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Oligospermia

MedGen UID:
18162
•Concept ID:
C0028960
•
Disease or Syndrome
Synonyms: Hypospermatogeneses; Hypospermatogenesis; Low Sperm Count; Low Sperm Counts; Oligoasthenoteratozoospermia; Oligoasthenoteratozoospermias; Oligozoospermia; Sperm Count, Low; Sperm Counts, Low
 
Monarch Initiative: MONDO:0001913

Definition

Decreased number of spermatozoa in the semen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOligospermia

Professional guidelines

PubMed

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin A
J Endocrinol Invest 2023 Jun;46(6):1079-1085. Epub 2023 Jan 12 doi: 10.1007/s40618-022-02000-4. PMID: 36633791Free PMC Article
The treatment of oligospermia with stilbestrol and vitamin B.
GOODHOPE CD
Fertil Steril 1961 Sep-Oct;12:469-73. doi: 10.1016/s0015-0282(16)34271-6. PMID: 13707021
Oligospermia; a clinical study of treatment with methylandrostenediol.
SCHULTZ JM
Fertil Steril 1956 Nov-Dec;7(6):523-39. PMID: 13375713

Recent clinical studies

Etiology

Fertility preservation in male patients with cancer.
Barak S
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:59-66. Epub 2018 Dec 20 doi: 10.1016/j.bpobgyn.2018.12.004. PMID: 30744950
Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
Meistrich ML
Fertil Steril 2013 Nov;100(5):1180-6. Epub 2013 Sep 4 doi: 10.1016/j.fertnstert.2013.08.010. PMID: 24012199Free PMC Article
Nonobstructive azoospermia.
Chan PT, Schlegel PN
Curr Opin Urol 2000 Nov;10(6):617-24. doi: 10.1097/00042307-200011000-00015. PMID: 11148736
Oocyte insemination with spermatozoa precursors.
Schoysman R, Vanderzwalmen P, Bertin G, Nijs M, Van Damme B
Curr Opin Urol 1999 Nov;9(6):541-5. doi: 10.1097/00042307-199911000-00009. PMID: 10668575
Hyperprolactinemic male infertility.
Segal S, Polishuk WZ, Ben-David M
Fertil Steril 1976 Dec;27(12):1425-7. doi: 10.1016/s0015-0282(16)42259-4. PMID: 1001530

Diagnosis

Initial Andrological Evaluation of the Infertile Male.
Pozzi E, Ramasamy R, Salonia A
Eur Urol Focus 2023 Jan;9(1):51-54. Epub 2022 Oct 7 doi: 10.1016/j.euf.2022.09.012. PMID: 36210297
Sports-related Male Infertility.
Hwang K, Guo D
Eur Urol Focus 2019 Nov;5(6):1143-1145. Epub 2018 May 3 doi: 10.1016/j.euf.2018.04.010. PMID: 29729871
European Academy of Andrology guideline Management of oligo-astheno-teratozoospermia.
Colpi GM, Francavilla S, Haidl G, Link K, Behre HM, Goulis DG, Krausz C, Giwercman A
Andrology 2018 Jul;6(4):513-524. doi: 10.1111/andr.12502. PMID: 30134082
The importance of semen analysis in the context of azoospermia.
Aziz N
Clinics (Sao Paulo) 2013;68 Suppl 1(Suppl 1):35-8. doi: 10.6061/clinics/2013(sup01)05. PMID: 23503953Free PMC Article
Male infertility.
de Kretser DM
Lancet 1997 Mar 15;349(9054):787-90. doi: 10.1016/s0140-6736(96)08341-9. PMID: 9074589

Therapy

Effect of antioxidants on semen parameters in men with oligo-astheno-teratozoospermia: a network meta-analysis.
Barbonetti A, Tienforti D, Castellini C, Giulio FD, Muselli M, Pizzocaro A, Vena W, Baroni MG, Pivonello R, Isidori AM, Maggi M, Corona G
Andrology 2024 Mar;12(3):538-552. Epub 2023 Jul 26 doi: 10.1111/andr.13498. PMID: 37495550
Sports-related Male Infertility.
Hwang K, Guo D
Eur Urol Focus 2019 Nov;5(6):1143-1145. Epub 2018 May 3 doi: 10.1016/j.euf.2018.04.010. PMID: 29729871
Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine: a group consensus.
Qu F, Li R, Sun W, Lin G, Zhang R, Yang J, Tian L, Xing GG, Jiang H, Gong F, Liang XY, Meng Y, Liu JY, Zhou LY, Wang SY, Wu Y, He YJ, Ye JY, Han SP, Han JS
J Zhejiang Univ Sci B 2017 Mar.;18(3):186-193. doi: 10.1631/jzus.B1600437. PMID: 28271655Free PMC Article
Male contraception.
Chao J, Page ST, Anderson RA
Best Pract Res Clin Obstet Gynaecol 2014 Aug;28(6):845-57. Epub 2014 Jun 5 doi: 10.1016/j.bpobgyn.2014.05.008. PMID: 24947599Free PMC Article
Male hormonal contraception.
Roth MY
Virtual Mentor 2012 Feb 1;14(2):126-32. doi: 10.1001/virtualmentor.2012.14.2.stas1-1202. PMID: 23116954Free PMC Article

Prognosis

Clinical implications of Y chromosome microdeletions among infertile men.
Punjani N, Kang C, Schlegel PN
Best Pract Res Clin Endocrinol Metab 2020 Dec;34(6):101471. Epub 2020 Nov 5 doi: 10.1016/j.beem.2020.101471. PMID: 33214080
Testing for genetic contributions to infertility: potential clinical impact.
Krausz C, Cioppi F, Riera-Escamilla A
Expert Rev Mol Diagn 2018 Apr;18(4):331-346. Epub 2018 Mar 22 doi: 10.1080/14737159.2018.1453358. PMID: 29540081
Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
Meistrich ML
Fertil Steril 2013 Nov;100(5):1180-6. Epub 2013 Sep 4 doi: 10.1016/j.fertnstert.2013.08.010. PMID: 24012199Free PMC Article
Nonobstructive azoospermia.
Chan PT, Schlegel PN
Curr Opin Urol 2000 Nov;10(6):617-24. doi: 10.1097/00042307-200011000-00015. PMID: 11148736
Microscopic vasectomy reversal.
Silber SJ
Fertil Steril 1977 Nov;28(11):1191-202. PMID: 923835

Clinical prediction guides

Leydig cell insufficiency in hypospermatogenesis: a paracrine effect of activin-inhibin signaling?
Winters SJ, Moore JP Jr, Clark BJ
Andrology 2018 Mar;6(2):262-271. Epub 2018 Feb 6 doi: 10.1111/andr.12459. PMID: 29409132
Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
Meistrich ML
Fertil Steril 2013 Nov;100(5):1180-6. Epub 2013 Sep 4 doi: 10.1016/j.fertnstert.2013.08.010. PMID: 24012199Free PMC Article
Follicle-stimulating hormone treatment in normogonadotropic infertile men.
Valenti D, La Vignera S, Condorelli RA, Rago R, Barone N, Vicari E, Calogero AE
Nat Rev Urol 2013 Jan;10(1):55-62. Epub 2012 Dec 11 doi: 10.1038/nrurol.2012.234. PMID: 23229508
Hormonal treatment of male infertility: FSH.
Foresta C, Selice R, Ferlin A, Arslan P, Garolla A
Reprod Biomed Online 2007 Dec;15(6):666-72. doi: 10.1016/s1472-6483(10)60533-0. PMID: 18062863
Tamoxifen and oligospermia.
Noci I, Chelo E, Saltarelli O, Donati Cori G, Scarselli G
Arch Androl 1985;15(1):83-8. doi: 10.3109/01485018508986896. PMID: 3938205

Recent systematic reviews

Modeling methods for busulfan-induced oligospermia and asthenozoospermia in mice: a systematic review and meta-analysis.
Pu R, Liu J, Zhang A, Yang J, Zhang W, Long X, Ren X, Hua H, Shi D, Zhang W, Liu L, Liu Y, Wu Y, Bai Y, Cheng N
J Assist Reprod Genet 2023 Jan;40(1):19-32. Epub 2022 Dec 12 doi: 10.1007/s10815-022-02674-y. PMID: 36508035Free PMC Article
Acupuncture for oligospermia and asthenozoospermia: A systematic review and meta-analysis.
Jia W, Wang C, Yin Y
Medicine (Baltimore) 2021 Dec 3;100(48):e27816. doi: 10.1097/MD.0000000000027816. PMID: 35049183Free PMC Article
Efficacy and safety of acupuncture for the treatment of oligoasthenozoospermia: A systematic review.
You F, Ruan L, Zeng L, Zhang Y
Andrologia 2020 Feb;52(1):e13415. Epub 2019 Oct 31 doi: 10.1111/and.13415. PMID: 31670423
Aromatase inhibitors in the treatment of oligozoospermic or azoospermic men: a systematic review of randomized controlled trials.
Ribeiro MA, Gameiro LF, Scarano WR, Briton-Jones C, Kapoor A, Rosa MB, El Dib R
JBRA Assist Reprod 2016 May 1;20(2):82-8. doi: 10.5935/1518-0557.20160019. PMID: 27244767
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM
Cancer Treat Rev 2015 Dec;41(10):925-34. Epub 2015 Sep 10 doi: 10.1016/j.ctrv.2015.09.001. PMID: 26421813

Supplemental Content

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    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
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      Related information in PubMed Central Links
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