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Esophageal cancer, alcohol-related, susceptibility to

MedGen UID:
460576
•Concept ID:
C3149226
•
Finding
Synonym: ESOPHAGEAL CANCER, ALCOHOL-RELATED, SUSCEPTIBILITY TO
 
OMIM®: 100650

Professional guidelines

PubMed

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.
Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K; BioBank Japan Project, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K
Sci Adv 2024 Jan 26;10(4):eade2780. doi: 10.1126/sciadv.ade2780. PMID: 38277453Free PMC Article
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
Yokoyama M, Yokoyama A, Yokoyama T, Hamana G, Funazu K, Kondo S, Yamashita T, Yoshimizu H, Nakamura H
Alcohol Clin Exp Res 2003 Sep;27(9):1395-401. doi: 10.1097/01.ALC.0000085589.47243.8D. PMID: 14506399

Recent clinical studies

Etiology

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.
Koyanagi YN, Nakatochi M, Namba S, Oze I, Charvat H, Narita A, Kawaguchi T, Ikezaki H, Hishida A, Hara M, Takezaki T, Koyama T, Nakamura Y, Suzuki S, Katsuura-Kamano S, Kuriki K, Nakamura Y, Takeuchi K, Hozawa A, Kinoshita K, Sutoh Y, Tanno K, Shimizu A, Ito H, Kasugai Y, Kawakatsu Y, Taniyama Y, Tajika M, Shimizu Y, Suzuki E, Hosono Y, Imoto I, Tabara Y, Takahashi M, Setoh K; BioBank Japan Project, Matsuda K, Nakano S, Goto A, Katagiri R, Yamaji T, Sawada N, Tsugane S, Wakai K, Yamamoto M, Sasaki M, Matsuda F, Okada Y, Iwasaki M, Brennan P, Matsuo K
Sci Adv 2024 Jan 26;10(4):eade2780. doi: 10.1126/sciadv.ade2780. PMID: 38277453Free PMC Article
Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.
Zhang B, Peng YH, Luo Y, Hong CQ, Lin YW, Zhang YL, Xu YW, Su XF, Wu FC
Cancer Med 2023 Oct;12(20):20437-20449. Epub 2023 Oct 5 doi: 10.1002/cam4.6610. PMID: 37795758Free PMC Article
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180
ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Chang JS, Hsiao JR, Chen CH
J Biomed Sci 2017 Mar 3;24(1):19. doi: 10.1186/s12929-017-0327-y. PMID: 28253921Free PMC Article
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.
Yokoyama A, Omori T
Jpn J Clin Oncol 2003 Mar;33(3):111-21. doi: 10.1093/jjco/hyg026. PMID: 12672787

Diagnosis

Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.
Yu C, Guo Y, Bian Z, Yang L, Millwood IY, Walters RG, Chen Y, Chen Y, Zhang X, Lei Y, Chen J, Chen Z, Lv J, Li L; China Kadoorie Biobank Collaborative Group
Int J Cancer 2018 Oct 1;143(7):1652-1661. Epub 2018 Jun 11 doi: 10.1002/ijc.31566. PMID: 29707772Free PMC Article
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
Yokoyama M, Yokoyama A, Yokoyama T, Hamana G, Funazu K, Kondo S, Yamashita T, Yoshimizu H, Nakamura H
Alcohol Clin Exp Res 2003 Sep;27(9):1395-401. doi: 10.1097/01.ALC.0000085589.47243.8D. PMID: 14506399
Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers.
Yokoyama A, Omori T
Jpn J Clin Oncol 2003 Mar;33(3):111-21. doi: 10.1093/jjco/hyg026. PMID: 12672787

Therapy

Impact of Alcohol-Induced Facial Flushing Phenotype on Alcohol Consumption Among Korean Adults: 2-Year Cross-Sectional Study.
Kang B, Kim C, Shin SH, Shin H, Cho Y
JMIR Public Health Surveill 2024 Jul 31;10:e49826. doi: 10.2196/49826. PMID: 38796304Free PMC Article
Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.
Zhang B, Peng YH, Luo Y, Hong CQ, Lin YW, Zhang YL, Xu YW, Su XF, Wu FC
Cancer Med 2023 Oct;12(20):20437-20449. Epub 2023 Oct 5 doi: 10.1002/cam4.6610. PMID: 37795758Free PMC Article
Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.
Yu C, Guo Y, Bian Z, Yang L, Millwood IY, Walters RG, Chen Y, Chen Y, Zhang X, Lei Y, Chen J, Chen Z, Lv J, Li L; China Kadoorie Biobank Collaborative Group
Int J Cancer 2018 Oct 1;143(7):1652-1661. Epub 2018 Jun 11 doi: 10.1002/ijc.31566. PMID: 29707772Free PMC Article
Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180
Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers.
Homann N, Stickel F, König IR, Jacobs A, Junghanns K, Benesova M, Schuppan D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz HK
Int J Cancer 2006 Apr 15;118(8):1998-2002. doi: 10.1002/ijc.21583. PMID: 16287084

Prognosis

Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study.
Yu C, Guo Y, Bian Z, Yang L, Millwood IY, Walters RG, Chen Y, Chen Y, Zhang X, Lei Y, Chen J, Chen Z, Lv J, Li L; China Kadoorie Biobank Collaborative Group
Int J Cancer 2018 Oct 1;143(7):1652-1661. Epub 2018 Jun 11 doi: 10.1002/ijc.31566. PMID: 29707772Free PMC Article
ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Chang JS, Hsiao JR, Chen CH
J Biomed Sci 2017 Mar 3;24(1):19. doi: 10.1186/s12929-017-0327-y. PMID: 28253921Free PMC Article
The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.
Park SL, Lee YC, Marron M, Agudo A, Ahrens W, Barzan L, Bencko V, Benhamou S, Bouchardy C, Canova C, Castellsague X, Conway DI, Healy CM, Holcátová I, Kjaerheim K, Lagiou P, Lowry RJ, Macfarlane TV, Macfarlane GJ, McCartan BE, McKinney PA, Merletti F, Pohlabeln H, Richiardi L, Simonato L, Sneddon L, Talamini R, Trichopoulos D, Znaor A, Brennan P, Hashibe M
Int J Cancer 2011 Mar 15;128(6):1449-61. doi: 10.1002/ijc.25468. PMID: 20506380Free PMC Article
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.
Yokoyama A, Muramatsu T, Omori T, Matsushita S, Yoshimizu H, Higuchi S, Yokoyama T, Maruyama K, Ishii H
Alcohol Clin Exp Res 1999 Nov;23(11):1705-10. PMID: 10591585

Clinical prediction guides

The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.
Park SL, Lee YC, Marron M, Agudo A, Ahrens W, Barzan L, Bencko V, Benhamou S, Bouchardy C, Canova C, Castellsague X, Conway DI, Healy CM, Holcátová I, Kjaerheim K, Lagiou P, Lowry RJ, Macfarlane TV, Macfarlane GJ, McCartan BE, McKinney PA, Merletti F, Pohlabeln H, Richiardi L, Simonato L, Sneddon L, Talamini R, Trichopoulos D, Znaor A, Brennan P, Hashibe M
Int J Cancer 2011 Mar 15;128(6):1449-61. doi: 10.1002/ijc.25468. PMID: 20506380Free PMC Article
Identification of new single nucleotid polymorphisms (SNP) in alcohol dehydrogenase class IV ADH7 gene within a French population.
Abbas A, Lechevrel M, Sichel F
Arch Toxicol 2006 Apr;80(4):201-5. doi: 10.1007/s00204-005-0031-7. PMID: 16180008
Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
Yokoyama M, Yokoyama A, Yokoyama T, Hamana G, Funazu K, Kondo S, Yamashita T, Yoshimizu H, Nakamura H
Alcohol Clin Exp Res 2003 Sep;27(9):1395-401. doi: 10.1097/01.ALC.0000085589.47243.8D. PMID: 14506399
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics.
Yokoyama A, Muramatsu T, Omori T, Matsushita S, Yoshimizu H, Higuchi S, Yokoyama T, Maruyama K, Ishii H
Alcohol Clin Exp Res 1999 Nov;23(11):1705-10. PMID: 10591585

Recent systematic reviews

Alcohol metabolism and oesophageal cancer: a systematic review of the evidence.
Matejcic M, Gunter MJ, Ferrari P
Carcinogenesis 2017 Sep 1;38(9):859-872. doi: 10.1093/carcin/bgx067. PMID: 28645180

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