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Glipizide response

MedGen UID:
322023
Concept ID:
C1832730
Finding
Synonym: Glipizide poor metabolizer
Drug:
Glipizide
MedGen UID:
4900
Concept ID:
C0017642
Pharmacologic Substance
A short-acting, second-generation sulfonylurea with hypoglycemic activity. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine. [from NCI]
 
Gene (location): G6PD (Xq28)
 
OMIM®: 601130

Professional guidelines

PubMed

Tomlinson B, Li YH, Chan P
Expert Opin Pharmacother 2022 Dec;23(17):1869-1877. Epub 2022 Nov 10 doi: 10.1080/14656566.2022.2141108. PMID: 36300277
Temple C, Hoang R, Kusin S
Clin Toxicol (Phila) 2022 Nov;60(11):1235-1239. Epub 2022 Oct 25 doi: 10.1080/15563650.2022.2125875. PMID: 36282178
Vaughan EM, Rueda JJ, Samson SL, Hyman DJ
Curr Diabetes Rev 2020;16(8):851-858. doi: 10.2174/1573399816666200206112318. PMID: 32026779Free PMC Article

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

DailyMed Drug Label, glipizide, 2022

DailyMed Drug Label, GLIPIZIDE, 2019

Recent clinical studies

Etiology

Dorsey-Trevino EG, Kaur V, Mercader JM, Florez JC, Leong A
J Clin Endocrinol Metab 2022 Aug 18;107(9):2580-2588. doi: 10.1210/clinem/dgac374. PMID: 35723666Free PMC Article
Mintz ML, Minervini G
Curr Med Res Opin 2014 May;30(5):761-70. Epub 2014 Jan 30 doi: 10.1185/03007995.2014.880674. PMID: 24397584
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Melander A
Diabetes 2004 Dec;53 Suppl 3:S151-5. doi: 10.2337/diabetes.53.suppl_3.s151. PMID: 15561903
Melander A
Diabet Med 1996 Sep;13(9 Suppl 6):S143-7. PMID: 8894498

Diagnosis

Zhang X, Ren H, Zhao C, Shi Z, Qiu L, Yang F, Zhou X, Han X, Wu K, Zhong H, Li Y, Li J, Ji L
Diabetologia 2022 Oct;65(10):1613-1626. Epub 2022 Aug 5 doi: 10.1007/s00125-022-05768-5. PMID: 35930018Free PMC Article
Xu H, Murray M, McLachlan AJ
Curr Drug Metab 2009 Jul;10(6):643-58. doi: 10.2174/138920009789375388. PMID: 19799532
Dörschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M
Mol Pharmacol 1999 Jun;55(6):1060-6. doi: 10.1124/mol.55.6.1060. PMID: 10347249
Miller TR, Taber RD, Molinari EJ, Whiteaker KL, Monteggia LM, Scott VE, Brioni JD, Sullivan JP, Gopalakrishnan M
Eur J Pharmacol 1999 Apr 9;370(2):179-85. doi: 10.1016/s0014-2999(99)00128-4. PMID: 10323267
Melander A
Diabet Med 1996 Sep;13(9 Suppl 6):S143-7. PMID: 8894498

Therapy

Abdul-Ghani T, Puckett C, Migahid O, Abdelgani S, Migahed A, Adams J, Triplitt C, DeFronzo R, Jayyousi A, Abdul-Ghani M
Diabetes Obes Metab 2022 Sep;24(9):1810-1818. Epub 2022 Jun 29 doi: 10.1111/dom.14767. PMID: 35581905
Lyseng-Williamson KA
Drugs 2007;67(4):587-97. doi: 10.2165/00003495-200767040-00007. PMID: 17352516
Bell DS
Clin Ther 2004 Nov;26(11):1714-27. doi: 10.1016/j.clinthera.2004.10.014. PMID: 15639686
Melander A
Diabet Med 1996 Sep;13(9 Suppl 6):S143-7. PMID: 8894498
Shuman CR
Am J Med 1983 Nov 30;75(5B):55-9. doi: 10.1016/0002-9343(83)90254-1. PMID: 6369968

Prognosis

Lavynenko O, Abdul-Ghani M, Alatrach M, Puckett C, Adams J, Abdelgani S, Alkhouri N, Triplitt C, Clarke GD, Vasquez JA, Li J, Cersosimo E, Gastaldelli A, DeFronzo RA
Diabetes Obes Metab 2022 May;24(5):899-907. Epub 2022 Feb 9 doi: 10.1111/dom.14650. PMID: 35014145
Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
Diabetes Obes Metab 2021 Jul;23(7):1631-1639. Epub 2021 May 6 doi: 10.1111/dom.14383. PMID: 33852204Free PMC Article
Strøm Halden TA, Åsberg A, Vik K, Hartmann A, Jenssen T
Nephrol Dial Transplant 2014 Apr;29(4):926-33. Epub 2014 Jan 22 doi: 10.1093/ndt/gft536. PMID: 24452849
Abraira C, Henderson WG, Colwell JA, Nuttall FQ, Comstock JP, Emanuele NV, Levin SR, Sawin CT, Silbert CK
Diabetes Care 1998 Apr;21(4):574-9. doi: 10.2337/diacare.21.4.574. PMID: 9571345
Schwartz SL, Fischer JS, Kipnes MS, Boyle M
Am J Med 1987 Sep 18;83(3A):22-30. doi: 10.1016/0002-9343(87)90800-x. PMID: 3307403

Clinical prediction guides

Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGen Plus, for the DIRECT Consortium; MetGen Plus investigators:
Diabetes Care 2021 Dec;44(12):2673-2682. Epub 2021 Oct 4 doi: 10.2337/dc21-1152. PMID: 34607834Free PMC Article
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Miller TR, Taber RD, Molinari EJ, Whiteaker KL, Monteggia LM, Scott VE, Brioni JD, Sullivan JP, Gopalakrishnan M
Eur J Pharmacol 1999 Apr 9;370(2):179-85. doi: 10.1016/s0014-2999(99)00128-4. PMID: 10323267
Müller G, Satoh Y, Geisen K
Diabetes Res Clin Pract 1995 Aug;28 Suppl:S115-37. doi: 10.1016/0168-8227(95)01089-v. PMID: 8529504
Shuman CR
Am J Med 1983 Nov 30;75(5B):55-9. doi: 10.1016/0002-9343(83)90254-1. PMID: 6369968

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2022
      DailyMed Drug Label, glipizide, 2022
    • DailyMed Drug Label, 2019
      DailyMed Drug Label, GLIPIZIDE, 2019

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