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Hemorrhage, intracerebral, susceptibility to(ICH)

MedGen UID:
482735
•Concept ID:
C3281105
•
Finding
Synonyms: ICH; Stroke, hemorrhagic, susceptibility to
 
Genes (locations): ACE (17q23.3); COL4A1 (13q34); COL4A2 (13q34)
 
Monarch Initiative: MONDO:0100533
OMIM®: 614519

Definition

An inherited susceptibility or predisposition to developing intracerebral hemorrhage. [from MONDO]

Professional guidelines

PubMed

Risk and Management of Intracerebral Hemorrhage in Patients with Bleeding Disorders.
Dorgalaleh A, Farshi Y, Haeri K, Ghanbari OB, Ahmadi A
Semin Thromb Hemost 2022 Apr;48(3):344-355. Epub 2022 Jan 6 doi: 10.1055/s-0041-1740566. PMID: 34991167
Management of intracerebral hemorrhage.
Thabet AM, Kottapally M, Hemphill JC 3rd
Handb Clin Neurol 2017;140:177-194. doi: 10.1016/B978-0-444-63600-3.00011-8. PMID: 28187799
The clinical utility of QSM: disease diagnosis, medical management, and surgical planning.
Eskreis-Winkler S, Zhang Y, Zhang J, Liu Z, Dimov A, Gupta A, Wang Y
NMR Biomed 2017 Apr;30(4) Epub 2016 Dec 1 doi: 10.1002/nbm.3668. PMID: 27906525

Recent clinical studies

Etiology

Genetic Polymorphisms Associated with Spontaneous Intracerebral Hemorrhage.
Chen YC, Chang KH, Chen CM
Int J Mol Sci 2018 Dec 4;19(12) doi: 10.3390/ijms19123879. PMID: 30518145Free PMC Article
Genetics of Spontaneous Intracerebral Hemorrhage.
Falcone GJ, Woo D
Stroke 2017 Dec;48(12):3420-3424. Epub 2017 Nov 7 doi: 10.1161/STROKEAHA.117.017072. PMID: 29114093Free PMC Article
Uncommon Causes of Cerebral Microbleeds.
Noorbakhsh-Sabet N, Pulakanti VC, Zand R
J Stroke Cerebrovasc Dis 2017 Oct;26(10):2043-2049. Epub 2017 Aug 18 doi: 10.1016/j.jstrokecerebrovasdis.2017.07.012. PMID: 28826581
Genetics of intracerebral hemorrhage: Insights from candidate gene approaches.
Liu B, Zhang L, Yang Q
Neurol India 2012 Jan-Feb;60(1):3-8. doi: 10.4103/0028-3886.93581. PMID: 22406772
Stroke genetics update.
Alberts MJ
Stroke 2003 Feb;34(2):342-4. doi: 10.1161/01.str.0000054263.67434.be. PMID: 12574530

Diagnosis

Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA.
Jensen PN, Rashid T, Ware JB, Cui Y, Sitlani CM, Austin TR, Longstreth WT Jr, Bertoni AG, Mamourian E, Bryan RN, Nasrallah IM, Habes M, Heckbert SR
Alzheimers Dement 2023 Sep;19(9):4139-4149. Epub 2023 Jun 8 doi: 10.1002/alz.13346. PMID: 37289978Free PMC Article
Cerebral Amyloid Angiopathy.
Szidonya L, Nickerson JP
Radiol Clin North Am 2023 May;61(3):551-562. Epub 2023 Feb 20 doi: 10.1016/j.rcl.2023.01.009. PMID: 36931769
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Uncommon Causes of Cerebral Microbleeds.
Noorbakhsh-Sabet N, Pulakanti VC, Zand R
J Stroke Cerebrovasc Dis 2017 Oct;26(10):2043-2049. Epub 2017 Aug 18 doi: 10.1016/j.jstrokecerebrovasdis.2017.07.012. PMID: 28826581
Imaging of Cerebral Microbleeds.
Linn J
Clin Neuroradiol 2015 Oct;25 Suppl 2:167-75. Epub 2015 Sep 4 doi: 10.1007/s00062-015-0458-z. PMID: 26337706

Therapy

Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease.
Mehta RI, Carpenter JS, Mehta RI, Haut MW, Wang P, Ranjan M, Najib U, D'Haese PF, Rezai AR
Fluids Barriers CNS 2023 Jun 16;20(1):46. doi: 10.1186/s12987-023-00447-y. PMID: 37328855Free PMC Article
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Cerebral Autoregulation in Sick Infants: Current Insights.
Kooi EMW, Richter AE
Clin Perinatol 2020 Sep;47(3):449-467. Epub 2020 May 14 doi: 10.1016/j.clp.2020.05.003. PMID: 32713444
Smoking and stroke: A mendelian randomization study.
Larsson SC, Burgess S, Michaëlsson K
Ann Neurol 2019 Sep;86(3):468-471. Epub 2019 Jul 3 doi: 10.1002/ana.25534. PMID: 31237718Free PMC Article

Prognosis

Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms.
Xu Z, Rui YN, Hagan JP, Kim DH
Neuromolecular Med 2019 Dec;21(4):325-343. Epub 2019 May 4 doi: 10.1007/s12017-019-08537-7. PMID: 31055715Free PMC Article
Uncommon Causes of Cerebral Microbleeds.
Noorbakhsh-Sabet N, Pulakanti VC, Zand R
J Stroke Cerebrovasc Dis 2017 Oct;26(10):2043-2049. Epub 2017 Aug 18 doi: 10.1016/j.jstrokecerebrovasdis.2017.07.012. PMID: 28826581
Cerebral microbleeds, cognitive impairment, and MRI in patients with diabetes mellitus.
Zhou H, Yang J, Xie P, Dong Y, You Y, Liu J
Clin Chim Acta 2017 Jul;470:14-19. Epub 2017 Apr 24 doi: 10.1016/j.cca.2017.04.019. PMID: 28450131

Clinical prediction guides

Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease.
Mehta RI, Carpenter JS, Mehta RI, Haut MW, Wang P, Ranjan M, Najib U, D'Haese PF, Rezai AR
Fluids Barriers CNS 2023 Jun 16;20(1):46. doi: 10.1186/s12987-023-00447-y. PMID: 37328855Free PMC Article
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study.
Yuan S, Carter P, Mason AM, Burgess S, Larsson SC
Nutrients 2021 Jun 28;13(7) doi: 10.3390/nu13072218. PMID: 34203356Free PMC Article
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
Stroke 2021 Mar;52(3):931-936. Epub 2021 Feb 4 doi: 10.1161/STROKEAHA.120.031710. PMID: 33535786Free PMC Article
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology 2021 Mar 30;96(13):e1732-e1742. Epub 2021 Jan 25 doi: 10.1212/WNL.0000000000011555. PMID: 33495378Free PMC Article
Cerebral microbleeds, cognitive impairment, and MRI in patients with diabetes mellitus.
Zhou H, Yang J, Xie P, Dong Y, You Y, Liu J
Clin Chim Acta 2017 Jul;470:14-19. Epub 2017 Apr 24 doi: 10.1016/j.cca.2017.04.019. PMID: 28450131

Recent systematic reviews

A systematic review on intracranial aneurysm and hemorrhage detection using machine learning and deep learning techniques.
Nafees Ahmed S, Prakasam P
Prog Biophys Mol Biol 2023 Oct;183:1-16. Epub 2023 Jul 25 doi: 10.1016/j.pbiomolbio.2023.07.001. PMID: 37499766
Neuroimaging features of FOXR2-activated CNS neuroblastoma: A case series and systematic review.
Shimazaki K, Kurokawa R, Franson A, Kurokawa M, Baba A, Bou-Maroun L, Kim J, Moritani T
J Neuroimaging 2023 May-Jun;33(3):359-367. Epub 2023 Feb 20 doi: 10.1111/jon.13095. PMID: 36806312
Systematic Review on Apolipoprotein E: A Strong Genetic Cause of Hemorrhagic Stroke.
Talha KA, Selina F, Nasir M, Kausar A, Islam T, Perveen RA
Mymensingh Med J 2020 Oct;29(4):1026-1032. PMID: 33116113
Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.
Wahab KW, Tiwari HK, Ovbiagele B, Sarfo F, Akinyemi R, Traylor M, Rotimi C, Markus HS, Owolabi M
J Neurol Sci 2019 Dec 15;407:116526. Epub 2019 Oct 13 doi: 10.1016/j.jns.2019.116526. PMID: 31669726Free PMC Article
Genetic susceptibility to cerebrovascular disease: A systematic review.
Griessenauer CJ, Farrell S, Sarkar A, Zand R, Abedi V, Holland N, Michael A, Cummings CL, Metpally R, Carey DJ, Goren O, Martin N, Hendrix P, Schirmer CM
J Cereb Blood Flow Metab 2018 Nov;38(11):1853-1871. Epub 2018 Sep 5 doi: 10.1177/0271678X18797958. PMID: 30182779Free PMC Article

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