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Chronic hepatitis B virus infection

MedGen UID:
99834
•Concept ID:
C0524909
•
Disease or Syndrome
Synonyms: Chronic Hepatitis B; Chronic Hepatitis B Virus Infection; Hepatitis B Virus Infection, Chronic; Hepatitis B, Chronic
SNOMED CT: Chronic type B viral hepatitis (61977001); Chronic viral hepatitis B (61977001)
 
Monarch Initiative: MONDO:0005366

Definition

Chronic form of hepatitis B infection. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic hepatitis B virus infection

Professional guidelines

PubMed

Treatment Algorithm for Managing Chronic Hepatitis B Virus Infection in the United States: 2021 Update.
Martin P, Nguyen MH, Dieterich DT, Lau DT, Janssen HLA, Peters MG, Jacobson IM
Clin Gastroenterol Hepatol 2022 Aug;20(8):1766-1775. Epub 2021 Jul 27 doi: 10.1016/j.cgh.2021.07.036. PMID: 34329775
Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.
Tan M, Bhadoria AS, Cui F, Tan A, Van Holten J, Easterbrook P, Ford N, Han Q, Lu Y, Bulterys M, Hutin Y
Lancet Gastroenterol Hepatol 2021 Feb;6(2):106-119. Epub 2020 Nov 14 doi: 10.1016/S2468-1253(20)30307-1. PMID: 33197397Free PMC Article
New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection.
Coffin CS, Zhou K, Terrault NA
Gastroenterology 2019 Jan;156(2):355-368.e3. Epub 2018 Nov 22 doi: 10.1053/j.gastro.2018.11.037. PMID: 30472225Free PMC Article

Recent clinical studies

Etiology

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
Treatment Algorithm for Managing Chronic Hepatitis B Virus Infection in the United States: 2021 Update.
Martin P, Nguyen MH, Dieterich DT, Lau DT, Janssen HLA, Peters MG, Jacobson IM
Clin Gastroenterol Hepatol 2022 Aug;20(8):1766-1775. Epub 2021 Jul 27 doi: 10.1016/j.cgh.2021.07.036. PMID: 34329775
Chronic hepatitis B virus infection.
Seto WK, Lo YR, Pawlotsky JM, Yuen MF
Lancet 2018 Nov 24;392(10161):2313-2324. doi: 10.1016/S0140-6736(18)31865-8. PMID: 30496122
Immunotherapy for Chronic Hepatitis B Virus Infection.
Bertoletti A, Le Bert N
Gut Liver 2018 Sep 15;12(5):497-507. doi: 10.5009/gnl17233. PMID: 29316747Free PMC Article
Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013.
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ
Lancet 2015 Oct 17;386(10003):1546-55. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)61412-X. PMID: 26231459

Diagnosis

Cost-effectiveness of universal screening for chronic hepatitis B virus infection in China: an economic evaluation.
Su S, Wong WC, Zou Z, Cheng DD, Ong JJ, Chan P, Ji F, Yuen MF, Zhuang G, Seto WK, Zhang L
Lancet Glob Health 2022 Feb;10(2):e278-e287. doi: 10.1016/S2214-109X(21)00517-9. PMID: 35063115Free PMC Article
Chronic hepatitis B virus infection and fibrosis: novel non-invasive approaches for diagnosis and risk stratification.
Stalla F, Armandi A, Marinoni C, Fagoonee S, Pellicano R, Caviglia GP
Minerva Gastroenterol (Torino) 2022 Sep;68(3):306-318. Epub 2021 Apr 19 doi: 10.23736/S2724-5985.21.02911-9. PMID: 33871225
Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.
Tan M, Bhadoria AS, Cui F, Tan A, Van Holten J, Easterbrook P, Ford N, Han Q, Lu Y, Bulterys M, Hutin Y
Lancet Gastroenterol Hepatol 2021 Feb;6(2):106-119. Epub 2020 Nov 14 doi: 10.1016/S2468-1253(20)30307-1. PMID: 33197397Free PMC Article
New and Old Biomarkers for Diagnosis and Management of Chronic Hepatitis B Virus Infection.
Coffin CS, Zhou K, Terrault NA
Gastroenterology 2019 Jan;156(2):355-368.e3. Epub 2018 Nov 22 doi: 10.1053/j.gastro.2018.11.037. PMID: 30472225Free PMC Article
A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.
Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, Zhou L, Wang X, Li Y, Chen H, Gao L, Lu X, Wu T, Wang H, Niu J, Xu G
Hepatology 2018 Feb;67(2):662-675. Epub 2018 Jan 2 doi: 10.1002/hep.29561. PMID: 28960374Free PMC Article

Therapy

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
Treatment Algorithm for Managing Chronic Hepatitis B Virus Infection in the United States: 2021 Update.
Martin P, Nguyen MH, Dieterich DT, Lau DT, Janssen HLA, Peters MG, Jacobson IM
Clin Gastroenterol Hepatol 2022 Aug;20(8):1766-1775. Epub 2021 Jul 27 doi: 10.1016/j.cgh.2021.07.036. PMID: 34329775
Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.
Tan M, Bhadoria AS, Cui F, Tan A, Van Holten J, Easterbrook P, Ford N, Han Q, Lu Y, Bulterys M, Hutin Y
Lancet Gastroenterol Hepatol 2021 Feb;6(2):106-119. Epub 2020 Nov 14 doi: 10.1016/S2468-1253(20)30307-1. PMID: 33197397Free PMC Article
Chronic hepatitis B virus infection.
Seto WK, Lo YR, Pawlotsky JM, Yuen MF
Lancet 2018 Nov 24;392(10161):2313-2324. doi: 10.1016/S0140-6736(18)31865-8. PMID: 30496122

Prognosis

Alterations in gut microbiome and metabolomics in chronic hepatitis B infection-associated liver disease and their impact on peripheral immune response.
Shen Y, Wu SD, Chen Y, Li XY, Zhu Q, Nakayama K, Zhang WQ, Weng CZ, Zhang J, Wang HK, Wu J, Jiang W
Gut Microbes 2023 Jan-Dec;15(1):2155018. doi: 10.1080/19490976.2022.2155018. PMID: 36519342Free PMC Article
A single-cell atlas of diffuse large B cell lymphoma.
Ye X, Wang L, Nie M, Wang Y, Dong S, Ren W, Li G, Li ZM, Wu K, Pan-Hammarström Q
Cell Rep 2022 Apr 19;39(3):110713. doi: 10.1016/j.celrep.2022.110713. PMID: 35443163
Epigenetic modulation in chronic hepatitis B virus infection.
Dandri M
Semin Immunopathol 2020 Apr;42(2):173-185. Epub 2020 Mar 17 doi: 10.1007/s00281-020-00780-6. PMID: 32185454Free PMC Article
A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.
Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, Zhou L, Wang X, Li Y, Chen H, Gao L, Lu X, Wu T, Wang H, Niu J, Xu G
Hepatology 2018 Feb;67(2):662-675. Epub 2018 Jan 2 doi: 10.1002/hep.29561. PMID: 28960374Free PMC Article
Impact of etiological treatment on prognosis.
Su CW, Yang YY, Lin HC
Hepatol Int 2018 Feb;12(Suppl 1):56-67. Epub 2017 Jul 12 doi: 10.1007/s12072-017-9807-0. PMID: 28702738

Clinical prediction guides

Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
A single-cell atlas of diffuse large B cell lymphoma.
Ye X, Wang L, Nie M, Wang Y, Dong S, Ren W, Li G, Li ZM, Wu K, Pan-Hammarström Q
Cell Rep 2022 Apr 19;39(3):110713. doi: 10.1016/j.celrep.2022.110713. PMID: 35443163
A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma.
Luo P, Yin P, Hua R, Tan Y, Li Z, Qiu G, Yin Z, Xie X, Wang X, Chen W, Zhou L, Wang X, Li Y, Chen H, Gao L, Lu X, Wu T, Wang H, Niu J, Xu G
Hepatology 2018 Feb;67(2):662-675. Epub 2018 Jan 2 doi: 10.1002/hep.29561. PMID: 28960374Free PMC Article
Chronic Hepatitis C Virus Infection and Depression.
Adinolfi LE, Nevola R, Rinaldi L, Romano C, Giordano M
Clin Liver Dis 2017 Aug;21(3):517-534. Epub 2017 Apr 25 doi: 10.1016/j.cld.2017.03.007. PMID: 28689590
Chronic Hepatitis B Virus Infection: Disease Revisit and Management Recommendations.
Yuen MF, Ahn SH, Chen DS, Chen PJ, Dusheiko GM, Hou JL, Maddrey WC, Mizokami M, Seto WK, Zoulim F, Lai CL
J Clin Gastroenterol 2016 Apr;50(4):286-94. doi: 10.1097/MCG.0000000000000478. PMID: 26840752

Recent systematic reviews

Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.
Tan M, Bhadoria AS, Cui F, Tan A, Van Holten J, Easterbrook P, Ford N, Han Q, Lu Y, Bulterys M, Hutin Y
Lancet Gastroenterol Hepatol 2021 Feb;6(2):106-119. Epub 2020 Nov 14 doi: 10.1016/S2468-1253(20)30307-1. PMID: 33197397Free PMC Article
Chronic hepatitis B virus infection and preterm labor(birth) in pregnant women-an updated systematic review and meta-analysis.
Ma X, Sun D, Li C, Ying J, Yan Y
J Med Virol 2018 Jan;90(1):93-100. Epub 2017 Sep 12 doi: 10.1002/jmv.24927. PMID: 28851115
Prevalence of chronic hepatitis B virus infection in Thailand: a systematic review and meta-analysis.
Leroi C, Adam P, Khamduang W, Kawilapat S, Ngo-Giang-Huong N, Ongwandee S, Jiamsiri S, Jourdain G
Int J Infect Dis 2016 Oct;51:36-43. Epub 2016 Aug 28 doi: 10.1016/j.ijid.2016.08.017. PMID: 27580678
Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013.
Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ
Lancet 2015 Oct 17;386(10003):1546-55. Epub 2015 Jul 28 doi: 10.1016/S0140-6736(15)61412-X. PMID: 26231459
Seroprevalence of chronic hepatitis B virus infection and prior immunity in immigrants and refugees: a systematic review and meta-analysis.
Rossi C, Shrier I, Marshall L, Cnossen S, Schwartzman K, Klein MB, Schwarzer G, Greenaway C
PLoS One 2012;7(9):e44611. Epub 2012 Sep 5 doi: 10.1371/journal.pone.0044611. PMID: 22957088Free PMC Article

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