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Glioma susceptibility 7(GLM7)

MedGen UID:
416602
•Concept ID:
C2751638
•
Finding
Synonym: GLM7
 
Gene (location): CCDC26 (8q24.21)
 
Monarch Initiative: MONDO:0013096
OMIM®: 613032

Professional guidelines

PubMed

Hybrid [(18)F]-F-DOPA PET/MRI Interpretation Criteria and Scores for Glioma Follow-up After Radiotherapy.
Bertaux M, Berenbaum A, Di Stefano AL, Rozenblum L, Soret M, Bergeret S, Hoang-Xuan K, Tainturier LE, Sgard B, Habert MO, Delattre JY, Dehais C, Idbaih A, Pyatigorskaya N, Kas A
Clin Neuroradiol 2022 Sep;32(3):735-747. Epub 2022 Feb 11 doi: 10.1007/s00062-022-01139-0. PMID: 35147721
Genotype-based gene signature of glioma risk.
Huang YT, Zhang Y, Wu Z, Michaud DS
Neuro Oncol 2017 Jul 1;19(7):940-950. doi: 10.1093/neuonc/now288. PMID: 28339748Free PMC Article
Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas.
Lamszus K, Meyerhof W, Westphal M
J Neurooncol 1997 Dec;35(3):353-64. doi: 10.1023/a:1005893223090. PMID: 9440032

Recent clinical studies

Etiology

Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma.
Kurokawa R, Umemura Y, Capizzano A, Kurokawa M, Baba A, Holmes A, Kim J, Ota Y, Srinivasan A, Moritani T
J Neuroimaging 2022 May;32(3):511-520. Epub 2022 Jan 7 doi: 10.1111/jon.12962. PMID: 34997668
Comparison of Cancer Prevalence in Patients With Neurofibromatosis Type 1 at an Academic Cancer Center vs in the General Population From 1985 to 2020.
Landry JP, Schertz KL, Chiang YJ, Bhalla AD, Yi M, Keung EZ, Scally CP, Feig BW, Hunt KK, Roland CL, Guadagnolo A, Bishop AJ, Lazar AJ, Slopis JM, McCutcheon IE, Torres KE
JAMA Netw Open 2021 Mar 1;4(3):e210945. doi: 10.1001/jamanetworkopen.2021.0945. PMID: 33734413Free PMC Article
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Melin BS, Barnholtz-Sloan JS, Wrensch MR, Johansen C, Il'yasova D, Kinnersley B, Ostrom QT, Labreche K, Chen Y, Armstrong G, Liu Y, Eckel-Passow JE, Decker PA, Labussière M, Idbaih A, Hoang-Xuan K, Di Stefano AL, Mokhtari K, Delattre JY, Broderick P, Galan P, Gousias K, Schramm J, Schoemaker MJ, Fleming SJ, Herms S, Heilmann S, Nöthen MM, Wichmann HE, Schreiber S, Swerdlow A, Lathrop M, Simon M, Sanson M, Andersson U, Rajaraman P, Chanock S, Linet M, Wang Z, Yeager M; GliomaScan Consortium, Wiencke JK, Hansen H, McCoy L, Rice T, Kosel ML, Sicotte H, Amos CI, Bernstein JL, Davis F, Lachance D, Lau C, Merrell RT, Shildkraut J, Ali-Osman F, Sadetzki S, Scheurer M, Shete S, Lai RK, Claus EB, Olson SH, Jenkins RB, Houlston RS, Bondy ML
Nat Genet 2017 May;49(5):789-794. Epub 2017 Mar 27 doi: 10.1038/ng.3823. PMID: 28346443Free PMC Article
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Diagnosis

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Chen X, Liu J, Li Y, Zeng Y, Wang F, Cheng Z, Duan H, Pan G, Yang S, Chen Y, Li Q, Shen X, Li Y, Qin Z, Chen J, Huang Y, Wang X, Lu Y, Shu M, Zhang Y, Wang G, Li K, Lin X, Xing F, Zhang H
Nat Commun 2023 Oct 25;14(1):6781. doi: 10.1038/s41467-023-42545-3. PMID: 37880243Free PMC Article
Comparison of Cancer Prevalence in Patients With Neurofibromatosis Type 1 at an Academic Cancer Center vs in the General Population From 1985 to 2020.
Landry JP, Schertz KL, Chiang YJ, Bhalla AD, Yi M, Keung EZ, Scally CP, Feig BW, Hunt KK, Roland CL, Guadagnolo A, Bishop AJ, Lazar AJ, Slopis JM, McCutcheon IE, Torres KE
JAMA Netw Open 2021 Mar 1;4(3):e210945. doi: 10.1001/jamanetworkopen.2021.0945. PMID: 33734413Free PMC Article
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Discrimination between Glioma Grades II and III Using Dynamic Susceptibility Perfusion MRI: A Meta-Analysis.
Delgado AF, Delgado AF
AJNR Am J Neuroradiol 2017 Jul;38(7):1348-1355. Epub 2017 May 18 doi: 10.3174/ajnr.A5218. PMID: 28522666Free PMC Article
Radiation-induced moyamoya syndrome.
Desai SS, Paulino AC, Mai WY, Teh BS
Int J Radiat Oncol Biol Phys 2006 Jul 15;65(4):1222-7. Epub 2006 Apr 19 doi: 10.1016/j.ijrobp.2006.01.038. PMID: 16626890

Therapy

Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Discrimination between Glioma Grades II and III Using Dynamic Susceptibility Perfusion MRI: A Meta-Analysis.
Delgado AF, Delgado AF
AJNR Am J Neuroradiol 2017 Jul;38(7):1348-1355. Epub 2017 May 18 doi: 10.3174/ajnr.A5218. PMID: 28522666Free PMC Article
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Association between DNA repair gene polymorphisms and risk of glioma: a systematic review and meta-analysis.
Adel Fahmideh M, Schwartzbaum J, Frumento P, Feychting M
Neuro Oncol 2014 Jun;16(6):807-14. Epub 2014 Feb 4 doi: 10.1093/neuonc/nou003. PMID: 24500421Free PMC Article
Radiation-induced moyamoya syndrome.
Desai SS, Paulino AC, Mai WY, Teh BS
Int J Radiat Oncol Biol Phys 2006 Jul 15;65(4):1222-7. Epub 2006 Apr 19 doi: 10.1016/j.ijrobp.2006.01.038. PMID: 16626890

Prognosis

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Chen X, Liu J, Li Y, Zeng Y, Wang F, Cheng Z, Duan H, Pan G, Yang S, Chen Y, Li Q, Shen X, Li Y, Qin Z, Chen J, Huang Y, Wang X, Lu Y, Shu M, Zhang Y, Wang G, Li K, Lin X, Xing F, Zhang H
Nat Commun 2023 Oct 25;14(1):6781. doi: 10.1038/s41467-023-42545-3. PMID: 37880243Free PMC Article
Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma.
Kurokawa R, Umemura Y, Capizzano A, Kurokawa M, Baba A, Holmes A, Kim J, Ota Y, Srinivasan A, Moritani T
J Neuroimaging 2022 May;32(3):511-520. Epub 2022 Jan 7 doi: 10.1111/jon.12962. PMID: 34997668
Clinical feasibility of brain quantitative susceptibility mapping.
Zhang S, Liu Z, Nguyen TD, Yao Y, Gillen KM, Spincemaille P, Kovanlikaya I, Gupta A, Wang Y
Magn Reson Imaging 2019 Jul;60:44-51. Epub 2019 Apr 4 doi: 10.1016/j.mri.2019.04.003. PMID: 30954651Free PMC Article
Immunotherapy for Glioblastoma: Adoptive T-cell Strategies.
Choi BD, Maus MV, June CH, Sampson JH
Clin Cancer Res 2019 Apr 1;25(7):2042-2048. Epub 2018 Nov 16 doi: 10.1158/1078-0432.CCR-18-1625. PMID: 30446589Free PMC Article
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370

Clinical prediction guides

IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Chen X, Liu J, Li Y, Zeng Y, Wang F, Cheng Z, Duan H, Pan G, Yang S, Chen Y, Li Q, Shen X, Li Y, Qin Z, Chen J, Huang Y, Wang X, Lu Y, Shu M, Zhang Y, Wang G, Li K, Lin X, Xing F, Zhang H
Nat Commun 2023 Oct 25;14(1):6781. doi: 10.1038/s41467-023-42545-3. PMID: 37880243Free PMC Article
MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma.
Nazem A, Guiry SC, Pourfathi M, Ware JB, Anderson H, Iyer SK, Moon BF, Fan Y, Witschey WR, Rizi R, Bagley SJ, Desai A, O'Rourke DM, Brem S, Nasrallah M, Nabavizadeh A
J Neurooncol 2022 Feb;156(3):645-653. Epub 2022 Jan 19 doi: 10.1007/s11060-022-03947-3. PMID: 35043276
Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma.
Kurokawa R, Umemura Y, Capizzano A, Kurokawa M, Baba A, Holmes A, Kim J, Ota Y, Srinivasan A, Moritani T
J Neuroimaging 2022 May;32(3):511-520. Epub 2022 Jan 7 doi: 10.1111/jon.12962. PMID: 34997668
Comparison of Cancer Prevalence in Patients With Neurofibromatosis Type 1 at an Academic Cancer Center vs in the General Population From 1985 to 2020.
Landry JP, Schertz KL, Chiang YJ, Bhalla AD, Yi M, Keung EZ, Scally CP, Feig BW, Hunt KK, Roland CL, Guadagnolo A, Bishop AJ, Lazar AJ, Slopis JM, McCutcheon IE, Torres KE
JAMA Netw Open 2021 Mar 1;4(3):e210945. doi: 10.1001/jamanetworkopen.2021.0945. PMID: 33734413Free PMC Article
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Recent systematic reviews

Cerebral and tumoral blood flow in adult gliomas: a systematic review of results from magnetic resonance imaging.
Waqar M, Lewis D, Agushi E, Gittins M, Jackson A, Coope D
Br J Radiol 2021 Sep 1;94(1125):20201450. Epub 2021 Jun 9 doi: 10.1259/bjr.20201450. PMID: 34106749Free PMC Article
Cumulative evidence of relationships between multiple variants in 8q24 region and cancer incidence.
Tong Y, Tang Y, Li S, Zhao F, Ying J, Qu Y, Niu X, Mu D
Medicine (Baltimore) 2020 Jun 26;99(26):e20716. doi: 10.1097/MD.0000000000020716. PMID: 32590746Free PMC Article
Application of Ultrahigh Field Magnetic Resonance Imaging in the Treatment of Brain Tumors: A Meta-Analysis.
Barrett TF, Sarkiss CA, Dyvorne HA, Lee J, Balchandani P, Shrivastava RK
World Neurosurg 2016 Feb;86:450-65. Epub 2015 Sep 25 doi: 10.1016/j.wneu.2015.09.048. PMID: 26409071
Association between DNA repair gene polymorphisms and risk of glioma: a systematic review and meta-analysis.
Adel Fahmideh M, Schwartzbaum J, Frumento P, Feychting M
Neuro Oncol 2014 Jun;16(6):807-14. Epub 2014 Feb 4 doi: 10.1093/neuonc/nou003. PMID: 24500421Free PMC Article

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