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Malaria, mild, susceptibility to(MALS)

MedGen UID:
332274
•Concept ID:
C1836721
•
Finding
Synonym: MALS
 
Gene (location): NCR3 (6p21.33)
 
Monarch Initiative: MONDO:0012202
OMIM®: 609148

Professional guidelines

PubMed

Imbalanced distribution of Plasmodium falciparum MSP-1 genotypes related to sickle-cell trait.
Ntoumi F, Rogier C, Dieye A, Trape JF, Millet P, Mercereau-Puijalon O
Mol Med 1997 Sep;3(9):581-92. PMID: 9323709Free PMC Article

Recent clinical studies

Etiology

G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.
Thiam F, Diop G, Coulonges C, Derbois C, Mbengue B, Thiam A, Nguer CM, Zagury JF, Deleuze JF, Dieye A
PeerJ 2022;10:e13487. Epub 2022 Jul 5 doi: 10.7717/peerj.13487. PMID: 35811813Free PMC Article
Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation.
Vinhaes CL, Carmo TA, Queiroz ATL, Fukutani KF, Araújo-Pereira M, Arriaga MB, Lacerda MVG, Barral-Netto M, Andrade BB
PLoS Negl Trop Dis 2021 Nov;15(11):e0009886. Epub 2021 Nov 2 doi: 10.1371/journal.pntd.0009886. PMID: 34727121Free PMC Article
Malaria in pregnancy: a passive surveillance study of pregnant women in low transmission areas of Colombia, Latin America.
Lopez-Perez M, Pacheco MA, Buriticá L, Escalante AA, Herrera S, Arévalo-Herrera M
Malar J 2016 Feb 5;15:66. doi: 10.1186/s12936-016-1125-9. PMID: 26850108Free PMC Article
FOXO3A regulatory polymorphism and susceptibility to severe malaria in Gabonese children.
Nguetse CN, Kremsner PG, Velavan TP
Immunogenetics 2015 Feb;67(2):67-71. Epub 2014 Nov 25 doi: 10.1007/s00251-014-0816-z. PMID: 25421486
Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon.
Melo GC, Monteiro WM, Siqueira AM, Silva SR, Magalhães BM, Alencar AC, Kuehn A, del Portillo HA, Fernandez-Becerra C, Lacerda MV
PLoS One 2014;9(8):e105922. Epub 2014 Aug 26 doi: 10.1371/journal.pone.0105922. PMID: 25157811Free PMC Article

Diagnosis

Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever.
Kotliar D, Raju S, Tabrizi S, Odia I, Goba A, Momoh M, Sandi JD, Nair P, Phelan E, Tariyal R, Eromon PE, Mehta S, Robles-Sikisaka R, Siddle KJ, Stremlau M, Jalloh S, Gire SK, Winnicki S, Chak B, Schaffner SF, Pauthner M, Karlsson EK, Chapin SR, Kennedy SG, Branco LM, Kanneh L, Vitti JJ, Broodie N, Gladden-Young A, Omoniwa O, Jiang PP, Yozwiak N, Heuklom S, Moses LM, Akpede GO, Asogun DA, Rubins K, Kales S, Happi AN, Iruolagbe CO, Dic-Ijiewere M, Iraoyah K, Osazuwa OO, Okonkwo AK, Kunz S, McCormick JB, Khan SH, Honko AN, Lander ES, Oldstone MBA, Hensley L, Folarin OA, Okogbenin SA, Günther S, Ollila HM, Tewhey R, Okokhere PO, Schieffelin JS, Andersen KG, Reilly SK, Grant DS, Garry RF, Barnes KG, Happi CT, Sabeti PC
Nat Microbiol 2024 Mar;9(3):751-762. Epub 2024 Feb 7 doi: 10.1038/s41564-023-01589-3. PMID: 38326571Free PMC Article
Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.
Daily JP, Minuti A, Khan N
JAMA 2022 Aug 2;328(5):460-471. doi: 10.1001/jama.2022.12366. PMID: 35916842
Overview of human genetic susceptibility to malaria: From parasitemia control to severe disease.
Marquet S
Infect Genet Evol 2018 Dec;66:399-409. Epub 2017 Jun 1 doi: 10.1016/j.meegid.2017.06.001. PMID: 28579526
Malaria in pregnancy: a passive surveillance study of pregnant women in low transmission areas of Colombia, Latin America.
Lopez-Perez M, Pacheco MA, Buriticá L, Escalante AA, Herrera S, Arévalo-Herrera M
Malar J 2016 Feb 5;15:66. doi: 10.1186/s12936-016-1125-9. PMID: 26850108Free PMC Article
Sickle cell disease: current activities, public health implications, and future directions.
Creary M, Williamson D, Kulkarni R
J Womens Health (Larchmt) 2007 Jun;16(5):575-82. doi: 10.1089/jwh.2007.CDC4. PMID: 17627395

Therapy

Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Chamchoy K, Sudsumrit S, Thita T, Krudsood S, Patrapuvich R, Boonyuen U
PLoS Negl Trop Dis 2022 Dec;16(12):e0010986. Epub 2022 Dec 12 doi: 10.1371/journal.pntd.0010986. PMID: 36508454Free PMC Article
Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.
Daily JP, Minuti A, Khan N
JAMA 2022 Aug 2;328(5):460-471. doi: 10.1001/jama.2022.12366. PMID: 35916842
Expression levels of pvcrt-o and pvmdr-1 are associated with chloroquine resistance and severe Plasmodium vivax malaria in patients of the Brazilian Amazon.
Melo GC, Monteiro WM, Siqueira AM, Silva SR, Magalhães BM, Alencar AC, Kuehn A, del Portillo HA, Fernandez-Becerra C, Lacerda MV
PLoS One 2014;9(8):e105922. Epub 2014 Aug 26 doi: 10.1371/journal.pone.0105922. PMID: 25157811Free PMC Article
Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia.
von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M
Trans R Soc Trop Med Hyg 1997 Jul-Aug;91(4):450-3. doi: 10.1016/s0035-9203(97)90281-9. PMID: 9373652
Artemether-pyrimethamine in the treatment of pyrimethamine-resistant falciparum malaria.
Na-Bangchang K, Tipwangso P, Thanavibul A, Tan-ariya P, Suprakob K, Kanda T, Karbwang J
Southeast Asian J Trop Med Public Health 1996 Mar;27(1):19-23. PMID: 9031394

Prognosis

Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Chamchoy K, Sudsumrit S, Thita T, Krudsood S, Patrapuvich R, Boonyuen U
PLoS Negl Trop Dis 2022 Dec;16(12):e0010986. Epub 2022 Dec 12 doi: 10.1371/journal.pntd.0010986. PMID: 36508454Free PMC Article
G6PD and HBB polymorphisms in the Senegalese population: prevalence, correlation with clinical malaria.
Thiam F, Diop G, Coulonges C, Derbois C, Mbengue B, Thiam A, Nguer CM, Zagury JF, Deleuze JF, Dieye A
PeerJ 2022;10:e13487. Epub 2022 Jul 5 doi: 10.7717/peerj.13487. PMID: 35811813Free PMC Article
Health Problems Encountered by Short-Term European Volunteers in a Nongovernmental Organization in Cambodia.
Barrio-Cortes J, Rojas-Muñoz C, Acosta-Benito MÁ, Hidalgo-Baz Á, Vicario-Merino Á, Beca-Martínez MT, Ruiz-López M
Am J Trop Med Hyg 2022 Jan 10;106(3):985-992. doi: 10.4269/ajtmh.21-0372. PMID: 35008060Free PMC Article
FOXO3A regulatory polymorphism and susceptibility to severe malaria in Gabonese children.
Nguetse CN, Kremsner PG, Velavan TP
Immunogenetics 2015 Feb;67(2):67-71. Epub 2014 Nov 25 doi: 10.1007/s00251-014-0816-z. PMID: 25421486
Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali.
Maiga B, Dolo A, Campino S, Sepulveda N, Corran P, Rockett KA, Troye-Blomberg M, Doumbo OK, Clark TG
Malar J 2014 Jul 11;13:270. doi: 10.1186/1475-2875-13-270. PMID: 25015414Free PMC Article

Clinical prediction guides

Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure.
Chamchoy K, Sudsumrit S, Thita T, Krudsood S, Patrapuvich R, Boonyuen U
PLoS Negl Trop Dis 2022 Dec;16(12):e0010986. Epub 2022 Dec 12 doi: 10.1371/journal.pntd.0010986. PMID: 36508454Free PMC Article
Diagnosis, Treatment, and Prevention of Malaria in the US: A Review.
Daily JP, Minuti A, Khan N
JAMA 2022 Aug 2;328(5):460-471. doi: 10.1001/jama.2022.12366. PMID: 35916842
Evidence of Brain Alterations in Noncerebral Falciparum Malaria.
Mohanty S, Sahu PK, Pattnaik R, Majhi M, Maharana S, Bage J, Mohanty A, Mohanty A, Bendszus M, Patterson C, Gupta H, Dondorp AM, Pirpamer L, Hoffmann A, Wassmer SC
Clin Infect Dis 2022 Aug 24;75(1):11-18. doi: 10.1093/cid/ciab907. PMID: 34905777Free PMC Article
Dissecting disease tolerance in Plasmodium vivax malaria using the systemic degree of inflammatory perturbation.
Vinhaes CL, Carmo TA, Queiroz ATL, Fukutani KF, Araújo-Pereira M, Arriaga MB, Lacerda MVG, Barral-Netto M, Andrade BB
PLoS Negl Trop Dis 2021 Nov;15(11):e0009886. Epub 2021 Nov 2 doi: 10.1371/journal.pntd.0009886. PMID: 34727121Free PMC Article
Community expansion and gene geography of sickle cell trait and G6PD deficiency, and natural selection against malaria: experience from tribal land of India.
Balgir RS
Cardiovasc Hematol Agents Med Chem 2012 Mar 1;10(1):3-13. doi: 10.2174/187152512799201190. PMID: 22264009

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