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Increased body weight

MedGen UID:
12145
Concept ID:
C0043094
Finding
Synonym: Weight gain
SNOMED CT: Weight gain (8943002); Weight increasing (161831008); Measured weight gain (816159004); Weight gain (816159004); Weight increased (262286000)
 
HPO: HP:0004324

Definition

Abnormally increased body weight. [from HPO]

Conditions with this feature

Sotos syndrome
MedGen UID:
61232
Concept ID:
C0175695
Disease or Syndrome
Sotos syndrome is characterized by a distinctive facial appearance (broad and prominent forehead with a dolichocephalic head shape, sparse frontotemporal hair, downslanting palpebral fissures, malar flushing, long and narrow face, long chin); learning disability (early developmental delay, mild-to-severe intellectual impairment); and overgrowth (height and/or head circumference =2 SD above the mean). These three clinical features are considered the cardinal features of Sotos syndrome. Major features of Sotos syndrome include behavioral problems (most notably autistic spectrum disorder), advanced bone age, cardiac anomalies, cranial MRI/CT abnormalities, joint hyperlaxity with or without pes planus, maternal preeclampsia, neonatal complications, renal anomalies, scoliosis, and seizures.
Smith-Magenis syndrome
MedGen UID:
162881
Concept ID:
C0795864
Disease or Syndrome
Smith-Magenis syndrome (SMS) is characterized by distinctive physical features (particularly coarse facial features that progress with age), developmental delay, cognitive impairment, behavioral abnormalities, sleep disturbance, and childhood-onset abdominal obesity. Infants have feeding difficulties, failure to thrive, hypotonia, hyporeflexia, prolonged napping or need to be awakened for feeds, and generalized lethargy. The majority of individuals function in the mild-to-moderate range of intellectual disability. The behavioral phenotype, including significant sleep disturbance, stereotypies, and maladaptive and self-injurious behaviors, is generally not recognized until age 18 months or older and continues to change until adulthood. Sensory issues are frequently noted; these may include avoidant behavior, as well as repetitive seeking of textures, sounds, and experiences. Toileting difficulties are common. Significant anxiety is common as are problems with executive functioning, including inattention, distractibility, hyperactivity, and impulsivity. Maladaptive behaviors include frequent outbursts / temper tantrums, attention-seeking behaviors, opposition, aggression, and self-injurious behaviors including self-hitting, self-biting, skin picking, inserting foreign objects into body orifices (polyembolokoilamania), and yanking fingernails and/or toenails (onychotillomania). Among the stereotypic behaviors described, the spasmodic upper-body squeeze or "self-hug" seems to be highly associated with SMS. An underlying developmental asynchrony, specifically emotional maturity delayed beyond intellectual functioning, may also contribute to maladaptive behaviors in people with SMS.
Syndromic X-linked intellectual disability Nascimento type
MedGen UID:
477095
Concept ID:
C3275464
Disease or Syndrome
The Nascimento type of X-linked syndromic intellectual developmental disorder (MRXSN) is characterized by dysmorphic features, including large head, synophrys, prominent supraorbital ridges, almond-shaped and deep-set eyes, large ears, wide mouth, myxedematous appearance, hirsutism, abnormal hair whorls, micropenis, and onychodystrophy. Female carriers have normal cognition, but may show subtle facial features (summary by Budny et al., 2010).
Congenital nongoitrous hypothryoidism 6
MedGen UID:
482447
Concept ID:
C3280817
Disease or Syndrome
Any hypothyroidism, congenital, nongoitrous in which the cause of the disease is a mutation in the THRA gene.
Thyroid hormone resistance, generalized, autosomal recessive
MedGen UID:
483749
Concept ID:
C3489796
Disease or Syndrome
A rare, autosomal recessive inherited disorder usually caused by mutations in the THRB gene. It is characterized by a defective physiological resistance to thyroid hormones, resulting in the elevation of thyroxin and triiodothyronine in the serum.
Pigmented nodular adrenocortical disease, primary, 4
MedGen UID:
862862
Concept ID:
C4014425
Disease or Syndrome
Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014).
ACTH-independent macronodular adrenal hyperplasia 2
MedGen UID:
863240
Concept ID:
C4014803
Disease or Syndrome
ACTH-independent macronodular adrenal hyperplasia-2 is an autosomal dominant tumor susceptibility with syndromic incomplete penetrance, as a second hit to the ARMC5 gene is required to develop macronodular hyperplasia (Assie et al., 2013).

Professional guidelines

PubMed

Charchar FJ, Prestes PR, Mills C, Ching SM, Neupane D, Marques FZ, Sharman JE, Vogt L, Burrell LM, Korostovtseva L, Zec M, Patil M, Schultz MG, Wallen MP, Renna NF, Islam SMS, Hiremath S, Gyeltshen T, Chia YC, Gupta A, Schutte AE, Klein B, Borghi C, Browning CJ, Czesnikiewicz-Guzik M, Lee HY, Itoh H, Miura K, Brunström M, Campbell NRC, Akinnibossun OA, Veerabhadrappa P, Wainford RD, Kruger R, Thomas SA, Komori T, Ralapanawa U, Cornelissen VA, Kapil V, Li Y, Zhang Y, Jafar TH, Khan N, Williams B, Stergiou G, Tomaszewski M
J Hypertens 2024 Jan 1;42(1):23-49. Epub 2023 Sep 12 doi: 10.1097/HJH.0000000000003563. PMID: 37712135Free PMC Article
Wiechert M, Holzapfel C
Nutrients 2021 Dec 30;14(1) doi: 10.3390/nu14010169. PMID: 35011045Free PMC Article
Eliakim A, Litmanovitz I, Nemet D
Pediatr Exerc Sci 2017 Nov 1;29(4):450-455. Epub 2017 Oct 10 doi: 10.1123/pes.2017-0017. PMID: 28338426

Recent clinical studies

Etiology

Huang Y, Chen Z, Chen B, Li J, Yuan X, Li J, Wang W, Dai T, Chen H, Wang Y, Wang R, Wang P, Guo J, Dong Q, Liu C, Wei Q, Cao D, Liu L
BMJ 2023 Apr 5;381:e071609. doi: 10.1136/bmj-2022-071609. PMID: 37019448Free PMC Article
Wiechert M, Holzapfel C
Nutrients 2021 Dec 30;14(1) doi: 10.3390/nu14010169. PMID: 35011045Free PMC Article
Wang Y, Zhao T, Zhang Y, Li S, Cong X
Breastfeed Med 2021 Apr;16(4):282-291. Epub 2021 Feb 2 doi: 10.1089/bfm.2020.0358. PMID: 33533688
Kawabe H, Azegami T, Takeda A, Kanda T, Saito I, Saruta T, Hirose H
Hypertens Res 2019 Jul;42(7):935-948. Epub 2019 Mar 20 doi: 10.1038/s41440-019-0229-3. PMID: 30894695Free PMC Article
Stanhope KL
Crit Rev Clin Lab Sci 2016;53(1):52-67. Epub 2015 Sep 17 doi: 10.3109/10408363.2015.1084990. PMID: 26376619Free PMC Article

Diagnosis

Kawabe H, Azegami T, Takeda A, Kanda T, Saito I, Saruta T, Hirose H
Hypertens Res 2019 Jul;42(7):935-948. Epub 2019 Mar 20 doi: 10.1038/s41440-019-0229-3. PMID: 30894695Free PMC Article
Legeay S, Faure S
Fundam Clin Pharmacol 2017 Dec;31(6):594-609. Epub 2017 Jul 7 doi: 10.1111/fcp.12300. PMID: 28622415
Vilahur G, Ben-Aicha S, Badimon L
Cardiovasc Res 2017 Jul 1;113(9):1046-1054. doi: 10.1093/cvr/cvx086. PMID: 28472252
Stanhope KL
Crit Rev Clin Lab Sci 2016;53(1):52-67. Epub 2015 Sep 17 doi: 10.3109/10408363.2015.1084990. PMID: 26376619Free PMC Article
Tappy L, Lê KA
Physiol Rev 2010 Jan;90(1):23-46. doi: 10.1152/physrev.00019.2009. PMID: 20086073

Therapy

Huang Y, Chen Z, Chen B, Li J, Yuan X, Li J, Wang W, Dai T, Chen H, Wang Y, Wang R, Wang P, Guo J, Dong Q, Liu C, Wei Q, Cao D, Liu L
BMJ 2023 Apr 5;381:e071609. doi: 10.1136/bmj-2022-071609. PMID: 37019448Free PMC Article
Wiechert M, Holzapfel C
Nutrients 2021 Dec 30;14(1) doi: 10.3390/nu14010169. PMID: 35011045Free PMC Article
Wang Y, Zhao T, Zhang Y, Li S, Cong X
Breastfeed Med 2021 Apr;16(4):282-291. Epub 2021 Feb 2 doi: 10.1089/bfm.2020.0358. PMID: 33533688
Alonso-Pedrero L, Bes-Rastrollo M, Marti A
Obes Rev 2019 Dec;20(12):1680-1690. Epub 2019 Sep 16 doi: 10.1111/obr.12934. PMID: 31524318
Stanhope KL
Crit Rev Clin Lab Sci 2016;53(1):52-67. Epub 2015 Sep 17 doi: 10.3109/10408363.2015.1084990. PMID: 26376619Free PMC Article

Prognosis

Ludwig M, Richter M, Goltermann J, Redlich R, Repple J, Flint C, Grotegerd D, Koch K, Leehr EJ, Meinert S, Hülsmann C, Enneking V, Kugel H, Hahn T, Baune BT, Dannlowski U, Opel N
Psychoneuroendocrinology 2021 Apr;126:105148. Epub 2021 Jan 19 doi: 10.1016/j.psyneuen.2021.105148. PMID: 33513455
Avraam J, Dawson A, Rochford PD, Brazzale DJ, O'donoghue FJ, Trinder J, Jordan AS
Sleep 2019 Oct 9;42(10) doi: 10.1093/sleep/zsz141. PMID: 31322697
Kovesdy CP, Furth S, Zoccali C; World Kidney Day Steering Committee
Physiol Int 2017 Mar 1;104(1):1-14. doi: 10.1556/2060.104.2017.1.9. PMID: 28361575
Uguz F, Sahingoz M, Gungor B, Aksoy F, Askin R
Gen Hosp Psychiatry 2015 Jan-Feb;37(1):46-8. Epub 2014 Oct 31 doi: 10.1016/j.genhosppsych.2014.10.011. PMID: 25467076
Abu-Abid S, Szold A, Klausner J
J Med 2002;33(1-4):73-86. PMID: 12939106

Clinical prediction guides

Huang Y, Chen Z, Chen B, Li J, Yuan X, Li J, Wang W, Dai T, Chen H, Wang Y, Wang R, Wang P, Guo J, Dong Q, Liu C, Wei Q, Cao D, Liu L
BMJ 2023 Apr 5;381:e071609. doi: 10.1136/bmj-2022-071609. PMID: 37019448Free PMC Article
Wang Y, Zhao T, Zhang Y, Li S, Cong X
Breastfeed Med 2021 Apr;16(4):282-291. Epub 2021 Feb 2 doi: 10.1089/bfm.2020.0358. PMID: 33533688
Alonso-Pedrero L, Bes-Rastrollo M, Marti A
Obes Rev 2019 Dec;20(12):1680-1690. Epub 2019 Sep 16 doi: 10.1111/obr.12934. PMID: 31524318
Debédat J, Clément K, Aron-Wisnewsky J
Curr Obes Rep 2019 Sep;8(3):229-242. doi: 10.1007/s13679-019-00351-3. PMID: 31197613
Uguz F, Sahingoz M, Gungor B, Aksoy F, Askin R
Gen Hosp Psychiatry 2015 Jan-Feb;37(1):46-8. Epub 2014 Oct 31 doi: 10.1016/j.genhosppsych.2014.10.011. PMID: 25467076

Recent systematic reviews

Santi D, Lotti F, Sparano C, Rastrelli G, Isidori AM, Pivonello R, Barbonetti A, Salonia A, Minhas S, Krausz C, Vignozzi L, Maggi M, Corona G
Andrology 2024 Jan;12(1):123-136. Epub 2023 Jun 5 doi: 10.1111/andr.13460. PMID: 37226894
Chiavaroli L, Cheung A, Ayoub-Charette S, Ahmed A, Lee D, Au-Yeung F, Qi X, Back S, McGlynn N, Ha V, Lai E, Khan TA, Blanco Mejia S, Zurbau A, Choo VL, de Souza RJ, Wolever TM, Leiter LA, Kendall CW, Jenkins DJ, Sievenpiper JL
Am J Clin Nutr 2023 Apr;117(4):741-765. Epub 2023 Feb 23 doi: 10.1016/j.ajcnut.2023.01.023. PMID: 36842451
Alonso-Pedrero L, Bes-Rastrollo M, Marti A
Obes Rev 2019 Dec;20(12):1680-1690. Epub 2019 Sep 16 doi: 10.1111/obr.12934. PMID: 31524318
Glisic M, Kastrati N, Musa J, Milic J, Asllanaj E, Portilla Fernandez E, Nano J, Ochoa Rosales C, Amiri M, Kraja B, Bano A, Bramer WM, Roks AJM, Danser AHJ, Franco OH, Muka T
Maturitas 2018 Sep;115:74-83. Epub 2018 Jun 22 doi: 10.1016/j.maturitas.2018.06.012. PMID: 30049351
Sievenpiper JL, de Souza RJ, Mirrahimi A, Yu ME, Carleton AJ, Beyene J, Chiavaroli L, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Kendall CW, Jenkins DJ
Ann Intern Med 2012 Feb 21;156(4):291-304. doi: 10.7326/0003-4819-156-4-201202210-00007. PMID: 22351714

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