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Transient myeloproliferative disorder of Down syndrome

MedGen UID:: 349892
•Concept ID:: C1860788
•: Disease or Syndrome

Synonym:	Transient Myeloproliferative Disorder of Down Syndrome

OMIM®:	151385; 190685

Recent clinical studies

Etiology

Hematological disorders and leukemia in children with Down syndrome.

Bruwier A, Chantrain CF
Eur J Pediatr 2012 Sep;171(9):1301-7. Epub 2011 Nov 24 doi: 10.1007/s00431-011-1624-1. PMID: 22113227

Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome.

Brink DS
Adv Anat Pathol 2006 Sep;13(5):256-62. doi: 10.1097/01.pap.0000213039.93328.44. PMID: 16998319

See all (2)

Diagnosis

Common signs and symptoms and unusual diagnoses: part 1.

Hageman JR
Pediatr Ann 2015 Jan;44(1):26. doi: 10.3928/00904481-20151226-06. PMID: 25621625

Neonatal vesiculopustular eruption associated with transient myeloproliferative disorder: report of four cases.

Narvaez-Rosales V, de-Ocariz MS, Carrasco-Daza D, Ramirez-Davila B, Orozco-Covarrubias L, Duran-McKinster C, Palacios-Lopez C
Int J Dermatol 2013 Oct;52(10):1202-9. Epub 2012 Oct 9 doi: 10.1111/j.1365-4632.2012.05501.x. PMID: 23046498

Medical update for children with Down syndrome for the pediatrician and family practitioner.

Hickey F, Hickey E, Summar KL
Adv Pediatr 2012;59(1):137-57. doi: 10.1016/j.yapd.2012.04.006. PMID: 22789577

Hematological disorders and leukemia in children with Down syndrome.

Bruwier A, Chantrain CF
Eur J Pediatr 2012 Sep;171(9):1301-7. Epub 2011 Nov 24 doi: 10.1007/s00431-011-1624-1. PMID: 22113227

Transient leukemia (transient myeloproliferative disorder, transient abnormal myelopoiesis) of Down syndrome.

Brink DS
Adv Anat Pathol 2006 Sep;13(5):256-62. doi: 10.1097/01.pap.0000213039.93328.44. PMID: 16998319

See all (9)

Therapy

Are GATA1 mutations occurring at random in Down syndrome transient leukemia?

Satgé D
Med Hypotheses 2014 Aug;83(2):154-9. Epub 2014 May 20 doi: 10.1016/j.mehy.2014.05.005. PMID: 24880866

Hematological disorders and leukemia in children with Down syndrome.

Bruwier A, Chantrain CF
Eur J Pediatr 2012 Sep;171(9):1301-7. Epub 2011 Nov 24 doi: 10.1007/s00431-011-1624-1. PMID: 22113227

See all (2)

Prognosis

Severe leukemoid reaction in a preterm infant with congenital cytomegalovirus infection.

Isik DU, Aydemir O, Kale Y, Yucel H, Bas AY, Demirel N, Arda N, Apaydin S
J Pediatr Hematol Oncol 2014 Jul;36(5):e310-2. doi: 10.1097/MPH.0000000000000030. PMID: 24072252

Hematological disorders and leukemia in children with Down syndrome.

Bruwier A, Chantrain CF
Eur J Pediatr 2012 Sep;171(9):1301-7. Epub 2011 Nov 24 doi: 10.1007/s00431-011-1624-1. PMID: 22113227

A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes.

Gassas A, Doyle JJ, Weitzman S, Freedman MH, Hitzler JK, Sharathkumar A, Dror Y
J Pediatr Hematol Oncol 2005 Apr;27(4):192-6. doi: 10.1097/01.mph.0000159934.35079.b5. PMID: 15838389

See all (3)

Clinical prediction guides

Are GATA1 mutations occurring at random in Down syndrome transient leukemia?

Satgé D
Med Hypotheses 2014 Aug;83(2):154-9. Epub 2014 May 20 doi: 10.1016/j.mehy.2014.05.005. PMID: 24880866

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome.

Xu G, Nagano M, Kanezaki R, Toki T, Hayashi Y, Taketani T, Taki T, Mitui T, Koike K, Kato K, Imaizumi M, Sekine I, Ikeda Y, Hanada R, Sako M, Kudo K, Kojima S, Ohneda O, Yamamoto M, Ito E
Blood 2003 Oct 15;102(8):2960-8. Epub 2003 Jun 19 doi: 10.1182/blood-2003-02-0390. PMID: 12816863

See all (2)

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Transient myeloproliferative disorder of Down syndrome

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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