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Colchicine resistance(CLCS)

MedGen UID:
396151
Concept ID:
C1861502
Disease or Syndrome
Synonym: COLCHICINE SENSITIVITY
Drug:
colchicine
MedGen UID:
3148
Concept ID:
C0009262
Pharmacologic Substance
An alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. [from NCI]
 
Gene (location): ABCB1 (7q21.12)
 
OMIM®: 120080

Professional guidelines

PubMed

Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, Boffa JJ, Delplanque M, Bourguiba R, Monfort JB, Touitou I, Grateau G; Collaborators, Kone-Paut I, Hentgen V
Rev Med Interne 2023 Nov;44(11):602-616. Epub 2023 Oct 29 doi: 10.1016/j.revmed.2023.10.441. PMID: 37903671
Ehlers L, Rolfes E, Lieber M, Müller D, Lainka E, Gohar F, Klaus G, Girschick H, Hörstermann J, Kümmerle-Deschner J, Brunner J, Palm-Beden K, Tenbrock K, von Wrangel L, Faßhauer M, Blank N, Trauzeddel R, von Stuckrad ASL, Higgins S, Welzel T, Lutz T, Hentgen V, Foell D, Wittkowski H, Kallinich T
Pediatr Rheumatol Online J 2023 Sep 26;21(1):108. doi: 10.1186/s12969-023-00875-y. PMID: 37752496Free PMC Article
Corsia A, Georgin-Lavialle S, Hentgen V, Hachulla E, Grateau G, Faye A, Quartier P, Rossi-Semerano L, Koné-Paut I
Orphanet J Rare Dis 2017 Mar 16;12(1):54. doi: 10.1186/s13023-017-0609-1. PMID: 28302131Free PMC Article

Recent clinical studies

Etiology

Sener S, Cam V, Batu ED, Kasap Cuceoglu M, Balik Z, Aliyev E, Bayindir Y, Basaran O, Bilginer Y, Ozen S
Rheumatology (Oxford) 2023 Nov 2;62(11):3700-3705. doi: 10.1093/rheumatology/kead128. PMID: 36961326Free PMC Article
Özen S, Sag E, Ben-Chetrit E, Gattorno M, Gül A, Hashkes PJ, Kone-Paut I, Lachmann HJ, Tsitsami E, Twilt M, Benedetti F, Kuemmerle-Deschner JB
Rheumatology (Oxford) 2021 Aug 2;60(8):3799-3808. doi: 10.1093/rheumatology/keaa863. PMID: 33331943
Ozen S, Kone-Paut I, Gül A
Semin Arthritis Rheum 2017 Aug;47(1):115-120. Epub 2017 Mar 20 doi: 10.1016/j.semarthrit.2017.03.006. PMID: 28413100
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, Finetti M, Cumetti D, Carobbio A, Ruperto N, Marcolongo R, Lorini M, Rimini A, Valenti A, Erre GL, Sormani MP, Belli R, Gaita F, Martini A
JAMA 2016 Nov 8;316(18):1906-1912. doi: 10.1001/jama.2016.15826. PMID: 27825009

Diagnosis

Georgin-Lavialle S, Savey L, Cuisset L, Boursier G, Boffa JJ, Delplanque M, Bourguiba R, Monfort JB, Touitou I, Grateau G; Collaborators, Kone-Paut I, Hentgen V
Rev Med Interne 2023 Nov;44(11):602-616. Epub 2023 Oct 29 doi: 10.1016/j.revmed.2023.10.441. PMID: 37903671
Ehlers L, Rolfes E, Lieber M, Müller D, Lainka E, Gohar F, Klaus G, Girschick H, Hörstermann J, Kümmerle-Deschner J, Brunner J, Palm-Beden K, Tenbrock K, von Wrangel L, Faßhauer M, Blank N, Trauzeddel R, von Stuckrad ASL, Higgins S, Welzel T, Lutz T, Hentgen V, Foell D, Wittkowski H, Kallinich T
Pediatr Rheumatol Online J 2023 Sep 26;21(1):108. doi: 10.1186/s12969-023-00875-y. PMID: 37752496Free PMC Article
Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Volpi S, Caorsi R, Gattorno M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119584. PMID: 37298536Free PMC Article
Lo Presti S, Elajami TK, Reyaldeen R, Anthony C, Imazio M, Klein AL
J Am Heart Assoc 2021 Oct 5;10(19):e021685. Epub 2021 Sep 25 doi: 10.1161/JAHA.121.021685. PMID: 34569270Free PMC Article
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173

Therapy

Lancieri M, Bustaffa M, Palmeri S, Prigione I, Penco F, Papa R, Volpi S, Caorsi R, Gattorno M
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119584. PMID: 37298536Free PMC Article
Sener S, Cam V, Batu ED, Kasap Cuceoglu M, Balik Z, Aliyev E, Bayindir Y, Basaran O, Bilginer Y, Ozen S
Rheumatology (Oxford) 2023 Nov 2;62(11):3700-3705. doi: 10.1093/rheumatology/kead128. PMID: 36961326Free PMC Article
Ozen S, Kone-Paut I, Gül A
Semin Arthritis Rheum 2017 Aug;47(1):115-120. Epub 2017 Mar 20 doi: 10.1016/j.semarthrit.2017.03.006. PMID: 28413100
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, Finetti M, Cumetti D, Carobbio A, Ruperto N, Marcolongo R, Lorini M, Rimini A, Valenti A, Erre GL, Sormani MP, Belli R, Gaita F, Martini A
JAMA 2016 Nov 8;316(18):1906-1912. doi: 10.1001/jama.2016.15826. PMID: 27825009

Prognosis

Aktay Ayaz N, Demirkan FG, Coşkuner T, Demir F, Tanatar A, Çakan M, Karadağ ŞG, Yener GO, Öztürk K, Bağlan E, Çakmak F, Çağlayan Ş, Özdel S, Ulu K, Sözeri B, Sönmez HE
Mod Rheumatol 2023 Dec 22;34(1):220-225. doi: 10.1093/mr/road008. PMID: 36680425
Mosad Mosa D, Shokry D, Ahmed DB, Sobh A
Mod Rheumatol 2023 Jul 4;33(4):830-835. doi: 10.1093/mr/roac068. PMID: 35789271
Sahin N, Ozdemir Cicek S, Pac Kisaarslan A, Poyrazoglu MH, Gunduz Z, Dusunsel R
Mod Rheumatol 2022 Jan 5;32(1):177-185. doi: 10.1080/14397595.2021.1908502. PMID: 33775204
Imazio M, Gribaudo E, Gaita F
Prog Cardiovasc Dis 2017 Jan-Feb;59(4):360-368. Epub 2016 Oct 7 doi: 10.1016/j.pcad.2016.10.001. PMID: 27725173
Imazio M, Adler Y, Charron P
Curr Cardiol Rep 2016 Jun;18(6):50. doi: 10.1007/s11886-016-0727-8. PMID: 27108360

Clinical prediction guides

Collini V, Andreis A, De Biasio M, De Martino M, Isola M, Croatto N, Lepre V, Cantarini L, Merlo M, Sinagra G, Abbate A, Lazaros G, Brucato A, Klein AL, Imazio M
Open Heart 2024 Mar 15;11(1) doi: 10.1136/openhrt-2023-002599. PMID: 38490715Free PMC Article
Aktay Ayaz N, Demirkan FG, Coşkuner T, Demir F, Tanatar A, Çakan M, Karadağ ŞG, Yener GO, Öztürk K, Bağlan E, Çakmak F, Çağlayan Ş, Özdel S, Ulu K, Sözeri B, Sönmez HE
Mod Rheumatol 2023 Dec 22;34(1):220-225. doi: 10.1093/mr/road008. PMID: 36680425
Mosad Mosa D, Shokry D, Ahmed DB, Sobh A
Mod Rheumatol 2023 Jul 4;33(4):830-835. doi: 10.1093/mr/roac068. PMID: 35789271
Erdem Gürsoy D, Gezer HH, Öz N, Özer A, Acer Kasman S, Duruöz MT
Int J Rheum Dis 2022 Nov;25(11):1239-1245. Epub 2022 Jul 29 doi: 10.1111/1756-185X.14407. PMID: 35903906
Corsia A, Georgin-Lavialle S, Hentgen V, Hachulla E, Grateau G, Faye A, Quartier P, Rossi-Semerano L, Koné-Paut I
Orphanet J Rare Dis 2017 Mar 16;12(1):54. doi: 10.1186/s13023-017-0609-1. PMID: 28302131Free PMC Article

Recent systematic reviews

Kilic B, Guler Y, Azman FN, Bostanci E, Ugurlu S
Rheumatology (Oxford) 2024 Apr 2;63(4):925-935. doi: 10.1093/rheumatology/kead514. PMID: 37769252
Lacout C, Savey L, Bourguiba R, Giurgea I, Amselem S, Hoyeau N, Galland J, Amiot X, Grateau G, Ducharme-Bénard S, Georgin-Lavialle S
Helicobacter 2021 Apr;26(2):e12789. Epub 2021 Feb 15 doi: 10.1111/hel.12789. PMID: 33586832
Kuemmerle-Deschner JB, Gautam R, George AT, Raza S, Lomax KG, Hur P
Rheumatology (Oxford) 2020 Oct 1;59(10):2711-2724. doi: 10.1093/rheumatology/keaa205. PMID: 32533192

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