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Schizoaffective disorder, depressive type

MedGen UID:
542782
•Concept ID:
C0270497
•
Mental or Behavioral Dysfunction
Synonyms: Schizoaffective Disorder, Depressive Type; Schizophreniform psychosis, depressive type
SNOMED CT: Schizophreniform psychosis, depressive type (84760002); Schizoaffective disorder, depressive type (84760002)

Definition

Schizoaffective disorder with episodes of depression only. [from NCI]

Professional guidelines

PubMed

Duration of lithium treatment and brain lithium concentration in patients with unipolar and schizoaffective disorder--a study with magnetic resonance spectroscopy.
Riedl U, Barocka A, Kolem H, Demling J, Kaschka WP, Schelp R, Stemmler M, Ebert D
Biol Psychiatry 1997 Apr 15;41(8):844-50. doi: 10.1016/S0006-3223(96)00330-7. PMID: 9099410
New developments in the pharmacologic treatment of schizoaffective disorder.
Keck PE Jr, McElroy SL, Strakowski SM
J Clin Psychiatry 1996;57 Suppl 9:41-8. PMID: 8823349

Recent clinical studies

Etiology

A naturalistic cohort study of first-episode schizophrenia spectrum disorder: A description of the early phase of illness in the PSYSCAN cohort.
Slot MIE, van Hell HH, Rossum IW, Dazzan P, Maat A, de Haan L, Crespo-Facorro B, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango C, Kircher T, Nelson B, Galderisi S, Weiser M, Sachs G, Maatz A, Bressan RA, Kwon JS, Mizrahi R; PSYSCAN Consortium, McGuire P, Kahn RS
Schizophr Res 2024 Apr;266:237-248. Epub 2024 Mar 2 doi: 10.1016/j.schres.2024.02.018. PMID: 38431986
Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
Dennison CA, Legge SE, Hubbard L, Lynham AJ, Zammit S, Holmans P, Cardno AG, Owen MJ, O'Donovan MC, Walters JTR
Schizophr Bull 2021 Aug 21;47(5):1375-1384. doi: 10.1093/schbul/sbab036. PMID: 33837784Free PMC Article
Examining cognition across the bipolar/schizophrenia diagnostic spectrum.
Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, Jones IR, Walters JTR
J Psychiatry Neurosci 2018 Jul;43(4):245-253. doi: 10.1503/jpn.170076. PMID: 29947606Free PMC Article
A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and nonpsychotic major depression.
Maj M, Starace F, Pirozzi R
Am J Psychiatry 1991 May;148(5):612-6. doi: 10.1176/ajp.148.5.612. PMID: 2018162
Long-term course and outcome in unipolar affective and schizoaffective psychoses.
Opjordsmoen S
Acta Psychiatr Scand 1989 Apr;79(4):317-26. doi: 10.1111/j.1600-0447.1989.tb10265.x. PMID: 2735203

Diagnosis

A naturalistic cohort study of first-episode schizophrenia spectrum disorder: A description of the early phase of illness in the PSYSCAN cohort.
Slot MIE, van Hell HH, Rossum IW, Dazzan P, Maat A, de Haan L, Crespo-Facorro B, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango C, Kircher T, Nelson B, Galderisi S, Weiser M, Sachs G, Maatz A, Bressan RA, Kwon JS, Mizrahi R; PSYSCAN Consortium, McGuire P, Kahn RS
Schizophr Res 2024 Apr;266:237-248. Epub 2024 Mar 2 doi: 10.1016/j.schres.2024.02.018. PMID: 38431986
Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
Dennison CA, Legge SE, Hubbard L, Lynham AJ, Zammit S, Holmans P, Cardno AG, Owen MJ, O'Donovan MC, Walters JTR
Schizophr Bull 2021 Aug 21;47(5):1375-1384. doi: 10.1093/schbul/sbab036. PMID: 33837784Free PMC Article
Examining cognition across the bipolar/schizophrenia diagnostic spectrum.
Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, Jones IR, Walters JTR
J Psychiatry Neurosci 2018 Jul;43(4):245-253. doi: 10.1503/jpn.170076. PMID: 29947606Free PMC Article
Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome.
Müller-Siecheneder F, Müller MJ, Hillert A, Szegedi A, Wetzel H, Benkert O
J Clin Psychopharmacol 1998 Apr;18(2):111-20. doi: 10.1097/00004714-199804000-00003. PMID: 9555596
A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and nonpsychotic major depression.
Maj M, Starace F, Pirozzi R
Am J Psychiatry 1991 May;148(5):612-6. doi: 10.1176/ajp.148.5.612. PMID: 2018162

Therapy

A naturalistic cohort study of first-episode schizophrenia spectrum disorder: A description of the early phase of illness in the PSYSCAN cohort.
Slot MIE, van Hell HH, Rossum IW, Dazzan P, Maat A, de Haan L, Crespo-Facorro B, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango C, Kircher T, Nelson B, Galderisi S, Weiser M, Sachs G, Maatz A, Bressan RA, Kwon JS, Mizrahi R; PSYSCAN Consortium, McGuire P, Kahn RS
Schizophr Res 2024 Apr;266:237-248. Epub 2024 Mar 2 doi: 10.1016/j.schres.2024.02.018. PMID: 38431986
Impact of Ramadan fasting on medical and psychiatric health.
Chehovich C, Demler TL, Leppien E
Int Clin Psychopharmacol 2019 Nov;34(6):317-322. doi: 10.1097/YIC.0000000000000275. PMID: 31274697
Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome.
Müller-Siecheneder F, Müller MJ, Hillert A, Szegedi A, Wetzel H, Benkert O
J Clin Psychopharmacol 1998 Apr;18(2):111-20. doi: 10.1097/00004714-199804000-00003. PMID: 9555596
New developments in the pharmacologic treatment of schizoaffective disorder.
Keck PE Jr, McElroy SL, Strakowski SM
J Clin Psychiatry 1996;57 Suppl 9:41-8. PMID: 8823349
Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.
Keck PE Jr, Wilson DR, Strakowski SM, McElroy SL, Kizer DL, Balistreri TM, Holtman HM, DePriest M
J Clin Psychiatry 1995 Oct;56(10):466-70. PMID: 7559373

Prognosis

A naturalistic cohort study of first-episode schizophrenia spectrum disorder: A description of the early phase of illness in the PSYSCAN cohort.
Slot MIE, van Hell HH, Rossum IW, Dazzan P, Maat A, de Haan L, Crespo-Facorro B, Glenthøj B, Lawrie SM, McDonald C, Gruber O, van Amelsvoort T, Arango C, Kircher T, Nelson B, Galderisi S, Weiser M, Sachs G, Maatz A, Bressan RA, Kwon JS, Mizrahi R; PSYSCAN Consortium, McGuire P, Kahn RS
Schizophr Res 2024 Apr;266:237-248. Epub 2024 Mar 2 doi: 10.1016/j.schres.2024.02.018. PMID: 38431986
Time-related cognitive deficiency in four different types of depression.
Neu P, Kiesslinger U, Schlattmann P, Reischies FM
Psychiatry Res 2001 Sep 20;103(2-3):237-47. doi: 10.1016/s0165-1781(01)00286-4. PMID: 11549411
Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.
Keck PE Jr, Wilson DR, Strakowski SM, McElroy SL, Kizer DL, Balistreri TM, Holtman HM, DePriest M
J Clin Psychiatry 1995 Oct;56(10):466-70. PMID: 7559373
Long-term course and outcome in unipolar affective and schizoaffective psychoses.
Opjordsmoen S
Acta Psychiatr Scand 1989 Apr;79(4):317-26. doi: 10.1111/j.1600-0447.1989.tb10265.x. PMID: 2735203

Clinical prediction guides

Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type.
Dennison CA, Legge SE, Hubbard L, Lynham AJ, Zammit S, Holmans P, Cardno AG, Owen MJ, O'Donovan MC, Walters JTR
Schizophr Bull 2021 Aug 21;47(5):1375-1384. doi: 10.1093/schbul/sbab036. PMID: 33837784Free PMC Article
Examining cognition across the bipolar/schizophrenia diagnostic spectrum.
Lynham AJ, Hubbard L, Tansey KE, Hamshere ML, Legge SE, Owen MJ, Jones IR, Walters JTR
J Psychiatry Neurosci 2018 Jul;43(4):245-253. doi: 10.1503/jpn.170076. PMID: 29947606Free PMC Article
Risperidone versus haloperidol and amitriptyline in the treatment of patients with a combined psychotic and depressive syndrome.
Müller-Siecheneder F, Müller MJ, Hillert A, Szegedi A, Wetzel H, Benkert O
J Clin Psychopharmacol 1998 Apr;18(2):111-20. doi: 10.1097/00004714-199804000-00003. PMID: 9555596
Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.
Keck PE Jr, Wilson DR, Strakowski SM, McElroy SL, Kizer DL, Balistreri TM, Holtman HM, DePriest M
J Clin Psychiatry 1995 Oct;56(10):466-70. PMID: 7559373
Long-term course and outcome in unipolar affective and schizoaffective psychoses.
Opjordsmoen S
Acta Psychiatr Scand 1989 Apr;79(4):317-26. doi: 10.1111/j.1600-0447.1989.tb10265.x. PMID: 2735203

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