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Anorexia nervosa, susceptibility to, 1(ANON)

MedGen UID:
376139
Concept ID:
C1847492
Finding
Synonyms: ANON; Anorexia nervosa 1
 
Gene (location): HTR2A (13q14.2)
 
Monarch Initiative: MONDO:0011727
OMIM®: 606788

Definition

Eating disorders are characterized by severe disturbances in eating behavior that typically have onset during late adolescence and early adulthood. Three major types are recognized: anorexia nervosa (AN), bulimia nervosa (BN; 607499), and eating disorder not otherwise specified (EDNOS). AN is characterized by obsessive fear of weight gain, severely restricted eating, and low body weight. In women, AN has the highest mortality among the psychiatric disorders (Sullivan, 1995). AN is divided into 2 clinical subtypes, restricting anorexia nervosa (RAN) and binge-eating/purging anorexia nervosa (BPAN). BN can occur at any body weight and is characterized by binge-eating and compensatory weight-loss behaviors. Family studies have indicated an increased prevalence of eating disorders in relatives of probands with AN (Lilenfeld et al., 1998), and twin studies (Holland et al., 1984; Wade et al., 2000) have estimated concordance rates for monozygotic twins with AN to be 52 to 56%, whereas concordance rates for dizygotic twins with AN have been estimated to be 5 to 11% (Grice et al., 2002). [from OMIM]

Professional guidelines

PubMed

Carbone EA, D'Amato P, Vicchio G, De Fazio P, Segura-Garcia C
Eur Psychiatry 2020 Dec 16;64(1):e2. doi: 10.1192/j.eurpsy.2020.109. PMID: 33416044Free PMC Article
Shih PB
Prostaglandins Other Lipid Mediat 2017 Sep;132:69-76. Epub 2017 Feb 21 doi: 10.1016/j.prostaglandins.2017.02.002. PMID: 28232135Free PMC Article
Gorwood P
Am J Pharmacogenomics 2004;4(1):9-17. doi: 10.2165/00129785-200404010-00002. PMID: 14987118

Curated

UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

Recent clinical studies

Etiology

Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium
Cell 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028Free PMC Article
Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JRI, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Medland SE, Ripke S, Yao S, Giusti-Rodríguez P; Anorexia Nervosa Genetics Initiative, Hanscombe KB, Purves KL; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Baker JH, Berrettini WH, Boehm I, Boni C, Perica VB, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Mayora MG, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Kaprio J, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klareskog L, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Munn-Chernoff MA, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op 't Landt MCT, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell JE, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Stuber GD, Gordon S, Grove J, Henders AK, Juréus A, Kirk KM, Larsen JT, Parker R, Petersen L, Jordan J, Kennedy M, Montgomery GW, Wade TD, Birgegård A, Lichtenstein P, Norring C, Landén M, Martin NG, Mortensen PB, Sullivan PF, Breen G, Bulik CM
Nat Genet 2019 Aug;51(8):1207-1214. Epub 2019 Jul 15 doi: 10.1038/s41588-019-0439-2. PMID: 31308545Free PMC Article
Timko CA, DeFilipp L, Dakanalis A
Curr Psychiatry Rep 2019 Jan 12;21(1):1. doi: 10.1007/s11920-019-0988-1. PMID: 30637488Free PMC Article
Br Med J 1973 Mar 24;1(5855):689-90. PMID: 4735136Free PMC Article

Diagnosis

Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Yan P, Gao B, Wang S, Wang S, Li J, Song M
Neurosci Lett 2021 Jun 11;755:135918. Epub 2021 Apr 30 doi: 10.1016/j.neulet.2021.135918. PMID: 33940056
Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium
Cell 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028Free PMC Article
Jaffe AE, Deep-Soboslay A, Tao R, Hauptman DT, Kaye WH, Arango V, Weinberger DR, Hyde TM, Kleinman JE
Transl Psychiatry 2014 Sep 2;4(9):e432. doi: 10.1038/tp.2014.68. PMID: 25180571Free PMC Article
Helder SG, Collier DA
Curr Top Behav Neurosci 2011;6:157-75. doi: 10.1007/7854_2010_79. PMID: 21243475

Therapy

Bevilacqua A, Santini F, La Porta D, Cimino S
Eat Weight Disord 2024 Apr 26;29(1):31. doi: 10.1007/s40519-024-01659-3. PMID: 38668826Free PMC Article
Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Gong W, Guo P, Li Y, Liu L, Yan R, Liu S, Wang S, Xue F, Zhou X, Yuan Z
JAMA Psychiatry 2023 Apr 1;80(4):360-370. doi: 10.1001/jamapsychiatry.2022.4974. PMID: 36753304Free PMC Article
Gorwood P
Am J Pharmacogenomics 2004;4(1):9-17. doi: 10.2165/00129785-200404010-00002. PMID: 14987118
Br Med J 1973 Mar 24;1(5855):689-90. PMID: 4735136Free PMC Article

Prognosis

Aston SA, Caffo BS, Bhasin H, Moran TH, Tamashiro KL
Physiol Behav 2023 Nov 1;271:114349. Epub 2023 Sep 12 doi: 10.1016/j.physbeh.2023.114349. PMID: 37709000
Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium
Cell 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028Free PMC Article
Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JRI, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Medland SE, Ripke S, Yao S, Giusti-Rodríguez P; Anorexia Nervosa Genetics Initiative, Hanscombe KB, Purves KL; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Baker JH, Berrettini WH, Boehm I, Boni C, Perica VB, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Mayora MG, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Kaprio J, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klareskog L, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Munn-Chernoff MA, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op 't Landt MCT, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell JE, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Stuber GD, Gordon S, Grove J, Henders AK, Juréus A, Kirk KM, Larsen JT, Parker R, Petersen L, Jordan J, Kennedy M, Montgomery GW, Wade TD, Birgegård A, Lichtenstein P, Norring C, Landén M, Martin NG, Mortensen PB, Sullivan PF, Breen G, Bulik CM
Nat Genet 2019 Aug;51(8):1207-1214. Epub 2019 Jul 15 doi: 10.1038/s41588-019-0439-2. PMID: 31308545Free PMC Article
Shih PB
Prostaglandins Other Lipid Mediat 2017 Sep;132:69-76. Epub 2017 Feb 21 doi: 10.1016/j.prostaglandins.2017.02.002. PMID: 28232135Free PMC Article
Disanto G, Handel AE, Para AE, Ramagopalan SV, Handunnetthi L
Br J Psychiatry 2011 May;198(5):404-5. Epub 2011 Mar 17 doi: 10.1192/bjp.bp.110.085944. PMID: 21415047Free PMC Article

Clinical prediction guides

Wilcox H, Paz V, Saxena R, Winkelman JW, Garfield V, Dashti HS
JAMA Netw Open 2024 Jan 2;7(1):e2350358. doi: 10.1001/jamanetworkopen.2023.50358. PMID: 38175645Free PMC Article
Yan P, Gao B, Wang S, Wang S, Li J, Song M
Neurosci Lett 2021 Jun 11;755:135918. Epub 2021 Apr 30 doi: 10.1016/j.neulet.2021.135918. PMID: 33940056
Herle M, Abdulkadir M, Hübel C, Ferreira DS, Bryant-Waugh R, Loos RJF, Bulik CM, De Stavola B, Micali N
Nat Hum Behav 2021 May;5(5):625-630. Epub 2021 Jan 11 doi: 10.1038/s41562-020-01019-y. PMID: 33432183Free PMC Article
Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium
Cell 2019 Dec 12;179(7):1469-1482.e11. doi: 10.1016/j.cell.2019.11.020. PMID: 31835028Free PMC Article
Br Med J 1973 Mar 24;1(5855):689-90. PMID: 4735136Free PMC Article

Recent systematic reviews

Bevilacqua A, Santini F, La Porta D, Cimino S
Eat Weight Disord 2024 Apr 26;29(1):31. doi: 10.1007/s40519-024-01659-3. PMID: 38668826Free PMC Article
Yuan S, Xiong Y, Michaëlsson M, Michaëlsson K, Larsson SC
Sci Rep 2021 Feb 22;11(1):4296. doi: 10.1038/s41598-021-83801-0. PMID: 33619316Free PMC Article
Carbone EA, D'Amato P, Vicchio G, De Fazio P, Segura-Garcia C
Eur Psychiatry 2020 Dec 16;64(1):e2. doi: 10.1192/j.eurpsy.2020.109. PMID: 33416044Free PMC Article
Brandys MK, Kas MJ, van Elburg AA, Ophoff R, Slof-Op't Landt MC, Middeldorp CM, Boomsma DI, van Furth EF, Slagboom PE, Adan RA
World J Biol Psychiatry 2013 Aug;14(6):441-51. Epub 2011 Sep 21 doi: 10.3109/15622975.2011.605470. PMID: 21936709

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

    Consumer resources

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