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Cerebral ischemia

MedGen UID:
182975
Concept ID:
C0917798
Pathologic Function
Synonym: Brain ischemia
SNOMED CT: Cerebral ischemia (287731003)
 
HPO: HP:0002637
Monarch Initiative: MONDO:0005299

Definition

Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral ischemia

Conditions with this feature

Acquired polycythemia vera
MedGen UID:
45996
Concept ID:
C0032463
Neoplastic Process
Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005).
Schimke immuno-osseous dysplasia
MedGen UID:
164078
Concept ID:
C0877024
Congenital Abnormality
Schimke immunoosseous dysplasia (SIOD) is characterized by spondyloepiphyseal dysplasia (SED) resulting in short stature, nephropathy, and T-cell deficiency. Radiographic manifestations of SED include ovoid and mildly flattened vertebral bodies, small ilia with shallow dysplastic acetabular fossae, and small deformed capital femoral epiphyses. Nearly all affected individuals have progressive steroid-resistant nephropathy, usually developing within five years of the diagnosis of growth failure and terminating with end-stage renal disease. The majority of tested individuals have T-cell deficiency and an associated risk for opportunistic infection, a common cause of death. SIOD involves a spectrum that ranges from an infantile or severe early-onset form with a greater risk of death during childhood to a juvenile or milder later-onset form with likely survival into adulthood if renal disease is appropriately treated.
Internal carotid arteries, hypoplasia of
MedGen UID:
383757
Concept ID:
C1855736
Finding
Cerebral amyloid angiopathy, APP-related
MedGen UID:
414044
Concept ID:
C2751536
Disease or Syndrome
Cerebral amyloid angiopathy, or cerebroarterial amyloidosis, refers to a pathologic process in which amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions, and progressive dementia. APP-related CAA is the most common form of CAA (Revesz et al., 2003, 2009).

Professional guidelines

PubMed

Thilak S, Brown P, Whitehouse T, Gautam N, Lawrence E, Ahmed Z, Veenith T
Nat Commun 2024 Feb 29;15(1):1850. doi: 10.1038/s41467-024-46015-2. PMID: 38424037Free PMC Article
Osgood ML
Curr Neurol Neurosci Rep 2021 Jul 26;21(9):50. doi: 10.1007/s11910-021-01136-9. PMID: 34308493
Gąsecki D, Kwarciany M, Kowalczyk K, Narkiewicz K, Karaszewski B
Curr Hypertens Rep 2020 Dec 10;23(1):3. doi: 10.1007/s11906-020-01120-7. PMID: 33305339Free PMC Article

Recent clinical studies

Etiology

Shah VA, Gonzalez LF, Suarez JI
Neurocrit Care 2023 Aug;39(1):36-50. Epub 2023 May 25 doi: 10.1007/s12028-023-01747-9. PMID: 37231236
Yao Y, Bade R, Li G, Zhang A, Zhao H, Fan L, Zhu R, Yuan J
Cell Mol Neurobiol 2023 Jul;43(5):1989-2004. Epub 2022 Aug 27 doi: 10.1007/s10571-022-01277-6. PMID: 36030297
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Przykaza Ł
Front Immunol 2021;12:782569. Epub 2021 Nov 15 doi: 10.3389/fimmu.2021.782569. PMID: 34868060Free PMC Article
Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, Mocco J, Macdonald RL
Transl Stroke Res 2021 Jun;12(3):428-446. Epub 2020 Oct 19 doi: 10.1007/s12975-020-00867-0. PMID: 33078345

Diagnosis

Abdulazim A, Heilig M, Rinkel G, Etminan N
Neurocrit Care 2023 Oct;39(2):311-319. Epub 2023 Aug 3 doi: 10.1007/s12028-023-01812-3. PMID: 37537496Free PMC Article
Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, Mocco J, Macdonald RL
Transl Stroke Res 2021 Jun;12(3):428-446. Epub 2020 Oct 19 doi: 10.1007/s12975-020-00867-0. PMID: 33078345
Shin TH, Lee DY, Basith S, Manavalan B, Paik MJ, Rybinnik I, Mouradian MM, Ahn JH, Lee G
Cells 2020 Jul 7;9(7) doi: 10.3390/cells9071630. PMID: 32645907Free PMC Article
Farooq S, Testai FD
Curr Neurol Neurosci Rep 2019 Feb 28;19(4):17. doi: 10.1007/s11910-019-0932-0. PMID: 30820687
Findlay JM, Nisar J, Darsaut T
Can J Neurol Sci 2016 Jan;43(1):15-32. Epub 2015 Sep 2 doi: 10.1017/cjn.2015.288. PMID: 26332908

Therapy

Wolf S, Mielke D, Barner C, Malinova V, Kerz T, Wostrack M, Czorlich P, Salih F, Engel DC, Ehlert A, Staykov D, Alturki AY, Sure U, Bardutzky J, Schroeder HWS, Schürer L, Beck J, Juratli TA, Fritsch M, Lemcke J, Pohrt A, Meyer B, Schwab S, Rohde V, Vajkoczy P; EARLYDRAIN Study Group
JAMA Neurol 2023 Aug 1;80(8):833-842. doi: 10.1001/jamaneurol.2023.1792. PMID: 37330974Free PMC Article
Shah VA, Gonzalez LF, Suarez JI
Neurocrit Care 2023 Aug;39(1):36-50. Epub 2023 May 25 doi: 10.1007/s12028-023-01747-9. PMID: 37231236
Rosenthal ES
Continuum (Minneap Minn) 2021 Oct 1;27(5):1321-1343. doi: 10.1212/CON.0000000000001012. PMID: 34618762
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070
Hickenbottom SL, Grotta J
Semin Neurol 1998;18(4):485-92. doi: 10.1055/s-2008-1040901. PMID: 9932619

Prognosis

Abulhasan YB, Ortiz Jimenez J, Teitelbaum J, Simoneau G, Angle MR
J Neurosurg 2021 Mar 1;134(3):971-982. Epub 2020 Mar 27 doi: 10.3171/2020.1.JNS193107. PMID: 32217799
Aagaard P, Briceno D, Csanadi Z, Mohanty S, Gianni C, Trivedi C, Nagy-Baló E, Danik S, Barrett C, Santoro F, Burkhardt JD, Sanchez J, Natale A, Di Biase L
Cardiol Clin 2016 May;34(2):307-16. doi: 10.1016/j.ccl.2015.12.012. PMID: 27150179
Quinn CT
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):438-43. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.438. PMID: 25696891
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Shea S, Di Tullio M
J Am Coll Cardiol 2013 Nov 19;62(21):1998-1999. Epub 2013 Jul 10 doi: 10.1016/j.jacc.2013.06.025. PMID: 23850915

Clinical prediction guides

Otlivanchik O, Liberman AL
Curr Pain Headache Rep 2019 Jul 29;23(9):63. doi: 10.1007/s11916-019-0801-1. PMID: 31359176
Fragata I, Canhão P
Acta Radiol 2019 Feb;60(2):247-259. Epub 2018 May 23 doi: 10.1177/0284185118778877. PMID: 29792042
Spina R, Simon N, Markus R, Muller DW, Kathir K
Catheter Cardiovasc Interv 2017 Aug 1;90(2):257-268. Epub 2016 Nov 29 doi: 10.1002/ccd.26871. PMID: 27896904
Wang Y, Zhao X, Liu L, Soo YO, Pu Y, Pan Y, Wang Y, Zou X, Leung TW, Cai Y, Bai Q, Wu Y, Wang C, Pan X, Luo B, Wong KS; CICAS Study Group
Stroke 2014 Mar;45(3):663-9. Epub 2014 Jan 30 doi: 10.1161/STROKEAHA.113.003508. PMID: 24481975
Radak D, Sotirovic V, Obradovic M, Isenovic ER
Angiology 2014 Oct;65(9):769-72. Epub 2013 Oct 31 doi: 10.1177/0003319713508642. PMID: 24176911

Recent systematic reviews

Spears WE, Greer DM, Nguyen TN
Stroke 2023 Oct;54(10):2708-2712. Epub 2023 Aug 15 doi: 10.1161/STROKEAHA.123.043541. PMID: 37581267
Pontes JPM, Santos MDC, Gibram FC, Rodrigues NMV, Cavalcante-Neto JF, Barros ADM, Solla DJF
Neurosurgery 2023 Dec 1;93(6):1208-1219. Epub 2023 Jul 18 doi: 10.1227/neu.0000000000002601. PMID: 37462365
Geraldini F, De Cassai A, Diana P, Correale C, Boscolo A, Zampirollo S, Disarò L, Carere A, Cacco N, Navalesi P, Munari M
Neurocrit Care 2022 Jun;36(3):1071-1079. Epub 2022 Apr 13 doi: 10.1007/s12028-022-01493-4. PMID: 35419702
Dayyani M, Sadeghirad B, Grotta JC, Zabihyan S, Ahmadvand S, Wang Y, Guyatt GH, Amin-Hanjani S
Stroke 2022 Jun;53(6):1993-2005. Epub 2022 Mar 31 doi: 10.1161/STROKEAHA.121.035699. PMID: 35354302
Feng Y, Chen H
Am J Emerg Med 2021 Dec;50:748-752. Epub 2021 Sep 22 doi: 10.1016/j.ajem.2021.09.047. PMID: 34879498

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