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Cerebral ischemia

MedGen UID:
182975
Concept ID:
C0917798
Pathologic Function
Synonym: Brain ischemia
SNOMED CT: Cerebral ischemia (287731003)
 
HPO: HP:0002637
Monarch Initiative: MONDO:0005299

Definition

Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue. [from HPO]

Conditions with this feature

Acquired polycythemia vera
MedGen UID:
45996
Concept ID:
C0032463
Neoplastic Process
Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005).
Schimke immuno-osseous dysplasia
MedGen UID:
164078
Concept ID:
C0877024
Congenital Abnormality
Schimke immunoosseous dysplasia (SIOD) is characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T-cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small ilia with shallow dysplastic acetabular fossae, and small deformed capital femoral epiphyses. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease. The majority of tested individuals have T-cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with a greater risk of death during childhood to a juvenile or milder later-onset form with likely survival into adulthood if renal disease is appropriately treated.
Internal carotid arteries, hypoplasia of
MedGen UID:
383757
Concept ID:
C1855736
Finding
Cerebral amyloid angiopathy, APP-related
MedGen UID:
414044
Concept ID:
C2751536
Disease or Syndrome
Cerebral amyloid angiopathy, or cerebroarterial amyloidosis, refers to a pathologic process in which amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions, and progressive dementia. APP-related CAA is the most common form of CAA (Revesz et al., 2003, 2009).

Professional guidelines

PubMed

Osgood ML
Curr Neurol Neurosci Rep 2021 Jul 26;21(9):50. doi: 10.1007/s11910-021-01136-9. PMID: 34308493
Li K, Barras CD, Chandra RV, Kok HK, Maingard JT, Carter NS, Russell JH, Lai L, Brooks M, Asadi H
World Neurosurg 2019 Jun;126:513-527. Epub 2019 Mar 18 doi: 10.1016/j.wneu.2019.03.083. PMID: 30898740
Oddo M, Poole D, Helbok R, Meyfroidt G, Stocchetti N, Bouzat P, Cecconi M, Geeraerts T, Martin-Loeches I, Quintard H, Taccone FS, Geocadin RG, Hemphill C, Ichai C, Menon D, Payen JF, Perner A, Smith M, Suarez J, Videtta W, Zanier ER, Citerio G
Intensive Care Med 2018 Apr;44(4):449-463. Epub 2018 Mar 2 doi: 10.1007/s00134-018-5086-z. PMID: 29500701

Recent clinical studies

Etiology

Shah VA, Gonzalez LF, Suarez JI
Neurocrit Care 2023 Aug;39(1):36-50. Epub 2023 May 25 doi: 10.1007/s12028-023-01747-9. PMID: 37231236
Simon MV, Malcharek M, Ulkatan S
Handb Clin Neurol 2022;186:355-374. doi: 10.1016/B978-0-12-819826-1.00015-6. PMID: 35772895
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Przykaza Ł
Front Immunol 2021;12:782569. Epub 2021 Nov 15 doi: 10.3389/fimmu.2021.782569. PMID: 34868060Free PMC Article
Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, Mocco J, Macdonald RL
Transl Stroke Res 2021 Jun;12(3):428-446. Epub 2020 Oct 19 doi: 10.1007/s12975-020-00867-0. PMID: 33078345

Diagnosis

Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, Mocco J, Macdonald RL
Transl Stroke Res 2021 Jun;12(3):428-446. Epub 2020 Oct 19 doi: 10.1007/s12975-020-00867-0. PMID: 33078345
Shin TH, Lee DY, Basith S, Manavalan B, Paik MJ, Rybinnik I, Mouradian MM, Ahn JH, Lee G
Cells 2020 Jul 7;9(7) doi: 10.3390/cells9071630. PMID: 32645907Free PMC Article
Farooq S, Testai FD
Curr Neurol Neurosci Rep 2019 Feb 28;19(4):17. doi: 10.1007/s11910-019-0932-0. PMID: 30820687
Findlay JM, Nisar J, Darsaut T
Can J Neurol Sci 2016 Jan;43(1):15-32. Epub 2015 Sep 2 doi: 10.1017/cjn.2015.288. PMID: 26332908

Therapy

Wolf S, Mielke D, Barner C, Malinova V, Kerz T, Wostrack M, Czorlich P, Salih F, Engel DC, Ehlert A, Staykov D, Alturki AY, Sure U, Bardutzky J, Schroeder HWS, Schürer L, Beck J, Juratli TA, Fritsch M, Lemcke J, Pohrt A, Meyer B, Schwab S, Rohde V, Vajkoczy P; EARLYDRAIN Study Group
JAMA Neurol 2023 Aug 1;80(8):833-842. doi: 10.1001/jamaneurol.2023.1792. PMID: 37330974Free PMC Article
Shah VA, Gonzalez LF, Suarez JI
Neurocrit Care 2023 Aug;39(1):36-50. Epub 2023 May 25 doi: 10.1007/s12028-023-01747-9. PMID: 37231236
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070

Prognosis

Zeineddine HA, Honarpisheh P, McBride D, Pandit PKT, Dienel A, Hong SH, Grotta J, Blackburn S
Transl Stroke Res 2022 Oct;13(5):725-735. Epub 2022 Feb 14 doi: 10.1007/s12975-022-00995-9. PMID: 35157256Free PMC Article
Aagaard P, Briceno D, Csanadi Z, Mohanty S, Gianni C, Trivedi C, Nagy-Baló E, Danik S, Barrett C, Santoro F, Burkhardt JD, Sanchez J, Natale A, Di Biase L
Cardiol Clin 2016 May;34(2):307-16. doi: 10.1016/j.ccl.2015.12.012. PMID: 27150179
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Shea S, Di Tullio M
J Am Coll Cardiol 2013 Nov 19;62(21):1998-1999. Epub 2013 Jul 10 doi: 10.1016/j.jacc.2013.06.025. PMID: 23850915
Fukudome EY, Alam HB
Crit Care Med 2009 Jul;37(7 Suppl):S265-72. doi: 10.1097/CCM.0b013e3181aa60ac. PMID: 19535957

Clinical prediction guides

Angermann M, Jablawi F, Angermann M, Conzen-Dilger C, Schubert GA, Höllig A, Veldeman M, Reich A, Hasan D, Ridwan H, Clusmann H, Wiesmann M, Nikoubashman O
World Neurosurg 2022 Sep;165:e512-e519. Epub 2022 Jun 24 doi: 10.1016/j.wneu.2022.06.086. PMID: 35753679
Otlivanchik O, Liberman AL
Curr Pain Headache Rep 2019 Jul 29;23(9):63. doi: 10.1007/s11916-019-0801-1. PMID: 31359176
Kumar G, Dumitrascu OM, Chiang CC, O'Carroll CB, Alexandrov AV
Neurocrit Care 2019 Feb;30(1):62-71. doi: 10.1007/s12028-018-0572-2. PMID: 29998428
Spina R, Simon N, Markus R, Muller DW, Kathir K
Catheter Cardiovasc Interv 2017 Aug 1;90(2):257-268. Epub 2016 Nov 29 doi: 10.1002/ccd.26871. PMID: 27896904
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975

Recent systematic reviews

Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Dayyani M, Sadeghirad B, Grotta JC, Zabihyan S, Ahmadvand S, Wang Y, Guyatt GH, Amin-Hanjani S
Stroke 2022 Jun;53(6):1993-2005. Epub 2022 Mar 31 doi: 10.1161/STROKEAHA.121.035699. PMID: 35354302
Castle-Kirszbaum M, Parkin WG, Goldschlager T, Lewis PM
J Neurosurg Anesthesiol 2022 Oct 1;34(4):352-363. Epub 2021 Mar 29 doi: 10.1097/ANA.0000000000000768. PMID: 33782372
Feng Y, Chen H
Am J Emerg Med 2021 Dec;50:748-752. Epub 2021 Sep 22 doi: 10.1016/j.ajem.2021.09.047. PMID: 34879498
Vidale S
Neurol Sci 2020 Dec;41(Suppl 2):395-399. doi: 10.1007/s10072-020-04651-8. PMID: 32852688

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