PMID: 26916251 Free PMC Article

Surgical Management of Retroperitoneal Soft Tissue Sarcomas: Role of Curative Resection.

Rosa F, Fiorillo C, Tortorelli AP, Sánchez AM, Costamagna G, Doglietto GB, Alfieri S
Am Surg 2016 Feb;82(2):128-33. PMID: 26874134

MR spectroscopy using normalized and non-normalized metabolite ratios for differentiating recurrent brain tumor from radiation injury.

Elias AE, Carlos RC, Smith EA, Frechtling D, George B, Maly P, Sundgren PC
Acad Radiol 2011 Sep;18(9):1101-8. doi: 10.1016/j.acra.2011.05.006. PMID: 21820634

Pharyngography after head and neck irradiation: differentiation of postirradiation edema from recurrent tumor.

Quillin SP, Balfe DM, Glick SN
AJR Am J Roentgenol 1993 Dec;161(6):1205-8. doi: 10.2214/ajr.161.6.8249726. PMID: 8249726

See all (40)

Diagnosis

Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.

Aseel A, McCarthy P, Mohammed A
J Neuroimaging 2023 Mar;33(2):189-201. Epub 2023 Jan 11 doi: 10.1111/jon.13080. PMID: 36631883

Imaging of the Postoperative Orbit.

Learned KO, Nasseri F, Mohan S
Neuroimaging Clin N Am 2015 Aug;25(3):457-76. doi: 10.1016/j.nic.2015.05.008. PMID: 26208420

Myocutaneous flaps and other vascularized grafts in head and neck reconstruction for cancer treatment.

Learned KO, Malloy KM, Loevner LA
Magn Reson Imaging Clin N Am 2012 Aug;20(3):495-513. Epub 2012 Jun 17 doi: 10.1016/j.mric.2012.05.004. PMID: 22877953

Imaging of denervation in the head and neck.

Borges A
Eur J Radiol 2010 May;74(2):378-90. Epub 2010 Mar 11 doi: 10.1016/j.ejrad.2009.06.034. PMID: 20226611

PET/CT imaging in recurrent head and neck cancer.

Fukui MB, Blodgett TM, Meltzer CC
Semin Ultrasound CT MR 2003 Jun;24(3):157-63. doi: 10.1016/s0887-2171(03)90037-0. PMID: 12877412

See all (63)

Therapy

Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster.

Teng CW, Amirshaghaghi A, Cho SS, Cai SS, De Ravin E, Singh Y, Miller J, Sheikh S, Delikatny E, Cheng Z, Busch TM, Dorsey JF, Singhal S, Tsourkas A, Lee JYK
J Neurooncol 2020 Sep;149(2):243-252. Epub 2020 Sep 10 doi: 10.1007/s11060-020-03618-1. PMID: 32914293 Free PMC Article

A systematic review examining quality of life following pelvic exenteration for locally advanced and recurrent rectal cancer.

Rausa E, Kelly ME, Bonavina L, O'Connell PR, Winter DC
Colorectal Dis 2017 May;19(5):430-436. doi: 10.1111/codi.13647. PMID: 28267255

Imaging in Endoscopic Cranial Skull Base and Pituitary Surgery.

Nunes RH, Abello AL, Zanation AM, Sasaki-Adams D, Huang BY
Otolaryngol Clin North Am 2016 Feb;49(1):33-62. doi: 10.1016/j.otc.2015.09.003. PMID: 26614828

Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.

Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350 Free PMC Article

Osteoradionecrosis of the hyoid bone: a report of 3 cases.

Monceaux G, Périé S, Montravers F, Angelard B, Corlieu P, St Guily JL
Am J Otolaryngol 1999 Nov-Dec;20(6):400-4. doi: 10.1016/s0196-0709(99)90081-9. PMID: 10609486

See all (27)

Prognosis

Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.

Aseel A, McCarthy P, Mohammed A
J Neuroimaging 2023 Mar;33(2):189-201. Epub 2023 Jan 11 doi: 10.1111/jon.13080. PMID: 36631883

A systematic review examining quality of life following pelvic exenteration for locally advanced and recurrent rectal cancer.

Rausa E, Kelly ME, Bonavina L, O'Connell PR, Winter DC
Colorectal Dis 2017 May;19(5):430-436. doi: 10.1111/codi.13647. PMID: 28267255

Comparison of Diffusion Tensor Imaging and Magnetic Resonance Perfusion Imaging in Differentiating Recurrent Brain Neoplasm From Radiation Necrosis.

Masch WR, Wang PI, Chenevert TL, Junck L, Tsien C, Heth JA, Sundgren PC
Acad Radiol 2016 May;23(5):569-76. Epub 2016 Feb 23 doi: 10.1016/j.acra.2015.11.015. PMID: 26916251 Free PMC Article

Imaging of the Postoperative Orbit.

Learned KO, Nasseri F, Mohan S
Neuroimaging Clin N Am 2015 Aug;25(3):457-76. doi: 10.1016/j.nic.2015.05.008. PMID: 26208420

Imaging of denervation in the head and neck.

Borges A
Eur J Radiol 2010 May;74(2):378-90. Epub 2010 Mar 11 doi: 10.1016/j.ejrad.2009.06.034. PMID: 20226611

See all (35)

Clinical prediction guides

Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.

Aseel A, McCarthy P, Mohammed A
J Neuroimaging 2023 Mar;33(2):189-201. Epub 2023 Jan 11 doi: 10.1111/jon.13080. PMID: 36631883

A systematic review examining quality of life following pelvic exenteration for locally advanced and recurrent rectal cancer.

Rausa E, Kelly ME, Bonavina L, O'Connell PR, Winter DC
Colorectal Dis 2017 May;19(5):430-436. doi: 10.1111/codi.13647. PMID: 28267255

Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.

Shih LY, Wei CK, Lin CW, Tseng CE
World J Gastroenterol 2012 Nov 14;18(42):6172-6. doi: 10.3748/wjg.v18.i42.6172. PMID: 23155350 Free PMC Article

Imaging of denervation in the head and neck.

Borges A
Eur J Radiol 2010 May;74(2):378-90. Epub 2010 Mar 11 doi: 10.1016/j.ejrad.2009.06.034. PMID: 20226611

Pharyngography after head and neck irradiation: differentiation of postirradiation edema from recurrent tumor.

Quillin SP, Balfe DM, Glick SN
AJR Am J Roentgenol 1993 Dec;161(6):1205-8. doi: 10.2214/ajr.161.6.8249726. PMID: 8249726

See all (21)

Recent systematic reviews

Brain magnetic resonance spectroscopy to differentiate recurrent neoplasm from radiation necrosis: A systematic review and meta-analysis.

Aseel A, McCarthy P, Mohammed A
J Neuroimaging 2023 Mar;33(2):189-201. Epub 2023 Jan 11 doi: 10.1111/jon.13080. PMID: 36631883

A systematic review examining quality of life following pelvic exenteration for locally advanced and recurrent rectal cancer.

Rausa E, Kelly ME, Bonavina L, O'Connell PR, Winter DC
Colorectal Dis 2017 May;19(5):430-436. doi: 10.1111/codi.13647. PMID: 28267255

See all (2)

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Recurrent Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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