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Trichomegaly(TCMGLY)

MedGen UID:
163139
•Concept ID:
C0854699
•
Finding
Synonym: TCMGLY
 
Gene (location): FGF5 (4q21.21)
 
Monarch Initiative: MONDO:0008593
OMIM®: 190330

Definition

Trichomegaly (TCMGLY), or excessively long eyelashes, is a rare familial trait (Higgins et al., 2014). [from OMIM]

Clinical features

From HPO
Long eyelashes
MedGen UID:
342955
•Concept ID:
C1853738
•
Finding
Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective).
See: Feature record | Search on this feature
Cataract
MedGen UID:
39462
•Concept ID:
C0086543
•
Disease or Syndrome
A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Skin Toxicities During Colorectal Cancer Chemotherapy: Incidence and Pearls of Treatment in Our Experience.
Panariello L, Donnarumma M, Iaffaioli RV, Chiodini P, Annunziata MC, Peduto T, Fabbrocini G
Clin Colorectal Cancer 2020 Dec;19(4):e235-e242. Epub 2020 May 29 doi: 10.1016/j.clcc.2020.05.006. PMID: 32665093
Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities.
Chu CY, Chen KY, Wen-Cheng Chang J, Wei YF, Lee CH, Wang WM
J Formos Med Assoc 2017 Jun;116(6):413-423. Epub 2017 Mar 27 doi: 10.1016/j.jfma.2017.03.001. PMID: 28351555
Ocular toxicities of epidermal growth factor receptor inhibitors and their management.
Basti S
Cancer Nurs 2007 Jul-Aug;30(4 Suppl 1):S10-6. doi: 10.1097/01.NCC.0000281759.23823.82. PMID: 17666986

Recent clinical studies

Etiology

Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Ocular side effects and trichomegaly of eyelashes induced by erlotinib: a case report and review of the literature.
Celik T, Kosker M
Cont Lens Anterior Eye 2015 Feb;38(1):59-60. Epub 2014 Sep 22 doi: 10.1016/j.clae.2014.08.005. PMID: 25249292
Progressive trichomegaly.
Vano-Galvan S, Moreno-Martin P, Jaén P
Neth J Med 2009 Jan;67(1):35-6. PMID: 19155549

Diagnosis

Pinnae and facial hypertrichosis induced by cetuximab.
Alexandris D, Alevizopoulos N, Palamaris K, Gakiopoulou C, Theocharis S
J Oncol Pharm Pract 2023 Apr;29(3):731-737. Epub 2022 Jul 12 doi: 10.1177/10781552221114073. PMID: 35821579
Periocular Manifestations of Afatinib Therapy.
Joganathan V, Norris JH
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e12-e13. doi: 10.1097/IOP.0000000000001277. PMID: 30531213
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Essential trichomegaly: case report.
Rossetto JD, Nascimento H, Muccioli C, Belfort R Jr
Arq Bras Oftalmol 2013 Jan-Feb;76(1):50-1. doi: 10.1590/s0004-27492013000100015. PMID: 23812530
Erlotinib-associated trichomegaly.
Lane K, Goldstein SM
Ophthalmic Plast Reconstr Surg 2007 Jan-Feb;23(1):65-6. doi: 10.1097/IOP.0b013e31802d9802. PMID: 17237698

Therapy

Panitumumab-induced trichomegaly.
Sütcüoğlu O, Özet A
Curr Probl Cancer 2021 Dec;45(6):100748. Epub 2021 Apr 23 doi: 10.1016/j.currproblcancer.2021.100748. PMID: 33933278
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Hair disorders in patients with cancer.
Freites-Martinez A, Shapiro J, Goldfarb S, Nangia J, Jimenez JJ, Paus R, Lacouture ME
J Am Acad Dermatol 2019 May;80(5):1179-1196. Epub 2018 Apr 14 doi: 10.1016/j.jaad.2018.03.055. PMID: 29660422Free PMC Article
Trichomegaly Induced by Cetuximab: Case Series and Review the Literature.
Koksal UI, Pilanci KN, Ordu C, Okutur K, Saglam S, Demir G
Am J Ther 2016 Sep-Oct;23(5):e1226-9. doi: 10.1097/MJT.0000000000000189. PMID: 26079631
Erlotinib-associated trichomegaly.
Lane K, Goldstein SM
Ophthalmic Plast Reconstr Surg 2007 Jan-Feb;23(1):65-6. doi: 10.1097/IOP.0b013e31802d9802. PMID: 17237698

Prognosis

Trichomegaly Associated with Panitumumab.
Goyal A, Blaes A
N Engl J Med 2020 Oct 15;383(16):e94. doi: 10.1056/NEJMicm2003622. PMID: 33053288
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Madarosis, milphosis, eyelash trichomegaly, and dermatochalasis.
Vij A, Bergfeld WF
Clin Dermatol 2015 Mar-Apr;33(2):217-26. doi: 10.1016/j.clindermatol.2014.10.013. PMID: 25704941
Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.
Hufnagel RB, Arno G, Hein ND, Hersheson J, Prasad M, Anderson Y, Krueger LA, Gregory LC, Stoetzel C, Jaworek TJ, Hull S, Li A, Plagnol V, Willen CM, Morgan TM, Prows CA, Hegde RS, Riazuddin S, Grabowski GA, Richardson RJ, Dieterich K, Huang T, Revesz T, Martinez-Barbera JP, Sisk RA, Jefferies C, Houlden H, Dattani MT, Fink JK, Dollfus H, Moore AT, Ahmed ZM
J Med Genet 2015 Feb;52(2):85-94. Epub 2014 Dec 5 doi: 10.1136/jmedgenet-2014-102856. PMID: 25480986Free PMC Article
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949

Clinical prediction guides

Dermatological side effects of targeted antineoplastic therapies: a prospective study.
Agirgol S, Çaytemel C, Pilanci KN
Cutan Ocul Toxicol 2020 Dec;39(4):380-384. Epub 2020 Oct 20 doi: 10.1080/15569527.2020.1833028. PMID: 33028137
Prostaglandin-Associated Periorbitopathy in Children and Young Adults with Glaucoma.
Kim JS, Blizzard S, Woodward JA, Leyngold IM, Liss J, Freedman SF
Ophthalmol Glaucoma 2020 Jul-Aug;3(4):288-294. Epub 2020 Apr 3 doi: 10.1016/j.ogla.2020.03.009. PMID: 33008561
Alopecia and Hair Damage Induced by Oncological Therapy.
Jedličková H, Vokurka S, Vojtíšek R, Malečková A
Klin Onkol 2019 Fall;32(5):353-359. doi: 10.14735/amko2019353. PMID: 31610668
Hair disorders associated with autoimmune connective tissue diseases.
Cassano N, Amerio P, D'Ovidio R, Vena GA
G Ital Dermatol Venereol 2014 Oct;149(5):555-65. Epub 2014 Jun 30 PMID: 24975949
The cutaneous epidermal growth factor network: Can it be translated clinically to stimulate hair growth?
Alexandrescu DT, Kauffman CL, Dasanu CA
Dermatol Online J 2009 Mar 15;15(3):1. PMID: 19379645

Recent systematic reviews

Ophthalmologic and facial abnormalities of Nicolaides-Baraitser syndrome.
Simmers R, Goodwin A, Al Saif H, Couser N
Ophthalmic Genet 2022 Oct;43(5):699-702. Epub 2022 Jun 27 doi: 10.1080/13816810.2022.2089358. PMID: 35762114
Eyelash trichomegaly: a systematic review of acquired and congenital aetiologies of lengthened lashes.
Hutchison DM, Duffens A, Yale K, Park A, Cardenas K, Mesinkovska NA
J Eur Acad Dermatol Venereol 2022 Apr;36(4):536-546. Epub 2021 Dec 31 doi: 10.1111/jdv.17877. PMID: 34919300

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    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

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