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Keloid formation(KLDF)

MedGen UID:
460844
Concept ID:
C3149494
Finding
Synonyms: KELOID FORMATION; KLDF
 
Monarch Initiative: MONDO:0007847
OMIM®: 148100

Definition

Keloid is a dermal fibroproliferative growth caused by pathologic wound healing following skin injury. Keloid is defined as a scar growing continuously and invasively beyond the confines of the original wound and is characterized by excessive fibroblast proliferation and deposition of extracellular matrix and collagen fibers. Local tissue factors, especially wound tension or infection, and endocrine factors are known to be involved in keloid formation. However, the fact that the incidence of keloid is higher in darker-skinned individuals suggests that genetic factors also play an important role (summary by Nakashima et al., 2010). [from OMIM]

Clinical features

From HPO
Keloid
MedGen UID:
7197
Concept ID:
C0022548
Acquired Abnormality
An irregularly shaped, elevated mark on the skin caused by deposits of excessive amounts of collagen during wound healing. It extends beyond the original boundaries of the wound and may enlarge progressively.
  • Abnormality of the musculoskeletal system

Professional guidelines

PubMed

Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J
Matrix Biol 2016 Apr;51:37-46. Epub 2016 Feb 2 doi: 10.1016/j.matbio.2016.01.013. PMID: 26844756Free PMC Article
Sidle DM, Kim H
Facial Plast Surg Clin North Am 2011 Aug;19(3):505-15. doi: 10.1016/j.fsc.2011.06.005. PMID: 21856538
Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG
Mol Med 2011 Jan-Feb;17(1-2):113-25. Epub 2010 Oct 5 doi: 10.2119/molmed.2009.00153. PMID: 20927486Free PMC Article

Recent clinical studies

Etiology

Cohen AJ, Nikbakht N, Uitto J
Cold Spring Harb Perspect Biol 2023 Jul 5;15(7) doi: 10.1101/cshperspect.a041245. PMID: 36411063Free PMC Article
Xu H, Zhu Z, Hu J, Sun J, Wo Y, Wang X, Zou H, Li B, Zhang Y
Cell Mol Immunol 2022 Apr;19(4):527-539. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00834-1. PMID: 35039632Free PMC Article
Macarak EJ, Wermuth PJ, Rosenbloom J, Uitto J
Exp Dermatol 2021 Jan;30(1):132-145. Epub 2020 Dec 20 doi: 10.1111/exd.14243. PMID: 33211348
Wang MZ, Warshaw EM
Dermatitis 2012 Nov-Dec;23(6):281-3. doi: 10.1097/DER.0b013e318273a4dd. PMID: 23169210
Viera MH, Caperton CV, Berman B
J Drugs Dermatol 2011 May;10(5):468-80. PMID: 21533292

Diagnosis

Li Z, Zhang C, Zhang Q, Dong Y, Sha X, Jiang M, Yan J, Wang W, Li H, Zhang Y, Zhou YL
Eur J Med Res 2023 Nov 2;28(1):476. doi: 10.1186/s40001-023-01421-y. PMID: 37915086Free PMC Article
Hermenean A, Oatis D, Herman H, Ciceu A, D'Amico G, Trotta MC
Int J Mol Sci 2022 May 16;23(10) doi: 10.3390/ijms23105548. PMID: 35628357Free PMC Article
Xu H, Zhu Z, Hu J, Sun J, Wo Y, Wang X, Zou H, Li B, Zhang Y
Cell Mol Immunol 2022 Apr;19(4):527-539. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00834-1. PMID: 35039632Free PMC Article
Huang C, Ogawa R
FASEB J 2020 Oct;34(10):13171-13184. Epub 2020 Aug 28 doi: 10.1096/fj.202001157R. PMID: 32856341
He Y, Deng Z, Alghamdi M, Lu L, Fear MW, He L
Cell Prolif 2017 Apr;50(2) Epub 2017 Jan 5 doi: 10.1111/cpr.12326. PMID: 28054407Free PMC Article

Therapy

Hedayatyanfard K, Haddadi NS, Ziai SA, Karim H, Niazi F, Steckelings UM, Habibi B, Modarressi A, Dehpour AR
Exp Dermatol 2020 Sep;29(9):902-909. Epub 2020 Aug 5 doi: 10.1111/exd.14154. PMID: 32678966
Grabowski G, Pacana MJ, Chen E
J Am Acad Orthop Surg 2020 May 15;28(10):e408-e414. doi: 10.5435/JAAOS-D-19-00690. PMID: 32109921
Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J
Matrix Biol 2016 Apr;51:37-46. Epub 2016 Feb 2 doi: 10.1016/j.matbio.2016.01.013. PMID: 26844756Free PMC Article
Wang MZ, Warshaw EM
Dermatitis 2012 Nov-Dec;23(6):281-3. doi: 10.1097/DER.0b013e318273a4dd. PMID: 23169210
Al-Attar A, Mess S, Thomassen JM, Kauffman CL, Davison SP
Plast Reconstr Surg 2006 Jan;117(1):286-300. doi: 10.1097/01.prs.0000195073.73580.46. PMID: 16404281

Prognosis

Liu S, Yang H, Song J, Zhang Y, Abualhssain ATH, Yang B
Exp Dermatol 2022 Nov;31(11):1665-1675. Epub 2022 Sep 11 doi: 10.1111/exd.14671. PMID: 36052657
Hermenean A, Oatis D, Herman H, Ciceu A, D'Amico G, Trotta MC
Int J Mol Sci 2022 May 16;23(10) doi: 10.3390/ijms23105548. PMID: 35628357Free PMC Article
Xu H, Zhu Z, Hu J, Sun J, Wo Y, Wang X, Zou H, Li B, Zhang Y
Cell Mol Immunol 2022 Apr;19(4):527-539. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00834-1. PMID: 35039632Free PMC Article
He Y, Deng Z, Alghamdi M, Lu L, Fear MW, He L
Cell Prolif 2017 Apr;50(2) Epub 2017 Jan 5 doi: 10.1111/cpr.12326. PMID: 28054407Free PMC Article
Viera MH, Caperton CV, Berman B
J Drugs Dermatol 2011 May;10(5):468-80. PMID: 21533292

Clinical prediction guides

Li Z, Zhang C, Zhang Q, Dong Y, Sha X, Jiang M, Yan J, Wang W, Li H, Zhang Y, Zhou YL
Eur J Med Res 2023 Nov 2;28(1):476. doi: 10.1186/s40001-023-01421-y. PMID: 37915086Free PMC Article
Hahn JM, Combs KA, Powell HM, Supp DM
Wound Repair Regen 2023 Sep-Oct;31(5):563-575. Epub 2023 Jul 27 doi: 10.1111/wrr.13109. PMID: 37458255
Santiago S, Brown R, Shao K, Hooper J, Perez M
J Drugs Dermatol 2023 Jul 1;22(7):641-646. doi: 10.36849/JDD.6859. PMID: 37410041
Serror K, Ferrero L, Boismal F, Sintes M, Thery M, Vianay B, Henry E, Gentien D, DE LA Grange P, Boccara D, Mimoun M, Bouaziz JD, Benssussan A, Michel L
Exp Dermatol 2023 Jul;32(7):1096-1107. Epub 2023 May 6 doi: 10.1111/exd.14817. PMID: 37148203
Xu H, Zhu Z, Hu J, Sun J, Wo Y, Wang X, Zou H, Li B, Zhang Y
Cell Mol Immunol 2022 Apr;19(4):527-539. Epub 2022 Jan 17 doi: 10.1038/s41423-021-00834-1. PMID: 35039632Free PMC Article

Recent systematic reviews

Garg SP, Williams T, Taritsa IC, Wan R, Goel C, Harris R, Huffman K, Galiano RD
Wound Repair Regen 2023 Nov-Dec;31(6):731-737. Epub 2023 Oct 15 doi: 10.1111/wrr.13120. PMID: 37768279
Anderson L, Vankawala J, Gupta N, Dorfman R, Pflibsen L, Vardanian A, Delong M
Aesthet Surg J 2023 Jul 15;43(8):820-829. doi: 10.1093/asj/sjad034. PMID: 36797842
Mirza FN, Mirza HN, Khatri KA
Dermatol Ther 2020 Nov;33(6):e14022. Epub 2020 Aug 14 doi: 10.1111/dth.14022. PMID: 32677092
Shin JY, Lee JW, Roh SG, Lee NH, Yang KM
Plast Reconstr Surg 2016 Jun;137(6):1718-1725. doi: 10.1097/PRS.0000000000002165. PMID: 27219228
Shin JY, Kim JS
J Oral Maxillofac Surg 2016 May;74(5):1055-60. Epub 2015 Oct 22 doi: 10.1016/j.joms.2015.10.002. PMID: 26529198

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