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Hair morphology 1(HRM1)

MedGen UID:
390803
•Concept ID:
C2675460
•
Finding
Synonyms: HAIR THICKNESS, VARIATION IN; HRM1
 
Gene (location): EDAR (2q13)
 
OMIM®: 612630

Professional guidelines

PubMed

Energy-based devices for the treatment of Acne Scars: 2022 International consensus recommendations.
Salameh F, Shumaker PR, Goodman GJ, Spring LK, Seago M, Alam M, Al-Niaimi F, Cassuto D, Chan HH, Dierickx C, Donelan M, Gauglitz GG, Haedersdal M, Krakowski AC, Manuskiatti W, Norbury WB, Ogawa R, Ozog DM, Paasch U, Victor Ross E, Clementoni MT, Waibel J, Bayat A, Goo BL, Artzi O
Lasers Surg Med 2022 Jan;54(1):10-26. Epub 2021 Oct 31 doi: 10.1002/lsm.23484. PMID: 34719045
Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES)
Endocr Pract 2015 Nov;21(11):1291-300. doi: 10.4158/EP15748.DSC. PMID: 26509855

Recent clinical studies

Etiology

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia.
Pakhomova EE, Smirnova IO
Int J Mol Sci 2020 Sep 6;21(18) doi: 10.3390/ijms21186516. PMID: 32899959Free PMC Article
The Genetics of Human Skin and Hair Pigmentation.
Pavan WJ, Sturm RA
Annu Rev Genomics Hum Genet 2019 Aug 31;20:41-72. Epub 2019 May 17 doi: 10.1146/annurev-genom-083118-015230. PMID: 31100995
Effect of a nutritional supplement on hair loss in women.
Le Floc'h C, Cheniti A, Connétable S, Piccardi N, Vincenzi C, Tosti A
J Cosmet Dermatol 2015 Mar;14(1):76-82. Epub 2015 Jan 8 doi: 10.1111/jocd.12127. PMID: 25573272
Alopecia--a challenge for dermatologists.
Brănişteanu DE, Voicu CM, Brănişteanu DC
Rev Med Chir Soc Med Nat Iasi 2014 Jan-Mar;118(1):11-8. PMID: 24741769
Primary cicatricial alopecias.
Otberg N
Dermatol Clin 2013 Jan;31(1):155-66. Epub 2012 Oct 26 doi: 10.1016/j.det.2012.08.016. PMID: 23159184

Diagnosis

Pressure alopecias: A review.
Corona-Rodarte E, Cano-Aguilar LE, Baldassarri-Ortego LF, Tosti A, Asz-Sigall D
J Am Acad Dermatol 2024 Jan;90(1):125-132. Epub 2023 Jul 14 doi: 10.1016/j.jaad.2023.07.009. PMID: 37454698
Treatment of Alopecia in Children.
Mishra P, Patil A, Sinclair R, Gold M, Rudnicka L, Grabbe S, Goldust M
J Drugs Dermatol 2022 Jan 1;21(1):49-53. doi: 10.36849/JDD.2022.6096. PMID: 35005859
Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
Trichoscopy: an update.
Torres F, Tosti A
G Ital Dermatol Venereol 2014 Feb;149(1):83-91. PMID: 24566568
Primary cicatricial alopecias.
Otberg N
Dermatol Clin 2013 Jan;31(1):155-66. Epub 2012 Oct 26 doi: 10.1016/j.det.2012.08.016. PMID: 23159184

Therapy

Alopecia Areata: Current Treatments and New Directions.
Dahabreh D, Jung S, Renert-Yuval Y, Bar J, Del Duca E, Guttman-Yassky E
Am J Clin Dermatol 2023 Nov;24(6):895-912. Epub 2023 Aug 22 doi: 10.1007/s40257-023-00808-1. PMID: 37606849
Female Androgenetic Alopecia: An Update on Diagnosis and Management.
Starace M, Orlando G, Alessandrini A, Piraccini BM
Am J Clin Dermatol 2020 Feb;21(1):69-84. doi: 10.1007/s40257-019-00479-x. PMID: 31677111
Alopecia areata: A multifactorial autoimmune condition.
Simakou T, Butcher JP, Reid S, Henriquez FL
J Autoimmun 2019 Mar;98:74-85. Epub 2018 Dec 15 doi: 10.1016/j.jaut.2018.12.001. PMID: 30558963
Effect of a nutritional supplement on hair loss in women.
Le Floc'h C, Cheniti A, Connétable S, Piccardi N, Vincenzi C, Tosti A
J Cosmet Dermatol 2015 Mar;14(1):76-82. Epub 2015 Jan 8 doi: 10.1111/jocd.12127. PMID: 25573272
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563

Prognosis

Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.
Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, Shapiro J
J Am Acad Dermatol 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141. PMID: 29241771
Androgenetic alopecia.
Piraccini BM, Alessandrini A
G Ital Dermatol Venereol 2014 Feb;149(1):15-24. PMID: 24566563
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial.
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarbá JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE
J Clin Oncol 2010 Feb 20;28(6):1061-8. Epub 2010 Jan 25 doi: 10.1200/JCO.2009.23.9764. PMID: 20100962
Delayed adolescence.
Prader A
Clin Endocrinol Metab 1975 Mar;4(1):143-55. doi: 10.1016/s0300-595x(75)80037-5. PMID: 166776

Clinical prediction guides

Investigating the morphology and genetics of scalp and facial hair characteristics for phenotype prediction.
Kataria S, Dabas P, Saraswathy KN, Sachdeva MP, Jain S
Sci Justice 2023 Jan;63(1):135-148. Epub 2022 Dec 15 doi: 10.1016/j.scijus.2022.12.002. PMID: 36631178
Hair-bearing human skin generated entirely from pluripotent stem cells.
Lee J, Rabbani CC, Gao H, Steinhart MR, Woodruff BM, Pflum ZE, Kim A, Heller S, Liu Y, Shipchandler TZ, Koehler KR
Nature 2020 Jun;582(7812):399-404. Epub 2020 Jun 3 doi: 10.1038/s41586-020-2352-3. PMID: 32494013Free PMC Article
Visually scoring hirsutism.
Yildiz BO, Bolour S, Woods K, Moore A, Azziz R
Hum Reprod Update 2010 Jan-Feb;16(1):51-64. doi: 10.1093/humupd/dmp024. PMID: 19567450Free PMC Article
Diagnosis of hair disorders.
Hillmann K, Blume-Peytavi U
Semin Cutan Med Surg 2009 Mar;28(1):33-8. doi: 10.1016/j.sder.2008.12.005. PMID: 19341940
Alopecia: histologic changes.
Bergfeld WF
Adv Dermatol 1989;4:301-20; discussion 321. PMID: 2701796

Recent systematic reviews

Frontal fibrosing alopecia and personal care product use: a systematic review and meta-analysis.
Kam O, Na S, Guo W, Tejeda CI, Kaufmann T
Arch Dermatol Res 2023 Oct;315(8):2313-2331. Epub 2023 Apr 4 doi: 10.1007/s00403-023-02604-7. PMID: 37014396
Reference values for skin microanatomy: A systematic review and meta-analysis of ex vivo studies.
Xu H, Fonseca M, Wolner Z, Chung E, Wu X, Geller S, Dusza SW, DeRosa AP, Marghoob AA, Busam KJ, Halpern AC, Marchetti MA
J Am Acad Dermatol 2017 Dec;77(6):1133-1144.e4. Epub 2017 Jul 14 doi: 10.1016/j.jaad.2017.06.009. PMID: 28716435Free PMC Article
Platinum-containing regimens for metastatic breast cancer.
Egger SJ, Willson ML, Morgan J, Walker HS, Carrick S, Ghersi D, Wilcken N
Cochrane Database Syst Rev 2017 Jun 23;6(6):CD003374. doi: 10.1002/14651858.CD003374.pub4. PMID: 28643430Free PMC Article
Uveal Melanoma Risk Factors: A Systematic Review of Meta-Analyses.
Nayman T, Bostan C, Logan P, Burnier MN Jr
Curr Eye Res 2017 Aug;42(8):1085-1093. Epub 2017 May 11 doi: 10.1080/02713683.2017.1297997. PMID: 28494168
Topical medication instillation techniques for glaucoma.
Xu L, Wang X, Wu M
Cochrane Database Syst Rev 2017 Feb 20;2(2):CD010520. doi: 10.1002/14651858.CD010520.pub2. PMID: 28218404Free PMC Article

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      OMIM records containing genes associated with phenotypes registered in MedGen
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