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Bilateral cleft lip and palate

MedGen UID:
853256
•Concept ID:
C1398522
•
Congenital Abnormality
Synonym: Bilateral cleft lip/palate
SNOMED CT: Cleft palate and bilateral cleft lip (1085331000119107); Uranostaphyloschisis with bilateral cleft lip (1085331000119107); Cleft hard and soft palate and bilateral cleft lip (1085331000119107)

Professional guidelines

PubMed

Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.
Hattori Y, Pai BC, Saito T, Chou PY, Lu TC, Chang CS, Chen YR, Lo LJ
Int J Surg 2023 Jun 1;109(6):1656-1667. doi: 10.1097/JS9.0000000000000406. PMID: 37073546Free PMC Article
Primary Palatal Surgery in Nonsyndromic Cleft Palate Children and Velopharyngeal Insufficiency Correction Outcomes.
Carvajal Álvarez DC, Palomares-Aguilera MM, Meneses Geldres MB, Villarroel Giugliano C
J Craniofac Surg 2021 Mar-Apr 01;32(2):698-704. doi: 10.1097/SCS.0000000000007514. PMID: 33705013
Management of the protuberant premaxilla: where does it fit in?
Morris L
Curr Opin Otolaryngol Head Neck Surg 2019 Aug;27(4):302-309. doi: 10.1097/MOO.0000000000000558. PMID: 31219831

Recent clinical studies

Etiology

Premaxillary Setback in Bilateral Cleft Lip and Palate Repair.
Stanton E, Kondra K, Jimenez C, Shakoori P, Yen S, Urata MM, Hammoudeh JA, Magee WP 3rd
Cleft Palate Craniofac J 2024 Mar;61(3):416-421. Epub 2022 Nov 29 doi: 10.1177/10556656221130166. PMID: 36448087
Long-term treatment outcome of patients with complete bilateral cleft lip and palate: a retrospective cohort study.
Hattori Y, Pai BC, Saito T, Chou PY, Lu TC, Chang CS, Chen YR, Lo LJ
Int J Surg 2023 Jun 1;109(6):1656-1667. doi: 10.1097/JS9.0000000000000406. PMID: 37073546Free PMC Article
Alveolar bone grafting and gingivoperiosteoplasty in bilateral cleft lip and palate.
Chhajlani R, Chhajlani P, Bonanthaya K, Mahajan RK
Curr Opin Otolaryngol Head Neck Surg 2021 Aug 1;29(4):327-332. doi: 10.1097/MOO.0000000000000737. PMID: 34091502
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Malpuech syndrome: broadening the clinical spectrum and molecular analysis by array-CGH.
Priolo M, Ciccone R, Bova I, Campolo G, Laganà C, Zuffardi O
Eur J Med Genet 2007 Mar-Apr;50(2):139-43. Epub 2006 Oct 28 doi: 10.1016/j.ejmg.2006.10.004. PMID: 17140870

Diagnosis

Severe phenotype in two half-sibs with Adams Oliver syndrome.
Sevilla-Montoya R, Ríos-Flores B, Moreno-Verduzco E, Domínguez-Castro M, Rivera-Pedroza CI, Aguinaga-Ríos DM
Arch Argent Pediatr 2014 Jun;112(3):e108-12. doi: 10.5546/aap.2014.eng.e108. PMID: 24862819
A case of Fryns syndrome without diaphragmatic hernia and review of the literature.
Vasudevan PC, Stewart H
Clin Dysmorphol 2004 Jul;13(3):179-182. doi: 10.1097/01.mcd.0000115198.90437.02. PMID: 15194956
Prenatal diagnosis of a fetus with partial monosomy 7(q34-->qter) and partial trisomy 18(q21-->qter).
Pluchon E, Giovangrandi Y, Labbe F, Le Bris MJ, Collet M, Brettes JP, Riviere D, Riviere MR
Prenat Diagn 1993 Oct;13(10):983-8. doi: 10.1002/pd.1970131013. PMID: 8309904
Vasopressin and gonadotropin deficiency in a boy with the ectrodactyly-ectodermal dysplasia-clefting syndrome.
Van Maldergem L, Gillerot Y, Vamos E, Toppet M, Watillon P, Van Vliet G
Acta Paediatr 1992 Apr;81(4):365-7. doi: 10.1111/j.1651-2227.1992.tb12246.x. PMID: 1606403
Sonographic findings in septo-optic dysplasia in the fetus and newborn infant.
Pilu G, Sandri F, Cerisoli M, Alvisi C, Salvioli GP, Bovicelli L
Am J Perinatol 1990 Oct;7(4):337-9. doi: 10.1055/s-2007-999517. PMID: 2222623

Therapy

Treatment Outcome in Bilateral Cleft lip and Palate Patients Evaluated With the Huddart-Bodenham Scoring System and the Bilateral Cleft lip and Palate Yardstick: A Systematic Review.
Kuang W, Aarts M, Kuijpers-Jagtman AM, He H, Ongkosuwito EM
Cleft Palate Craniofac J 2022 Nov;59(11):1377-1390. Epub 2021 Oct 18 doi: 10.1177/10556656211041883. PMID: 34658258Free PMC Article
Bilateral Cleft Lip and Palate, With Facial Dysplasia: Interdisciplinary Treatment and Long-Term Follow-Up.
Bennun RD, Harfin JH
J Craniofac Surg 2018 Sep;29(6):1441-1444. doi: 10.1097/SCS.0000000000004756. PMID: 30015740
Invasive cervical resorption and the oro-facial cleft patient: a review and case series.
O'Mahony A, McNamara C, Ireland A, Sandy J, Puryer J
Br Dent J 2017 May 12;222(9):677-681. doi: 10.1038/sj.bdj.2017.405. PMID: 28496230
Bite force of children with repaired unilateral and bilateral cleft lip and palate.
Garcia MA, Rios D, Honório HM, Trindade-Suedam IK
Arch Oral Biol 2016 Aug;68:83-7. Epub 2016 Mar 31 doi: 10.1016/j.archoralbio.2016.03.019. PMID: 27107381
Teratogenic effects of diphenylhydantoin.
Dabee V, Hart AG, Hurley RM
Can Med Assoc J 1975 Jan 11;112(1):75, 77. PMID: 1167341Free PMC Article

Prognosis

Zygomaticomaxillary suture maturation evaluation in patients with and without cleft lip and palate.
Li R, Shan Y, Li Y, Huang S, Tong Q, Zhou Z, Zheng M, Zhang X, Weng M, Chen Z
Am J Orthod Dentofacial Orthop 2022 Aug;162(2):162-172. Epub 2022 May 30 doi: 10.1016/j.ajodo.2021.01.030. PMID: 35654687
Three-Dimensional Analysis of Bilateral Cleft Lip and Palate Nasal Deformity.
Harrison LM, Hallac RR, Derderian CA
Cleft Palate Craniofac J 2021 Jan;58(1):105-113. Epub 2020 Jul 21 doi: 10.1177/1055665620940190. PMID: 32691613
Severe phenotype in two half-sibs with Adams Oliver syndrome.
Sevilla-Montoya R, Ríos-Flores B, Moreno-Verduzco E, Domínguez-Castro M, Rivera-Pedroza CI, Aguinaga-Ríos DM
Arch Argent Pediatr 2014 Jun;112(3):e108-12. doi: 10.5546/aap.2014.eng.e108. PMID: 24862819
Malpuech syndrome: broadening the clinical spectrum and molecular analysis by array-CGH.
Priolo M, Ciccone R, Bova I, Campolo G, Laganà C, Zuffardi O
Eur J Med Genet 2007 Mar-Apr;50(2):139-43. Epub 2006 Oct 28 doi: 10.1016/j.ejmg.2006.10.004. PMID: 17140870
Suggestion for orthodontic and speech improving measures in CLP patients.
Lisson J, Schönweiler R, Tränkmann J, Ptok M
J Orofac Orthop 2001 Sep;62(5):367-74. doi: 10.1007/pl00001942. PMID: 11590825

Clinical prediction guides

Long-term Follow-up of Bilateral Cleft Lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation.
Gustafsson C, Heliövaara A, Rautio J, Leikola J
Cleft Palate Craniofac J 2023 Oct;60(10):1241-1249. Epub 2022 Jun 20 doi: 10.1177/10556656221102816. PMID: 35726173Free PMC Article
Adults With Unilateral Cleft Lip and Palate Present Reduced Internal Nasal Volumes: Findings of a Three-Dimensional Morphometric Assessment in Cone-Beam Computed Tomography Scans.
Dos Inocentes RJM, Marzano-Rodrigues MN, de Espíndola GG, García-Usó M, Yatabe-Ioshida MS, Trindade IEK, Trindade-Suedam IK
J Craniofac Surg 2021 Jan-Feb 01;32(1):e15-e19. doi: 10.1097/SCS.0000000000006820. PMID: 33278248
Premaxillary Repositioning in the Severe Form of Bilateral Cleft Lip and Palate.
Koh KS, Han WY, Jeong WS, Oh TS, Kwon SM, Choi JW
J Craniofac Surg 2016 Sep;27(6):1440-4. doi: 10.1097/SCS.0000000000002729. PMID: 27300460
Severe phenotype in two half-sibs with Adams Oliver syndrome.
Sevilla-Montoya R, Ríos-Flores B, Moreno-Verduzco E, Domínguez-Castro M, Rivera-Pedroza CI, Aguinaga-Ríos DM
Arch Argent Pediatr 2014 Jun;112(3):e108-12. doi: 10.5546/aap.2014.eng.e108. PMID: 24862819
Three siblings with Robert's syndrome.
Zergollern L, Hitrec F
Clin Genet 1976 Apr;9(4):433-6. doi: 10.1111/j.1399-0004.1976.tb02273.x. PMID: 177235

Recent systematic reviews

A systematic review of differences in outcome between one and two stage palate repair in cleft lip and palate.
Cornefjord M, Arnebrant K, Guné H, Holst J, Klintö K, Stiernman M, Svensson H, Wiedel AP, Becker M
J Plast Surg Hand Surg 2023 Dec 14;58:132-141. doi: 10.2340/jphs.v58.13368. PMID: 38095226
What is the Effectiveness of Premaxilla Surgical Repositioning and its Stabilization Methods in Mixed Dentition Patients With Bilateral Cleft Lip and Palate?
Normande Neto HV, Oliveira-Neto OB, Ribeiro ILH, Andrade CS, Sales PHDH, Lima FJC
Cleft Palate Craniofac J 2023 Oct;60(10):1211-1219. Epub 2022 May 9 doi: 10.1177/10556656221096304. PMID: 35535395
Cranial Base Angle in Patients With Cleft Lip and Palate-A Systematic Review and Meta-Analysis.
Murugan C, Kailasam V
Cleft Palate Craniofac J 2023 Jan;60(1):39-54. Epub 2021 Nov 17 doi: 10.1177/10556656211053545. PMID: 34787478
Repair Sequence and Management of the Premaxilla in Patients With Bilateral Cleft Lip and Palate: A Systematic Review of the Literature.
Chang IA, Bassiri Gharb B, Papay FA, Rampazzo A
J Craniofac Surg 2022 Mar-Apr 01;33(2):421-425. doi: 10.1097/SCS.0000000000008184. PMID: 34560740
Effects of labial adhesion on maxillary arch dimensions and nasolabial esthetics in cleft lip and palate: a systematic review.
Thierens L, Brusselaers N, De Roo N, De Pauw G
Oral Dis 2017 Oct;23(7):889-896. Epub 2017 Jan 24 doi: 10.1111/odi.12613. PMID: 27878905

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