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Diabetes mellitus, noninsulin-dependent, 1(T2D1)

MedGen UID:
321979
•Concept ID:
C1832544
•
Disease or Syndrome
Synonym: T2D1
 
Gene (location): CAPN10 (2q37.3)
 
Monarch Initiative: MONDO:0011027
OMIM®: 601283

Recent clinical studies

Etiology

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.
Gyldenkerne C, Mortensen MB, Kahlert J, Thrane PG, Warnakula Olesen KK, Sørensen HT, Thomsen RW, Maeng M
J Am Coll Cardiol 2023 Oct 17;82(16):1583-1594. doi: 10.1016/j.jacc.2023.08.015. PMID: 37821168
Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case-control study in individuals aged 65-80 years.
Sugita Y, Ito K, Yoshioka Y, Sakai S
Cardiovasc Diabetol 2023 Apr 28;22(1):97. doi: 10.1186/s12933-023-01835-2. PMID: 37118820Free PMC Article
Post-pancreatitis diabetes mellitus: insight on optimal management with nutrition and lifestyle approaches.
Singh A, Aggarwal M, Garg R, Stevens T, Chahal P
Ann Med 2022 Dec;54(1):1776-1786. doi: 10.1080/07853890.2022.2090601. PMID: 35786076Free PMC Article
Sleeve gastrectomy versus Roux-en-Y Gastric Bypass for remission of type 2 diabetes mellitus at 1, 3 and 5 years: a systematic review and meta-analysis.
Fatima K, Farooqui SK, Ajaz I, Ali ST, Hashmi N, Nadeem S, Ghazi SA, Kaleem SH, Bozdar FS, Noorani M
Minerva Gastroenterol (Torino) 2022 Dec;68(4):450-458. Epub 2022 Apr 7 doi: 10.23736/S2724-5985.22.03117-5. PMID: 35388663
Remission of Type II Diabetes Mellitus 1-Year Postoperative Following One Anastomosis Gastric Bypass in Correlation with ABCD, DiaRem, and DRS Scores.
Eskandaros MS, Abbass A, Ebeid EF, Darwish AA
Obes Surg 2022 Feb;32(2):450-456. Epub 2021 Nov 15 doi: 10.1007/s11695-021-05793-0. PMID: 34780027

Diagnosis

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.
Gyldenkerne C, Mortensen MB, Kahlert J, Thrane PG, Warnakula Olesen KK, Sørensen HT, Thomsen RW, Maeng M
J Am Coll Cardiol 2023 Oct 17;82(16):1583-1594. doi: 10.1016/j.jacc.2023.08.015. PMID: 37821168
Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case-control study in individuals aged 65-80 years.
Sugita Y, Ito K, Yoshioka Y, Sakai S
Cardiovasc Diabetol 2023 Apr 28;22(1):97. doi: 10.1186/s12933-023-01835-2. PMID: 37118820Free PMC Article
The Risk of Type 2 Diabetes Mellitus according to Changes in Obesity Status in Late Middle-Aged Adults: A Nationwide Cohort Study of Korea.
Moon JH, Jang Y, Oh TJ, Jung SY
Diabetes Metab J 2023 Jul;47(4):514-522. Epub 2023 Apr 25 doi: 10.4093/dmj.2022.0159. PMID: 37096375Free PMC Article
Post-pancreatitis diabetes mellitus: insight on optimal management with nutrition and lifestyle approaches.
Singh A, Aggarwal M, Garg R, Stevens T, Chahal P
Ann Med 2022 Dec;54(1):1776-1786. doi: 10.1080/07853890.2022.2090601. PMID: 35786076Free PMC Article
Remission of Type II Diabetes Mellitus 1-Year Postoperative Following One Anastomosis Gastric Bypass in Correlation with ABCD, DiaRem, and DRS Scores.
Eskandaros MS, Abbass A, Ebeid EF, Darwish AA
Obes Surg 2022 Feb;32(2):450-456. Epub 2021 Nov 15 doi: 10.1007/s11695-021-05793-0. PMID: 34780027

Therapy

Sleeve gastrectomy versus Roux-en-Y Gastric Bypass for remission of type 2 diabetes mellitus at 1, 3 and 5 years: a systematic review and meta-analysis.
Fatima K, Farooqui SK, Ajaz I, Ali ST, Hashmi N, Nadeem S, Ghazi SA, Kaleem SH, Bozdar FS, Noorani M
Minerva Gastroenterol (Torino) 2022 Dec;68(4):450-458. Epub 2022 Apr 7 doi: 10.23736/S2724-5985.22.03117-5. PMID: 35388663

Prognosis

Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review.
Wambua S, Singh M, Okoth K, Snell KIE, Riley RD, Yau C, Thangaratinam S, Nirantharakumar K, Crowe FL; MuM-PreDiCT Group
BMC Med 2024 Feb 14;22(1):66. doi: 10.1186/s12916-024-03284-4. PMID: 38355631Free PMC Article
Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case-control study in individuals aged 65-80 years.
Sugita Y, Ito K, Yoshioka Y, Sakai S
Cardiovasc Diabetol 2023 Apr 28;22(1):97. doi: 10.1186/s12933-023-01835-2. PMID: 37118820Free PMC Article
Long-term weight loss outcome of laparoscopic Roux-en-Y gastric bypass predicted by weight loss at 6 months in Chinese patients with BMI ≥ 32.5 kg/m2.
Wuyun Q, Wang D, Tian C, Xu G, Amin B, Lian D, Du D, Zhang W, Jiang M, Chen G, Zhang N, Wang L
Medicine (Baltimore) 2023 Mar 24;102(12):e33235. doi: 10.1097/MD.0000000000033235. PMID: 36961197Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Remission of Type II Diabetes Mellitus 1-Year Postoperative Following One Anastomosis Gastric Bypass in Correlation with ABCD, DiaRem, and DRS Scores.
Eskandaros MS, Abbass A, Ebeid EF, Darwish AA
Obes Surg 2022 Feb;32(2):450-456. Epub 2021 Nov 15 doi: 10.1007/s11695-021-05793-0. PMID: 34780027

Clinical prediction guides

Association of complication of type 2 diabetes mellitus with hemodynamics and exercise capacity in patients with heart failure with preserved ejection fraction: a case-control study in individuals aged 65-80 years.
Sugita Y, Ito K, Yoshioka Y, Sakai S
Cardiovasc Diabetol 2023 Apr 28;22(1):97. doi: 10.1186/s12933-023-01835-2. PMID: 37118820Free PMC Article
Long-term weight loss outcome of laparoscopic Roux-en-Y gastric bypass predicted by weight loss at 6 months in Chinese patients with BMI ≥ 32.5 kg/m2.
Wuyun Q, Wang D, Tian C, Xu G, Amin B, Lian D, Du D, Zhang W, Jiang M, Chen G, Zhang N, Wang L
Medicine (Baltimore) 2023 Mar 24;102(12):e33235. doi: 10.1097/MD.0000000000033235. PMID: 36961197Free PMC Article
Genetic risk score is associated with T2DM and diabetes complications risks.
Hubacek JA, Dlouha L, Adamkova V, Dlouha D, Pacal L, Kankova K, Galuska D, Lanska V, Veleba J, Pelikanova T
Gene 2023 Jan 15;849:146921. Epub 2022 Sep 26 doi: 10.1016/j.gene.2022.146921. PMID: 36174902
Remission of Type II Diabetes Mellitus 1-Year Postoperative Following One Anastomosis Gastric Bypass in Correlation with ABCD, DiaRem, and DRS Scores.
Eskandaros MS, Abbass A, Ebeid EF, Darwish AA
Obes Surg 2022 Feb;32(2):450-456. Epub 2021 Nov 15 doi: 10.1007/s11695-021-05793-0. PMID: 34780027
β-Cell function improvements in grade I/II obese subjects with type 2 diabetes 1 month after biliopancreatic diversion: results from modeling analyses of oral glucose tolerance tests and hyperglycemic clamp studies.
Junqueira Vasques AC, Pareja JC, de Oliveira Mda S, Satake Novaes F, Miranda de Oliveira Lima M, Chaim ÉA, Piccinini F, Dalla Man C, Cobelli C, Geloneze B
Diabetes Care 2013 Dec;36(12):4117-24. Epub 2013 Oct 17 doi: 10.2337/dc13-0530. PMID: 24135388Free PMC Article

Recent systematic reviews

Sleeve gastrectomy versus Roux-en-Y Gastric Bypass for remission of type 2 diabetes mellitus at 1, 3 and 5 years: a systematic review and meta-analysis.
Fatima K, Farooqui SK, Ajaz I, Ali ST, Hashmi N, Nadeem S, Ghazi SA, Kaleem SH, Bozdar FS, Noorani M
Minerva Gastroenterol (Torino) 2022 Dec;68(4):450-458. Epub 2022 Apr 7 doi: 10.23736/S2724-5985.22.03117-5. PMID: 35388663

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guidance, Clinical Guideline CG181, Cardiovascular disease: risk assessment and reduction, including lipid modification, 2023
    • NICE, 2019
      UK NICE Guideline NG19, Diabetic foot problems: prevention and management, 2019

    Reviews

    Related information

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      Clinical tests in GTR
    • MeSH
      Related Medical Subject Headings
    • OMIM
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
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    • PubMed (OMIM)
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