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Classic pyoderma gangrenosum

MedGen UID:
993890
Concept ID:
CN312517
Disease or Syndrome
Synonyms: classic pyoderma gangrenosum; Ulcerative pyoderma gangrenosum
 
Monarch Initiative: MONDO:0035235
Orphanet: ORPHA538863

Definition

A rare subtype of pyoderma gangrenosum disease characterized by rapidly progressive, single or multiple, painful, aseptic ulcers which present overhanging, violaceous and undermined borders, surrounding induration and erythema, and granulation tissue (occasionally necrotic tissue and/or a purulent exudate) at the base, mainly affecting the legs (but other body surfaces may also be involved), leading to chronic ulcerations and often regressing with cribriform mutilating scars. The disease presents a chronic relapsing course and systemic features (e.g. fever, malaise, arthralgia, myalgia) may be associated. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic pyoderma gangrenosum

Professional guidelines

PubMed

George C, Deroide F, Rustin M
Clin Med (Lond) 2019 May;19(3):224-228. doi: 10.7861/clinmedicine.19-3-224. PMID: 31092515Free PMC Article
Patel F, Fitzmaurice S, Duong C, He Y, Fergus J, Raychaudhuri SP, Garcia MS, Maverakis E
Acta Derm Venereol 2015 May;95(5):525-31. doi: 10.2340/00015555-2008. PMID: 25387526
Ahronowitz I, Harp J, Shinkai K
Am J Clin Dermatol 2012 Jun 1;13(3):191-211. doi: 10.2165/11595240-000000000-00000. PMID: 22356259

Recent clinical studies

Etiology

Dobson CM, Parslew RA, Evans S
J Am Acad Dermatol 2003 Mar;48(3):456-60. doi: 10.1067/mjd.2003.172. PMID: 12637931
Thami GP, Kaur S, Punia RS, Kanwart AJ
J Eur Acad Dermatol Venereol 2002 Mar;16(2):159-61. doi: 10.1046/j.1468-3083.2002.00425.x. PMID: 12046823

Diagnosis

Dobson CM, Parslew RA, Evans S
J Am Acad Dermatol 2003 Mar;48(3):456-60. doi: 10.1067/mjd.2003.172. PMID: 12637931
Thami GP, Kaur S, Punia RS, Kanwart AJ
J Eur Acad Dermatol Venereol 2002 Mar;16(2):159-61. doi: 10.1046/j.1468-3083.2002.00425.x. PMID: 12046823
Wolfsen HC, Brubacher LL, Ng CS, Kayne AL, Kozarek RA
J Clin Gastroenterol 1990 Dec;12(6):651-5. doi: 10.1097/00004836-199012000-00011. PMID: 1979985

Therapy

Ahmadi K, Aflaki E, Akbarzade Jahromi M, Dastgheib L
Australas J Dermatol 2023 Aug;64(3):e252-e255. Epub 2023 May 16 doi: 10.1111/ajd.14072. PMID: 37192138
Tollefson MM, Cook-Norris RH, Theos A, Davis DM
Pediatr Dermatol 2010 Sep-Oct;27(5):496-9. doi: 10.1111/j.1525-1470.2010.01271.x. PMID: 21182640
Dobson CM, Parslew RA, Evans S
J Am Acad Dermatol 2003 Mar;48(3):456-60. doi: 10.1067/mjd.2003.172. PMID: 12637931
Thami GP, Kaur S, Punia RS, Kanwart AJ
J Eur Acad Dermatol Venereol 2002 Mar;16(2):159-61. doi: 10.1046/j.1468-3083.2002.00425.x. PMID: 12046823
Wolfsen HC, Brubacher LL, Ng CS, Kayne AL, Kozarek RA
J Clin Gastroenterol 1990 Dec;12(6):651-5. doi: 10.1097/00004836-199012000-00011. PMID: 1979985

Prognosis

Kim RH, Lewin J, Hale CS, Meehan SA, Stein J, Ramachandran S
Dermatol Online J 2014 Dec 16;20(12) PMID: 25526339
Tollefson MM, Cook-Norris RH, Theos A, Davis DM
Pediatr Dermatol 2010 Sep-Oct;27(5):496-9. doi: 10.1111/j.1525-1470.2010.01271.x. PMID: 21182640
Dobson CM, Parslew RA, Evans S
J Am Acad Dermatol 2003 Mar;48(3):456-60. doi: 10.1067/mjd.2003.172. PMID: 12637931
Thami GP, Kaur S, Punia RS, Kanwart AJ
J Eur Acad Dermatol Venereol 2002 Mar;16(2):159-61. doi: 10.1046/j.1468-3083.2002.00425.x. PMID: 12046823

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