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Kallikrein, decreased urinary activity of

MedGen UID:
322759
•Concept ID:
C1835808
•
Finding
Synonym: Kallikrein, Decreased Urinary Activity of
 
Gene (location): KLK1 (19q13.33)
 
Monarch Initiative: MONDO:0014415
OMIM®: 615953

Professional guidelines

PubMed

Prostate cancer. Mortality and morbidity after non-curative treatment with aspects on diagnosis and treatment.
Aus G
Scand J Urol Nephrol Suppl 1994;167:1-41. PMID: 7542397
Lithium treatment reduces the renal kallikrein excretion rate.
Gross P, Reinhard C, Marin-Grez M, Fink E, Sauer H
Kidney Int 1990 Jul;38(1):124-8. doi: 10.1038/ki.1990.176. PMID: 2385081
Mechanism of antihypertensive effect of atenolol in patients with borderline hypertension during short-term treatment. A comprehensive study.
Imai Y, Abe K, Sato M, Kasai Y, Sato K, Omata K, Sasaki S, Nihei M, Sekino H, Yoshinaga K
Arzneimittelforschung 1986 May;36(5):869-73. PMID: 3730023

Recent clinical studies

Etiology

Hematological and renal toxicity in mice after three cycles of high activity [(177)Lu]Lu-PSMA-617 with or without human α(1)-microglobulin.
Kristiansson A, Vilhelmsson Timmermand O, Altai M, Strand SE, Åkerström B, Örbom A
Sci Rep 2024 May 11;14(1):10787. doi: 10.1038/s41598-024-61370-2. PMID: 38734765Free PMC Article
Decreased plasma kallikrein activity is associated with reduced kidney function in individuals with type 1 diabetes.
Härma MA, Dahlström EH, Sandholm N, Forsblom C, Groop PH, Lehto M; FinnDiane Study Group
Diabetologia 2020 Jul;63(7):1349-1354. Epub 2020 Apr 8 doi: 10.1007/s00125-020-05144-1. PMID: 32270254Free PMC Article
Salt sensitivity: a review with a focus on non-Hispanic blacks and Hispanics.
Richardson SI, Freedman BI, Ellison DH, Rodriguez CJ
J Am Soc Hypertens 2013 Mar-Apr;7(2):170-9. Epub 2013 Feb 19 doi: 10.1016/j.jash.2013.01.003. PMID: 23428408Free PMC Article
The urine proteome as a radiation biodosimeter.
Sharma M, Moulder JE
Adv Exp Med Biol 2013;990:87-100. doi: 10.1007/978-94-007-5896-4_5. PMID: 23378004
The kallikrein-kinin system as a regulator of cardiovascular and renal function.
Rhaleb NE, Yang XP, Carretero OA
Compr Physiol 2011 Apr;1(2):971-93. doi: 10.1002/cphy.c100053. PMID: 23737209Free PMC Article

Diagnosis

High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker.
Liu S, Hawley SJ, Kunder CA, Hsu EC, Shen M, Westphalen L, Auman H, Newcomb LF, Lin DW, Nelson PS, Feng Z, Tretiakova MS, True LD, Vakar-Lopez F, Carroll PR, Simko J, Gleave ME, Troyer DA, McKenney JK, Brooks JD, Liss MA, Stoyanova T
Sci Rep 2024 Jan 4;14(1):486. doi: 10.1038/s41598-023-50215-z. PMID: 38177207Free PMC Article
The profile of Black South African men diagnosed with prostate cancer in the Free State, South Africa.
Benedict MOA, Steinberg WJ, Claassen FM, Mofolo N
S Afr Fam Pract (2004) 2023 Jan 10;65(1):e1-e10. doi: 10.4102/safp.v65i1.5553. PMID: 36744484Free PMC Article
Salt sensitivity: a review with a focus on non-Hispanic blacks and Hispanics.
Richardson SI, Freedman BI, Ellison DH, Rodriguez CJ
J Am Soc Hypertens 2013 Mar-Apr;7(2):170-9. Epub 2013 Feb 19 doi: 10.1016/j.jash.2013.01.003. PMID: 23428408Free PMC Article
The urine proteome as a radiation biodosimeter.
Sharma M, Moulder JE
Adv Exp Med Biol 2013;990:87-100. doi: 10.1007/978-94-007-5896-4_5. PMID: 23378004
The kallikrein-kinin system as a regulator of cardiovascular and renal function.
Rhaleb NE, Yang XP, Carretero OA
Compr Physiol 2011 Apr;1(2):971-93. doi: 10.1002/cphy.c100053. PMID: 23737209Free PMC Article

Therapy

Prediction of Response to (177)Lu-PSMA Therapy Based on Tumor-to-Kidney Ratio on Pretherapeutic PSMA PET/CT and Posttherapeutic Tumor-Dose Evaluation in mCRPC.
Hohberg M, Reifegerst M, Drzezga A, Wild M, Schmidt M
J Nucl Med 2023 Nov;64(11):1758-1764. Epub 2023 Aug 31 doi: 10.2967/jnumed.122.264953. PMID: 37652546
Effects and mechanism of urinary kallidinogenase in the survival of random skin flaps in rats.
Lin Y, Huang G, Jin Y, Fang M, Lin D
Int Immunopharmacol 2019 Sep;74:105720. Epub 2019 Jul 9 doi: 10.1016/j.intimp.2019.105720. PMID: 31299611
Is the renal kallikrein-kinin system a factor that modulates calciuria?
Negri AL
Nefrologia 2017 Jan-Feb;37(1):5-8. Epub 2016 Jul 26 doi: 10.1016/j.nefro.2016.04.008. PMID: 27469036
Salt sensitivity: a review with a focus on non-Hispanic blacks and Hispanics.
Richardson SI, Freedman BI, Ellison DH, Rodriguez CJ
J Am Soc Hypertens 2013 Mar-Apr;7(2):170-9. Epub 2013 Feb 19 doi: 10.1016/j.jash.2013.01.003. PMID: 23428408Free PMC Article
Effect of race on hypertension and antihypertensive therapy.
Richardson AD, Piepho RW
Int J Clin Pharmacol Ther 2000 Feb;38(2):75-9. doi: 10.5414/cpp38075. PMID: 10706194

Prognosis

High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker.
Liu S, Hawley SJ, Kunder CA, Hsu EC, Shen M, Westphalen L, Auman H, Newcomb LF, Lin DW, Nelson PS, Feng Z, Tretiakova MS, True LD, Vakar-Lopez F, Carroll PR, Simko J, Gleave ME, Troyer DA, McKenney JK, Brooks JD, Liss MA, Stoyanova T
Sci Rep 2024 Jan 4;14(1):486. doi: 10.1038/s41598-023-50215-z. PMID: 38177207Free PMC Article
Examining Absorbed Doses of Indigenously Developed (177)Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer Patients at Baseline and During Course of Peptide Receptor Radioligand Therapy.
Kamaldeep, Wanage G, Sahu SK, Maletha P, Adnan A, Suman S, Basu S, Das T, Banerjee S
Cancer Biother Radiopharm 2021 Apr;36(3):292-304. Epub 2020 May 5 doi: 10.1089/cbr.2020.3640. PMID: 32379495
Diabetes-induced upregulation of kallistatin levels exacerbates diabetic nephropathy via RAS activation.
Yang Y, He X, Cheng R, Chen Q, Shan C, Chen L, Ma JX
FASEB J 2020 Jun;34(6):8428-8441. Epub 2020 Apr 30 doi: 10.1096/fj.201903149R. PMID: 32352602Free PMC Article
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.
Krochmal M, Kontostathi G, Magalhães P, Makridakis M, Klein J, Husi H, Leierer J, Mayer G, Bascands JL, Denis C, Zoidakis J, Zürbig P, Delles C, Schanstra JP, Mischak H, Vlahou A
Sci Rep 2017 Nov 9;7(1):15160. doi: 10.1038/s41598-017-15359-9. PMID: 29123184Free PMC Article
Effect of race on hypertension and antihypertensive therapy.
Richardson AD, Piepho RW
Int J Clin Pharmacol Ther 2000 Feb;38(2):75-9. doi: 10.5414/cpp38075. PMID: 10706194

Clinical prediction guides

High expression of Trop2 is associated with aggressive localized prostate cancer and is a candidate urinary biomarker.
Liu S, Hawley SJ, Kunder CA, Hsu EC, Shen M, Westphalen L, Auman H, Newcomb LF, Lin DW, Nelson PS, Feng Z, Tretiakova MS, True LD, Vakar-Lopez F, Carroll PR, Simko J, Gleave ME, Troyer DA, McKenney JK, Brooks JD, Liss MA, Stoyanova T
Sci Rep 2024 Jan 4;14(1):486. doi: 10.1038/s41598-023-50215-z. PMID: 38177207Free PMC Article
Prediction of Response to (177)Lu-PSMA Therapy Based on Tumor-to-Kidney Ratio on Pretherapeutic PSMA PET/CT and Posttherapeutic Tumor-Dose Evaluation in mCRPC.
Hohberg M, Reifegerst M, Drzezga A, Wild M, Schmidt M
J Nucl Med 2023 Nov;64(11):1758-1764. Epub 2023 Aug 31 doi: 10.2967/jnumed.122.264953. PMID: 37652546
Effects and mechanism of urinary kallidinogenase in the survival of random skin flaps in rats.
Lin Y, Huang G, Jin Y, Fang M, Lin D
Int Immunopharmacol 2019 Sep;74:105720. Epub 2019 Jul 9 doi: 10.1016/j.intimp.2019.105720. PMID: 31299611
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.
Krochmal M, Kontostathi G, Magalhães P, Makridakis M, Klein J, Husi H, Leierer J, Mayer G, Bascands JL, Denis C, Zoidakis J, Zürbig P, Delles C, Schanstra JP, Mischak H, Vlahou A
Sci Rep 2017 Nov 9;7(1):15160. doi: 10.1038/s41598-017-15359-9. PMID: 29123184Free PMC Article
The urine proteome as a radiation biodosimeter.
Sharma M, Moulder JE
Adv Exp Med Biol 2013;990:87-100. doi: 10.1007/978-94-007-5896-4_5. PMID: 23378004

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